| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4746 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Perhexiline relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PAH | phenylalanine hydroxylase | 3.44 |
| ABHD2 | abhydrolase domain containing 2 | 3.21 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 2.34 |
| POF1B | premature ovarian failure, 1B | 2.32 |
| APOB | apolipoprotein B | 2.27 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | 2.14 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 2.02 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 1.86 |
| ITM2B | integral membrane protein 2B | 1.84 |
| PSAP | prosaposin | 1.79 |
| ACTN2 | actinin, alpha 2 | 1.78 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.72 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.67 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 1.64 |
| ITM2C | integral membrane protein 2C | 1.62 |
| AREG | amphiregulin | 1.55 |
| ZG16B | zymogen granule protein 16B | 1.52 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 1.48 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 1.48 |
| MFAP3L | microfibrillar-associated protein 3-like | 1.45 |
| APOE | apolipoprotein E | 1.44 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 1.42 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 1.39 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 1.35 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | 1.35 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.35 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.34 |
| APP | amyloid beta (A4) precursor protein | 1.32 |
| PIP | prolactin-induced protein | 1.31 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 1.28 |
| HGFAC | HGF activator | 1.26 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.25 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 1.24 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 1.24 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.23 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 1.23 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 1.22 |
| NCOA4 | nuclear receptor coactivator 4 | 1.21 |
| RNF149 | ring finger protein 149 | 1.2 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 1.19 |
| MCL1 | myeloid cell leukemia 1 | 1.17 |
| SLC38A2 | solute carrier family 38, member 2 | 1.16 |
| GPANK1 | G patch domain and ankyrin repeats 1 | 1.16 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 1.16 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 1.16 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 1.14 |
| PRELID1 | PRELI domain containing 1 | 1.12 |
| GLRX | glutaredoxin (thioltransferase) | 1.12 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 1.12 |
| VGF | VGF nerve growth factor inducible | 1.11 |
| GINM1 | glycoprotein integral membrane 1 | 1.1 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 1.1 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 1.09 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 1.08 |
| TSPAN3 | tetraspanin 3 | 1.08 |
| RNF130 | ring finger protein 130 | 1.08 |
| ANKRD22 | ankyrin repeat domain 22 | 1.07 |
| RAMAC | RNA guanine-7 methyltransferase activating subunit | 1.07 |
| NBR1 | neighbor of BRCA1 gene 1 | 1.07 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 1.06 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.06 |
| NOTCH3 | notch 3 | 1.05 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 1.05 |
| SQLE | squalene epoxidase | 1.05 |
| NCKAP1L | NCK-associated protein 1-like | 1.04 |
| CERS4 | ceramide synthase 4 | 1.03 |
| HIPK2 | homeodomain interacting protein kinase 2 | 1.03 |
| PCDH1 | protocadherin 1 | 1.03 |
| TMEM41B | transmembrane protein 41B | 1.03 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 1.01 |
| CCDC158 | coiled-coil domain containing 158 | 1.01 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 1.01 |
| TRIM2 | tripartite motif containing 2 | 1.0 |
| LDLR | low density lipoprotein receptor | 1.0 |
| NDFIP2 | Nedd4 family interacting protein 2 | 1.0 |
| INHBA | inhibin, beta A | 0.99 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 0.98 |
| FTL | ferritin, light polypeptide | 0.98 |
| RNASET2 | ribonuclease T2 | 0.98 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.97 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.97 |
| PRELID3B | PRELI domain containing 3B | 0.97 |
| MSMO1 | methylsterol monooxygenase 1 | 0.97 |
| IL10RB | interleukin 10 receptor, beta | 0.95 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.94 |
| IFNGR1 | interferon gamma receptor 1 | 0.94 |
| OSMR | oncostatin M receptor | 0.93 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.93 |
| GRN | granulin | 0.92 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.92 |
| NMRK1 | nicotinamide riboside kinase 1 | 0.91 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.9 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.9 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.9 |
| SERINC5 | serine incorporator 5 | 0.9 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.9 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | 0.89 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.89 |
| HMOX1 | heme oxygenase 1 | 0.88 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 0.88 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAST3 | microtubule associated serine/threonine kinase 3 | -1.6 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -1.56 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -1.52 |
| ARSK | arylsulfatase family, member K | -1.51 |
| C6ORF62 | chromosome 6 open reading frame 62 | -1.46 |
| LYRM1 | LYR motif containing 1 | -1.34 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | -1.33 |
| PLIN2 | perilipin 2 | -1.32 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -1.3 |
| ZSCAN29 | zinc finger and SCAN domain containing 29 | -1.28 |
| MRPS18C | mitochondrial ribosomal protein S18C | -1.27 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -1.23 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | -1.2 |
| PRDM16 | PR domain containing 16 | -1.2 |
| ZNF658 | zinc finger protein 658 | -1.17 |
| ODC1 | ornithine decarboxylase 1 | -1.15 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | -1.15 |
| MKRN3 | makorin ring finger protein 3 | -1.13 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | -1.11 |
| MIEF1 | mitochondrial elongation factor 1 | -1.11 |
| COA5 | cytochrome c oxidase assembly factor 5 | -1.1 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | -1.09 |
| TSPAN14 | tetraspanin 14 | -1.09 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | -1.08 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -1.07 |
| MTERF3 | mitochondrial transcription termination factor 3 | -1.04 |
| SMIM26 | small integral membrane protein 26 | -1.0 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -0.99 |
| KNSTRN | kinetochore-localized astrin/SPAG5 binding protein | -0.99 |
| NSUN3 | NOP2/Sun domain family, member 3 | -0.98 |
| TMEM70 | transmembrane protein 70 | -0.97 |
| BPTF | bromodomain PHD finger transcription factor | -0.97 |
| SPAG5 | sperm associated antigen 5 | -0.96 |
| PLSCR1 | phospholipid scramblase 1 | -0.95 |
| PTMA | prothymosin, alpha | -0.95 |
| NMU | neuromedin U | -0.95 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -0.94 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | -0.93 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | -0.93 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.92 |
| FANCE | Fanconi anemia, complementation group E | -0.92 |
| COX15 | cytochrome c oxidase assembly homolog 15 (yeast) | -0.91 |
| SLC12A8 | solute carrier family 12, member 8 | -0.89 |
| ARL16 | ADP-ribosylation factor-like 16 | -0.89 |
| NAAA | N-acylethanolamine acid amidase | -0.89 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.88 |
| CNOT6 | CCR4-NOT transcription complex, subunit 6 | -0.88 |
| MIS18A | MIS18 kinetochore protein A | -0.88 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.87 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | -0.87 |
| MRM2 | mitochondrial rRNA methyltransferase 2 | -0.85 |
| PLK1 | polo-like kinase 1 | -0.85 |
| GTPBP8 | GTP-binding protein 8 (putative) | -0.85 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | -0.85 |
| ZNF543 | zinc finger protein 543 | -0.84 |
| RNF41 | ring finger protein 41, E3 ubiquitin protein ligase | -0.84 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | -0.83 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | -0.83 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.83 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -0.82 |
| UCK1 | uridine-cytidine kinase 1 | -0.82 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | -0.81 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.8 |
| CCNB1 | cyclin B1 | -0.8 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | -0.8 |
| DLEC1 | deleted in lung and esophageal cancer 1 | -0.79 |
| SP100 | SP100 nuclear antigen | -0.79 |
| ACAD10 | acyl-CoA dehydrogenase family, member 10 | -0.79 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | -0.79 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | -0.79 |
| MRPL23 | mitochondrial ribosomal protein L23 | -0.79 |
| PTTG1 | pituitary tumor-transforming 1 | -0.78 |
| SACK1D | scaffolding CK1 anchoring protein D | -0.78 |
| TMEM11 | transmembrane protein 11 | -0.78 |
| CCN1 | cellular communication network factor 1 | -0.78 |
| TRIM37 | tripartite motif containing 37 | -0.78 |
| NET1 | neuroepithelial cell transforming 1 | -0.77 |
| ASB3 | ankyrin repeat and SOCS box containing 3 | -0.77 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | -0.77 |
| CCDC90B | coiled-coil domain containing 90B | -0.77 |
| DET1 | de-etiolated homolog 1 (Arabidopsis) | -0.76 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.76 |
| RWDD1 | RWD domain containing 1 | -0.76 |
| PIF1 | PIF1 5'-to-3' DNA helicase | -0.76 |
| SDF4 | stromal cell derived factor 4 | -0.76 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | -0.75 |
| OIP5 | Opa interacting protein 5 | -0.74 |
| MRPS34 | mitochondrial ribosomal protein S34 | -0.74 |
| CHDH | choline dehydrogenase | -0.74 |
| C15ORF61 | chromosome 15 open reading frame 61 | -0.74 |
| WWC2 | WW and C2 domain containing 2 | -0.74 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.73 |
| ABHD5 | abhydrolase domain containing 5 | -0.73 |
| MADD | MAP-kinase activating death domain | -0.73 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.73 |
| KIF20A | kinesin family member 20A | -0.73 |
| NDUFB11 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa | -0.73 |
| CDC20 | cell division cycle 20 | -0.72 |
| PBK | PDZ binding kinase | -0.72 |
