Pentoxifylline_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.103513
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0988818
VIM vimentin 0.0969761
GDA guanine deaminase 0.0886983
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0840494
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0826484
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0761141
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0740859
FN1 fibronectin 1 0.0708112
NRCAM neuronal cell adhesion molecule 0.0704304
FTH1 ferritin, heavy polypeptide 1 0.0675818
PCBP3 poly(rC) binding protein 3 0.062879
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.061494
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0608653
RPS24 ribosomal protein S24 0.0589202
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0550275
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0544475
TFPI2 tissue factor pathway inhibitor 2 0.053978
NPAS2 neuronal PAS domain protein 2 0.0508302
PDLIM5 PDZ and LIM domain 5 0.0503911
COL8A1 collagen, type VIII, alpha 1 0.0452346
VCL vinculin 0.0435966
RPLP0 ribosomal protein, large, P0 0.0435542
TMX4 thioredoxin-related transmembrane protein 4 0.043546
CTSC cathepsin C 0.0434216
TBXT T-box transcription factor T 0.042438
SH3KBP1 SH3-domain kinase binding protein 1 0.0423342
MFF mitochondrial fission factor 0.0411262
S100A6 S100 calcium binding protein A6 0.0407713
BMERB1 bMERB domain containing 1 0.0402056
PSD3 pleckstrin and Sec7 domain containing 3 0.0400607
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0388981
RPL35A ribosomal protein L35a 0.0388752
TGFBI transforming growth factor, beta-induced, 68kDa 0.0375304
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0370813
NEK7 NIMA-related kinase 7 0.0368088
RPL36A ribosomal protein L36a 0.0366014
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0365432
DOCK5 dedicator of cytokinesis 5 0.0364468
RPL31 ribosomal protein L31 0.0340139
RPLP1 ribosomal protein, large, P1 0.0337737
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0335778
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0329487
SOX4 SRY (sex determining region Y)-box 4 0.0323576
STC1 stanniocalcin 1 0.0320089
HLA-A major histocompatibility complex, class I, A 0.0305186
RPL34 ribosomal protein L34 0.0303752
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0303566
RTN1 reticulon 1 0.0302122
GRAMD1B GRAM domain containing 1B 0.0296663
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0294948
RPS25 ribosomal protein S25 0.0294481
RPL9 ribosomal protein L9 0.0289338
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0284635
RPL12 ribosomal protein L12 0.0281587
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0280977
RAB3B RAB3B, member RAS oncogene family 0.02788
TM4SF1 transmembrane 4 L six family member 1 0.0278756
NT5E 5'-nucleotidase, ecto (CD73) 0.0277722
HLA-B major histocompatibility complex, class I, B 0.0276419
ZEB2 zinc finger E-box binding homeobox 2 0.0276277
RPL7A ribosomal protein L7a 0.0273312
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0270017
WWTR1 WW domain containing transcription regulator 1 0.0267216
NT5C2 5'-nucleotidase, cytosolic II 0.0266937
HSPA8 heat shock 70kDa protein 8 0.0264288
EXT1 exostosin glycosyltransferase 1 0.026228
NFE2L2 nuclear factor, erythroid 2-like 2 0.0260406
KPNB1 karyopherin (importin) beta 1 0.0258472
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0256947
GPRIN3 GPRIN family member 3 0.0255526
KYNU kynureninase 0.0252097
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.0249237
RPL26 ribosomal protein L26 0.0246669
RPS16 ribosomal protein S16 0.024429
EFNA5 ephrin-A5 0.0237586
DUSP4 dual specificity phosphatase 4 0.0237013
RPS8 ribosomal protein S8 0.0236457
BCAR3 breast cancer anti-estrogen resistance 3 0.0235105
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0233218
RPS6 ribosomal protein S6 0.0231843
LOC112694756 uncharaterized LOC112694756 0.0230841
CCDC68 coiled-coil domain containing 68 0.0230692
IGFBP3 insulin-like growth factor binding protein 3 0.0223844
TRIM56 tripartite motif containing 56 0.0222036
TMSB4X thymosin beta 4, X-linked 0.0221591
SAMD4A sterile alpha motif domain containing 4A 0.0220271
SLFN5 schlafen family member 5 0.0217774
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0216707
RPS12 ribosomal protein S12 0.0215699
OSMR oncostatin M receptor 0.0210611
CFLAR CASP8 and FADD-like apoptosis regulator 0.0205511
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0205192
BZW1 basic leucine zipper and W2 domains 1 0.020234
BDNF brain-derived neurotrophic factor 0.0202272
RACK1 receptor for activated C kinase 1 0.0202264
NAMPT nicotinamide phosphoribosyltransferase 0.0201376
RPS27A ribosomal protein S27a 0.020097
CTSL cathepsin L 0.0200511
INHBA inhibin, beta A 0.0200045

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.176237
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.132385
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.124507
PDE10A phosphodiesterase 10A -0.105873
SPAG9 sperm associated antigen 9 -0.0923153
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0890884
PDE4D phosphodiesterase 4D, cAMP-specific -0.0870954
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0654439
CTBP2 C-terminal binding protein 2 -0.0584386
NALF1 NALCN channel auxiliary factor 1 -0.0575701
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0572113
LSAMP limbic system-associated membrane protein -0.0545062
SMYD3 SET and MYND domain containing 3 -0.0499184
LIMCH1 LIM and calponin homology domains 1 -0.0499116
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0494824
KMT2C lysine (K)-specific methyltransferase 2C -0.0481437
DDIT4 DNA-damage-inducible transcript 4 -0.0479246
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0444317
NUP58 nucleoporin 58 -0.0437624
PTPRM protein tyrosine phosphatase, receptor type, M -0.0418307
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0407896
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0406187
WDR43 WD repeat domain 43 -0.0400442
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0398946
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0383847
PCBP2 poly(rC) binding protein 2 -0.0379322
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0377484
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0376542
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0365328
GARS1 glycyl-tRNA synthetase 1 -0.0357002
MCL1 myeloid cell leukemia 1 -0.0356276
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0355193
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0351753
ZNF638 zinc finger protein 638 -0.0344911
ESYT2 extended synaptotagmin-like protein 2 -0.0343158
MARCHF1 membrane associated ring-CH-type finger 1 -0.0342162
KMT2E lysine (K)-specific methyltransferase 2E -0.0341823
WARS1 tryptophanyl-tRNA synthetase 1 -0.0336641
TRIO trio Rho guanine nucleotide exchange factor -0.033559
FAM13A family with sequence similarity 13, member A -0.033115
CADM2 cell adhesion molecule 2 -0.032715
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0327115
RBM39 RNA binding motif protein 39 -0.0319712
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0314578
KDM6A lysine (K)-specific demethylase 6A -0.0314575
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0312777
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0311912
RAB7A RAB7A, member RAS oncogene family -0.0308512
NBAS neuroblastoma amplified sequence -0.0308441
FOSL1 FOS-like antigen 1 -0.03077
NDRG1 N-myc downstream regulated 1 -0.0305238
EGR1 early growth response 1 -0.0302471
TPD52 tumor protein D52 -0.0299763
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0297555
CHD1 chromodomain helicase DNA binding protein 1 -0.0297348
COPA coatomer protein complex, subunit alpha -0.0296353
GRB10 growth factor receptor-bound protein 10 -0.0294696
MAML3 mastermind-like 3 (Drosophila) -0.0294157
EZR ezrin -0.0293698
FTL ferritin, light polypeptide -0.0292589
RUNX1 runt-related transcription factor 1 -0.0290281
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0290072
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0289396
PUM2 pumilio RNA-binding family member 2 -0.0283369
GOLGA4 golgin A4 -0.0281791
CTIF CBP80/20-dependent translation initiation factor -0.0280793
BIRC6 baculoviral IAP repeat containing 6 -0.0275062
SUCO SUN domain containing ossification factor -0.0274141
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0273245
MORF4L2 mortality factor 4 like 2 -0.0270378
ANXA1 annexin A1 -0.0269695
IARS1 isoleucyl-tRNA synthetase 1 -0.0269247
CAMTA1 calmodulin binding transcription activator 1 -0.0268879
HELZ helicase with zinc finger -0.0268044
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0266321
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0266113
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0266071
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0265778
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0265388
TOP1 topoisomerase (DNA) I -0.0264392
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.02618
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.025716
HYOU1 hypoxia up-regulated 1 -0.0255309
CDC73 cell division cycle 73 -0.0254073
USP34 ubiquitin specific peptidase 34 -0.0253949
QKI QKI, KH domain containing, RNA binding -0.0251536
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0250989
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0248752
USP3 ubiquitin specific peptidase 3 -0.0248285
NCOR2 nuclear receptor corepressor 2 -0.024809
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0247552
UBAP2L ubiquitin associated protein 2-like -0.024663
RNF145 ring finger protein 145 -0.0246172
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0245155
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0243623
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0242882
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0241979
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0240217
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.023744
OLA1 Obg-like ATPase 1 -0.0237214