Pepstatin A Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5478883
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Genes

199 proteins with high or low expression in Pepstatin A relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
KMT2B lysine (K)-specific methyltransferase 2B 1.42
GREB1 growth regulation by estrogen in breast cancer 1 1.3
CUX2 cut-like homeobox 2 1.28
TRIM29 tripartite motif containing 29 1.01
PRR3 proline rich 3 0.69
GAS2L1 growth arrest-specific 2 like 1 0.62
UCK1 uridine-cytidine kinase 1 0.61
C20ORF194 chromosome 20 open reading frame 194 0.6
HMGB2 high mobility group box 2 0.6
CTNND2 catenin (cadherin-associated protein), delta 2 0.59
LRRC28 leucine rich repeat containing 28 0.59
OLFM2 olfactomedin 2 0.53
ANKRD39 ankyrin repeat domain 39 0.53
ZBTB38 zinc finger and BTB domain containing 38 0.52
LTN1 listerin E3 ubiquitin protein ligase 1 0.48
HNF4A hepatocyte nuclear factor 4, alpha 0.47
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.47
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.46
CDV3 CDV3 homolog (mouse) 0.46
HEXIM2 hexamethylene bis-acetamide inducible 2 0.46
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.45
RPL15 ribosomal protein L15 0.45
REEP5 receptor accessory protein 5 0.42
STX1A syntaxin 1A (brain) 0.41
MOCOS molybdenum cofactor sulfurase 0.41
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.4
KIAA1958 KIAA1958 0.4
TTN titin 0.4
RPL37 ribosomal protein L37 0.39
RPL7A ribosomal protein L7a 0.39
PAH phenylalanine hydroxylase 0.38
ELOB elongin B 0.38
LCOR ligand dependent nuclear receptor corepressor 0.38
H1-4 H1.4 linker histone, cluster member 0.37
RNF115 ring finger protein 115 0.37
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.37
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 0.36
IGFBP6 insulin-like growth factor binding protein 6 0.36
ALPK3 alpha-kinase 3 0.36
ECHDC3 enoyl CoA hydratase domain containing 3 0.36
DDN dendrin 0.36
RPL26L1 ribosomal protein L26-like 1 0.36
SLC25A39 solute carrier family 25, member 39 0.36
ZNF580 zinc finger protein 580 0.35
EIF4E2 eukaryotic translation initiation factor 4E family member 2 0.35
PRPS1 phosphoribosyl pyrophosphate synthetase 1 0.35
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.34
CUTA cutA divalent cation tolerance homolog (E. coli) 0.34
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 0.34
XIRP2 xin actin binding repeat containing 2 0.34
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.34
CHRD chordin 0.33
RPL7 ribosomal protein L7 0.33
NUCLEOLIN nucleolin multifunctional protein 0.33
CCDC170 coiled-coil domain containing 170 0.33
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 0.32
GRAMD1A GRAM domain containing 1A 0.32
KCTD21 potassium channel tetramerization domain containing 21 0.32
GCH1 GTP cyclohydrolase 1 0.32
SSB Sjogren syndrome antigen B (autoantigen La) 0.32
ZFP90 ZFP90 zinc finger protein 0.32
GUK1 guanylate kinase 1 0.31
RPL13 ribosomal protein L13 0.31
SLC4A3 solute carrier family 4 (anion exchanger), member 3 0.31
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.31
SP100 SP100 nuclear antigen 0.31
GNG5 guanine nucleotide binding protein (G protein), gamma 5 0.31
FSIP2 fibrous sheath interacting protein 2 0.3
GLI2 GLI family zinc finger 2 0.3
FAM89A family with sequence similarity 89, member A 0.3
TMEM11 transmembrane protein 11 0.3
LYRM7 LYR motif containing 7 0.3
UBL5 ubiquitin-like 5 0.3
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.29
PABPC1 poly(A) binding protein, cytoplasmic 1 0.29
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.29
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 0.29
LATS2 large tumor suppressor kinase 2 0.29
IRX4 iroquois homeobox 4 0.28
JPT1 Jupiter microtubule associated homolog 1 0.28
CAV1 caveolin 1, caveolae protein, 22kDa 0.28
BPTF bromodomain PHD finger transcription factor 0.28
EYS eyes shut homolog (Drosophila) 0.28
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.28
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 0.27
NUTF2 nuclear transport factor 2 0.27
RPS6 ribosomal protein S6 0.27
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 0.27
SLC30A6 solute carrier family 30 (zinc transporter), member 6 0.27
RAB14 RAB14, member RAS oncogene family 0.27
CDX2 caudal type homeobox 2 0.27
N4BP2L2 NEDD4 binding protein 2-like 2 0.26
KCTD6 potassium channel tetramerization domain containing 6 0.26
MYO15A myosin XVA 0.26
CD63 CD63 molecule 0.26
MRPS24 mitochondrial ribosomal protein S24 0.26
COA6 cytochrome c oxidase assembly factor 6 0.26
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.26
MRPL46 mitochondrial ribosomal protein L46 0.26
EWSR1 EWS RNA-binding protein 1 0.26

low expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 -1.74
DENND3 DENN/MADD domain containing 3 -0.82
UNC80 unc-80 homolog (C. elegans) -0.74
DNAH14 dynein, axonemal, heavy chain 14 -0.7
CCAR2 cell cycle and apoptosis regulator 2 -0.7
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.7
IRF7 interferon regulatory factor 7 -0.7
BAIAP3 BAI1-associated protein 3 -0.66
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.65
DTWD2 DTW domain containing 2 -0.61
NCKAP5L NCK-associated protein 5-like -0.57
FBXO33 F-box protein 33 -0.56
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.55
PXMP4 peroxisomal membrane protein 4, 24kDa -0.52
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -0.51
COL2A1 collagen, type II, alpha 1 -0.51
CNTLN centlein, centrosomal protein -0.5
OTC ornithine carbamoyltransferase -0.48
POMT2 protein-O-mannosyltransferase 2 -0.48
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.46
HOXA7 homeobox A7 -0.46
PEG10 paternally expressed 10 -0.45
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 -0.45
CLTA clathrin, light chain A -0.44
MEGF8 multiple EGF-like-domains 8 -0.43
TMEM38B transmembrane protein 38B -0.43
ANGPTL4 angiopoietin-like 4 -0.42
MYO1G myosin IG -0.42
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -0.41
SOX12 SRY (sex determining region Y)-box 12 -0.4
ZC3H10 zinc finger CCCH-type containing 10 -0.4
WIPI2 WD repeat domain, phosphoinositide interacting 2 -0.38
NT5C3B 5'-nucleotidase, cytosolic IIIB -0.38
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) -0.38
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.37
FGFR1OP2 FGFR1 oncogene partner 2 -0.36
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -0.36
COL11A1 collagen, type XI, alpha 1 -0.36
NPHP1 nephronophthisis 1 (juvenile) -0.36
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -0.36
PYGM phosphorylase, glycogen, muscle -0.36
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 -0.35
SZT2 seizure threshold 2 homolog (mouse) -0.35
SLC39A3 solute carrier family 39 (zinc transporter), member 3 -0.35
NRXN3 neurexin 3 -0.34
RMDN2 regulator of microtubule dynamics 2 -0.34
CKM creatine kinase, muscle -0.34
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -0.34
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) -0.34
CLU clusterin -0.33
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -0.33
HACD1 3-hydroxyacyl-CoA dehydratase 1 -0.33
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.33
H1-0 H1.0 linker histone -0.33
SPTB spectrin, beta, erythrocytic -0.32
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -0.32
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -0.32
PLCD1 phospholipase C, delta 1 -0.32
ABLIM2 actin binding LIM protein family, member 2 -0.32
EMP3 epithelial membrane protein 3 -0.32
GPR179 G protein-coupled receptor 179 -0.32
VGF VGF nerve growth factor inducible -0.31
CCN2 cellular communication network factor 2 -0.31
PLXNB1 plexin B1 -0.31
TC2N tandem C2 domains, nuclear -0.31
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -0.31
CRIP2 cysteine-rich protein 2 -0.31
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -0.31
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -0.3
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.3
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -0.3
PRXL2A peroxiredoxin like 2A -0.3
ZDHHC6 zinc finger, DHHC-type containing 6 -0.3
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.3
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.29
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -0.29
C1QTNF3 C1q and tumor necrosis factor related protein 3 -0.29
AKR1C3 aldo-keto reductase family 1, member C3 -0.29
TMED9 transmembrane emp24 protein transport domain containing 9 -0.29
SMC1B structural maintenance of chromosomes 1B -0.29
JOSD1 Josephin domain containing 1 -0.29
NOVA1 neuro-oncological ventral antigen 1 -0.29
TRAM2 translocation associated membrane protein 2 -0.28
SAP30L SAP30-like -0.28
DNAL4 dynein, axonemal, light chain 4 -0.28
POC1B POC1 centriolar protein B -0.28
SEC61B Sec61 beta subunit -0.28
RRAGC Ras-related GTP binding C -0.28
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.28
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.28
GAB1 GRB2-associated binding protein 1 -0.28
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.28
SLC45A1 solute carrier family 45, member 1 -0.28
MAP2 microtubule-associated protein 2 -0.28
LRP4 low density lipoprotein receptor-related protein 4 -0.28
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -0.28
FAM171A1 family with sequence similarity 171, member A1 -0.28
COL14A1 collagen, type XIV, alpha 1 -0.28
ARID5B AT rich interactive domain 5B (MRF1-like) -0.28