Pentoxifylline_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 0.106004
YBX3 Y box binding protein 3 0.0777395
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0633164
RPS2 ribosomal protein S2 0.0529114
HSPA8 heat shock 70kDa protein 8 0.0489103
RPS8 ribosomal protein S8 0.0487416
RPL37A ribosomal protein L37a 0.0469091
RPS29 ribosomal protein S29 0.0462174
RPS12 ribosomal protein S12 0.0435695
MCL1 myeloid cell leukemia 1 0.0427271
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0417803
RPL38 ribosomal protein L38 0.0396455
IFI6 interferon, alpha-inducible protein 6 0.0390161
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0389796
RPL37 ribosomal protein L37 0.0377232
RPLP1 ribosomal protein, large, P1 0.0371448
HLA-B major histocompatibility complex, class I, B 0.0371297
RPL31 ribosomal protein L31 0.0330866
RPL9 ribosomal protein L9 0.0329762
RPS27 ribosomal protein S27 0.0323356
ELL2 elongation factor, RNA polymerase II, 2 0.0315263
RPS19 ribosomal protein S19 0.0311405
RRM2 ribonucleotide reductase M2 0.0309522
TM4SF1 transmembrane 4 L six family member 1 0.0304269
RPS17 ribosomal protein S17 0.0294925
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0294559
TPT1 tumor protein, translationally-controlled 1 0.0294332
RTN4 reticulon 4 0.0286112
RPLP2 ribosomal protein, large, P2 0.0279931
RPS10 ribosomal protein S10 0.0269309
RPL35A ribosomal protein L35a 0.0267884
RPL36 ribosomal protein L36 0.0264216
RPS21 ribosomal protein S21 0.0249199
RPL12 ribosomal protein L12 0.0244524
EEF1G eukaryotic translation elongation factor 1 gamma 0.0244288
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0241528
RPL26 ribosomal protein L26 0.0239797
TUBB4B tubulin, beta 4B class IVb 0.023846
ZSWIM6 zinc finger, SWIM-type containing 6 0.0237995
TMSB10 thymosin beta 10 0.0228023
GRAMD1B GRAM domain containing 1B 0.0225949
RPL27 ribosomal protein L27 0.0221698
MKI67 marker of proliferation Ki-67 0.0220047
ERRFI1 ERBB receptor feedback inhibitor 1 0.0219953
LOC112694756 uncharaterized LOC112694756 0.0218978
RACK1 receptor for activated C kinase 1 0.0215903
RPS6 ribosomal protein S6 0.0213423
TMEM41B transmembrane protein 41B 0.0211664
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0205938
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0204262
CTTNBP2NL CTTNBP2 N-terminal like 0.0202554
LUZP1 leucine zipper protein 1 0.0202188
FHL2 four and a half LIM domains 2 0.0202105
WNK1 WNK lysine deficient protein kinase 1 0.0201451
ATP5F1E ATP synthase F1 subunit epsilon 0.0200559
MYL12B myosin, light chain 12B, regulatory 0.0200466
RPS15 ribosomal protein S15 0.020008
CAMTA1 calmodulin binding transcription activator 1 0.0197892
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0193661
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0193226
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0193179
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0190196
RPL4 ribosomal protein L4 0.0183683
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0182262
MARCHF4 membrane associated ring-CH-type finger 4 0.0181372
AXL AXL receptor tyrosine kinase 0.0180134
RPL34 ribosomal protein L34 0.0177216
PRRC2A proline-rich coiled-coil 2A 0.0175122
RPL23 ribosomal protein L23 0.017404
DOCK5 dedicator of cytokinesis 5 0.017261
RPS3 ribosomal protein S3 0.0171028
MYPN myopalladin 0.017085
FTH1 ferritin, heavy polypeptide 1 0.0170546
RPL35 ribosomal protein L35 0.0170461
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0169438
MAGEA4 melanoma antigen family A4 0.0167646
DENR density-regulated protein 0.0166507
SNAP25 synaptosomal-associated protein, 25kDa 0.0164793
RPL11 ribosomal protein L11 0.0164702
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0164351
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0163806
RPS14 ribosomal protein S14 0.0162462
RPS13 ribosomal protein S13 0.0158871
PPME1 protein phosphatase methylesterase 1 0.0158191
ADRM1 adhesion regulating molecule 1 0.0157665
HLA-A major histocompatibility complex, class I, A 0.0155927
RPS23 ribosomal protein S23 0.0155472
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0155281
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0154956
KLF7 Kruppel-like factor 7 (ubiquitous) 0.015442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.01526
DNMBP dynamin binding protein 0.0151945
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0151378
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0150625
RPS27A ribosomal protein S27a 0.0149413
MYH9 myosin, heavy chain 9, non-muscle 0.0148666
VCL vinculin 0.0148346
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0147503
HSPE1 heat shock 10kDa protein 1 0.0146057
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.0144855

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.115522
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.115086
ZCCHC7 zinc finger, CCHC domain containing 7 -0.114837
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.101577
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0939785
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0819155
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0810803
COPA coatomer protein complex, subunit alpha -0.0798198
CSDE1 cold shock domain containing E1, RNA-binding -0.0770815
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0760924
EXOC4 exocyst complex component 4 -0.0721459
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0669149
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0660022
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0659925
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0652995
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0639253
BBX bobby sox homolog (Drosophila) -0.0635755
KDM2A lysine (K)-specific demethylase 2A -0.0631861
CANX calnexin -0.0630193
PTK2 protein tyrosine kinase 2 -0.0622731
NF1 neurofibromin 1 -0.0614439
PHF21A PHD finger protein 21A -0.0551224
EGFR epidermal growth factor receptor -0.0549924
VIM vimentin -0.0543699
ZBTB20 zinc finger and BTB domain containing 20 -0.0529663
TAS2R14 taste receptor, type 2, member 14 -0.0528547
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0522666
EML4 echinoderm microtubule associated protein like 4 -0.0522265
BIRC6 baculoviral IAP repeat containing 6 -0.0518793
RSF1 remodeling and spacing factor 1 -0.0507056
EEF2 eukaryotic translation elongation factor 2 -0.0504722
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0502358
WASF2 WAS protein family, member 2 -0.0490594
CCNL1 cyclin L1 -0.0488866
TBC1D5 TBC1 domain family, member 5 -0.0483394
USP34 ubiquitin specific peptidase 34 -0.0474551
AFF3 AF4/FMR2 family, member 3 -0.0456825
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0451346
SBF2 SET binding factor 2 -0.0449433
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0421358
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.04202
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0418934
ZNF638 zinc finger protein 638 -0.0413937
UBE2H ubiquitin-conjugating enzyme E2H -0.0406254
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0405922
NCOA7 nuclear receptor coactivator 7 -0.0402449
KMT2A lysine (K)-specific methyltransferase 2A -0.040205
SENP6 SUMO1/sentrin specific peptidase 6 -0.0391294
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0391091
CAMKMT calmodulin-lysine N-methyltransferase -0.0389667
NBEAL1 neurobeachin-like 1 -0.0386707
PATJ PATJ crumbs cell polarity complex component -0.0385776
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0384401
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0377661
MAP4 microtubule-associated protein 4 -0.0375334
TNRC6B trinucleotide repeat containing 6B -0.0374573
BABAM2 BRISC and BRCA1 A complex member 2 -0.0373642
BCAS3 breast carcinoma amplified sequence 3 -0.0369462
DENND5B DENN/MADD domain containing 5B -0.0368446
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.03678
LMAN1 lectin, mannose-binding, 1 -0.0361567
FMNL2 formin-like 2 -0.0356228
EHBP1 EH domain binding protein 1 -0.0341075
HMGA2 high mobility group AT-hook 2 -0.0337177
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0336106
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0333519
THSD4 thrombospondin, type I, domain containing 4 -0.0332675
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0331295
RABGAP1L RAB GTPase activating protein 1-like -0.0328693
ZNF292 zinc finger protein 292 -0.0325983
BPTF bromodomain PHD finger transcription factor -0.0322246
FAM168A family with sequence similarity 168, member A -0.0321913
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0317147
THADA thyroid adenoma associated -0.0316012
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0314969
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0313848
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0305719
RAB1A RAB1A, member RAS oncogene family -0.0304534
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.030209
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0300395
PHF20 PHD finger protein 20 -0.0299614
ATXN1 ataxin 1 -0.0299469
SRBD1 S1 RNA binding domain 1 -0.0299459
GARS1 glycyl-tRNA synthetase 1 -0.0294893
MON2 MON2 homolog (S. cerevisiae) -0.0294383
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0294252
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.029382
DARS1 aspartyl-tRNA synthetase 1 -0.0292429
WDR70 WD repeat domain 70 -0.0292234
ARB2A ARB2 cotranscriptional regulator A -0.0291385
ZMYND8 zinc finger, MYND-type containing 8 -0.0291293
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0291065
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0288259
LDHA lactate dehydrogenase A -0.0286187
FCHSD2 FCH and double SH3 domains 2 -0.0285372
DENND1A DENN/MADD domain containing 1A -0.0285166
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0284104
ANKRD17 ankyrin repeat domain 17 -0.0279064
HELZ helicase with zinc finger -0.0278089
CD2AP CD2-associated protein -0.0277934