Pentoxifylline_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PKM pyruvate kinase, muscle 0.124901
VCL vinculin 0.115287
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0977422
LOC112694756 uncharaterized LOC112694756 0.0878418
AHNAK AHNAK nucleoprotein 0.0854827
PYGB phosphorylase, glycogen; brain 0.0777997
TPT1 tumor protein, translationally-controlled 1 0.0649933
EGFR epidermal growth factor receptor 0.0620353
GLI2 GLI family zinc finger 2 0.0568895
TXNRD1 thioredoxin reductase 1 0.0533427
PTMA prothymosin, alpha 0.0525126
PDE4D phosphodiesterase 4D, cAMP-specific 0.0512641
FLNB filamin B, beta 0.0501109
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0485421
RPLP1 ribosomal protein, large, P1 0.0452015
RPS2 ribosomal protein S2 0.0408643
CCND1 cyclin D1 0.0391053
S100A6 S100 calcium binding protein A6 0.0376779
GSE1 Gse1 coiled-coil protein 0.0357431
S100A4 S100 calcium binding protein A4 0.0342083
RPL12 ribosomal protein L12 0.0334216
RPL35A ribosomal protein L35a 0.033108
SPRY4 sprouty homolog 4 (Drosophila) 0.0326395
PRPF38B pre-mRNA processing factor 38B 0.0321764
ATP9B ATPase, class II, type 9B 0.0301006
FBLN2 fibulin 2 0.029735
PRELID2 PRELI domain containing 2 0.0291475
RPL26 ribosomal protein L26 0.0279043
HSPA8 heat shock 70kDa protein 8 0.027634
RPL9 ribosomal protein L9 0.0270301
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0262038
RPS24 ribosomal protein S24 0.0252281
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0244695
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0243494
OSMR oncostatin M receptor 0.0238366
GNAS GNAS complex locus 0.0238169
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.02373
IRS1 insulin receptor substrate 1 0.0236496
PLXNA1 plexin A1 0.0235644
RPL34 ribosomal protein L34 0.0233521
HEG1 heart development protein with EGF-like domains 1 0.0232954
EEF1G eukaryotic translation elongation factor 1 gamma 0.0230365
TJP1 tight junction protein 1 0.0226453
RPS6 ribosomal protein S6 0.0226385
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0224134
NDE1 nudE neurodevelopment protein 1 0.0222684
LENG8 leukocyte receptor cluster (LRC) member 8 0.0218391
EBNA1BP2 EBNA1 binding protein 2 0.0213393
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0212897
PRDX2 peroxiredoxin 2 0.0210821
RPL23 ribosomal protein L23 0.0209417
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0206806
CDC25B cell division cycle 25B 0.0202099
RPL4 ribosomal protein L4 0.0201131
NFE2L2 nuclear factor, erythroid 2-like 2 0.0200467
PRRC2B proline-rich coiled-coil 2B 0.0199896
RACK1 receptor for activated C kinase 1 0.0199072
RPS21 ribosomal protein S21 0.0194533
RPL36 ribosomal protein L36 0.0191507
SQSTM1 sequestosome 1 0.019051
HMGA1 high mobility group AT-hook 1 0.0189559
RAB27B RAB27B, member RAS oncogene family 0.01857
RPL30 ribosomal protein L30 0.018388
RPS17 ribosomal protein S17 0.0182046
TUBB4B tubulin, beta 4B class IVb 0.0179659
RPL37A ribosomal protein L37a 0.0179535
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0179103
ARHGAP25 Rho GTPase activating protein 25 0.0178846
ZMYND8 zinc finger, MYND-type containing 8 0.0175862
GANAB glucosidase, alpha; neutral AB 0.0174245
PGAM4 phosphoglycerate mutase family member 4 0.0173329
LARP1 La ribonucleoprotein domain family, member 1 0.0171132
CAPNS1 calpain, small subunit 1 0.0170978
TM4SF1 transmembrane 4 L six family member 1 0.0165332
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0165317
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.016504
KLF3 Kruppel-like factor 3 (basic) 0.0162832
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0162812
KLC1 kinesin light chain 1 0.0161647
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0160924
TRIM25 tripartite motif containing 25 0.0158689
PARVA parvin, alpha 0.0158164
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0157229
THBD thrombomodulin 0.0157077
PRRC2A proline-rich coiled-coil 2A 0.015692
RPL27 ribosomal protein L27 0.0155484
RPL11 ribosomal protein L11 0.0155131
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.0154914
RPLP0 ribosomal protein, large, P0 0.0152909
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0150202
TUBB tubulin, beta class I 0.0149352
TAPBP TAP binding protein (tapasin) 0.0147574
GOLM1 golgi membrane protein 1 0.0145955
RASA3 RAS p21 protein activator 3 0.0145417
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0144951
MACROD2 MACRO domain containing 2 0.0144074
RPS19 ribosomal protein S19 0.014333
TCF25 transcription factor 25 (basic helix-loop-helix) 0.0142829
S100A10 S100 calcium binding protein A10 0.0138614
FHIT fragile histidine triad 0.0138397

decreased expression

Symbol Name Standardized Value
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.156017
PDE4B phosphodiesterase 4B, cAMP-specific -0.139657
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.129063
CPED1 cadherin-like and PC-esterase domain containing 1 -0.118189
SSBP2 single-stranded DNA binding protein 2 -0.10613
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0997723
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0978178
DLG1 discs, large homolog 1 (Drosophila) -0.0761442
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0760899
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0697791
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0682556
ADAM10 ADAM metallopeptidase domain 10 -0.0645299
HDAC9 histone deacetylase 9 -0.061238
JMJD1C jumonji domain containing 1C -0.0596629
MBNL1 muscleblind-like splicing regulator 1 -0.0593774
ZNF292 zinc finger protein 292 -0.0566493
HELZ helicase with zinc finger -0.0565127
KMT2E lysine (K)-specific methyltransferase 2E -0.0555899
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0553488
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0536153
BIRC6 baculoviral IAP repeat containing 6 -0.0535243
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0520316
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0515422
ANXA1 annexin A1 -0.0511053
NFIA nuclear factor I/A -0.0506337
RBM39 RNA binding motif protein 39 -0.0496892
ZFAND3 zinc finger, AN1-type domain 3 -0.04878
EML4 echinoderm microtubule associated protein like 4 -0.048633
SOX6 SRY (sex determining region Y)-box 6 -0.0485636
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0483856
RLF rearranged L-myc fusion -0.047527
ECT2 epithelial cell transforming 2 -0.0475175
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0452589
SEC31A SEC31 homolog A (S. cerevisiae) -0.0446103
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0444151
GLS2 glutaminase 2 (liver, mitochondrial) -0.0431003
ELOVL5 ELOVL fatty acid elongase 5 -0.0430618
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0429342
EPS8 epidermal growth factor receptor pathway substrate 8 -0.042285
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0414107
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0412816
SBF2 SET binding factor 2 -0.0409304
TXNIP thioredoxin interacting protein -0.0408243
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0407323
CALR calreticulin -0.040708
GOLGA4 golgin A4 -0.0406495
PTK2 protein tyrosine kinase 2 -0.0405456
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0405219
AKAP9 A kinase (PRKA) anchor protein 9 -0.0402432
QKI QKI, KH domain containing, RNA binding -0.039979
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0395097
KMT2C lysine (K)-specific methyltransferase 2C -0.0392096
CSDE1 cold shock domain containing E1, RNA-binding -0.0392014
TTC3 tetratricopeptide repeat domain 3 -0.0383841
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0381246
XPO1 exportin 1 -0.0374838
RNF145 ring finger protein 145 -0.0369465
MORF4L2 mortality factor 4 like 2 -0.0369232
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0364959
FAM13A family with sequence similarity 13, member A -0.0361242
PDIA3 protein disulfide isomerase family A, member 3 -0.0360203
FBXO11 F-box protein 11 -0.0359896
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0358221
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0351009
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0347509
GPHN gephyrin -0.0346276
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.034567
PICALM phosphatidylinositol binding clathrin assembly protein -0.0345104
TFG TRK-fused gene -0.0344879
KDM3A lysine (K)-specific demethylase 3A -0.0342158
UBA6 ubiquitin-like modifier activating enzyme 6 -0.034184
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0339262
USP47 ubiquitin specific peptidase 47 -0.0338945
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0337826
CCNL1 cyclin L1 -0.033728
KTN1 kinectin 1 (kinesin receptor) -0.0329583
NOP58 NOP58 ribonucleoprotein -0.0329322
CAMKMT calmodulin-lysine N-methyltransferase -0.0328337
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0327191
DSCAM Down syndrome cell adhesion molecule -0.0326001
WAC WW domain containing adaptor with coiled-coil -0.0325885
SRRM2 serine/arginine repetitive matrix 2 -0.0324707
IARS1 isoleucyl-tRNA synthetase 1 -0.0323177
SEPTIN7 septin 7 -0.0320551
DDIT4 DNA-damage-inducible transcript 4 -0.0320254
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0311828
SMNDC1 survival motor neuron domain containing 1 -0.0305679
RAD18 RAD18 E3 ubiquitin protein ligase -0.0304536
TNRC6B trinucleotide repeat containing 6B -0.0304017
BMP2K BMP2 inducible kinase -0.0301728
DIAPH3 diaphanous-related formin 3 -0.030071
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0298264
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0295676
MON2 MON2 homolog (S. cerevisiae) -0.0295361
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0295147
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0294918
ZEB1 zinc finger E-box binding homeobox 1 -0.0293634
COG5 component of oligomeric golgi complex 5 -0.0291843
RAB1A RAB1A, member RAS oncogene family -0.0291578
MED13L mediator complex subunit 13-like -0.029098