Peretinoin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.351467
AKAP12 A kinase (PRKA) anchor protein 12 0.286761
MYH9 myosin, heavy chain 9, non-muscle 0.167146
TMSB10 thymosin beta 10 0.155053
SDK1 sidekick cell adhesion molecule 1 0.131191
CDH13 cadherin 13 0.121213
NAV2 neuron navigator 2 0.0998558
MT2A metallothionein 2A 0.0943629
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0869435
TRIO trio Rho guanine nucleotide exchange factor 0.0866656
STC1 stanniocalcin 1 0.0866316
VIM vimentin 0.076335
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0724079
CREB5 cAMP responsive element binding protein 5 0.0694773
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0662354
ANGPTL4 angiopoietin-like 4 0.0658583
PTMA prothymosin, alpha 0.065048
THSD4 thrombospondin, type I, domain containing 4 0.0608365
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.060703
SAMD4A sterile alpha motif domain containing 4A 0.0591593
MACF1 microtubule-actin crosslinking factor 1 0.0585175
DTNA dystrobrevin, alpha 0.0584962
EEF2 eukaryotic translation elongation factor 2 0.0582087
ASPH aspartate beta-hydroxylase 0.058119
AHNAK AHNAK nucleoprotein 0.0580396
TNIP1 TNFAIP3 interacting protein 1 0.0579871
ELL2 elongation factor, RNA polymerase II, 2 0.0570016
APP amyloid beta (A4) precursor protein 0.0541214
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0531953
PRRC2C proline-rich coiled-coil 2C 0.0531798
ENO1 enolase 1, (alpha) 0.0525081
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0524961
DST dystonin 0.052466
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0519312
TXNRD1 thioredoxin reductase 1 0.0517471
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0497099
ERRFI1 ERBB receptor feedback inhibitor 1 0.0492245
MAP1B microtubule-associated protein 1B 0.0489613
RPL35 ribosomal protein L35 0.047707
TMSB4X thymosin beta 4, X-linked 0.0468289
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.046676
APLP2 amyloid beta (A4) precursor-like protein 2 0.0463476
RPL3 ribosomal protein L3 0.0460294
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0451034
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0441323
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0436963
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0436302
RPS3 ribosomal protein S3 0.043479
ACTG1 actin gamma 1 0.043321
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0431531
SFTPA2 surfactant protein A2 0.0426886
ATP13A3 ATPase type 13A3 0.042394
SRRM2 serine/arginine repetitive matrix 2 0.0423246
CDCP1 CUB domain containing protein 1 0.0421219
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0419172
MSN moesin 0.041872
CXCL5 chemokine (C-X-C motif) ligand 5 0.041669
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0414083
CEP250 centrosomal protein 250kDa 0.0413415
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0411727
KDM7A lysine (K)-specific demethylase 7A 0.0399859
FLNB filamin B, beta 0.039092
CPNE1 copine I 0.0390867
PFKP phosphofructokinase, platelet 0.0390864
PTPRF protein tyrosine phosphatase, receptor type, F 0.03853
RPS6 ribosomal protein S6 0.037965
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0378645
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0377357
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0369833
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0365885
RPL4 ribosomal protein L4 0.0363159
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0361384
HSPA8 heat shock 70kDa protein 8 0.0360173
FAM107B family with sequence similarity 107, member B 0.0358923
PABPC1 poly(A) binding protein, cytoplasmic 1 0.035869
HMGA2 high mobility group AT-hook 2 0.0356066
RPS12 ribosomal protein S12 0.0356014
RPLP2 ribosomal protein, large, P2 0.0351394
PDIA4 protein disulfide isomerase family A, member 4 0.0350902
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0346955
PKM pyruvate kinase, muscle 0.0341185
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0338754
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0337161
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0332082
PLAUR plasminogen activator, urokinase receptor 0.0329732
RPS8 ribosomal protein S8 0.0328759
PYGL phosphorylase, glycogen, liver 0.0326118
FMNL2 formin-like 2 0.0325152
FLNA filamin A, alpha 0.0324885
RPL32 ribosomal protein L32 0.0323203
MKI67 marker of proliferation Ki-67 0.0321942
SUN1 Sad1 and UNC84 domain containing 1 0.0321091
NAP1L1 nucleosome assembly protein 1-like 1 0.0318734
HIPK2 homeodomain interacting protein kinase 2 0.0315749
RPL19 ribosomal protein L19 0.0313582
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.031304
HYOU1 hypoxia up-regulated 1 0.0310932
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0309632
CALU calumenin 0.0309261
SET SET nuclear proto-oncogene 0.0307937

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.126148
PDE4D phosphodiesterase 4D, cAMP-specific -0.0806551
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0717802
GLCCI1 glucocorticoid induced 1 -0.0648509
FTH1 ferritin, heavy polypeptide 1 -0.0636665
DPYD dihydropyrimidine dehydrogenase -0.0632484
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0579972
LOX lysyl oxidase -0.0578679
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0554106
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0510263
GPC6 glypican 6 -0.0444523
ANKRD28 ankyrin repeat domain 28 -0.0439642
FN1 fibronectin 1 -0.0415645
KYNU kynureninase -0.0404823
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.036589
TENT5A terminal nucleotidyltransferase 5A -0.0363408
KMT2E lysine (K)-specific methyltransferase 2E -0.0349146
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0342848
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0341006
CD44 CD44 molecule (Indian blood group) -0.0339145
ETV6 ets variant 6 -0.0334672
AOPEP aminopeptidase O (putative) -0.0325707
ZEB2 zinc finger E-box binding homeobox 2 -0.0318714
FNDC3B fibronectin type III domain containing 3B -0.0317728
VRK2 vaccinia related kinase 2 -0.0317225
MEF2A myocyte enhancer factor 2A -0.0316619
TAS2R14 taste receptor, type 2, member 14 -0.0313281
MRPS6 mitochondrial ribosomal protein S6 -0.0308391
VMP1 vacuole membrane protein 1 -0.030759
NRG1 neuregulin 1 -0.0307499
EGR1 early growth response 1 -0.0293904
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.02916
HILPDA hypoxia inducible lipid droplet-associated -0.0290982
MYADM myeloid-associated differentiation marker -0.0282432
TTC3 tetratricopeptide repeat domain 3 -0.0271491
MBNL1 muscleblind-like splicing regulator 1 -0.0269926
FBXO11 F-box protein 11 -0.0263177
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0261332
NCOA7 nuclear receptor coactivator 7 -0.0261253
TMEM131 transmembrane protein 131 -0.0260972
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0260662
AKAP9 A kinase (PRKA) anchor protein 9 -0.0260549
KDM2A lysine (K)-specific demethylase 2A -0.0255405
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0244483
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0229032
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0228195
WTAP Wilms tumor 1 associated protein -0.0225556
SEC31A SEC31 homolog A (S. cerevisiae) -0.0220321
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0219926
LOC102724023 ES1 protein homolog, mitochondrial -0.0212508
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0210338
FNDC3A fibronectin type III domain containing 3A -0.0208987
NTN4 netrin 4 -0.0206683
DLG1 discs, large homolog 1 (Drosophila) -0.0206464
SIK3 SIK family kinase 3 -0.0205532
ADD3 adducin 3 (gamma) -0.0201828
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0200272
PRR16 proline rich 16 -0.0194882
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.0192178
SRP54 signal recognition particle 54kDa -0.0191905
GATAD2B GATA zinc finger domain containing 2B -0.0191558
FAM20C family with sequence similarity 20, member C -0.0190171
ATF7 activating transcription factor 7 -0.0188822
KLHL24 kelch-like family member 24 -0.0187245
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0183362
MECOM MDS1 and EVI1 complex locus -0.0181561
NRP1 neuropilin 1 -0.0178165
TAOK1 TAO kinase 1 -0.0178038
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0176603
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0175244
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0172991
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0172696
TGFB1 transforming growth factor, beta 1 -0.0172042
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0171007
HELZ helicase with zinc finger -0.0167777
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.016541
ATOSA atos homolog A -0.0164493
POM121C POM121 transmembrane nucleoporin C -0.0163762
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0163186
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0162805
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0162257
LCORL ligand dependent nuclear receptor corepressor-like -0.0161767
SOS2 son of sevenless homolog 2 (Drosophila) -0.0161627
CCDC88A coiled-coil domain containing 88A -0.0160804
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0160625
ZNF33A zinc finger protein 33A -0.0160537
AADAC arylacetamide deacetylase -0.0157582
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0157576
OSMR oncostatin M receptor -0.0153796
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0153374
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.015155
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0151419
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0150893
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0150231
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0150195
PIBF1 progesterone immunomodulatory binding factor 1 -0.0150129
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0150113
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0149991
BASP1 brain abundant, membrane attached signal protein 1 -0.0149224
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0149148