Pentoxifylline_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.191127
VIM vimentin 0.108383
SMC4 structural maintenance of chromosomes 4 0.0813868
OSMR oncostatin M receptor 0.079412
SMYD3 SET and MYND domain containing 3 0.0766894
LOC112694756 uncharaterized LOC112694756 0.0762903
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0651482
PTMA prothymosin, alpha 0.0649349
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0644867
AFF4 AF4/FMR2 family, member 4 0.062393
BHLHE40 basic helix-loop-helix family, member e40 0.0581433
YBX3 Y box binding protein 3 0.0578777
RPL4 ribosomal protein L4 0.055874
TAS2R14 taste receptor, type 2, member 14 0.0501158
ANKRD28 ankyrin repeat domain 28 0.0495147
RBM39 RNA binding motif protein 39 0.0486077
TPX2 TPX2, microtubule-associated 0.0479665
NCAPD2 non-SMC condensin I complex, subunit D2 0.0477305
EEF2 eukaryotic translation elongation factor 2 0.0464746
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0454521
WAC WW domain containing adaptor with coiled-coil 0.0448577
CUL5 cullin 5 0.0448374
ASXL1 additional sex combs like transcriptional regulator 1 0.0446644
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0432229
PRKCE protein kinase C, epsilon 0.043176
RBM25 RNA binding motif protein 25 0.0421817
CANX calnexin 0.0420784
GOLGA4 golgin A4 0.0418492
TNIP1 TNFAIP3 interacting protein 1 0.0418107
EEF1G eukaryotic translation elongation factor 1 gamma 0.0418031
CEP95 centrosomal protein 95kDa 0.041615
PNRC1 proline-rich nuclear receptor coactivator 1 0.0412483
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0381335
RRBP1 ribosome binding protein 1 0.037556
SETD5 SET domain containing 5 0.0374675
MKI67 marker of proliferation Ki-67 0.0356569
H1-0 H1.0 linker histone 0.0355105
NPTN neuroplastin 0.0353447
TRIO trio Rho guanine nucleotide exchange factor 0.0352092
YAP1 Yes-associated protein 1 0.0344807
GOLGA2 golgin A2 0.034294
PNISR PNN-interacting serine/arginine-rich protein 0.0342293
SGO2 shugoshin 2 0.0331069
MIS18BP1 MIS18 binding protein 1 0.0327533
KIAA1958 KIAA1958 0.0327529
DSCAM Down syndrome cell adhesion molecule 0.0325286
WWTR1 WW domain containing transcription regulator 1 0.0324399
KDM5A lysine (K)-specific demethylase 5A 0.0322562
MORF4L1 mortality factor 4 like 1 0.0322491
CCDC88A coiled-coil domain containing 88A 0.032093
LMAN1 lectin, mannose-binding, 1 0.0318389
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0318231
NF1 neurofibromin 1 0.0317924
CEP250 centrosomal protein 250kDa 0.0317107
SMAP1 small ArfGAP 1 0.0316872
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0315935
NCOA6 nuclear receptor coactivator 6 0.0309887
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0309414
PRRC2A proline-rich coiled-coil 2A 0.0308699
DERA deoxyribose-phosphate aldolase (putative) 0.0307738
SNX14 sorting nexin 14 0.0306528
DNER delta/notch-like EGF repeat containing 0.0305384
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.030534
SRPK2 SRSF protein kinase 2 0.0301327
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0301109
RNF213 ring finger protein 213 0.0299853
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0299843
XRN2 5'-3' exoribonuclease 2 0.0299247
XPO1 exportin 1 0.0296929
ZC3H15 zinc finger CCCH-type containing 15 0.0296238
PCNX1 pecanex 1 0.0295807
CEP295 centrosomal protein 295kDa 0.0295246
KIF18B kinesin family member 18B 0.0294603
BSG basigin (Ok blood group) 0.0292921
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.029154
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0288782
NSD2 nuclear receptor binding SET domain protein 2 0.0286358
GGNBP2 gametogenetin binding protein 2 0.0285046
AKAP9 A kinase (PRKA) anchor protein 9 0.0284979
ATXN2L ataxin 2-like 0.0283959
WDR45B WD repeat domain 45B 0.0283538
TCERG1 transcription elongation regulator 1 0.0281635
BASP1 brain abundant, membrane attached signal protein 1 0.028127
TCF12 transcription factor 12 0.0279933
BRD4 bromodomain containing 4 0.0278146
SMAD3 SMAD family member 3 0.0278004
NCOR1 nuclear receptor corepressor 1 0.0277692
STAU1 staufen double-stranded RNA binding protein 1 0.0274267
MYH9 myosin, heavy chain 9, non-muscle 0.0274096
CALU calumenin 0.0273482
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0273351
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0273068
PHF20 PHD finger protein 20 0.0272203
RBM27 RNA binding motif protein 27 0.0271904
JMJD1C jumonji domain containing 1C 0.0270891
CAVIN1 caveolae associated protein 1 0.02704
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0270309
KPNB1 karyopherin (importin) beta 1 0.0270168
DGKD diacylglycerol kinase, delta 130kDa 0.0268416
CKAP5 cytoskeleton associated protein 5 0.026776

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.0987619
INTS6 integrator complex subunit 6 -0.0803351
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0627436
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0611668
FMNL2 formin-like 2 -0.0588742
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0547501
IGFBP3 insulin-like growth factor binding protein 3 -0.0521148
POTEF POTE ankyrin domain family, member F -0.0519641
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.05165
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0495344
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0493809
ANXA1 annexin A1 -0.0460877
NDRG1 N-myc downstream regulated 1 -0.0435965
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0422366
MBNL1 muscleblind-like splicing regulator 1 -0.0416515
RIGI RNA sensor RIG-I -0.0408092
GPC5 glypican 5 -0.0392002
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0381295
GLS2 glutaminase 2 (liver, mitochondrial) -0.0370784
EGFR epidermal growth factor receptor -0.0370038
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0363315
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0361136
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0356631
AEBP2 AE binding protein 2 -0.0342422
NABP1 nucleic acid binding protein 1 -0.0336202
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0332056
PCED1B PC-esterase domain containing 1B -0.0317092
PRR16 proline rich 16 -0.0313753
SKIL SKI-like proto-oncogene -0.0312604
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0310877
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.030011
TLE4 transducin-like enhancer of split 4 -0.0298175
ASPH aspartate beta-hydroxylase -0.0287303
TMEM14B transmembrane protein 14B -0.0286216
PRSS23 protease, serine, 23 -0.0284348
NALCN sodium leak channel, non selective -0.0281171
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0276853
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0273696
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0271534
MYOF myoferlin -0.0271228
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0270112
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0266086
MACF1 microtubule-actin crosslinking factor 1 -0.0265119
ANGPTL4 angiopoietin-like 4 -0.0264087
PDIA3 protein disulfide isomerase family A, member 3 -0.0254202
HDAC9 histone deacetylase 9 -0.0253867
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0251871
SOD2 superoxide dismutase 2, mitochondrial -0.0250782
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0248064
PODXL podocalyxin-like -0.0247638
MT2A metallothionein 2A -0.0246451
PTPRM protein tyrosine phosphatase, receptor type, M -0.024484
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0242229
COPB1 coatomer protein complex, subunit beta 1 -0.0234865
GLRX glutaredoxin (thioltransferase) -0.0234755
GLG1 golgi glycoprotein 1 -0.0231698
CCDC138 coiled-coil domain containing 138 -0.0231094
ADM adrenomedullin -0.0230579
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0229672
SVIL supervillin -0.0226609
FLNB filamin B, beta -0.0226207
MON2 MON2 homolog (S. cerevisiae) -0.0225854
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0225751
RPS25 ribosomal protein S25 -0.0225225
SPDYA speedy/RINGO cell cycle regulator family member A -0.0225087
CEMIP2 cell migration inducing hyaluronidase 2 -0.022392
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0220918
PCNX2 pecanex 2 -0.0220051
RCOR1 REST corepressor 1 -0.0219745
RPL7A ribosomal protein L7a -0.0215374
NLRP1 NLR family, pyrin domain containing 1 -0.0215235
SAMD4A sterile alpha motif domain containing 4A -0.0214888
RPS17 ribosomal protein S17 -0.0212263
USP53 ubiquitin specific peptidase 53 -0.0211862
IFRD1 interferon-related developmental regulator 1 -0.0211685
TBC1D5 TBC1 domain family, member 5 -0.0211245
VCL vinculin -0.0209538
ADAM10 ADAM metallopeptidase domain 10 -0.0206962
RASAL2 RAS protein activator like 2 -0.0205776
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0205481
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0203546
TSC22D1 TSC22 domain family, member 1 -0.0203375
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0203077
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0201846
EFL1 elongation factor like GTPase 1 -0.0201842
PDLIM5 PDZ and LIM domain 5 -0.0201
CCDC82 coiled-coil domain containing 82 -0.0200774
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0199926
FMN1 formin 1 -0.019919
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0198085
HILPDA hypoxia inducible lipid droplet-associated -0.0196733
NAV3 neuron navigator 3 -0.0196382
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0195928
NEK7 NIMA-related kinase 7 -0.0195429
PFN1 profilin 1 -0.0195231
TARS3 threonyl-tRNA synthetase 3 -0.0194148
CAPRIN2 caprin family member 2 -0.0192963
PCNX4 pecanex 4 -0.0192341
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0192177
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0191946