Pentoxifylline_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.0610201
LOX lysyl oxidase 0.0608232
COL6A3 collagen, type VI, alpha 3 0.0439147
TIMP3 TIMP metallopeptidase inhibitor 3 0.0375072
CDH13 cadherin 13 0.0362134
FN1 fibronectin 1 0.0325846
AHNAK AHNAK nucleoprotein 0.0291877
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0259821
COL1A1 collagen, type I, alpha 1 0.025072
PTPRF protein tyrosine phosphatase, receptor type, F 0.0232121
AKAP12 A kinase (PRKA) anchor protein 12 0.0229746
FAM20C family with sequence similarity 20, member C 0.0227759
EFNA5 ephrin-A5 0.022697
CAVIN1 caveolae associated protein 1 0.0222438
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0221927
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0216277
ERRFI1 ERBB receptor feedback inhibitor 1 0.0215684
LENG8 leukocyte receptor cluster (LRC) member 8 0.0202113
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0198544
CD109 CD109 molecule 0.0193068
COL5A1 collagen, type V, alpha 1 0.0183196
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0181087
FKBP10 FK506 binding protein 10, 65 kDa 0.0178675
CMIP c-Maf inducing protein 0.0175665
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0175071
HDLBP high density lipoprotein binding protein 0.0173554
EGR1 early growth response 1 0.0165624
DPYSL2 dihydropyrimidinase-like 2 0.0165114
CLINT1 clathrin interactor 1 0.0161362
FLNB filamin B, beta 0.0160027
ANTXR2 anthrax toxin receptor 2 0.0159216
GCC2 GRIP and coiled-coil domain containing 2 0.0159074
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0159024
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0156975
MMP12 matrix metallopeptidase 12 0.0154697
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0154292
SAMD4A sterile alpha motif domain containing 4A 0.0154258
NOTCH3 notch 3 0.0150722
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0150091
ACTN1 actinin, alpha 1 0.015004
BACE2 beta-site APP-cleaving enzyme 2 0.0149468
MYO18A myosin XVIIIA 0.0148939
AMPD3 adenosine monophosphate deaminase 3 0.014806
FLNA filamin A, alpha 0.0146746
GOSR1 golgi SNAP receptor complex member 1 0.0146212
F11R F11 receptor 0.0145655
STK40 serine/threonine kinase 40 0.0141237
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0140494
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.013962
TET3 tet methylcytosine dioxygenase 3 0.0139526
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.01378
DENND1A DENN/MADD domain containing 1A 0.013731
NEMF nuclear export mediator factor 0.0137045
SH3BP2 SH3-domain binding protein 2 0.0136867
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0136315
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0134633
GPR173 G protein-coupled receptor 173 0.013414
YEATS2 YEATS domain containing 2 0.0133768
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0132484
SCFD1 sec1 family domain containing 1 0.0132004
AGRN agrin 0.0131369
ARHGAP22 Rho GTPase activating protein 22 0.0130921
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0130177
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0130049
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0129152
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0129104
MOSMO modulator of smoothened 0.012834
CIRSR corepressor of RBPJ and splicing regulator 0.0127309
TRIO trio Rho guanine nucleotide exchange factor 0.012518
SIN3B SIN3 transcription regulator family member B 0.0124967
ATXN10 ataxin 10 0.0124784
IQSEC1 IQ motif and Sec7 domain 1 0.0123172
PPHLN1 periphilin 1 0.0122613
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0121957
FSCN1 fascin actin-bundling protein 1 0.0121624
NUP155 nucleoporin 155kDa 0.0121606
HMGXB4 HMG box domain containing 4 0.0121092
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.0120735
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0120317
CCDC138 coiled-coil domain containing 138 0.0120217
IGFBP5 insulin-like growth factor binding protein 5 0.0120006
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0119824
TRRAP transformation/transcription domain-associated protein 0.0119601
ABI3BP ABI family, member 3 (NESH) binding protein 0.0119067
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.0118948
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0118527
CAPN15 calpain 15 0.0118238
VEGFC vascular endothelial growth factor C 0.0118225
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0118106
PYGL phosphorylase, glycogen, liver 0.0118027
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.011791
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0117647
EIF4A1 eukaryotic translation initiation factor 4A1 0.0117451
GNG5 guanine nucleotide binding protein (G protein), gamma 5 0.0117245
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough 0.0116742
ARFIP1 ADP-ribosylation factor interacting protein 1 0.0116675
KLF10 Kruppel-like factor 10 0.0115427
FNDC3A fibronectin type III domain containing 3A 0.0115413
USP48 ubiquitin specific peptidase 48 0.0115365
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0115208

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.190776
MT2A metallothionein 2A -0.189665
VIM vimentin -0.129312
B2M beta-2-microglobulin -0.115724
FTL ferritin, light polypeptide -0.105016
TMSB10 thymosin beta 10 -0.102222
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0795117
PTMA prothymosin, alpha -0.0704181
HLA-B major histocompatibility complex, class I, B -0.0671878
POTEF POTE ankyrin domain family, member F -0.0520451
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0513584
MAP1B microtubule-associated protein 1B -0.0488169
PTN pleiotrophin -0.0486251
CALD1 caldesmon 1 -0.0460248
RTN4 reticulon 4 -0.0442577
PGK1 phosphoglycerate kinase 1 -0.0433166
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0400689
PKM pyruvate kinase, muscle -0.0400652
EIF1 eukaryotic translation initiation factor 1 -0.0391206
H3-3B H3.3 histone B -0.03802
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0367973
CALR calreticulin -0.0362164
TRA2A transformer 2 alpha homolog (Drosophila) -0.0340994
ANXA2 annexin A2 -0.0336453
S100A9 S100 calcium binding protein A9 -0.0335999
RPS8 ribosomal protein S8 -0.0332131
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0332018
RAD51B RAD51 paralog B -0.0317269
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0313865
RPL11 ribosomal protein L11 -0.0309473
PTGES2 prostaglandin E synthase 2 -0.0305009
LDHA lactate dehydrogenase A -0.0301859
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0301082
MED13L mediator complex subunit 13-like -0.0300498
SETD5 SET domain containing 5 -0.0299343
RNF145 ring finger protein 145 -0.0293313
PDIA3 protein disulfide isomerase family A, member 3 -0.0292815
TRIP12 thyroid hormone receptor interactor 12 -0.02917
TPM4 tropomyosin 4 -0.0291656
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0290869
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.028669
IL6 interleukin 6 -0.0286312
LMNA lamin A/C -0.0281154
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0279636
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0267225
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.026194
RPS3 ribosomal protein S3 -0.026124
IGFBP7 insulin-like growth factor binding protein 7 -0.0261173
MT1X metallothionein 1X -0.0261133
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0255765
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0249818
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0249376
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0244138
ENO1 enolase 1, (alpha) -0.0242335
TMSB4X thymosin beta 4, X-linked -0.0242046
ANKRD11 ankyrin repeat domain 11 -0.0239912
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0237707
SLPI secretory leukocyte peptidase inhibitor -0.0236444
ELL2 elongation factor, RNA polymerase II, 2 -0.0235766
FAM13A family with sequence similarity 13, member A -0.0235325
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0234009
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0233168
CTSB cathepsin B -0.0230519
SEPTIN7 septin 7 -0.023002
CDK6 cyclin-dependent kinase 6 -0.0229937
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0226792
TMEM165 transmembrane protein 165 -0.0224889
UBC ubiquitin C -0.0219817
MATR3 matrin 3 -0.0218612
ANKRD12 ankyrin repeat domain 12 -0.0218536
MARCHF6 membrane associated ring-CH-type finger 6 -0.0217967
BBX bobby sox homolog (Drosophila) -0.0216351
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0216235
CAV1 caveolin 1, caveolae protein, 22kDa -0.0215542
TGFBI transforming growth factor, beta-induced, 68kDa -0.0215144
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0214913
AOPEP aminopeptidase O (putative) -0.0211623
NIPBL Nipped-B homolog (Drosophila) -0.021115
UGCG UDP-glucose ceramide glucosyltransferase -0.021057
CYLD cylindromatosis (turban tumor syndrome) -0.0209536
MEF2A myocyte enhancer factor 2A -0.0207821
MORF4L2 mortality factor 4 like 2 -0.0207621
ESYT2 extended synaptotagmin-like protein 2 -0.020698
SRSF11 serine/arginine-rich splicing factor 11 -0.0206489
HOOK2 hook microtubule-tethering protein 2 -0.0206296
KTN1 kinectin 1 (kinesin receptor) -0.020389
EEF2 eukaryotic translation elongation factor 2 -0.0202576
ZC3H15 zinc finger CCCH-type containing 15 -0.0202418
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0202396
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0202275
HLA-C major histocompatibility complex, class I, C -0.020205
CANX calnexin -0.0201242
NDRG1 N-myc downstream regulated 1 -0.0198727
ZNF654 zinc finger protein 654 -0.0198394
DSTN destrin (actin depolymerizing factor) -0.0197686
PFN1 profilin 1 -0.0197449
DST dystonin -0.0196704
VEGFA vascular endothelial growth factor A -0.019668
NOP58 NOP58 ribonucleoprotein -0.0196345
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0194426