Peretinoin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PALM2AKAP2 PALM2 and AKAP2 fusion 0.137659
FNDC3B fibronectin type III domain containing 3B 0.107587
FMNL2 formin-like 2 0.0958193
CD44 CD44 molecule (Indian blood group) 0.0923794
TRIO trio Rho guanine nucleotide exchange factor 0.0831623
DTNA dystrobrevin, alpha 0.0820316
TPT1 tumor protein, translationally-controlled 1 0.0801212
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0796195
MYH9 myosin, heavy chain 9, non-muscle 0.0785429
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0748443
MSN moesin 0.0741787
MAP1B microtubule-associated protein 1B 0.0725514
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0676522
AKAP12 A kinase (PRKA) anchor protein 12 0.0670262
ERRFI1 ERBB receptor feedback inhibitor 1 0.0668383
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0668276
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0661865
ANXA2 annexin A2 0.0641715
FLNB filamin B, beta 0.0596251
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0596013
TM4SF1 transmembrane 4 L six family member 1 0.0588124
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0554891
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0543156
ANKRD11 ankyrin repeat domain 11 0.0540943
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0537146
AHNAK AHNAK nucleoprotein 0.0536678
SPAG9 sperm associated antigen 9 0.0522429
ANGPTL4 angiopoietin-like 4 0.0502021
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0499817
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0487927
HOOK2 hook microtubule-tethering protein 2 0.0470334
PTK2 protein tyrosine kinase 2 0.0464028
LMO7 LIM domain 7 0.0454075
DST dystonin 0.0453188
ACTN1 actinin, alpha 1 0.0451279
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0449603
HSPA8 heat shock 70kDa protein 8 0.0440502
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0438251
SAMD4A sterile alpha motif domain containing 4A 0.0436344
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0434063
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0422275
HILPDA hypoxia inducible lipid droplet-associated 0.0404604
AKAP13 A kinase (PRKA) anchor protein 13 0.0396878
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0392339
SH3KBP1 SH3-domain kinase binding protein 1 0.0392205
THSD4 thrombospondin, type I, domain containing 4 0.039156
RAB6A RAB6A, member RAS oncogene family 0.0390915
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0386616
CAVIN1 caveolae associated protein 1 0.0386124
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0381187
SDC4 syndecan 4 0.0380845
SETD5 SET domain containing 5 0.0379605
ATXN1 ataxin 1 0.0375019
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0374034
ZFAND3 zinc finger, AN1-type domain 3 0.0373511
ANLN anillin, actin binding protein 0.037331
ZEB1 zinc finger E-box binding homeobox 1 0.0373201
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0371862
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0369103
LDHA lactate dehydrogenase A 0.0367572
PBX3 pre-B-cell leukemia homeobox 3 0.0365671
ELL2 elongation factor, RNA polymerase II, 2 0.0363522
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0361515
CANX calnexin 0.0356445
OGA O-GlcNAcase 0.0353644
S100A10 S100 calcium binding protein A10 0.035316
WSB1 WD repeat and SOCS box containing 1 0.0346779
ANXA5 annexin A5 0.0340442
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0339084
TOP2B topoisomerase (DNA) II beta 180kDa 0.0338758
GOLGA3 golgin A3 0.0334237
EXT1 exostosin glycosyltransferase 1 0.0332457
CALR calreticulin 0.0332329
XPO1 exportin 1 0.0330003
PKM pyruvate kinase, muscle 0.0329
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0324507
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0323888
TIMP1 TIMP metallopeptidase inhibitor 1 0.0320989
MEF2A myocyte enhancer factor 2A 0.0318739
PRSS23 protease, serine, 23 0.0317973
NSD2 nuclear receptor binding SET domain protein 2 0.0316813
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0314335
PGK1 phosphoglycerate kinase 1 0.0311589
SYNJ2 synaptojanin 2 0.0311397
HIPK2 homeodomain interacting protein kinase 2 0.0311008
WAC WW domain containing adaptor with coiled-coil 0.0309047
NUMA1 nuclear mitotic apparatus protein 1 0.0306262
RNF24 ring finger protein 24 0.0304628
B2M beta-2-microglobulin 0.0304357
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.030433
SQSTM1 sequestosome 1 0.0303106
TPM4 tropomyosin 4 0.0300048
NDRG1 N-myc downstream regulated 1 0.0297998
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0297015
DIAPH1 diaphanous-related formin 1 0.0295795
MATR3 matrin 3 0.0294696
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0294586
CDK6 cyclin-dependent kinase 6 0.0292927
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0292738
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0291072

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.179771
IGFBP3 insulin-like growth factor binding protein 3 -0.0973198
AKAP9 A kinase (PRKA) anchor protein 9 -0.052908
ANKRD28 ankyrin repeat domain 28 -0.0473845
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0384742
MIS18BP1 MIS18 binding protein 1 -0.0380303
DNER delta/notch-like EGF repeat containing -0.0364486
RSF1 remodeling and spacing factor 1 -0.0357655
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0338883
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0336001
MBD5 methyl-CpG binding domain protein 5 -0.0320404
BPTF bromodomain PHD finger transcription factor -0.0313238
TAS2R14 taste receptor, type 2, member 14 -0.0297439
BCAS3 breast carcinoma amplified sequence 3 -0.0296462
PCNX4 pecanex 4 -0.029412
MBNL1 muscleblind-like splicing regulator 1 -0.0286051
RSRC2 arginine/serine-rich coiled-coil 2 -0.0281541
RBM26 RNA binding motif protein 26 -0.0280004
FBXL17 F-box and leucine-rich repeat protein 17 -0.0278438
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -0.0275973
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0270484
PTMA prothymosin, alpha -0.0268318
ZC3H12B zinc finger CCCH-type containing 12B -0.0254979
NCEH1 neutral cholesterol ester hydrolase 1 -0.0249039
EXOC6B exocyst complex component 6B -0.024766
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0247576
CEP290 centrosomal protein 290kDa -0.0246243
SGO2 shugoshin 2 -0.02453
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0243407
SCFD1 sec1 family domain containing 1 -0.0236972
MBNL2 muscleblind-like splicing regulator 2 -0.0236819
FTH1 ferritin, heavy polypeptide 1 -0.0235209
EFNA5 ephrin-A5 -0.023204
TCF12 transcription factor 12 -0.0231747
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0231476
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0230304
PRH1 proline-rich protein HaeIII subfamily 1 -0.0229187
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0226915
DPYD dihydropyrimidine dehydrogenase -0.0224655
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0223585
ETV6 ets variant 6 -0.0221553
RB1 retinoblastoma 1 -0.0221496
CDC25C cell division cycle 25C -0.0220882
BBX bobby sox homolog (Drosophila) -0.0216333
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0215304
SIK2 salt-inducible kinase 2 -0.0214013
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0213613
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0213133
CEP70 centrosomal protein 70kDa -0.0210506
ITCH itchy E3 ubiquitin protein ligase -0.0207418
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0207227
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0206022
KIAA1328 KIAA1328 -0.0205018
DARS1 aspartyl-tRNA synthetase 1 -0.0204708
WWTR1 WW domain containing transcription regulator 1 -0.0204393
STRN3 striatin, calmodulin binding protein 3 -0.020379
RABGAP1 RAB GTPase activating protein 1 -0.020357
PDE4D phosphodiesterase 4D, cAMP-specific -0.020308
C2ORF42 chromosome 2 open reading frame 42 -0.0202563
RFC3 replication factor C (activator 1) 3, 38kDa -0.0201795
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0201498
DIAPH3 diaphanous-related formin 3 -0.020035
ARL8B ADP-ribosylation factor-like 8B -0.0200229
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0197654
BRCA2 breast cancer 2, early onset -0.0197526
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0194755
KIAA1958 KIAA1958 -0.0194383
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0192495
ATF6 activating transcription factor 6 -0.0192442
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.01924
MRE11 MRE11 homolog, double strand break repair nuclease -0.0192389
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0191025
ATM ATM serine/threonine kinase -0.0190724
RIN2 Ras and Rab interactor 2 -0.0190224
ADIPOR2 adiponectin receptor 2 -0.0190113
GPC6 glypican 6 -0.0189827
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0189558
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0189449
KRIT1 KRIT1, ankyrin repeat containing -0.0188068
R3HDM1 R3H domain containing 1 -0.0187542
MECP2 methyl CpG binding protein 2 -0.0186168
RB1CC1 RB1-inducible coiled-coil 1 -0.0182422
SAR1B secretion associated, Ras related GTPase 1B -0.0182382
FNIP1 folliculin interacting protein 1 -0.0181275
PIBF1 progesterone immunomodulatory binding factor 1 -0.0179571
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0179377
EVI5 ecotropic viral integration site 5 -0.0179348
CERT1 ceramide transporter 1 -0.0178038
NPAT nuclear protein, ataxia-telangiectasia locus -0.0177462
CKAP2L cytoskeleton associated protein 2-like -0.0176973
SRPK1 SRSF protein kinase 1 -0.0175928
RPLP1 ribosomal protein, large, P1 -0.0175016
THOC2 THO complex 2 -0.0174539
C2CD3 C2 calcium-dependent domain containing 3 -0.017409
AKAP11 A kinase (PRKA) anchor protein 11 -0.0172802
SMAD2 SMAD family member 2 -0.0172793
FRS2 fibroblast growth factor receptor substrate 2 -0.0172572
SRBD1 S1 RNA binding domain 1 -0.0171856
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0171438
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0171116