Peptic Ulcer Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An ulcer of the gastrointestinal tract. (Human Phenotype Ontology, HP_0004398)
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Genes

49 genes associated with the Peptic Ulcer phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
CCND1 cyclin D1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
FUT2 fucosyltransferase 2 (secretor status included)
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL6 interleukin 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KRAS Kirsten rat sarcoma viral oncogene homolog
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MPO myeloperoxidase
NFE2L2 nuclear factor, erythroid 2-like 2
PPARG peroxisome proliferator-activated receptor gamma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
SLCO1B1 solute carrier organic anion transporter family, member 1B1
TGFB1 transforming growth factor, beta 1
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TP53 tumor protein p53
TRB T cell receptor beta locus
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
VEGFA vascular endothelial growth factor A