Peretinoin_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.135541
KRT17 keratin 17, type I 0.126456
FN1 fibronectin 1 0.125304
NDRG1 N-myc downstream regulated 1 0.114591
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.108154
BACE2 beta-site APP-cleaving enzyme 2 0.0944988
UBE2H ubiquitin-conjugating enzyme E2H 0.0865595
AKAP13 A kinase (PRKA) anchor protein 13 0.0856819
ERRFI1 ERBB receptor feedback inhibitor 1 0.0812887
NPTN neuroplastin 0.0761221
TSC22D2 TSC22 domain family, member 2 0.0757106
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0742536
DSCAM Down syndrome cell adhesion molecule 0.0721305
ESYT2 extended synaptotagmin-like protein 2 0.0711948
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0682915
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0657706
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.06553
FMNL2 formin-like 2 0.0642785
LIMCH1 LIM and calponin homology domains 1 0.0627357
PLEC plectin 0.0618957
CEMIP cell migration inducing protein, hyaluronan binding 0.0585326
SLTM SAFB-like, transcription modulator 0.0548732
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0542825
ITPRID2 ITPR interacting domain containing 2 0.0542265
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0537559
EZR ezrin 0.0531202
FLNB filamin B, beta 0.0523825
SVIL supervillin 0.0517756
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0495185
DSPP dentin sialophosphoprotein 0.0495149
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0492631
PTK2 protein tyrosine kinase 2 0.0487469
CD46 CD46 molecule, complement regulatory protein 0.0474454
PTPRM protein tyrosine phosphatase, receptor type, M 0.0453066
ZNF292 zinc finger protein 292 0.0448035
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0447625
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0442208
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0440777
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0433016
HOOK2 hook microtubule-tethering protein 2 0.0429987
DSG2 desmoglein 2 0.0426835
KLF6 Kruppel-like factor 6 0.04253
NCOR2 nuclear receptor corepressor 2 0.0422926
RHOB ras homolog family member B 0.0421561
PPARD peroxisome proliferator-activated receptor delta 0.0420966
DUSP10 dual specificity phosphatase 10 0.0412541
IGFBP5 insulin-like growth factor binding protein 5 0.0410632
EPS8 epidermal growth factor receptor pathway substrate 8 0.0409722
MARCHF7 membrane associated ring-CH-type finger 7 0.0409234
KDM3A lysine (K)-specific demethylase 3A 0.0403315
TAOK3 TAO kinase 3 0.0402728
SPNS2 spinster homolog 2 (Drosophila) 0.0390288
SLIT2 slit homolog 2 (Drosophila) 0.0388686
NCKAP1 NCK-associated protein 1 0.038685
HSPA8 heat shock 70kDa protein 8 0.0375057
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0374216
YTHDC1 YTH domain containing 1 0.0372341
MCTP2 multiple C2 domains, transmembrane 2 0.0368732
LMO7 LIM domain 7 0.0362877
TACSTD2 tumor-associated calcium signal transducer 2 0.0362045
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.035839
ETNK1 ethanolamine kinase 1 0.0357939
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0355369
WWC2 WW and C2 domain containing 2 0.0353871
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0353867
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0351509
KMT2E lysine (K)-specific methyltransferase 2E 0.0350742
FAT1 FAT atypical cadherin 1 0.0350617
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.0347345
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0345406
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0344913
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0343362
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0339836
IFRD1 interferon-related developmental regulator 1 0.033661
FOXK1 forkhead box K1 0.0334189
IQGAP1 IQ motif containing GTPase activating protein 1 0.0332521
ABHD17C abhydrolase domain containing 17C 0.0332346
ATOSA atos homolog A 0.0331795
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0330344
KRT18 keratin 18, type I 0.0329621
FNDC3A fibronectin type III domain containing 3A 0.0328076
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0327981
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0325742
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0321163
NSD3 nuclear receptor binding SET domain protein 3 0.0319597
ZMYND8 zinc finger, MYND-type containing 8 0.0318278
CXXC1 CXXC finger protein 1 0.0318097
ASXL1 additional sex combs like transcriptional regulator 1 0.031724
DAAM1 dishevelled associated activator of morphogenesis 1 0.0316773
MXD1 MAX dimerization protein 1 0.0313285
CD59 CD59 molecule, complement regulatory protein 0.0312667
SRRM2 serine/arginine repetitive matrix 2 0.0307696
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0305387
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0302506
TJP2 tight junction protein 2 0.0302018
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0301874
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0301718
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0299844
GMDS GDP-mannose 4,6-dehydratase 0.0297436
ZNF544 zinc finger protein 544 0.0296832

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.137873
TXNRD1 thioredoxin reductase 1 -0.118882
PARD3 par-3 family cell polarity regulator -0.0900569
SPAG9 sperm associated antigen 9 -0.0850362
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0815491
FNDC3B fibronectin type III domain containing 3B -0.0796458
LSAMP limbic system-associated membrane protein -0.0782843
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0769414
KYNU kynureninase -0.0761039
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0748721
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0746222
NAMPT nicotinamide phosphoribosyltransferase -0.0712171
ENO1 enolase 1, (alpha) -0.0706043
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0692485
MORF4L2 mortality factor 4 like 2 -0.068444
RNF145 ring finger protein 145 -0.0682955
GPC6 glypican 6 -0.066318
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0658974
EGR1 early growth response 1 -0.0655161
INHBA inhibin, beta A -0.0627964
CHD1 chromodomain helicase DNA binding protein 1 -0.0620444
RIGI RNA sensor RIG-I -0.0618395
STC1 stanniocalcin 1 -0.0604864
B2M beta-2-microglobulin -0.0604184
TMSB10 thymosin beta 10 -0.0565884
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0550061
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0541639
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0541633
MSN moesin -0.05279
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0516884
COL6A3 collagen, type VI, alpha 3 -0.0501799
ISG15 ISG15 ubiquitin-like modifier -0.0494569
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0485158
MT2A metallothionein 2A -0.0484841
SQSTM1 sequestosome 1 -0.0484821
QKI QKI, KH domain containing, RNA binding -0.0481137
SOD2 superoxide dismutase 2, mitochondrial -0.0480082
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0478121
LDHA lactate dehydrogenase A -0.0477569
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0457368
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0454453
NBAS neuroblastoma amplified sequence -0.0450832
FNIP1 folliculin interacting protein 1 -0.0446145
RPL28 ribosomal protein L28 -0.0439628
RACK1 receptor for activated C kinase 1 -0.0439261
FAF1 Fas (TNFRSF6) associated factor 1 -0.0435143
ZXDC ZXD family zinc finger C -0.0434599
HLA-B major histocompatibility complex, class I, B -0.043124
TJP1 tight junction protein 1 -0.0429306
ZBTB20 zinc finger and BTB domain containing 20 -0.0425971
RPL12 ribosomal protein L12 -0.0425153
SMYD3 SET and MYND domain containing 3 -0.0424713
RPLP2 ribosomal protein, large, P2 -0.0421661
GLG1 golgi glycoprotein 1 -0.04187
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0413421
WDFY2 WD repeat and FYVE domain containing 2 -0.0409573
ASPH aspartate beta-hydroxylase -0.0408371
RPS16 ribosomal protein S16 -0.0407279
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0402718
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0402557
CANX calnexin -0.0395542
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0394077
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.03907
MATR3 matrin 3 -0.0390315
AK1 adenylate kinase 1 -0.0388479
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0387407
PATJ PATJ crumbs cell polarity complex component -0.03807
DOCK4 dedicator of cytokinesis 4 -0.0373826
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0372769
VMP1 vacuole membrane protein 1 -0.0372453
PLAUR plasminogen activator, urokinase receptor -0.0368505
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0367803
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0367414
MYO10 myosin X -0.0366868
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0365546
RAD51B RAD51 paralog B -0.0364212
AKAP12 A kinase (PRKA) anchor protein 12 -0.0362217
FTL ferritin, light polypeptide -0.0360788
EGFR epidermal growth factor receptor -0.0358601
CSDE1 cold shock domain containing E1, RNA-binding -0.0355918
WDR43 WD repeat domain 43 -0.035572
MED13L mediator complex subunit 13-like -0.0355478
CHD9 chromodomain helicase DNA binding protein 9 -0.0354135
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0353117
MACF1 microtubule-actin crosslinking factor 1 -0.0351254
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0350779
MYO1E myosin IE -0.0348741
RABGAP1L RAB GTPase activating protein 1-like -0.0345533
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0345383
CDH13 cadherin 13 -0.0344796
KMT2C lysine (K)-specific methyltransferase 2C -0.0343578
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0339418
AFF1 AF4/FMR2 family, member 1 -0.0331505
CYRIB CYFIP related Rac1 interactor B -0.0329899
BRWD1 bromodomain and WD repeat domain containing 1 -0.0326531
MTDH metadherin -0.032131
ARF4 ADP-ribosylation factor 4 -0.0319106
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0315091
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0309366
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0309047