Peretinoin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Peretinoin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Peretinoin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.270329
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.213743
MYH9 myosin, heavy chain 9, non-muscle 0.14855
AKAP12 A kinase (PRKA) anchor protein 12 0.133783
MT2A metallothionein 2A 0.115743
NDRG1 N-myc downstream regulated 1 0.111316
ERRFI1 ERBB receptor feedback inhibitor 1 0.100892
TRIO trio Rho guanine nucleotide exchange factor 0.0952932
TMSB10 thymosin beta 10 0.0930908
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0902213
MAP1B microtubule-associated protein 1B 0.089007
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0889153
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0803699
EXT1 exostosin glycosyltransferase 1 0.0723232
SFTPA2 surfactant protein A2 0.0709679
PTMA prothymosin, alpha 0.0706352
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.067081
SRRM2 serine/arginine repetitive matrix 2 0.0638686
ACTG1 actin gamma 1 0.0634906
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0632995
PABPC1 poly(A) binding protein, cytoplasmic 1 0.054981
ELL2 elongation factor, RNA polymerase II, 2 0.0535154
HIPK2 homeodomain interacting protein kinase 2 0.0531335
APLP2 amyloid beta (A4) precursor-like protein 2 0.0505939
RPS6 ribosomal protein S6 0.050043
MKI67 marker of proliferation Ki-67 0.0493255
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0490198
CENPF centromere protein F, 350/400kDa 0.0488943
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.047852
ACTN1 actinin, alpha 1 0.0475069
S100A10 S100 calcium binding protein A10 0.0464804
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0458468
MACF1 microtubule-actin crosslinking factor 1 0.0447809
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0445718
RPS27 ribosomal protein S27 0.0435543
EIF4A1 eukaryotic translation initiation factor 4A1 0.0422331
NAV2 neuron navigator 2 0.0421579
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.041947
DTNA dystrobrevin, alpha 0.0418247
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0417693
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0415658
PRRC2C proline-rich coiled-coil 2C 0.0412995
ZSWIM6 zinc finger, SWIM-type containing 6 0.0412442
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0409843
STC2 stanniocalcin 2 0.040613
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0405468
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.040406
RPL37A ribosomal protein L37a 0.0403676
AHNAK AHNAK nucleoprotein 0.038345
FTL ferritin, light polypeptide 0.0381493
GRB10 growth factor receptor-bound protein 10 0.0381212
SLC38A2 solute carrier family 38, member 2 0.0380187
SLC35F3 solute carrier family 35, member F3 0.0379699
JMJD1C jumonji domain containing 1C 0.0378652
VEGFA vascular endothelial growth factor A 0.0376815
RPL19 ribosomal protein L19 0.0376225
TM4SF1 transmembrane 4 L six family member 1 0.0374594
RPS19 ribosomal protein S19 0.037239
CLIP2 CAP-GLY domain containing linker protein 2 0.0372231
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0369256
BASP1 brain abundant, membrane attached signal protein 1 0.0364
ANLN anillin, actin binding protein 0.0362576
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0356094
TXNIP thioredoxin interacting protein 0.0352567
RTN4 reticulon 4 0.0335498
RPS12 ribosomal protein S12 0.0333204
AKAP13 A kinase (PRKA) anchor protein 13 0.0329325
STC1 stanniocalcin 1 0.0327465
CREB5 cAMP responsive element binding protein 5 0.0326691
HILPDA hypoxia inducible lipid droplet-associated 0.0325268
APP amyloid beta (A4) precursor protein 0.0324095
LTBP1 latent transforming growth factor beta binding protein 1 0.0323451
SETD5 SET domain containing 5 0.0323432
SNX9 sorting nexin 9 0.0318407
HSPA8 heat shock 70kDa protein 8 0.0316191
TOP2A topoisomerase (DNA) II alpha 170kDa 0.031557
FLNA filamin A, alpha 0.0314519
LMNA lamin A/C 0.0314225
NTN4 netrin 4 0.0309924
IQGAP3 IQ motif containing GTPase activating protein 3 0.0309561
RPS3 ribosomal protein S3 0.0308573
CAPN2 calpain 2, (m/II) large subunit 0.0307276
RPL37 ribosomal protein L37 0.0304047
FMNL2 formin-like 2 0.0303237
RPL35 ribosomal protein L35 0.0298628
COPA coatomer protein complex, subunit alpha 0.0296711
TPM3 tropomyosin 3 0.0295738
SPAG9 sperm associated antigen 9 0.029475
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.02934
ENO2 enolase 2 (gamma, neuronal) 0.0288339
FAT1 FAT atypical cadherin 1 0.0287151
MSN moesin 0.0285278
SHB Src homology 2 domain containing adaptor protein B 0.0284763
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0284676
NPAS2 neuronal PAS domain protein 2 0.0281336
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0278899
RACK1 receptor for activated C kinase 1 0.0278144
SAMD4A sterile alpha motif domain containing 4A 0.0276688
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0274408
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.0272418

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.237287
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.183895
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.137804
NRG1 neuregulin 1 -0.133021
NAMPT nicotinamide phosphoribosyltransferase -0.120355
ITGA1 integrin, alpha 1 -0.105103
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0972949
GLIS3 GLIS family zinc finger 3 -0.094278
AHR aryl hydrocarbon receptor -0.0566293
CANX calnexin -0.0563002
SYT1 synaptotagmin I -0.0481226
ETV1 ets variant 1 -0.0449466
NRIP1 nuclear receptor interacting protein 1 -0.0446375
ZBTB20 zinc finger and BTB domain containing 20 -0.0431412
TMEM165 transmembrane protein 165 -0.0423182
TMEM156 transmembrane protein 156 -0.0419987
STAT1 signal transducer and activator of transcription 1, 91kDa -0.038764
PDE4D phosphodiesterase 4D, cAMP-specific -0.0387481
EFNA5 ephrin-A5 -0.0366111
MBD5 methyl-CpG binding domain protein 5 -0.0342288
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0340418
CD44 CD44 molecule (Indian blood group) -0.033643
OSMR oncostatin M receptor -0.0325676
ETV6 ets variant 6 -0.032521
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0317583
TAS2R14 taste receptor, type 2, member 14 -0.0316681
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0294529
ZNF292 zinc finger protein 292 -0.0293461
CAB39 calcium binding protein 39 -0.0277803
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0273515
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0264249
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.026094
TENT5A terminal nucleotidyltransferase 5A -0.0259725
TGFA transforming growth factor, alpha -0.0252982
RUNX2 runt-related transcription factor 2 -0.0252775
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0250963
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0248598
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0247658
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0247097
DPYD dihydropyrimidine dehydrogenase -0.0245173
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0237795
CLTC clathrin, heavy chain (Hc) -0.0236715
MAML2 mastermind-like 2 (Drosophila) -0.0235488
SPIDR scaffolding protein involved in DNA repair -0.0233616
IFI16 interferon, gamma-inducible protein 16 -0.0230422
ZMYND8 zinc finger, MYND-type containing 8 -0.0220988
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0220123
PELO pelota homolog (Drosophila) -0.0219806
FTH1 ferritin, heavy polypeptide 1 -0.0218996
BIRC3 baculoviral IAP repeat containing 3 -0.0212598
AOPEP aminopeptidase O (putative) -0.0210588
AHI1 Abelson helper integration site 1 -0.0210319
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.020977
NRP1 neuropilin 1 -0.0209077
RBM39 RNA binding motif protein 39 -0.0209039
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0207274
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0204626
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0201606
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0201204
PRELID2 PRELI domain containing 2 -0.0199515
ETNK1 ethanolamine kinase 1 -0.0197546
MARCHF6 membrane associated ring-CH-type finger 6 -0.0194196
UBE2K ubiquitin-conjugating enzyme E2K -0.0193752
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0192933
SMOX spermine oxidase -0.019245
VEGFC vascular endothelial growth factor C -0.0189732
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0186568
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0186276
DNAH5 dynein, axonemal, heavy chain 5 -0.0184932
EREG epiregulin -0.0184107
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0183092
NCOA7 nuclear receptor coactivator 7 -0.0181418
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0176526
MGST1 microsomal glutathione S-transferase 1 -0.0175608
TRA2A transformer 2 alpha homolog (Drosophila) -0.0174687
DCAF5 DDB1 and CUL4 associated factor 5 -0.0173609
FBXO32 F-box protein 32 -0.0172787
PDIA3 protein disulfide isomerase family A, member 3 -0.0171614
SKAP2 src kinase associated phosphoprotein 2 -0.017104
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0169568
CD46 CD46 molecule, complement regulatory protein -0.0168294
UGDH UDP-glucose 6-dehydrogenase -0.0168159
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0167139
SUMF1 sulfatase modifying factor 1 -0.0166031
FAM20C family with sequence similarity 20, member C -0.0160422
SPDYA speedy/RINGO cell cycle regulator family member A -0.016035
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0160036
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0159515
SINHCAF SIN3-HDAC complex associated factor -0.0158502
PPME1 protein phosphatase methylesterase 1 -0.0157964
STAU1 staufen double-stranded RNA binding protein 1 -0.0157836
BZW1 basic leucine zipper and W2 domains 1 -0.0157754
LNPEP leucyl/cystinyl aminopeptidase -0.0157486
TBC1D22A TBC1 domain family, member 22A -0.0157049
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0156993
IFI44L interferon-induced protein 44-like -0.0156956
RNF10 ring finger protein 10 -0.0155558
PLSCR1 phospholipid scramblase 1 -0.0155336
GLUL glutamate-ammonia ligase -0.0155055
RIGI RNA sensor RIG-I -0.0155045