Peretinoin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.265187
AKAP12 A kinase (PRKA) anchor protein 12 0.217951
TRIO trio Rho guanine nucleotide exchange factor 0.214318
NAV2 neuron navigator 2 0.162498
DST dystonin 0.154935
SOD2 superoxide dismutase 2, mitochondrial 0.136347
MSN moesin 0.115345
ELL2 elongation factor, RNA polymerase II, 2 0.0999714
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0840504
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0802006
FNDC3B fibronectin type III domain containing 3B 0.0792829
RTN4 reticulon 4 0.0685024
NDRG1 N-myc downstream regulated 1 0.0682017
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0657206
HDAC9 histone deacetylase 9 0.065515
APLP2 amyloid beta (A4) precursor-like protein 2 0.0608251
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0560311
CREB5 cAMP responsive element binding protein 5 0.0558551
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0549002
FRMD4A FERM domain containing 4A 0.0545479
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0542546
NAMPT nicotinamide phosphoribosyltransferase 0.0540959
FMNL2 formin-like 2 0.053994
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0537791
JMJD1C jumonji domain containing 1C 0.0524658
SFTPA2 surfactant protein A2 0.0513742
FLNB filamin B, beta 0.0505179
ATXN1 ataxin 1 0.0477317
SDK1 sidekick cell adhesion molecule 1 0.0467603
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0466869
LPP LIM domain containing preferred translocation partner in lipoma 0.0465043
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0443586
PALM2AKAP2 PALM2 and AKAP2 fusion 0.042182
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.041708
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0416785
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0410791
RB1CC1 RB1-inducible coiled-coil 1 0.0403674
MACF1 microtubule-actin crosslinking factor 1 0.0402407
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0402329
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0398698
SAMD4A sterile alpha motif domain containing 4A 0.0388912
SLC35F3 solute carrier family 35, member F3 0.0384559
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.037564
RUNX1 runt-related transcription factor 1 0.0374308
EGR1 early growth response 1 0.0367669
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0362117
ADAM12 ADAM metallopeptidase domain 12 0.0352124
FRMD5 FERM domain containing 5 0.0345079
CEP250 centrosomal protein 250kDa 0.034111
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0336699
FOXO3 forkhead box O3 0.0335649
STC1 stanniocalcin 1 0.0335294
NONO non-POU domain containing, octamer-binding 0.033427
FRMD6 FERM domain containing 6 0.0331099
IGF2R insulin-like growth factor 2 receptor 0.0330426
PPARD peroxisome proliferator-activated receptor delta 0.0317564
ARF4 ADP-ribosylation factor 4 0.0312393
CORO1C coronin, actin binding protein, 1C 0.0309568
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0307637
FAM219A family with sequence similarity 219, member A 0.0306423
MT2A metallothionein 2A 0.0305859
DTNA dystrobrevin, alpha 0.030206
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0291284
MCL1 myeloid cell leukemia 1 0.0290116
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0287156
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0283349
CDCP1 CUB domain containing protein 1 0.0282457
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0281341
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0281219
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0280886
ABTB3 ankyrin repeat and BTB domain containing 3 0.028088
DIAPH2 diaphanous-related formin 2 0.0280264
VEGFA vascular endothelial growth factor A 0.0277053
TNIP1 TNFAIP3 interacting protein 1 0.0273679
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0272129
COL6A3 collagen, type VI, alpha 3 0.0271694
AFF3 AF4/FMR2 family, member 3 0.0271123
EGFR epidermal growth factor receptor 0.0269822
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0269691
SMYD3 SET and MYND domain containing 3 0.026708
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0266799
SPAG9 sperm associated antigen 9 0.0265101
MAP1B microtubule-associated protein 1B 0.0264849
BTBD9 BTB (POZ) domain containing 9 0.0263812
IL6ST interleukin 6 signal transducer 0.0262859
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.026089
USP9X ubiquitin specific peptidase 9, X-linked 0.0259846
RPL35 ribosomal protein L35 0.025699
ACTN1 actinin, alpha 1 0.0255976
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0255081
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0254729
SRRM2 serine/arginine repetitive matrix 2 0.0254031
CLIC4 chloride intracellular channel 4 0.0253203
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0252395
MYO10 myosin X 0.0251321
ZFAND3 zinc finger, AN1-type domain 3 0.0250024
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0249254
APP amyloid beta (A4) precursor protein 0.0248039
KIRREL1 kirre like nephrin family adhesion molecule 1 0.02422
AK1 adenylate kinase 1 0.0241493

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.157628
IGFBP3 insulin-like growth factor binding protein 3 -0.0883236
TPT1 tumor protein, translationally-controlled 1 -0.0722932
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0702199
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0613303
FTL ferritin, light polypeptide -0.0601405
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0600851
PTMA prothymosin, alpha -0.0586005
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0541518
RPS24 ribosomal protein S24 -0.0492851
BICC1 BicC family RNA binding protein 1 -0.0469649
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0439162
IER3 immediate early response 3 -0.0438404
RPL35A ribosomal protein L35a -0.0437418
RPLP1 ribosomal protein, large, P1 -0.0424544
UGCG UDP-glucose ceramide glucosyltransferase -0.0391901
NAP1L1 nucleosome assembly protein 1-like 1 -0.038289
ACTG1 actin gamma 1 -0.0367382
VCAN versican -0.0367172
POTEF POTE ankyrin domain family, member F -0.0355066
TPM4 tropomyosin 4 -0.0353877
HLA-B major histocompatibility complex, class I, B -0.0341077
CANX calnexin -0.0337239
FTH1 ferritin, heavy polypeptide 1 -0.0336587
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0332034
RPL23 ribosomal protein L23 -0.0331346
PGK1 phosphoglycerate kinase 1 -0.0320383
BTG1 B-cell translocation gene 1, anti-proliferative -0.0314574
GOLGA4 golgin A4 -0.0313427
CTSD cathepsin D -0.03132
LDHA lactate dehydrogenase A -0.0304825
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0300721
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0291987
TGFBI transforming growth factor, beta-induced, 68kDa -0.0290488
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0289758
COL1A1 collagen, type I, alpha 1 -0.0284834
DEK DEK proto-oncogene -0.0281981
COL1A2 collagen, type I, alpha 2 -0.028036
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0271811
THBS1 thrombospondin 1 -0.0269707
KPNB1 karyopherin (importin) beta 1 -0.0267804
RPL26 ribosomal protein L26 -0.0266242
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0265813
TPM1 tropomyosin 1 (alpha) -0.0264472
SFRP1 secreted frizzled-related protein 1 -0.0261686
VDAC1 voltage-dependent anion channel 1 -0.0261314
NPEPPS aminopeptidase puromycin sensitive -0.0245552
BIRC3 baculoviral IAP repeat containing 3 -0.024487
BHLHE40 basic helix-loop-helix family, member e40 -0.024467
SEPTIN7 septin 7 -0.0241844
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0241744
SLC38A1 solute carrier family 38, member 1 -0.0236085
SRGN serglycin -0.0229264
WTAP Wilms tumor 1 associated protein -0.022868
GNAS GNAS complex locus -0.0227098
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0224402
HLA-E major histocompatibility complex, class I, E -0.0223137
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0221039
TMEM123 transmembrane protein 123 -0.021938
TKT transketolase -0.0213454
ANXA2 annexin A2 -0.0212658
RPL39 ribosomal protein L39 -0.021217
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0211188
EXT1 exostosin glycosyltransferase 1 -0.0203233
KDM3A lysine (K)-specific demethylase 3A -0.0202438
WSB1 WD repeat and SOCS box containing 1 -0.0202349
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.020165
MTDH metadherin -0.0201213
AHI1 Abelson helper integration site 1 -0.019914
SQSTM1 sequestosome 1 -0.0198866
RPL27A ribosomal protein L27a -0.0198554
MBNL2 muscleblind-like splicing regulator 2 -0.0198101
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0196039
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0195954
RPL34 ribosomal protein L34 -0.0195593
RPS6 ribosomal protein S6 -0.0195093
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0194898
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0193995
LOC102724023 ES1 protein homolog, mitochondrial -0.0192914
RPL38 ribosomal protein L38 -0.0191921
FUS FUS RNA binding protein -0.0190912
EIF1 eukaryotic translation initiation factor 1 -0.0189531
CALR calreticulin -0.018946
RPS25 ribosomal protein S25 -0.0187588
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0187524
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0187161
TMEM178B transmembrane protein 178B -0.0185309
LCORL ligand dependent nuclear receptor corepressor-like -0.0184848
BBX bobby sox homolog (Drosophila) -0.0182514
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.018241
RTN3 reticulon 3 -0.0180916
GPHN gephyrin -0.0174174
RPL37A ribosomal protein L37a -0.0174092
HLA-A major histocompatibility complex, class I, A -0.0171381
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0169096
ALCAM activated leukocyte cell adhesion molecule -0.0168662
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0168351
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0168005
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.016758
STAU1 staufen double-stranded RNA binding protein 1 -0.0166271