Peretinoin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.194791
MYH9 myosin, heavy chain 9, non-muscle 0.158515
ACTG1 actin gamma 1 0.150324
TMSB10 thymosin beta 10 0.147749
MYO5B myosin VB 0.134395
ASPH aspartate beta-hydroxylase 0.110279
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.108994
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.107927
ANXA2 annexin A2 0.107717
AHNAK AHNAK nucleoprotein 0.0965788
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0916189
SAMD4A sterile alpha motif domain containing 4A 0.0883987
LAMC2 laminin, gamma 2 0.0875314
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0857524
KRT8 keratin 8, type II 0.0851642
TMSB4X thymosin beta 4, X-linked 0.0763234
LMO7 LIM domain 7 0.0753694
AKAP12 A kinase (PRKA) anchor protein 12 0.0734463
ACTN4 actinin, alpha 4 0.0734104
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0723742
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0719896
TRIO trio Rho guanine nucleotide exchange factor 0.0698921
HSPA8 heat shock 70kDa protein 8 0.0690566
ERRFI1 ERBB receptor feedback inhibitor 1 0.0683699
TPM4 tropomyosin 4 0.0661927
ZFAND3 zinc finger, AN1-type domain 3 0.0655895
RPL3 ribosomal protein L3 0.0649091
LAMB3 laminin, beta 3 0.0626099
APP amyloid beta (A4) precursor protein 0.0624645
PLEC plectin 0.061623
MACF1 microtubule-actin crosslinking factor 1 0.0613943
PGK1 phosphoglycerate kinase 1 0.0612243
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0574507
ADAM9 ADAM metallopeptidase domain 9 0.0556735
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0546075
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0542007
RAP1B RAP1B, member of RAS oncogene family 0.0535491
ATXN1 ataxin 1 0.0534423
AFDN afadin, adherens junction formation factor 0.0534152
LPP LIM domain containing preferred translocation partner in lipoma 0.053287
ANXA3 annexin A3 0.0525902
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0519699
DSPP dentin sialophosphoprotein 0.051146
KDM3A lysine (K)-specific demethylase 3A 0.0504633
EEF2 eukaryotic translation elongation factor 2 0.0494778
NDRG1 N-myc downstream regulated 1 0.0485527
PARD3 par-3 family cell polarity regulator 0.0479727
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0477152
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.046947
USP53 ubiquitin specific peptidase 53 0.0467995
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0466469
KRT18 keratin 18, type I 0.0466157
TSC22D2 TSC22 domain family, member 2 0.0465899
ANKRD11 ankyrin repeat domain 11 0.0465398
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0464894
ANKRD10 ankyrin repeat domain 10 0.0464865
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0461709
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.044647
CCNY cyclin Y 0.0441814
MPRIP myosin phosphatase Rho interacting protein 0.0440264
SLC35F3 solute carrier family 35, member F3 0.0436132
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0433199
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0428804
TPM3 tropomyosin 3 0.0420243
FAM13A family with sequence similarity 13, member A 0.0417853
EZR ezrin 0.0416831
RTN4 reticulon 4 0.0416385
SMYD3 SET and MYND domain containing 3 0.041523
TPT1 tumor protein, translationally-controlled 1 0.0409223
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0408245
PRRC2C proline-rich coiled-coil 2C 0.0406007
DSG2 desmoglein 2 0.0403692
RPS3 ribosomal protein S3 0.0402007
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0400619
SRRM2 serine/arginine repetitive matrix 2 0.0399829
F3 coagulation factor III (thromboplastin, tissue factor) 0.039753
RPS12 ribosomal protein S12 0.0394318
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0391422
AKAP13 A kinase (PRKA) anchor protein 13 0.0389771
SNX9 sorting nexin 9 0.038778
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0380825
NPSR1 neuropeptide S receptor 1 0.0379571
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0375704
FLNA filamin A, alpha 0.0373988
JMJD1C jumonji domain containing 1C 0.0371816
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0367336
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0365737
DOCK5 dedicator of cytokinesis 5 0.0365292
FRMD5 FERM domain containing 5 0.0364456
NUMA1 nuclear mitotic apparatus protein 1 0.0363232
KLF6 Kruppel-like factor 6 0.0363039
ANXA1 annexin A1 0.0362333
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0357411
CD2AP CD2-associated protein 0.0355052
PPARD peroxisome proliferator-activated receptor delta 0.0354649
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0350044
SLMAP sarcolemma associated protein 0.0349734
KLC1 kinesin light chain 1 0.0347123
SPAG9 sperm associated antigen 9 0.0346801
MYO6 myosin VI 0.0344718

decreased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming -0.165026
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152567
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.119765
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103753
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0803936
GMDS GDP-mannose 4,6-dehydratase -0.0711581
FTH1 ferritin, heavy polypeptide 1 -0.0682024
GPHN gephyrin -0.0680456
GOLGA4 golgin A4 -0.0571382
LOC102724023 ES1 protein homolog, mitochondrial -0.0565509
TRIM2 tripartite motif containing 2 -0.0543803
NALF1 NALCN channel auxiliary factor 1 -0.0540281
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0488636
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0474544
RPL35A ribosomal protein L35a -0.0470984
TTC3 tetratricopeptide repeat domain 3 -0.0451659
MYO1E myosin IE -0.0438094
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0430619
GDF15 growth differentiation factor 15 -0.0372216
MLEC malectin -0.0365861
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0331249
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0321939
ATP5F1B ATP synthase F1 subunit beta -0.0301048
PTMA prothymosin, alpha -0.0296013
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0276703
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0274257
AKAP9 A kinase (PRKA) anchor protein 9 -0.0264424
IARS1 isoleucyl-tRNA synthetase 1 -0.0261824
POF1B premature ovarian failure, 1B -0.0248004
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0242831
PTEN phosphatase and tensin homolog -0.024131
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0240773
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0232586
ATF4 activating transcription factor 4 -0.0229095
CEMIP2 cell migration inducing hyaluronidase 2 -0.022695
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0222616
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0219415
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0210709
VEGFA vascular endothelial growth factor A -0.0207329
MON2 MON2 homolog (S. cerevisiae) -0.0204885
NUCB2 nucleobindin 2 -0.0204869
ESYT2 extended synaptotagmin-like protein 2 -0.0204774
RNF145 ring finger protein 145 -0.0202116
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0197995
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0197978
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.0197835
MED13 mediator complex subunit 13 -0.0195777
FNDC3B fibronectin type III domain containing 3B -0.0195196
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0194396
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0193977
GCC2 GRIP and coiled-coil domain containing 2 -0.0191678
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0189288
PKP2 plakophilin 2 -0.0188322
PTPRE protein tyrosine phosphatase, receptor type, E -0.0185403
PCDHB16 protocadherin beta 16 -0.0185249
PPARG peroxisome proliferator-activated receptor gamma -0.0184783
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0181538
TAS2R14 taste receptor, type 2, member 14 -0.0180661
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0179171
SOX9 SRY (sex determining region Y)-box 9 -0.0179093
MT1E metallothionein 1E -0.0179085
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0177775
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -0.0177452
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0177416
PTPRR protein tyrosine phosphatase, receptor type, R -0.0176809
SCARB2 scavenger receptor class B, member 2 -0.0176525
FBXO32 F-box protein 32 -0.0176372
PER2 period circadian clock 2 -0.0176366
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 -0.0174557
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0174329
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0173788
TUBB4B tubulin, beta 4B class IVb -0.0171148
NFIA nuclear factor I/A -0.0168166
MLF1 myeloid leukemia factor 1 -0.0166591
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0165767
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0165748
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0163507
FNDC3A fibronectin type III domain containing 3A -0.0163474
MBNL2 muscleblind-like splicing regulator 2 -0.0160756
NEBL nebulette -0.0159799
TMEM135 transmembrane protein 135 -0.0159389
ADIPOR2 adiponectin receptor 2 -0.0159347
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0158847
CYB5R3 cytochrome b5 reductase 3 -0.0156968
RNF43 ring finger protein 43 -0.0155768
HMGA1 high mobility group AT-hook 1 -0.0154745
FAAH2 fatty acid amide hydrolase 2 -0.0152923
GOLPH3L golgi phosphoprotein 3-like -0.0151968
EFNB2 ephrin-B2 -0.0151043
LCORL ligand dependent nuclear receptor corepressor-like -0.0150864
USP6NL USP6 N-terminal like -0.0150821
RORA RAR-related orphan receptor A -0.0150805
ANKRD17 ankyrin repeat domain 17 -0.0150594
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0149542
MARCHF3 membrane associated ring-CH-type finger 3 -0.0149509
PDIA3 protein disulfide isomerase family A, member 3 -0.0147892
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0147727
TENT5A terminal nucleotidyltransferase 5A -0.0147686
FTL ferritin, light polypeptide -0.0147053
CEMIP cell migration inducing protein, hyaluronan binding -0.0146984