Peretinoin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.345003
TRIO trio Rho guanine nucleotide exchange factor 0.162341
MYH9 myosin, heavy chain 9, non-muscle 0.160084
TMSB10 thymosin beta 10 0.109433
BCL2L1 BCL2-like 1 0.108123
PLEC plectin 0.107178
PLAT plasminogen activator, tissue 0.0969443
PODXL podocalyxin-like 0.0949722
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0861937
DOCK5 dedicator of cytokinesis 5 0.0851492
MT2A metallothionein 2A 0.0840758
CLU clusterin 0.0775728
KRT17 keratin 17, type I 0.073233
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0724954
FOXO1 forkhead box O1 0.0671154
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0617733
H1-0 H1.0 linker histone 0.0603849
ANLN anillin, actin binding protein 0.0596203
ARHGAP29 Rho GTPase activating protein 29 0.0568625
ENO1 enolase 1, (alpha) 0.0558782
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0557875
AHNAK AHNAK nucleoprotein 0.0546886
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.053151
MYO10 myosin X 0.0515547
EPHA2 EPH receptor A2 0.0505978
LAMC2 laminin, gamma 2 0.0500129
MSN moesin 0.0496439
APP amyloid beta (A4) precursor protein 0.0490536
SULF1 sulfatase 1 0.0488312
MACF1 microtubule-actin crosslinking factor 1 0.0487672
OSBPL3 oxysterol binding protein-like 3 0.0476948
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0450906
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0445444
SMAD3 SMAD family member 3 0.0442628
ASPH aspartate beta-hydroxylase 0.0430282
TPX2 TPX2, microtubule-associated 0.0427132
ANKRD33B ankyrin repeat domain 33B 0.0423388
APLP2 amyloid beta (A4) precursor-like protein 2 0.0421157
CUL4B cullin 4B 0.0417799
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0417723
DST dystonin 0.0417172
FLNA filamin A, alpha 0.0415921
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0410177
MBNL1 muscleblind-like splicing regulator 1 0.0390665
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0383688
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0376616
MKI67 marker of proliferation Ki-67 0.0368611
NRG1 neuregulin 1 0.0368532
ITGA6 integrin, alpha 6 0.0363522
PLK2 polo-like kinase 2 0.0355239
CMIP c-Maf inducing protein 0.0352256
KRT6A keratin 6A, type II 0.0339702
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0339513
RPL11 ribosomal protein L11 0.0337559
RPLP2 ribosomal protein, large, P2 0.0333967
S100A10 S100 calcium binding protein A10 0.0333155
NEK7 NIMA-related kinase 7 0.033178
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.03309
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0330431
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0325238
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0325204
MPRIP myosin phosphatase Rho interacting protein 0.032489
TXNRD1 thioredoxin reductase 1 0.0319767
TGM2 transglutaminase 2 0.0318177
TMSB4X thymosin beta 4, X-linked 0.0316873
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0315075
MYOF myoferlin 0.0311445
TNS4 tensin 4 0.0311385
CD59 CD59 molecule, complement regulatory protein 0.0311178
EFHD2 EF-hand domain family, member D2 0.0310406
CAVIN1 caveolae associated protein 1 0.0310109
LPAR1 lysophosphatidic acid receptor 1 0.0310103
LNPEP leucyl/cystinyl aminopeptidase 0.0307805
RPS19 ribosomal protein S19 0.0302402
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0301437
ACTN1 actinin, alpha 1 0.0298472
EEF2 eukaryotic translation elongation factor 2 0.0297646
RASAL2 RAS protein activator like 2 0.029668
RPL3 ribosomal protein L3 0.029595
RPS21 ribosomal protein S21 0.0294886
CPNE1 copine I 0.0294491
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0294095
ANXA2 annexin A2 0.0293743
TNIP1 TNFAIP3 interacting protein 1 0.029359
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.029248
RPS3 ribosomal protein S3 0.0291209
IFITM3 interferon induced transmembrane protein 3 0.0290338
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0289899
AFAP1 actin filament associated protein 1 0.0288064
KRT8 keratin 8, type II 0.0287621
PTPRF protein tyrosine phosphatase, receptor type, F 0.028594
PRELID2 PRELI domain containing 2 0.028572
RPL35 ribosomal protein L35 0.0284686
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0283688
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0277995
SYNJ2 synaptojanin 2 0.0270242
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0270062
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0269658
FN1 fibronectin 1 0.0267563
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0266058

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.190759
MTSS1 metastasis suppressor 1 -0.094682
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0889584
LMO7 LIM domain 7 -0.0872917
PDE4D phosphodiesterase 4D, cAMP-specific -0.0865989
RAI14 retinoic acid induced 14 -0.0768433
ABI3BP ABI family, member 3 (NESH) binding protein -0.0725109
FTH1 ferritin, heavy polypeptide 1 -0.0641018
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0634684
MEF2A myocyte enhancer factor 2A -0.0566812
ESYT2 extended synaptotagmin-like protein 2 -0.055902
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0556333
IGF2 insulin-like growth factor 2 -0.0482222
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0477217
GRB10 growth factor receptor-bound protein 10 -0.046726
ALCAM activated leukocyte cell adhesion molecule -0.0454272
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0450415
RIGI RNA sensor RIG-I -0.0427059
WARS1 tryptophanyl-tRNA synthetase 1 -0.0369934
MBNL2 muscleblind-like splicing regulator 2 -0.0362965
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0361225
IFI44L interferon-induced protein 44-like -0.0351954
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0351524
ANXA1 annexin A1 -0.0349434
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0335165
GOLGB1 golgin B1 -0.0328002
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0321307
ZCCHC7 zinc finger, CCHC domain containing 7 -0.03193
CALB1 calbindin 1, 28kDa -0.0313471
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.030856
LAMA5 laminin, alpha 5 -0.0306491
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0300204
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0297961
SULF2 sulfatase 2 -0.0292648
FNDC3A fibronectin type III domain containing 3A -0.0282995
IARS1 isoleucyl-tRNA synthetase 1 -0.0276551
HMGA1 high mobility group AT-hook 1 -0.0274837
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0270536
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0267525
CDK13 cyclin-dependent kinase 13 -0.0266179
PLS3 plastin 3 -0.0263149
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0262946
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0261081
FNIP1 folliculin interacting protein 1 -0.0260259
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0256216
RABGAP1L RAB GTPase activating protein 1-like -0.0256056
PPARG peroxisome proliferator-activated receptor gamma -0.025449
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0253386
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0251436
NDRG1 N-myc downstream regulated 1 -0.0251141
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0250918
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.025076
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0250104
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0248816
CSTB cystatin B (stefin B) -0.0244095
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0240163
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0240024
IFI44 interferon-induced protein 44 -0.0239899
COL17A1 collagen, type XVII, alpha 1 -0.0238942
DOK5 docking protein 5 -0.0238202
ATF4 activating transcription factor 4 -0.0234921
KCTD12 potassium channel tetramerization domain containing 12 -0.023487
JMJD1C jumonji domain containing 1C -0.0231974
RAB7A RAB7A, member RAS oncogene family -0.0230058
CD44 CD44 molecule (Indian blood group) -0.0229811
FBXO11 F-box protein 11 -0.0229804
INTS6 integrator complex subunit 6 -0.0228566
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0224944
KIF16B kinesin family member 16B -0.0224358
DIAPH1 diaphanous-related formin 1 -0.0222794
CNTNAP3 contactin associated protein-like 3 -0.0222165
CANX calnexin -0.0222024
NAV2 neuron navigator 2 -0.0219807
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0216876
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.021619
VEGFA vascular endothelial growth factor A -0.0215126
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0214599
AKAP9 A kinase (PRKA) anchor protein 9 -0.0214523
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0212718
RAB10 RAB10, member RAS oncogene family -0.0211116
ZNF395 zinc finger protein 395 -0.0209433
ZMYND8 zinc finger, MYND-type containing 8 -0.0209339
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0207675
TRIM56 tripartite motif containing 56 -0.0206216
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0203241
LRP1B low density lipoprotein receptor-related protein 1B -0.0201195
SAMD9 sterile alpha motif domain containing 9 -0.0201152
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0200498
DYNC2I1 dynein 2 intermediate chain 1 -0.0199911
MX1 MX dynamin-like GTPase 1 -0.0198803
WDFY2 WD repeat and FYVE domain containing 2 -0.019771
SPIRE1 spire-type actin nucleation factor 1 -0.0197276
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.019571
SP100 SP100 nuclear antigen -0.0190489
SQLE squalene epoxidase -0.0190476
RBM39 RNA binding motif protein 39 -0.0190247
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0189486
SQSTM1 sequestosome 1 -0.0188222
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0187669
HSPG2 heparan sulfate proteoglycan 2 -0.0184334