Peretinoin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.250119
EXT1 exostosin glycosyltransferase 1 0.109859
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0885022
STC1 stanniocalcin 1 0.0772704
NRG1 neuregulin 1 0.0733883
MYH9 myosin, heavy chain 9, non-muscle 0.0723227
TRIO trio Rho guanine nucleotide exchange factor 0.0664881
DTNA dystrobrevin, alpha 0.0652298
THSD4 thrombospondin, type I, domain containing 4 0.0636821
FMN1 formin 1 0.063431
LINGO2 leucine rich repeat and Ig domain containing 2 0.0611443
LSAMP limbic system-associated membrane protein 0.0552446
CEMIP cell migration inducing protein, hyaluronan binding 0.0496445
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0485277
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0434613
NALF1 NALCN channel auxiliary factor 1 0.0432007
ELL2 elongation factor, RNA polymerase II, 2 0.0431501
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.040404
PLAT plasminogen activator, tissue 0.0400501
GPC5 glypican 5 0.0396217
MACF1 microtubule-actin crosslinking factor 1 0.0387785
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0384153
ERRFI1 ERBB receptor feedback inhibitor 1 0.038151
PSD3 pleckstrin and Sec7 domain containing 3 0.0375202
CXCL8 chemokine (C-X-C motif) ligand 8 0.0372812
SMAD3 SMAD family member 3 0.0372743
DST dystonin 0.0370813
MAP1B microtubule-associated protein 1B 0.0348028
AKAP13 A kinase (PRKA) anchor protein 13 0.0346959
VGF VGF nerve growth factor inducible 0.034491
ITPRID2 ITPR interacting domain containing 2 0.0337064
HMGA2 high mobility group AT-hook 2 0.03346
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0334343
ZNF804A zinc finger protein 804A 0.0331655
AFF3 AF4/FMR2 family, member 3 0.0330541
CREB5 cAMP responsive element binding protein 5 0.0326067
CDH13 cadherin 13 0.0322449
SEPTIN9 septin 9 0.0312764
CRH corticotropin releasing hormone 0.0305063
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0300134
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0298388
RAI14 retinoic acid induced 14 0.0297766
LPP LIM domain containing preferred translocation partner in lipoma 0.0294459
MCL1 myeloid cell leukemia 1 0.0292029
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0287005
FLNB filamin B, beta 0.027498
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0274904
FNDC3B fibronectin type III domain containing 3B 0.0269372
NDRG1 N-myc downstream regulated 1 0.0265728
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0264747
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0258197
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0257032
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0254783
HSPA8 heat shock 70kDa protein 8 0.0250794
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0249813
AFDN afadin, adherens junction formation factor 0.0248659
HPCAL1 hippocalcin-like 1 0.024728
SAMD4A sterile alpha motif domain containing 4A 0.0243307
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0242981
ADARB1 adenosine deaminase, RNA-specific, B1 0.0240039
ATP13A3 ATPase type 13A3 0.02373
TOP1 topoisomerase (DNA) I 0.0231879
SLC35F3 solute carrier family 35, member F3 0.0226883
UBA6 ubiquitin-like modifier activating enzyme 6 0.022159
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0217114
PTPRE protein tyrosine phosphatase, receptor type, E 0.0212922
IGFBP3 insulin-like growth factor binding protein 3 0.0212638
SDK1 sidekick cell adhesion molecule 1 0.0211591
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0210268
LIMCH1 LIM and calponin homology domains 1 0.02083
RPL3 ribosomal protein L3 0.0208066
DIAPH2 diaphanous-related formin 2 0.0206098
USP53 ubiquitin specific peptidase 53 0.0203628
PACS1 phosphofurin acidic cluster sorting protein 1 0.0200768
PTK2 protein tyrosine kinase 2 0.019968
CYTH1 cytohesin 1 0.019888
TIMP3 TIMP metallopeptidase inhibitor 3 0.0197161
AHR aryl hydrocarbon receptor 0.0195385
SCG2 secretogranin II 0.0194195
NES nestin 0.019289
COL4A5 collagen, type IV, alpha 5 0.019138
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0191078
RUNX1 runt-related transcription factor 1 0.019011
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0185788
NUP58 nucleoporin 58 0.01837
SYNJ2 synaptojanin 2 0.0182757
KCTD16 potassium channel tetramerization domain containing 16 0.0181942
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0180159
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0178138
APP amyloid beta (A4) precursor protein 0.0173739
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.017357
ZC3H11A zinc finger CCCH-type containing 11A 0.0172999
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0172655
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0171477
PPARD peroxisome proliferator-activated receptor delta 0.0171394
NPAS2 neuronal PAS domain protein 2 0.0171365
SPAG9 sperm associated antigen 9 0.0171303
MYO9B myosin IXB 0.017048
CPNE8 copine VIII 0.0169369
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0166606

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.255908
IGF2 insulin-like growth factor 2 -0.187671
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175756
RPL23 ribosomal protein L23 -0.0734321
RPLP1 ribosomal protein, large, P1 -0.0651579
VIM vimentin -0.0607291
PTMA prothymosin, alpha -0.0565155
MEIS2 Meis homeobox 2 -0.0554151
TLE4 transducin-like enhancer of split 4 -0.0527273
RPS6 ribosomal protein S6 -0.0501861
RPL38 ribosomal protein L38 -0.0500858
RPL35A ribosomal protein L35a -0.0495999
EIF1 eukaryotic translation initiation factor 1 -0.046326
RPL34 ribosomal protein L34 -0.0423348
B2M beta-2-microglobulin -0.0378455
FTL ferritin, light polypeptide -0.0371714
RPL37A ribosomal protein L37a -0.0360734
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0354695
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0339528
SYT1 synaptotagmin I -0.0332378
RPL12 ribosomal protein L12 -0.0329953
RPS12 ribosomal protein S12 -0.032983
RPS23 ribosomal protein S23 -0.0318082
CHD9 chromodomain helicase DNA binding protein 9 -0.0303256
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0303081
DPH6 diphthamine biosynthesis 6 -0.0294756
RPL31 ribosomal protein L31 -0.0289699
RPS19 ribosomal protein S19 -0.0285198
CD36 CD36 molecule (thrombospondin receptor) -0.0284532
MBD5 methyl-CpG binding domain protein 5 -0.0268634
TBX2 T-box 2 -0.026853
TENT5A terminal nucleotidyltransferase 5A -0.0267396
GOLGA4 golgin A4 -0.0266245
DCAF7 DDB1 and CUL4 associated factor 7 -0.0255584
RPLP0 ribosomal protein, large, P0 -0.0253964
RPS24 ribosomal protein S24 -0.0253593
TMSB10 thymosin beta 10 -0.0241445
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0239801
RPL27 ribosomal protein L27 -0.023944
RPL36 ribosomal protein L36 -0.023479
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0234502
RPS29 ribosomal protein S29 -0.0232451
RPL19 ribosomal protein L19 -0.023151
RPS3 ribosomal protein S3 -0.0231294
RPL32 ribosomal protein L32 -0.0231128
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0225575
RPL7 ribosomal protein L7 -0.0224238
SMYD3 SET and MYND domain containing 3 -0.0223825
RPS27 ribosomal protein S27 -0.0220071
COL1A1 collagen, type I, alpha 1 -0.0213942
RPS11 ribosomal protein S11 -0.021188
H3-3B H3.3 histone B -0.0210125
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0209357
TPT1 tumor protein, translationally-controlled 1 -0.0208811
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.020592
RBM25 RNA binding motif protein 25 -0.0204418
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0203111
IFI16 interferon, gamma-inducible protein 16 -0.0201908
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0201472
S100A9 S100 calcium binding protein A9 -0.0200289
GATA3 GATA binding protein 3 -0.0200246
RPS25 ribosomal protein S25 -0.0197085
MBNL2 muscleblind-like splicing regulator 2 -0.019697
RPL30 ribosomal protein L30 -0.0195823
S100A6 S100 calcium binding protein A6 -0.0194493
RPS20 ribosomal protein S20 -0.019024
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0189985
RPL9 ribosomal protein L9 -0.0188254
RPL28 ribosomal protein L28 -0.0187928
GARS1 glycyl-tRNA synthetase 1 -0.0184984
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0183431
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0181743
BPTF bromodomain PHD finger transcription factor -0.0179544
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.017756
LDHB lactate dehydrogenase B -0.0174539
RPS14 ribosomal protein S14 -0.0171697
CAMKMT calmodulin-lysine N-methyltransferase -0.0171627
NAP1L1 nucleosome assembly protein 1-like 1 -0.0171432
RPL26 ribosomal protein L26 -0.0170463
ZNF638 zinc finger protein 638 -0.0168725
RNF150 ring finger protein 150 -0.0168008
RPS21 ribosomal protein S21 -0.0167575
PIBF1 progesterone immunomodulatory binding factor 1 -0.0165515
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0164041
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0162527
RPS15 ribosomal protein S15 -0.0160876
ZNF292 zinc finger protein 292 -0.0160017
CCDC47 coiled-coil domain containing 47 -0.0159674
HAS2 hyaluronan synthase 2 -0.0158933
RPL37 ribosomal protein L37 -0.0158347
TBCA tubulin folding cofactor A -0.0157991
AKAP9 A kinase (PRKA) anchor protein 9 -0.0156174
KIF21A kinesin family member 21A -0.0155844
LMNA lamin A/C -0.0155448
TRA2A transformer 2 alpha homolog (Drosophila) -0.0155423
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0154991
RBM39 RNA binding motif protein 39 -0.0154854
CFDP1 craniofacial development protein 1 -0.0153711
VDAC1 voltage-dependent anion channel 1 -0.0151208
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0150976