Peretinoin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.236513
HDAC9 histone deacetylase 9 0.105288
EZR ezrin 0.103408
ANXA1 annexin A1 0.100548
RPL3 ribosomal protein L3 0.0893331
PICALM phosphatidylinositol binding clathrin assembly protein 0.0869332
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0830133
RPS3 ribosomal protein S3 0.077168
FLNB filamin B, beta 0.0748387
ANKRD11 ankyrin repeat domain 11 0.0740083
RPS8 ribosomal protein S8 0.0721066
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0717795
PDGFC platelet derived growth factor C 0.0700461
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0687735
LPP LIM domain containing preferred translocation partner in lipoma 0.0666878
RPL7A ribosomal protein L7a 0.0663111
CLIP1 CAP-GLY domain containing linker protein 1 0.0624627
CLIC4 chloride intracellular channel 4 0.0614616
SLC38A2 solute carrier family 38, member 2 0.0610506
ERRFI1 ERBB receptor feedback inhibitor 1 0.0604042
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0594962
TMSB4X thymosin beta 4, X-linked 0.0567788
SAMD4A sterile alpha motif domain containing 4A 0.0564154
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0563622
TXNIP thioredoxin interacting protein 0.0559596
RTN4 reticulon 4 0.0540006
RPL19 ribosomal protein L19 0.0534338
TJP1 tight junction protein 1 0.052347
RPS6 ribosomal protein S6 0.0521561
RPS15A ribosomal protein S15a 0.0498474
DIAPH3 diaphanous-related formin 3 0.0491366
CREB5 cAMP responsive element binding protein 5 0.0467654
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0461536
PDE4B phosphodiesterase 4B, cAMP-specific 0.0460166
HSPA8 heat shock 70kDa protein 8 0.0456256
ANLN anillin, actin binding protein 0.0448444
MYOF myoferlin 0.0436815
RPL12 ribosomal protein L12 0.0434318
RAB27B RAB27B, member RAS oncogene family 0.0433166
TMSB10 thymosin beta 10 0.0426991
TM4SF1 transmembrane 4 L six family member 1 0.042596
SFTPA2 surfactant protein A2 0.0425356
RPS17 ribosomal protein S17 0.0424416
RPS12 ribosomal protein S12 0.0422502
CORO1C coronin, actin binding protein, 1C 0.0420311
TPM4 tropomyosin 4 0.0419101
SSBP2 single-stranded DNA binding protein 2 0.0416634
ENO1 enolase 1, (alpha) 0.0410876
RPL37A ribosomal protein L37a 0.0401648
RPL13A ribosomal protein L13a 0.0401311
APLP2 amyloid beta (A4) precursor-like protein 2 0.0398768
RPS13 ribosomal protein S13 0.0396419
CCNY cyclin Y 0.0396401
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0393606
MYH9 myosin, heavy chain 9, non-muscle 0.0392977
FAT1 FAT atypical cadherin 1 0.0381953
SRRM2 serine/arginine repetitive matrix 2 0.0381218
ITSN1 intersectin 1 (SH3 domain protein) 0.037921
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0378129
FRMD6 FERM domain containing 6 0.0371943
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0368837
ZEB1 zinc finger E-box binding homeobox 1 0.0368235
H1-4 H1.4 linker histone, cluster member 0.0362393
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0357831
EEF1G eukaryotic translation elongation factor 1 gamma 0.0354565
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0353827
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0351077
JMJD1C jumonji domain containing 1C 0.0343592
RPS27 ribosomal protein S27 0.0341664
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0338772
PRELID2 PRELI domain containing 2 0.0337075
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0336868
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0335791
EIF4A2 eukaryotic translation initiation factor 4A2 0.0331229
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0328855
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0327653
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0325808
RPL31 ribosomal protein L31 0.0324478
RPS23 ribosomal protein S23 0.0323953
CLCN5 chloride channel, voltage-sensitive 5 0.0323771
RPL35 ribosomal protein L35 0.0323406
EXT1 exostosin glycosyltransferase 1 0.0315771
DOCK5 dedicator of cytokinesis 5 0.0313816
CSNK1A1 casein kinase 1, alpha 1 0.0312668
EPS8 epidermal growth factor receptor pathway substrate 8 0.0311149
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0310196
RPL21 ribosomal protein L21 0.0304101
BMP2K BMP2 inducible kinase 0.0297463
NAP1L1 nucleosome assembly protein 1-like 1 0.0293608
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0291626
PDLIM5 PDZ and LIM domain 5 0.0290742
INTS6 integrator complex subunit 6 0.028559
NCEH1 neutral cholesterol ester hydrolase 1 0.0283992
FNDC3B fibronectin type III domain containing 3B 0.0283873
DST dystonin 0.028327
SESN2 sestrin 2 0.0280757
RAD18 RAD18 E3 ubiquitin protein ligase 0.0279072
MAST2 microtubule associated serine/threonine kinase 2 0.0276222
CPNE1 copine I 0.0273166
S100A9 S100 calcium binding protein A9 0.0272394

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.127524
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.125044
VCL vinculin -0.107539
FOXP1 forkhead box P1 -0.0887932
STAT1 signal transducer and activator of transcription 1, 91kDa -0.074838
ADAM10 ADAM metallopeptidase domain 10 -0.0715662
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0595046
ZBTB20 zinc finger and BTB domain containing 20 -0.0575031
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0550309
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0549681
GNAS GNAS complex locus -0.0535207
PKM pyruvate kinase, muscle -0.0532202
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0515552
EGFR epidermal growth factor receptor -0.0510492
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0502961
CCND1 cyclin D1 -0.049528
EFNA5 ephrin-A5 -0.0494453
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0468932
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0464971
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0454217
OSMR oncostatin M receptor -0.0453291
GPHN gephyrin -0.0449748
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0449295
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0421378
NFIA nuclear factor I/A -0.0411742
CBX3 chromobox homolog 3 -0.0381155
EXOC6B exocyst complex component 6B -0.0380672
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0367296
BRWD1 bromodomain and WD repeat domain containing 1 -0.0366746
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0365815
PTK2 protein tyrosine kinase 2 -0.0352201
RBM25 RNA binding motif protein 25 -0.0343652
MATR3 matrin 3 -0.0340355
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0336795
PYGB phosphorylase, glycogen; brain -0.0335792
PUM2 pumilio RNA-binding family member 2 -0.0327703
ZMYND8 zinc finger, MYND-type containing 8 -0.0313698
SPAG9 sperm associated antigen 9 -0.0308237
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0302928
ELOVL5 ELOVL fatty acid elongase 5 -0.029733
DGKH diacylglycerol kinase, eta -0.0292481
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0291109
CAMKMT calmodulin-lysine N-methyltransferase -0.0290872
MON2 MON2 homolog (S. cerevisiae) -0.0289603
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0289324
TUT4 terminal uridylyl transferase 4 -0.0289067
NBEA neurobeachin -0.0288975
TOB1 transducer of ERBB2, 1 -0.0287999
ARL4C ADP-ribosylation factor-like 4C -0.0286188
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0286058
UBE3A ubiquitin protein ligase E3A -0.0284354
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0284005
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0283391
SEC23A Sec23 homolog A (S. cerevisiae) -0.028301
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0279567
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0278477
SPRY4 sprouty homolog 4 (Drosophila) -0.027781
SEPTIN7 septin 7 -0.0277721
DYM dymeclin -0.0275769
CHD1 chromodomain helicase DNA binding protein 1 -0.0274588
ZNF644 zinc finger protein 644 -0.0271386
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0268188
RPL35A ribosomal protein L35a -0.0267462
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.026737
DPYD dihydropyrimidine dehydrogenase -0.0266818
ZNF292 zinc finger protein 292 -0.0266152
CCDC68 coiled-coil domain containing 68 -0.0265851
GOLGA4 golgin A4 -0.0265228
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0256885
SPIDR scaffolding protein involved in DNA repair -0.0256802
SFMBT1 Scm-like with four mbt domains 1 -0.0256626
CDC27 cell division cycle 27 -0.0253946
MBNL1 muscleblind-like splicing regulator 1 -0.0252766
TAPBP TAP binding protein (tapasin) -0.0252217
SMYD3 SET and MYND domain containing 3 -0.0250445
RAD21 RAD21 homolog (S. pombe) -0.0248729
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0247521
B2M beta-2-microglobulin -0.0245363
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0244793
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0241232
GLI2 GLI family zinc finger 2 -0.0240742
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.023613
RIGI RNA sensor RIG-I -0.0235967
BBS9 Bardet-Biedl syndrome 9 -0.0234999
NUP58 nucleoporin 58 -0.0233829
CARD16 caspase recruitment domain family, member 16 -0.0233533
SRPK2 SRSF protein kinase 2 -0.0232757
RAD51B RAD51 paralog B -0.0232535
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0231732
FBXL17 F-box and leucine-rich repeat protein 17 -0.0230883
PRRC2B proline-rich coiled-coil 2B -0.0228876
GOLM2 golgi membrane protein 2 -0.0227791
MED13L mediator complex subunit 13-like -0.0226163
OSBPL9 oxysterol binding protein-like 9 -0.0226012
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0225573
CLASP2 cytoplasmic linker associated protein 2 -0.02249
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0224695
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0224543
TRAM1 translocation associated membrane protein 1 -0.0222369
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0219431