Peretinoin_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.262036
TRIO trio Rho guanine nucleotide exchange factor 0.226949
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.202534
MYH9 myosin, heavy chain 9, non-muscle 0.18674
MT2A metallothionein 2A 0.149663
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.127337
DST dystonin 0.122392
PLAT plasminogen activator, tissue 0.11118
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.109855
CREB5 cAMP responsive element binding protein 5 0.0954026
CDH13 cadherin 13 0.0861501
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0855585
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0851634
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0824711
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0814173
TMSB10 thymosin beta 10 0.0811274
FNDC3B fibronectin type III domain containing 3B 0.0773742
SAMD4A sterile alpha motif domain containing 4A 0.0725362
AHNAK AHNAK nucleoprotein 0.0706686
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0667397
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0658696
CAVIN1 caveolae associated protein 1 0.065303
TGFB2 transforming growth factor, beta 2 0.0611705
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0602355
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0585767
LOX lysyl oxidase 0.0555895
FLNB filamin B, beta 0.0532884
APP amyloid beta (A4) precursor protein 0.0502375
HDAC9 histone deacetylase 9 0.0500177
MB21D2 Mab-21 domain containing 2 0.0493818
ACTN4 actinin, alpha 4 0.0493017
ELL2 elongation factor, RNA polymerase II, 2 0.0479409
TNIP1 TNFAIP3 interacting protein 1 0.0479012
RUNX1 runt-related transcription factor 1 0.0475729
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.046376
FBN1 fibrillin 1 0.0459132
ACTG1 actin gamma 1 0.04578
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0445616
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0429398
ERRFI1 ERBB receptor feedback inhibitor 1 0.0429207
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.042376
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0415878
TENM3 teneurin transmembrane protein 3 0.0415564
CORO1C coronin, actin binding protein, 1C 0.0412744
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.0408169
MSN moesin 0.0381899
EXT1 exostosin glycosyltransferase 1 0.0371395
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0370747
TSC22D2 TSC22 domain family, member 2 0.0370564
SFTPA2 surfactant protein A2 0.0359923
VCL vinculin 0.0357743
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0353093
TPM1 tropomyosin 1 (alpha) 0.0345638
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0345006
SDK1 sidekick cell adhesion molecule 1 0.0344652
RND3 Rho family GTPase 3 0.0337895
BCL2L1 BCL2-like 1 0.0337536
DTNA dystrobrevin, alpha 0.033543
ARL15 ADP-ribosylation factor-like 15 0.0334182
NEK7 NIMA-related kinase 7 0.0330481
FLNA filamin A, alpha 0.0323267
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.032168
CCN2 cellular communication network factor 2 0.0321014
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0318611
CLU clusterin 0.0306494
LIMA1 LIM domain and actin binding 1 0.0301898
SYT12 synaptotagmin XII 0.0301782
PLEC plectin 0.0300927
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.029859
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0295993
HEG1 heart development protein with EGF-like domains 1 0.0291966
ASPH aspartate beta-hydroxylase 0.0287023
NAV2 neuron navigator 2 0.0286924
NFE2L1 nuclear factor, erythroid 2-like 1 0.028217
TPM4 tropomyosin 4 0.0272601
LMO7 LIM domain 7 0.0272462
TLE4 transducin-like enhancer of split 4 0.0266887
PTPRM protein tyrosine phosphatase, receptor type, M 0.0266533
ATXN1 ataxin 1 0.0266185
ERBIN erbb2 interacting protein 0.0258893
PRRC2C proline-rich coiled-coil 2C 0.0258477
LIMCH1 LIM and calponin homology domains 1 0.0252172
TUFT1 tuftelin 1 0.0250386
ATP13A3 ATPase type 13A3 0.0247941
ZEB2 zinc finger E-box binding homeobox 2 0.0242968
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0242315
FSTL1 follistatin-like 1 0.0238289
FAT1 FAT atypical cadherin 1 0.0236329
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0235731
IQGAP1 IQ motif containing GTPase activating protein 1 0.0234392
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0229943
GLIS3 GLIS family zinc finger 3 0.0228528
PICALM phosphatidylinositol binding clathrin assembly protein 0.0225652
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0223653
OXTR oxytocin receptor 0.0222053
PRELID2 PRELI domain containing 2 0.0221675
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0221322
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0220809
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0220515
IGF2R insulin-like growth factor 2 receptor 0.02199

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.28304
VIM vimentin -0.164744
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.138979
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.115926
PODXL podocalyxin-like -0.0625784
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0610007
DLG1 discs, large homolog 1 (Drosophila) -0.0592091
S100A6 S100 calcium binding protein A6 -0.0564387
NDRG1 N-myc downstream regulated 1 -0.0562536
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0548156
SUCNR1 succinate receptor 1 -0.0507692
MYADM myeloid-associated differentiation marker -0.0495285
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0464864
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0447512
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0438508
CSTB cystatin B (stefin B) -0.0421542
MRPS6 mitochondrial ribosomal protein S6 -0.0401971
COL5A1 collagen, type V, alpha 1 -0.0401436
MEIS2 Meis homeobox 2 -0.0401045
CCND1 cyclin D1 -0.0398578
EGFR epidermal growth factor receptor -0.0393912
SLC39A11 solute carrier family 39, member 11 -0.0390298
ZBTB20 zinc finger and BTB domain containing 20 -0.0384761
SLC38A1 solute carrier family 38, member 1 -0.0374606
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0372941
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0355329
BHLHE40 basic helix-loop-helix family, member e40 -0.035089
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0348428
CD109 CD109 molecule -0.0346332
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0344604
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0338383
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0327969
CANX calnexin -0.0327164
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.032045
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0317883
FN1 fibronectin 1 -0.0310884
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0301107
BIRC6 baculoviral IAP repeat containing 6 -0.0297645
TAGLN2 transgelin 2 -0.0297067
TTC3 tetratricopeptide repeat domain 3 -0.0285995
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.028524
GOLGA4 golgin A4 -0.0283261
B2M beta-2-microglobulin -0.0283095
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0280369
FNDC3A fibronectin type III domain containing 3A -0.0274437
MX2 MX dynamin-like GTPase 2 -0.0267767
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0265751
RIGI RNA sensor RIG-I -0.0262423
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0261633
PRSS23 protease, serine, 23 -0.0261575
FTH1 ferritin, heavy polypeptide 1 -0.0249617
INSIG1 insulin induced gene 1 -0.0247078
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0237778
TGFB1 transforming growth factor, beta 1 -0.0236805
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.023668
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.02337
PDIA3 protein disulfide isomerase family A, member 3 -0.0233298
IARS1 isoleucyl-tRNA synthetase 1 -0.0229956
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0228554
LDHA lactate dehydrogenase A -0.0226767
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0224895
LIMS1 LIM and senescent cell antigen-like domains 1 -0.022341
CDK13 cyclin-dependent kinase 13 -0.0222673
RPL35A ribosomal protein L35a -0.0219791
VDAC1 voltage-dependent anion channel 1 -0.0213777
CMIP c-Maf inducing protein -0.0210929
GNAS GNAS complex locus -0.0210893
OASL 2'-5'-oligoadenylate synthetase-like -0.020826
HIP1 huntingtin interacting protein 1 -0.0208212
LMNA lamin A/C -0.0207216
SH3KBP1 SH3-domain kinase binding protein 1 -0.0207052
EPAS1 endothelial PAS domain protein 1 -0.0205251
SAMD9 sterile alpha motif domain containing 9 -0.0201471
SOD2 superoxide dismutase 2, mitochondrial -0.0201372
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.01978
FOSL1 FOS-like antigen 1 -0.0197702
WARS1 tryptophanyl-tRNA synthetase 1 -0.0197092
ABI3BP ABI family, member 3 (NESH) binding protein -0.0196026
CEP350 centrosomal protein 350kDa -0.0193457
GPBP1 GC-rich promoter binding protein 1 -0.0192283
DGKG diacylglycerol kinase, gamma 90kDa -0.0190796
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0187162
CXXC5 CXXC finger protein 5 -0.0185737
FNBP4 formin binding protein 4 -0.0183396
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0182927
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0180417
FLT1 fms-related tyrosine kinase 1 -0.017982
MON2 MON2 homolog (S. cerevisiae) -0.0174174
PFN1 profilin 1 -0.0171716
IL7R interleukin 7 receptor -0.0171561
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0171235
IKBIP IKBKB interacting protein -0.0170789
KDM6A lysine (K)-specific demethylase 6A -0.0169875
KIFAP3 kinesin-associated protein 3 -0.0167848
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0167286
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0166201
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0165452
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0163329
IFI16 interferon, gamma-inducible protein 16 -0.0162572
CEP170 centrosomal protein 170kDa -0.0161294