Peretinoin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.167523
MT2A metallothionein 2A 0.148727
TMSB10 thymosin beta 10 0.11668
TXNRD1 thioredoxin reductase 1 0.111463
MYH9 myosin, heavy chain 9, non-muscle 0.105114
FMNL2 formin-like 2 0.101093
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0986107
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0858382
FLNB filamin B, beta 0.085801
TM4SF1 transmembrane 4 L six family member 1 0.0801345
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0797793
MACF1 microtubule-actin crosslinking factor 1 0.0745845
CXCL8 chemokine (C-X-C motif) ligand 8 0.0725692
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0711819
ANKRD11 ankyrin repeat domain 11 0.0705495
RAI1 retinoic acid induced 1 0.0699952
KRT18 keratin 18, type I 0.0643216
CMIP c-Maf inducing protein 0.0606075
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.05972
TSC22D2 TSC22 domain family, member 2 0.0594723
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0585135
EZR ezrin 0.0568684
ZEB1 zinc finger E-box binding homeobox 1 0.0561817
ACTG1 actin gamma 1 0.0535598
SAMD4A sterile alpha motif domain containing 4A 0.0526704
CENPF centromere protein F, 350/400kDa 0.0526664
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0525741
TRIO trio Rho guanine nucleotide exchange factor 0.050158
RTN4 reticulon 4 0.0501549
PRDX1 peroxiredoxin 1 0.0501188
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0470831
HSPA8 heat shock 70kDa protein 8 0.0455919
RPL3 ribosomal protein L3 0.0455205
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.045468
MKI67 marker of proliferation Ki-67 0.0454083
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0451428
GARS1 glycyl-tRNA synthetase 1 0.0443282
UPP1 uridine phosphorylase 1 0.0425034
ARHGAP29 Rho GTPase activating protein 29 0.0407607
EEF2 eukaryotic translation elongation factor 2 0.0405782
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0395969
ADAM17 ADAM metallopeptidase domain 17 0.0394659
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0394306
MSN moesin 0.0393488
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0392444
AREG amphiregulin 0.0392068
ANLN anillin, actin binding protein 0.0391674
CAPRIN2 caprin family member 2 0.0390714
PTPRF protein tyrosine phosphatase, receptor type, F 0.038646
YBX3 Y box binding protein 3 0.037951
ADARB1 adenosine deaminase, RNA-specific, B1 0.0376257
RRM2 ribonucleotide reductase M2 0.0375698
RPL35 ribosomal protein L35 0.037359
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0370701
ZFAND3 zinc finger, AN1-type domain 3 0.0365919
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.035131
SPIRE1 spire-type actin nucleation factor 1 0.0349888
RASA2 RAS p21 protein activator 2 0.0346858
PYGL phosphorylase, glycogen, liver 0.0344574
APP amyloid beta (A4) precursor protein 0.0344035
EIF4A1 eukaryotic translation initiation factor 4A1 0.034121
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0325621
NAV2 neuron navigator 2 0.0323323
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0321346
NCEH1 neutral cholesterol ester hydrolase 1 0.0314268
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0313436
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.030762
TUBB6 tubulin, beta 6 class V 0.0306414
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0304459
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0304441
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0300763
NUP58 nucleoporin 58 0.0297497
ANXA2 annexin A2 0.0295088
PODXL podocalyxin-like 0.0293287
RPL23 ribosomal protein L23 0.0288109
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0285904
KRT8 keratin 8, type II 0.028535
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0282071
KCMF1 potassium channel modulatory factor 1 0.0281241
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0279672
PYGB phosphorylase, glycogen; brain 0.0272649
SFPQ splicing factor proline/glutamine-rich 0.0268191
SPAG9 sperm associated antigen 9 0.026652
TPM3 tropomyosin 3 0.0265484
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0260747
SRRM2 serine/arginine repetitive matrix 2 0.0260486
SRPK2 SRSF protein kinase 2 0.0258421
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0258148
TPX2 TPX2, microtubule-associated 0.0255627
CDCP1 CUB domain containing protein 1 0.0254607
ACTN1 actinin, alpha 1 0.0251116
SND1 staphylococcal nuclease and tudor domain containing 1 0.0251114
POTEF POTE ankyrin domain family, member F 0.0248855
CTBP2 C-terminal binding protein 2 0.0246959
WDR43 WD repeat domain 43 0.0246212
EREG epiregulin 0.0244776
ATP13A3 ATPase type 13A3 0.024262
MCL1 myeloid cell leukemia 1 0.0242503
JMJD1C jumonji domain containing 1C 0.0240002
SESN2 sestrin 2 0.0239366

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.219094
VIM vimentin -0.172425
HLA-B major histocompatibility complex, class I, B -0.151154
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.140632
CD44 CD44 molecule (Indian blood group) -0.125605
STAT1 signal transducer and activator of transcription 1, 91kDa -0.113863
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.109273
RIGI RNA sensor RIG-I -0.10139
CADM2 cell adhesion molecule 2 -0.0893713
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0884729
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0854779
TMSB4X thymosin beta 4, X-linked -0.0833893
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0832537
WARS1 tryptophanyl-tRNA synthetase 1 -0.0797166
DPYD dihydropyrimidine dehydrogenase -0.0761816
RNF213 ring finger protein 213 -0.0753384
ZMYND8 zinc finger, MYND-type containing 8 -0.0751451
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0729603
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0716169
IFIH1 interferon induced with helicase C domain 1 -0.0708149
SP100 SP100 nuclear antigen -0.0695111
EFNA5 ephrin-A5 -0.065286
TNS3 tensin 3 -0.0611203
HDAC9 histone deacetylase 9 -0.0596092
CANX calnexin -0.0548122
TRIM56 tripartite motif containing 56 -0.0544943
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0542524
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0542249
EPHA4 EPH receptor A4 -0.0536356
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0499703
B2M beta-2-microglobulin -0.0493422
RPL35A ribosomal protein L35a -0.0491102
TSC22D1 TSC22 domain family, member 1 -0.0476627
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0469784
WSB1 WD repeat and SOCS box containing 1 -0.0440182
SMYD3 SET and MYND domain containing 3 -0.0435634
RAD51B RAD51 paralog B -0.0426759
EXOC4 exocyst complex component 4 -0.0421917
IFITM1 interferon induced transmembrane protein 1 -0.0419928
TPT1 tumor protein, translationally-controlled 1 -0.0415934
FTH1 ferritin, heavy polypeptide 1 -0.0414636
PLSCR1 phospholipid scramblase 1 -0.0411632
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0404732
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0400156
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0392891
HLA-E major histocompatibility complex, class I, E -0.0383249
EHBP1 EH domain binding protein 1 -0.0378601
PMP22 peripheral myelin protein 22 -0.0374874
ARL4C ADP-ribosylation factor-like 4C -0.0370539
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0365784
BIRC3 baculoviral IAP repeat containing 3 -0.0364012
IFI6 interferon, alpha-inducible protein 6 -0.036241
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0356879
WWTR1 WW domain containing transcription regulator 1 -0.0343434
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0335781
AHNAK2 AHNAK nucleoprotein 2 -0.033475
KPNB1 karyopherin (importin) beta 1 -0.0332869
HMGA1 high mobility group AT-hook 1 -0.0332493
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.033206
DPH6 diphthamine biosynthesis 6 -0.0330402
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0325688
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0315922
CHD9 chromodomain helicase DNA binding protein 9 -0.0315089
ANKRD12 ankyrin repeat domain 12 -0.0314973
TPRG1 tumor protein p63 regulated 1 -0.0313973
PSD3 pleckstrin and Sec7 domain containing 3 -0.031209
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0311747
GNAS GNAS complex locus -0.0311719
RPL36A ribosomal protein L36a -0.0309295
MBD5 methyl-CpG binding domain protein 5 -0.0303271
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0301403
ISG15 ISG15 ubiquitin-like modifier -0.029982
ADAM10 ADAM metallopeptidase domain 10 -0.0298519
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0295983
BPTF bromodomain PHD finger transcription factor -0.0295652
PGK1 phosphoglycerate kinase 1 -0.0294165
SQSTM1 sequestosome 1 -0.0292854
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0291373
PTK2 protein tyrosine kinase 2 -0.0291179
AKAP9 A kinase (PRKA) anchor protein 9 -0.0290619
ARHGAP5 Rho GTPase activating protein 5 -0.0290055
TTC3 tetratricopeptide repeat domain 3 -0.0289147
RAD50 RAD50 homolog (S. cerevisiae) -0.0288832
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0286257
VCL vinculin -0.0280505
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0278616
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.027478
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.027477
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0274152
HLA-A major histocompatibility complex, class I, A -0.0270314
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -0.0269865
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0269057
ENOSF1 enolase superfamily member 1 -0.0267267
SUMF1 sulfatase modifying factor 1 -0.0259973
DNER delta/notch-like EGF repeat containing -0.0258152
DNAH14 dynein, axonemal, heavy chain 14 -0.0257872
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0255374
PATJ PATJ crumbs cell polarity complex component -0.0252468
SLK STE20-like kinase -0.0251491
EPB41 erythrocyte membrane protein band 4.1 -0.0250849