Peretinoin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.201515
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.149297
LAMC2 laminin, gamma 2 0.126167
PTMA prothymosin, alpha 0.122367
MYH9 myosin, heavy chain 9, non-muscle 0.120406
THSD4 thrombospondin, type I, domain containing 4 0.119937
DTNA dystrobrevin, alpha 0.105401
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0952159
RPS3 ribosomal protein S3 0.0853864
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0783077
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.076072
SAMD4A sterile alpha motif domain containing 4A 0.0748266
MT2A metallothionein 2A 0.0738857
NDRG1 N-myc downstream regulated 1 0.0726219
S100A10 S100 calcium binding protein A10 0.0710385
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0698647
ACTG1 actin gamma 1 0.0687953
GRAMD1B GRAM domain containing 1B 0.0682436
TRIO trio Rho guanine nucleotide exchange factor 0.0634221
SLTM SAFB-like, transcription modulator 0.0623941
SPAG9 sperm associated antigen 9 0.0605628
FAM13A family with sequence similarity 13, member A 0.0592816
PYGL phosphorylase, glycogen, liver 0.0590755
MYO5B myosin VB 0.0589006
TNIP1 TNFAIP3 interacting protein 1 0.0565768
GSK3B glycogen synthase kinase 3 beta 0.0547759
MSN moesin 0.0541783
RUNX1 runt-related transcription factor 1 0.0533919
RASA2 RAS p21 protein activator 2 0.0531435
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0529093
TSC22D2 TSC22 domain family, member 2 0.051202
SCEL sciellin 0.0508437
ANXA2 annexin A2 0.0494263
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0489939
PKM pyruvate kinase, muscle 0.0486838
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0474881
MACF1 microtubule-actin crosslinking factor 1 0.0472831
JMJD1C jumonji domain containing 1C 0.0468136
FTL ferritin, light polypeptide 0.0466156
AKAP12 A kinase (PRKA) anchor protein 12 0.046615
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0463341
EXT1 exostosin glycosyltransferase 1 0.0459398
LAMA4 laminin, alpha 4 0.0454719
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0454355
FTH1 ferritin, heavy polypeptide 1 0.0451933
RTN4 reticulon 4 0.0450123
LDHA lactate dehydrogenase A 0.0449973
TES testin LIM domain protein 0.0449566
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0445208
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0435947
KRT18 keratin 18, type I 0.0435682
ASPH aspartate beta-hydroxylase 0.0435559
AKAP13 A kinase (PRKA) anchor protein 13 0.043265
FNDC3B fibronectin type III domain containing 3B 0.0431936
ADAM9 ADAM metallopeptidase domain 9 0.0427837
LAMB3 laminin, beta 3 0.0418523
ERRFI1 ERBB receptor feedback inhibitor 1 0.041815
SMAD3 SMAD family member 3 0.0410315
STC1 stanniocalcin 1 0.0409831
CSTB cystatin B (stefin B) 0.0398772
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0398263
MORF4L2 mortality factor 4 like 2 0.03944
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0394311
RPL37A ribosomal protein L37a 0.0384264
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0383437
FLNB filamin B, beta 0.0382628
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0382271
RPS12 ribosomal protein S12 0.038103
AFF1 AF4/FMR2 family, member 1 0.038077
CSNK1A1 casein kinase 1, alpha 1 0.0375887
SEC61G Sec61 gamma subunit 0.0374214
RPS27 ribosomal protein S27 0.0364714
LMO7 LIM domain 7 0.0362928
MAST4 microtubule associated serine/threonine kinase family member 4 0.0358718
PDE8A phosphodiesterase 8A 0.0357051
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0355358
DSPP dentin sialophosphoprotein 0.0350281
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.034493
MCL1 myeloid cell leukemia 1 0.0343907
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0341647
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0341195
SRRM2 serine/arginine repetitive matrix 2 0.0338532
NAMPT nicotinamide phosphoribosyltransferase 0.033708
H1-0 H1.0 linker histone 0.0335938
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0335685
ANKRD11 ankyrin repeat domain 11 0.0335251
ELL2 elongation factor, RNA polymerase II, 2 0.0334198
BAIAP2L1 BAI1-associated protein 2-like 1 0.0331105
CREB5 cAMP responsive element binding protein 5 0.0329922
CST3 cystatin C 0.0326824
MAML3 mastermind-like 3 (Drosophila) 0.0323905
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0320438
ANXA1 annexin A1 0.0313551
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0312115
SON SON DNA binding protein 0.0311465
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0311361
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.031096
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0306806
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.030202
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0299713

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0899056
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0564629
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0465624
AGO2 argonaute RISC catalytic component 2 -0.0457155
TXNRD1 thioredoxin reductase 1 -0.03382
TMEM165 transmembrane protein 165 -0.0282631
ZBTB20 zinc finger and BTB domain containing 20 -0.027888
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.02623
MGST1 microsomal glutathione S-transferase 1 -0.0251241
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0238751
CANX calnexin -0.0222128
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0217893
BTG1 B-cell translocation gene 1, anti-proliferative -0.0212223
GCLC glutamate-cysteine ligase, catalytic subunit -0.0210601
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.020288
ANKRD10 ankyrin repeat domain 10 -0.0194538
GPHN gephyrin -0.0187457
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0185443
HDLBP high density lipoprotein binding protein -0.0184205
BIRC3 baculoviral IAP repeat containing 3 -0.017734
SENP5 SUMO1/sentrin specific peptidase 5 -0.0169623
RPL35A ribosomal protein L35a -0.0161559
ABLIM1 actin binding LIM protein 1 -0.015764
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -0.0152574
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0152379
ZBTB44 zinc finger and BTB domain containing 44 -0.0152108
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0148119
MARF1 meiosis regulator and mRNA stability factor 1 -0.0146801
ZBTB1 zinc finger and BTB domain containing 1 -0.0146001
MRPS6 mitochondrial ribosomal protein S6 -0.0145017
CCNH cyclin H -0.0144577
USP34 ubiquitin specific peptidase 34 -0.0143936
MCTP1 multiple C2 domains, transmembrane 1 -0.0143451
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0139024
NSUN6 NOP2/Sun domain family, member 6 -0.0136566
RPS24 ribosomal protein S24 -0.0134029
PMP22 peripheral myelin protein 22 -0.0133228
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0132446
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0131427
PTPRD protein tyrosine phosphatase, receptor type, D -0.0130006
KIAA1217 KIAA1217 -0.0130005
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0128662
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.0126701
CFDP1 craniofacial development protein 1 -0.0125883
ADGRF1 adhesion G protein-coupled receptor F1 -0.0123822
WWTR1 WW domain containing transcription regulator 1 -0.0123464
ZNF292 zinc finger protein 292 -0.0123422
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0119459
ARRDC3 arrestin domain containing 3 -0.0119157
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.0119083
TNRC6A trinucleotide repeat containing 6A -0.0118406
ARMH4 armadillo like helical domain containing 4 -0.0117043
CAMKMT calmodulin-lysine N-methyltransferase -0.0116662
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0116208
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0116118
IFIH1 interferon induced with helicase C domain 1 -0.0114718
TOGARAM1 TOG array regulator of axonemal microtubules 1 -0.011382
TULP3 tubby like protein 3 -0.0113558
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0112939
ZNF638 zinc finger protein 638 -0.0111801
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0111778
GAK cyclin G associated kinase -0.0110985
WDPCP WD repeat containing planar cell polarity effector -0.0110928
SMIM14 small integral membrane protein 14 -0.0110901
PSEN1 presenilin 1 -0.0110632
FAAH2 fatty acid amide hydrolase 2 -0.0108623
MGAT4C MGAT4 family, member C -0.0108415
RAP2B RAP2B, member of RAS oncogene family -0.01083
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.0106976
POM121C POM121 transmembrane nucleoporin C -0.0106288
CEP95 centrosomal protein 95kDa -0.0105967
KDM4C lysine (K)-specific demethylase 4C -0.0105913
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0105414
JAK1 Janus kinase 1 -0.010501
RBBP6 retinoblastoma binding protein 6 -0.0104363
GCC2 GRIP and coiled-coil domain containing 2 -0.010426
GOSR1 golgi SNAP receptor complex member 1 -0.0103687
NCOA7 nuclear receptor coactivator 7 -0.0103487
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0102695
FANK1 fibronectin type III and ankyrin repeat domains 1 -0.0102686
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0102682
ZXDC ZXD family zinc finger C -0.0102355
ALG11 ALG11, alpha-1,2-mannosyltransferase -0.0102145
ZC3H12B zinc finger CCCH-type containing 12B -0.0101282
TUT4 terminal uridylyl transferase 4 -0.0101226
BET1 Bet1 golgi vesicular membrane trafficking protein -0.0100235
MON2 MON2 homolog (S. cerevisiae) -0.00991052
ZBTB25 zinc finger and BTB domain containing 25 -0.00983212
TM9SF3 transmembrane 9 superfamily member 3 -0.00977527
CCDC59 coiled-coil domain containing 59 -0.00970697
MAGT1 magnesium transporter 1 -0.00964633
MTERF1 mitochondrial transcription termination factor 1 -0.00960564
XRN1 5'-3' exoribonuclease 1 -0.00952827
FNIP1 folliculin interacting protein 1 -0.00949496
KLHL24 kelch-like family member 24 -0.00949071
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.00945109
UGDH UDP-glucose 6-dehydrogenase -0.0094097
HDAC9 histone deacetylase 9 -0.00931755
GPATCH2 G patch domain containing 2 -0.00921407
ADAR adenosine deaminase, RNA-specific -0.00919506