Pentoxifylline_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.140574
TMSB10 thymosin beta 10 0.136881
FTL ferritin, light polypeptide 0.11653
LAMB3 laminin, beta 3 0.114454
MT2A metallothionein 2A 0.0822727
RPLP1 ribosomal protein, large, P1 0.0715522
TPT1 tumor protein, translationally-controlled 1 0.0580672
PTMA prothymosin, alpha 0.0550214
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0532096
RPL34 ribosomal protein L34 0.0498661
RPS19 ribosomal protein S19 0.0489976
SDC4 syndecan 4 0.0460093
RPL23 ribosomal protein L23 0.0451115
EFNA5 ephrin-A5 0.0444753
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0444626
EXT1 exostosin glycosyltransferase 1 0.0440936
LOC112694756 uncharaterized LOC112694756 0.0432794
RPL9 ribosomal protein L9 0.0428783
TACSTD2 tumor-associated calcium signal transducer 2 0.0420584
FTH1 ferritin, heavy polypeptide 1 0.0416597
TUBB4B tubulin, beta 4B class IVb 0.0412343
RPS29 ribosomal protein S29 0.0404554
LMO7 LIM domain 7 0.0398749
RPL35A ribosomal protein L35a 0.0392135
ISG15 ISG15 ubiquitin-like modifier 0.0387141
SAMD4A sterile alpha motif domain containing 4A 0.0363838
RPL36 ribosomal protein L36 0.0339333
RPLP2 ribosomal protein, large, P2 0.0334286
PLAUR plasminogen activator, urokinase receptor 0.0310928
RPS8 ribosomal protein S8 0.0306868
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0297233
LAMC2 laminin, gamma 2 0.0297044
RPS3 ribosomal protein S3 0.0295053
SLC38A1 solute carrier family 38, member 1 0.0287411
HLA-B major histocompatibility complex, class I, B 0.0282347
CTNND1 catenin (cadherin-associated protein), delta 1 0.0282101
BHLHE40 basic helix-loop-helix family, member e40 0.028203
WSB1 WD repeat and SOCS box containing 1 0.0278486
NAV2 neuron navigator 2 0.0266928
HLA-A major histocompatibility complex, class I, A 0.0264736
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0264572
RPL30 ribosomal protein L30 0.0256961
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0256802
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0254695
GPX4 glutathione peroxidase 4 0.0254383
RPS27 ribosomal protein S27 0.0254015
RPL37A ribosomal protein L37a 0.0252113
RPL13A ribosomal protein L13a 0.0251224
S100A11 S100 calcium binding protein A11 0.0250532
KLF6 Kruppel-like factor 6 0.0242136
RPS21 ribosomal protein S21 0.0241381
SOX4 SRY (sex determining region Y)-box 4 0.0239992
RPL27 ribosomal protein L27 0.0237928
RPL37 ribosomal protein L37 0.0237125
VGLL3 vestigial-like family member 3 0.0235122
RPL32 ribosomal protein L32 0.0233989
LMNA lamin A/C 0.0231969
RACK1 receptor for activated C kinase 1 0.0230598
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.022737
IFI6 interferon, alpha-inducible protein 6 0.0226109
SMAD3 SMAD family member 3 0.0225332
RPL19 ribosomal protein L19 0.0225144
MYO1E myosin IE 0.0213457
LOC102724023 ES1 protein homolog, mitochondrial 0.0211495
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0206036
RPL38 ribosomal protein L38 0.0204862
EGFR epidermal growth factor receptor 0.019834
HMGB2 high mobility group box 2 0.019765
RPL31 ribosomal protein L31 0.0196829
RPL18 ribosomal protein L18 0.0195072
JUP junction plakoglobin 0.0193032
ATXN1 ataxin 1 0.0189572
KPNB1 karyopherin (importin) beta 1 0.0189568
RPL12 ribosomal protein L12 0.0187732
RPS17 ribosomal protein S17 0.0186506
RPL36AL ribosomal protein L36a-like 0.0186341
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.0185473
AHNAK AHNAK nucleoprotein 0.0184623
FBXO32 F-box protein 32 0.0183188
COX6C cytochrome c oxidase subunit VIc 0.0182846
PLEC plectin 0.0180334
PTPRF protein tyrosine phosphatase, receptor type, F 0.0177403
OSMR oncostatin M receptor 0.0176836
CAVIN1 caveolae associated protein 1 0.0175681
YBX3 Y box binding protein 3 0.0175081
DOCK5 dedicator of cytokinesis 5 0.017214
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.0171161
H1-0 H1.0 linker histone 0.0169627
MACC1 metastasis associated in colon cancer 1 0.0169093
BCL2L1 BCL2-like 1 0.0167493
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0166484
MCTP2 multiple C2 domains, transmembrane 2 0.0166098
FBXO34 F-box protein 34 0.0165873
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0165422
HMGA1 high mobility group AT-hook 1 0.0164233
FLNA filamin A, alpha 0.0163526
EEF1G eukaryotic translation elongation factor 1 gamma 0.0163292
HSPG2 heparan sulfate proteoglycan 2 0.0161236
MYL12B myosin, light chain 12B, regulatory 0.0160591
RPS16 ribosomal protein S16 0.0158177

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.192247
TSC22D2 TSC22 domain family, member 2 -0.159275
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.144917
POTEF POTE ankyrin domain family, member F -0.125128
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.116326
IGFBP3 insulin-like growth factor binding protein 3 -0.113017
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.111139
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0882475
GRB10 growth factor receptor-bound protein 10 -0.0843045
FAM13A family with sequence similarity 13, member A -0.0809168
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0747468
FNDC3B fibronectin type III domain containing 3B -0.0697512
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0640945
CANX calnexin -0.0618568
KMT2E lysine (K)-specific methyltransferase 2E -0.0588749
ADAM9 ADAM metallopeptidase domain 9 -0.0577848
PTK2 protein tyrosine kinase 2 -0.0572895
RNF145 ring finger protein 145 -0.056464
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0556891
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0533028
MXD1 MAX dimerization protein 1 -0.0522317
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0512103
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0492834
PCBP2 poly(rC) binding protein 2 -0.0472217
PDIA3 protein disulfide isomerase family A, member 3 -0.0471506
DSTN destrin (actin depolymerizing factor) -0.047081
CCNL1 cyclin L1 -0.0464757
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0448212
ZNF292 zinc finger protein 292 -0.042582
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0417681
ZFAND3 zinc finger, AN1-type domain 3 -0.0416504
HILPDA hypoxia inducible lipid droplet-associated -0.040731
LDHA lactate dehydrogenase A -0.0397659
CALR calreticulin -0.0397119
RYBP RING1 and YY1 binding protein -0.0395077
NUP58 nucleoporin 58 -0.0391435
RLF rearranged L-myc fusion -0.0390744
SSBP2 single-stranded DNA binding protein 2 -0.0389868
NPEPPS aminopeptidase puromycin sensitive -0.0379911
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0375402
ZNF207 zinc finger protein 207 -0.0374721
TOP1 topoisomerase (DNA) I -0.0369413
UBC ubiquitin C -0.0368938
PDIA6 protein disulfide isomerase family A, member 6 -0.0368874
USP3 ubiquitin specific peptidase 3 -0.0359479
COPA coatomer protein complex, subunit alpha -0.0358619
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0357398
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0353553
TFG TRK-fused gene -0.0352745
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.035206
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0348868
SQSTM1 sequestosome 1 -0.0339303
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0330298
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0324001
VEGFA vascular endothelial growth factor A -0.0323671
NAMPT nicotinamide phosphoribosyltransferase -0.0320217
QKI QKI, KH domain containing, RNA binding -0.0318876
SETD5 SET domain containing 5 -0.0318755
GARS1 glycyl-tRNA synthetase 1 -0.0317334
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0313511
RIOK3 RIO kinase 3 -0.0310048
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0309633
KDM5B lysine (K)-specific demethylase 5B -0.0305368
RHOA ras homolog family member A -0.0304847
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.030434
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.030183
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.0298056
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0292182
RNASE3 ribonuclease, RNase A family, 3 -0.0291573
IRF6 interferon regulatory factor 6 -0.0290441
ARRDC3 arrestin domain containing 3 -0.0289617
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0288711
FOS FBJ murine osteosarcoma viral oncogene homolog -0.028855
CDC73 cell division cycle 73 -0.0287789
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0286889
WAC WW domain containing adaptor with coiled-coil -0.0284817
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0283432
PAPOLA poly(A) polymerase alpha -0.0282248
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0278456
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0277685
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0276478
GPBP1 GC-rich promoter binding protein 1 -0.0268297
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0267619
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0263699
EIF5 eukaryotic translation initiation factor 5 -0.0261176
MBNL1 muscleblind-like splicing regulator 1 -0.0258827
MEF2A myocyte enhancer factor 2A -0.0257418
TPM3 tropomyosin 3 -0.0254381
TRA2A transformer 2 alpha homolog (Drosophila) -0.0253932
ELL2 elongation factor, RNA polymerase II, 2 -0.0253277
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0251014
RHEB Ras homolog enriched in brain -0.0250288
MATR3 matrin 3 -0.0250192
YBX1 Y box binding protein 1 -0.0248858
PARD3 par-3 family cell polarity regulator -0.0247716
RAB7A RAB7A, member RAS oncogene family -0.0246864
WASF2 WAS protein family, member 2 -0.0243573
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0242785
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0240015
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0239743