Peretinoin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.164693
MYH9 myosin, heavy chain 9, non-muscle 0.146651
CDH13 cadherin 13 0.117276
MT2A metallothionein 2A 0.080705
SAMD4A sterile alpha motif domain containing 4A 0.0764966
CXCL8 chemokine (C-X-C motif) ligand 8 0.068844
VEGFA vascular endothelial growth factor A 0.0661775
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0643998
SDC4 syndecan 4 0.0627539
IL6 interleukin 6 0.0621008
ELL2 elongation factor, RNA polymerase II, 2 0.0592724
STC1 stanniocalcin 1 0.0542593
CALD1 caldesmon 1 0.0516009
TNIP1 TNFAIP3 interacting protein 1 0.0509016
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0498659
COL6A3 collagen, type VI, alpha 3 0.0452087
MSN moesin 0.0398297
GOLGA4 golgin A4 0.0381992
UGCG UDP-glucose ceramide glucosyltransferase 0.0368733
SLC38A2 solute carrier family 38, member 2 0.0368582
TMED9 transmembrane emp24 protein transport domain containing 9 0.0346255
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0344306
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0341663
COL1A2 collagen, type I, alpha 2 0.033209
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0328727
CREB5 cAMP responsive element binding protein 5 0.032794
INHBA inhibin, beta A 0.0322137
CAVIN1 caveolae associated protein 1 0.0319957
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0313572
PRRC2C proline-rich coiled-coil 2C 0.0310439
CCND1 cyclin D1 0.0308388
CADM1 cell adhesion molecule 1 0.0303277
GARS1 glycyl-tRNA synthetase 1 0.0301192
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0297694
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0296198
COL6A1 collagen, type VI, alpha 1 0.0294983
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0293453
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0291297
ARHGAP26 Rho GTPase activating protein 26 0.0291202
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0287785
SHB Src homology 2 domain containing adaptor protein B 0.0285604
NAV2 neuron navigator 2 0.0285046
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0282567
PSD3 pleckstrin and Sec7 domain containing 3 0.0280794
COL6A2 collagen, type VI, alpha 2 0.02733
USP53 ubiquitin specific peptidase 53 0.0269858
SND1 staphylococcal nuclease and tudor domain containing 1 0.0269129
HIPK2 homeodomain interacting protein kinase 2 0.0264475
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.0264006
PLAUR plasminogen activator, urokinase receptor 0.0263793
APLP2 amyloid beta (A4) precursor-like protein 2 0.0263739
ZCCHC7 zinc finger, CCHC domain containing 7 0.0263046
FOXO3 forkhead box O3 0.0261769
CSMD2 CUB and Sushi multiple domains 2 0.0247451
CSNK1A1 casein kinase 1, alpha 1 0.0247386
SRRM2 serine/arginine repetitive matrix 2 0.0240675
TMSB10 thymosin beta 10 0.0238001
SMTN smoothelin 0.023785
TRIO trio Rho guanine nucleotide exchange factor 0.0235877
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0235364
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0234777
NHSL1 NHS-like 1 0.0232008
ITSN2 intersectin 2 0.022668
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0225038
AFF1 AF4/FMR2 family, member 1 0.0224024
MYO10 myosin X 0.0224013
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0223845
PLEC plectin 0.0221248
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0218847
TFPI2 tissue factor pathway inhibitor 2 0.0217825
WNK1 WNK lysine deficient protein kinase 1 0.0213435
DCAF6 DDB1 and CUL4 associated factor 6 0.0213144
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0212948
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0211167
ANKRD17 ankyrin repeat domain 17 0.0210774
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.02105
ANLN anillin, actin binding protein 0.0208763
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0206841
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0206559
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0205678
AKAP13 A kinase (PRKA) anchor protein 13 0.020556
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0205136
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0204907
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0203013
SYNJ2 synaptojanin 2 0.0202222
NKTR natural killer cell triggering receptor 0.0200594
MAP7D1 MAP7 domain containing 1 0.0200345
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 0.019867
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0198462
POU2F2 POU class 2 homeobox 2 0.0198166
ARHGAP5 Rho GTPase activating protein 5 0.0196939
CDK6 cyclin-dependent kinase 6 0.0196
ITCH itchy E3 ubiquitin protein ligase 0.0195509
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0194431
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0193902
EXT1 exostosin glycosyltransferase 1 0.0192903
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0191607
GPC6 glypican 6 0.0191285
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0187438
KDM7A lysine (K)-specific demethylase 7A 0.0186279

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.349416
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.176531
FN1 fibronectin 1 -0.0965627
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0914783
FTH1 ferritin, heavy polypeptide 1 -0.0654964
LOX lysyl oxidase -0.0488284
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0485812
VIM vimentin -0.0476251
PDIA6 protein disulfide isomerase family A, member 6 -0.045117
COL1A1 collagen, type I, alpha 1 -0.0441046
FTL ferritin, light polypeptide -0.0437811
HIP1 huntingtin interacting protein 1 -0.0436746
MAP1B microtubule-associated protein 1B -0.0417771
CANX calnexin -0.0393729
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.038825
ZNF395 zinc finger protein 395 -0.0385379
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0381033
FAM13A family with sequence similarity 13, member A -0.0377736
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0373306
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0369986
ANXA2 annexin A2 -0.035586
ARRDC3 arrestin domain containing 3 -0.0354292
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.034531
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0338726
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0333406
NDRG1 N-myc downstream regulated 1 -0.0333291
SSBP2 single-stranded DNA binding protein 2 -0.0325637
PRKCA protein kinase C, alpha -0.0308238
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0305866
MED13L mediator complex subunit 13-like -0.0304832
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0304712
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0296943
RBM39 RNA binding motif protein 39 -0.0295708
CCNL1 cyclin L1 -0.0289974
NAV1 neuron navigator 1 -0.028985
COG5 component of oligomeric golgi complex 5 -0.0283728
TMEM123 transmembrane protein 123 -0.0282506
ANKHD1 ankyrin repeat and KH domain containing 1 -0.028102
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0269725
LOC112694756 uncharaterized LOC112694756 -0.0269571
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0268648
RNF145 ring finger protein 145 -0.0266603
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0266432
TNS3 tensin 3 -0.0265751
CCNI cyclin I -0.0263762
AKAP9 A kinase (PRKA) anchor protein 9 -0.02605
TMEM165 transmembrane protein 165 -0.026026
POTEF POTE ankyrin domain family, member F -0.026018
ITM2B integral membrane protein 2B -0.0257637
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0256644
HELZ helicase with zinc finger -0.0255745
RAB10 RAB10, member RAS oncogene family -0.0255132
LMAN1 lectin, mannose-binding, 1 -0.0252225
MYOF myoferlin -0.0251911
DNAH11 dynein, axonemal, heavy chain 11 -0.0251602
CLTC clathrin, heavy chain (Hc) -0.0249537
GSE1 Gse1 coiled-coil protein -0.0247193
PRELID2 PRELI domain containing 2 -0.0246924
SKIC3 SKI3 subunit of superkiller complex -0.0246074
EPAS1 endothelial PAS domain protein 1 -0.0239217
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0238177
AHNAK AHNAK nucleoprotein -0.0236655
DPYD dihydropyrimidine dehydrogenase -0.0235835
EGFR epidermal growth factor receptor -0.0233846
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.023347
BHLHE40 basic helix-loop-helix family, member e40 -0.0233347
RPL5 ribosomal protein L5 -0.0232104
MARCHF7 membrane associated ring-CH-type finger 7 -0.0226516
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0226166
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0225614
MORF4L2 mortality factor 4 like 2 -0.0222003
ARHGAP24 Rho GTPase activating protein 24 -0.0221976
WASHC4 WASH complex subunit 4 -0.0220281
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0217969
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0217923
VDAC1 voltage-dependent anion channel 1 -0.0215631
SEC31A SEC31 homolog A (S. cerevisiae) -0.0215396
PTN pleiotrophin -0.0215376
ANKRD37 ankyrin repeat domain 37 -0.0214377
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0208582
CCDC88A coiled-coil domain containing 88A -0.0207856
NRXN3 neurexin 3 -0.0206614
MYO9A myosin IXA -0.0206571
CFDP1 craniofacial development protein 1 -0.0204859
TPM4 tropomyosin 4 -0.0203892
QKI QKI, KH domain containing, RNA binding -0.0203075
SCARB2 scavenger receptor class B, member 2 -0.0200877
COL11A1 collagen, type XI, alpha 1 -0.019851
SETD5 SET domain containing 5 -0.0197128
ZNF292 zinc finger protein 292 -0.0196421
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0195093
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0194691
LOXL2 lysyl oxidase-like 2 -0.0194463
DYNC2I1 dynein 2 intermediate chain 1 -0.0194399
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0193969
CHD9 chromodomain helicase DNA binding protein 9 -0.0191762
STAU1 staufen double-stranded RNA binding protein 1 -0.0191029
NAMPT nicotinamide phosphoribosyltransferase -0.0188351
THBS1 thrombospondin 1 -0.0187452
CRLS1 cardiolipin synthase 1 -0.0187408