Pergolide Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction. (Chemical Entities of Biological Interest Ontology, CHEBI_63617)
External Link http://ctdbase.org/detail.go?type=chem&acc=D010479
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Genes

13 genes/proteins interacting with the chemical Pergolide from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
BAX BCL2-associated X protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
GDNF glial cell derived neurotrophic factor
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
MSH2 mutS homolog 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
TP53 tumor protein p53