Pentoxifylline_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM20C family with sequence similarity 20, member C 0.0912566
SDK1 sidekick cell adhesion molecule 1 0.0844436
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0585823
MTSS1 metastasis suppressor 1 0.0558956
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0541731
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0528023
HMGA2 high mobility group AT-hook 2 0.0527279
CDH13 cadherin 13 0.0483583
FN1 fibronectin 1 0.0468243
FTH1 ferritin, heavy polypeptide 1 0.0421632
TFPI2 tissue factor pathway inhibitor 2 0.0383895
TPT1 tumor protein, translationally-controlled 1 0.0361084
TIMP1 TIMP metallopeptidase inhibitor 1 0.0354743
RPL35A ribosomal protein L35a 0.0347605
AKAP12 A kinase (PRKA) anchor protein 12 0.0343829
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0343207
IFI6 interferon, alpha-inducible protein 6 0.0341325
SEPTIN9 septin 9 0.0338218
STC1 stanniocalcin 1 0.0337581
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0323554
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0312678
CUX1 cut-like homeobox 1 0.0275409
MLPH melanophilin 0.027392
NPC1 Niemann-Pick disease, type C1 0.026556
COL7A1 collagen, type VII, alpha 1 0.025275
HLA-B major histocompatibility complex, class I, B 0.0250073
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0248532
PRRX1 paired related homeobox 1 0.0247586
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0243726
ENO2 enolase 2 (gamma, neuronal) 0.0242502
IGFBP3 insulin-like growth factor binding protein 3 0.0238057
DOCK5 dedicator of cytokinesis 5 0.0227789
DNER delta/notch-like EGF repeat containing 0.0227246
NAV1 neuron navigator 1 0.022638
NAV2 neuron navigator 2 0.0223449
IFITM3 interferon induced transmembrane protein 3 0.0222958
NRP1 neuropilin 1 0.0222714
IL1B interleukin 1, beta 0.0222317
ANXA10 annexin A10 0.0221722
ARL4C ADP-ribosylation factor-like 4C 0.0216051
RPL31 ribosomal protein L31 0.0214832
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0213953
EXT1 exostosin glycosyltransferase 1 0.0212293
CLMP CXADR-like membrane protein 0.0209967
TMSB10 thymosin beta 10 0.0209928
HDAC4 histone deacetylase 4 0.0209446
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0208397
NHSL1 NHS-like 1 0.0208394
PTPRF protein tyrosine phosphatase, receptor type, F 0.020601
ANTXR2 anthrax toxin receptor 2 0.020145
NRG1 neuregulin 1 0.0198338
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.019705
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0191693
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0190562
SLFN5 schlafen family member 5 0.0189996
TRIOBP TRIO and F-actin binding protein 0.0188526
THBD thrombomodulin 0.0187108
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0186297
AHNAK AHNAK nucleoprotein 0.0181918
HIP1 huntingtin interacting protein 1 0.0180874
SOX4 SRY (sex determining region Y)-box 4 0.0178943
PYGL phosphorylase, glycogen, liver 0.0178712
HLA-A major histocompatibility complex, class I, A 0.0177672
EFCAB13 EF-hand calcium binding domain 13 0.017759
NCOR2 nuclear receptor corepressor 2 0.0177273
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0173537
IFIH1 interferon induced with helicase C domain 1 0.0171949
IGF1R insulin-like growth factor 1 receptor 0.0170728
LOXL2 lysyl oxidase-like 2 0.0169078
IFI44L interferon-induced protein 44-like 0.0168251
COL27A1 collagen, type XXVII, alpha 1 0.0166324
IFITM1 interferon induced transmembrane protein 1 0.0166291
SHISA5 shisa family member 5 0.0166148
MAML3 mastermind-like 3 (Drosophila) 0.0165691
OXR1 oxidation resistance 1 0.0162049
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0162043
PODXL podocalyxin-like 0.0161871
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0160148
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0157863
LAMB3 laminin, beta 3 0.0157226
ZNF804A zinc finger protein 804A 0.015671
PRELID2 PRELI domain containing 2 0.0156389
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0154152
INTS6 integrator complex subunit 6 0.0151574
TMEM165 transmembrane protein 165 0.015117
SEPTIN10 septin 10 0.0150899
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0150565
TBC1D22A TBC1 domain family, member 22A 0.0149315
GLCCI1 glucocorticoid induced 1 0.0149007
GYS1 glycogen synthase 1 (muscle) 0.0148534
ZBTB7A zinc finger and BTB domain containing 7A 0.0147859
NPAS2 neuronal PAS domain protein 2 0.0142934
BTG1 B-cell translocation gene 1, anti-proliferative 0.0142924
RPL38 ribosomal protein L38 0.0142283
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0141383
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0141201
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.0141174
BMERB1 bMERB domain containing 1 0.014061
RPL37A ribosomal protein L37a 0.0139782
CDCP1 CUB domain containing protein 1 0.01397

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.122494
GOLGA4 golgin A4 -0.120615
PCBP2 poly(rC) binding protein 2 -0.11238
NAMPT nicotinamide phosphoribosyltransferase -0.112076
RICTOR RPTOR independent companion of MTOR, complex 2 -0.107369
KDM2A lysine (K)-specific demethylase 2A -0.0906188
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0875465
ELL2 elongation factor, RNA polymerase II, 2 -0.0801559
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0750472
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0725173
CD44 CD44 molecule (Indian blood group) -0.0685194
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0657259
FTL ferritin, light polypeptide -0.0626573
FNDC3B fibronectin type III domain containing 3B -0.0613483
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0596938
SPAG9 sperm associated antigen 9 -0.0587906
RAB1A RAB1A, member RAS oncogene family -0.0587721
BASP1 brain abundant, membrane attached signal protein 1 -0.0586936
RBM39 RNA binding motif protein 39 -0.0584122
KDM3A lysine (K)-specific demethylase 3A -0.0566799
SOD2 superoxide dismutase 2, mitochondrial -0.0566002
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0541195
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0529603
PARD3 par-3 family cell polarity regulator -0.0512729
RIOK3 RIO kinase 3 -0.051191
USP3 ubiquitin specific peptidase 3 -0.0511484
FAM13A family with sequence similarity 13, member A -0.0504418
WAC WW domain containing adaptor with coiled-coil -0.0504318
COPA coatomer protein complex, subunit alpha -0.0497637
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0492427
ANKRD28 ankyrin repeat domain 28 -0.0489904
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0486775
ZNF292 zinc finger protein 292 -0.0483377
GRB10 growth factor receptor-bound protein 10 -0.0483193
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0473191
PDIA3 protein disulfide isomerase family A, member 3 -0.0470956
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0465799
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0448593
HELZ helicase with zinc finger -0.0439808
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0432514
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0428271
SBF2 SET binding factor 2 -0.0427328
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0427193
KMT2C lysine (K)-specific methyltransferase 2C -0.0422749
MBNL1 muscleblind-like splicing regulator 1 -0.0410681
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0407519
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0404217
RLF rearranged L-myc fusion -0.0404147
SYAP1 synapse associated protein 1 -0.0403619
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0402197
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0394131
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0388774
EXOC6B exocyst complex component 6B -0.0378229
DDIT3 DNA-damage-inducible transcript 3 -0.0377474
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0372388
CSDE1 cold shock domain containing E1, RNA-binding -0.0370695
MARCHF6 membrane associated ring-CH-type finger 6 -0.0370668
LMAN1 lectin, mannose-binding, 1 -0.0368175
ANXA1 annexin A1 -0.0367621
ATP13A3 ATPase type 13A3 -0.036438
YBX1 Y box binding protein 1 -0.0360249
SRP54 signal recognition particle 54kDa -0.0359297
COG5 component of oligomeric golgi complex 5 -0.0353865
YME1L1 YME1-like 1 ATPase -0.0353568
NIPBL Nipped-B homolog (Drosophila) -0.034561
ZFAND3 zinc finger, AN1-type domain 3 -0.0342743
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0342591
ANXA2 annexin A2 -0.0342232
SEC24A SEC24 family member A -0.0341775
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0337443
RB1CC1 RB1-inducible coiled-coil 1 -0.033569
ITCH itchy E3 ubiquitin protein ligase -0.0334577
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0331747
MED13L mediator complex subunit 13-like -0.0329292
CD109 CD109 molecule -0.0328643
RNF145 ring finger protein 145 -0.0327236
NCOA7 nuclear receptor coactivator 7 -0.0321824
FOXO3 forkhead box O3 -0.0319783
GARS1 glycyl-tRNA synthetase 1 -0.031458
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0312371
EZR ezrin -0.0308199
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0307977
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0307657
BHLHE40 basic helix-loop-helix family, member e40 -0.0304318
YBX3 Y box binding protein 3 -0.0303402
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.030103
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0300734
RNF24 ring finger protein 24 -0.029929
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.029693
KMT2E lysine (K)-specific methyltransferase 2E -0.0296523
SLC38A1 solute carrier family 38, member 1 -0.0294687
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0294394
BLZF1 basic leucine zipper nuclear factor 1 -0.0293069
SEC31A SEC31 homolog A (S. cerevisiae) -0.0290109
STRN3 striatin, calmodulin binding protein 3 -0.0289971
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0289903
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0288256
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0287648
QKI QKI, KH domain containing, RNA binding -0.0287152
KCMF1 potassium channel modulatory factor 1 -0.0285736