Perindopril (erbumine)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLAT plasminogen activator, tissue 0.117767
MT2A metallothionein 2A 0.113791
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0960086
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0769226
VIM vimentin 0.0525611
LOX lysyl oxidase 0.0518773
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0497233
COL3A1 collagen, type III, alpha 1 0.0463762
FBXL7 F-box and leucine-rich repeat protein 7 0.0426162
ZBTB20 zinc finger and BTB domain containing 20 0.042287
IQGAP1 IQ motif containing GTPase activating protein 1 0.0334084
RHOBTB3 Rho-related BTB domain containing 3 0.0321495
ANXA2 annexin A2 0.0318341
HLA-B major histocompatibility complex, class I, B 0.0304008
B2M beta-2-microglobulin 0.0295725
DST dystonin 0.0294578
TXNIP thioredoxin interacting protein 0.0276271
STC1 stanniocalcin 1 0.0275521
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0272615
USP34 ubiquitin specific peptidase 34 0.0263464
PODXL podocalyxin-like 0.0257433
MYADM myeloid-associated differentiation marker 0.0256362
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0255837
COL1A2 collagen, type I, alpha 2 0.025481
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0253321
TTC3 tetratricopeptide repeat domain 3 0.0249605
SMYD3 SET and MYND domain containing 3 0.0247241
ANKRD36 ankyrin repeat domain 36 0.024017
BPTF bromodomain PHD finger transcription factor 0.0235103
MYO9A myosin IXA 0.0233605
PSD3 pleckstrin and Sec7 domain containing 3 0.0228842
NAV1 neuron navigator 1 0.0226299
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0226037
AKAP9 A kinase (PRKA) anchor protein 9 0.0225339
EHBP1 EH domain binding protein 1 0.0224825
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0222312
COL8A1 collagen, type VIII, alpha 1 0.0220728
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0220447
RASAL2 RAS protein activator like 2 0.0220057
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0218694
OPTN optineurin 0.021426
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0213269
VMP1 vacuole membrane protein 1 0.0213247
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0213242
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0212979
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0207622
CTSB cathepsin B 0.0203675
EGFR epidermal growth factor receptor 0.0201608
DLG1 discs, large homolog 1 (Drosophila) 0.0199018
CHD9 chromodomain helicase DNA binding protein 9 0.0198168
HDAC9 histone deacetylase 9 0.0197498
TM4SF1 transmembrane 4 L six family member 1 0.0194385
NFE2L1 nuclear factor, erythroid 2-like 1 0.0193317
FBN1 fibrillin 1 0.0192521
GOLGA2 golgin A2 0.0189216
MAP4 microtubule-associated protein 4 0.0189062
ZNF148 zinc finger protein 148 0.0188101
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0187636
FNIP1 folliculin interacting protein 1 0.0187564
AVL9 AVL9 homolog (S. cerevisiase) 0.0187451
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0185388
PRRC2C proline-rich coiled-coil 2C 0.0185339
CD99 CD99 molecule 0.0184669
PTMA prothymosin, alpha 0.0183855
VCL vinculin 0.0183254
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0182607
EIF1 eukaryotic translation initiation factor 1 0.0180638
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0180522
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0180485
GLS2 glutaminase 2 (liver, mitochondrial) 0.0179062
RASA2 RAS p21 protein activator 2 0.0177836
DOCK5 dedicator of cytokinesis 5 0.0176312
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0175739
MCFD2 multiple coagulation factor deficiency 2 0.0175479
HDLBP high density lipoprotein binding protein 0.0173652
CELF1 CUGBP, Elav-like family member 1 0.0173177
TBC1D5 TBC1 domain family, member 5 0.0169986
FER fer (fps/fes related) tyrosine kinase 0.0169752
LOXL2 lysyl oxidase-like 2 0.016907
COL5A2 collagen, type V, alpha 2 0.0168631
LYST lysosomal trafficking regulator 0.0168442
BACE2 beta-site APP-cleaving enzyme 2 0.0168204
RBM25 RNA binding motif protein 25 0.0167748
CDK12 cyclin-dependent kinase 12 0.0166571
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0166508
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0166243
NKTR natural killer cell triggering receptor 0.016583
NBEAL1 neurobeachin-like 1 0.01658
MT1X metallothionein 1X 0.0165127
ATL3 atlastin GTPase 3 0.0164116
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.016237
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0160461
RABGAP1L RAB GTPase activating protein 1-like 0.0160313
DSCAM Down syndrome cell adhesion molecule 0.0159942
EXOC6B exocyst complex component 6B 0.0159683
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0159505
CD44 CD44 molecule (Indian blood group) 0.0158472
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0157569
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0156808
ZCCHC7 zinc finger, CCHC domain containing 7 0.0156435

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.118457
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0473162
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.046248
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.041111
TRIO trio Rho guanine nucleotide exchange factor -0.0404999
IGFBP3 insulin-like growth factor binding protein 3 -0.0392598
CDH13 cadherin 13 -0.0382675
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0377113
COL5A1 collagen, type V, alpha 1 -0.0374913
MAP1B microtubule-associated protein 1B -0.0352866
AHNAK AHNAK nucleoprotein -0.0340044
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0333057
FN1 fibronectin 1 -0.0314105
HILPDA hypoxia inducible lipid droplet-associated -0.0288198
MSI2 musashi RNA-binding protein 2 -0.0283715
BHLHE40 basic helix-loop-helix family, member e40 -0.0274101
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0270632
ABI3BP ABI family, member 3 (NESH) binding protein -0.0247817
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0237527
LOC112694756 uncharaterized LOC112694756 -0.0230134
ADM adrenomedullin -0.0220925
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0218101
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.02161
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0211778
ADAM9 ADAM metallopeptidase domain 9 -0.0209612
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0208366
PKM pyruvate kinase, muscle -0.0206043
SPAG9 sperm associated antigen 9 -0.0204526
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0195944
S100A10 S100 calcium binding protein A10 -0.0194872
COL4A2 collagen, type IV, alpha 2 -0.0189838
TPM1 tropomyosin 1 (alpha) -0.0189411
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0184889
SAMD9 sterile alpha motif domain containing 9 -0.0184041
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0183416
FGFR1 fibroblast growth factor receptor 1 -0.0167963
SDK1 sidekick cell adhesion molecule 1 -0.0167813
SUCNR1 succinate receptor 1 -0.016734
TMSB4X thymosin beta 4, X-linked -0.0163986
NAMPT nicotinamide phosphoribosyltransferase -0.0162849
OASL 2'-5'-oligoadenylate synthetase-like -0.0162847
ANKRD11 ankyrin repeat domain 11 -0.0156121
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0151752
ISG15 ISG15 ubiquitin-like modifier -0.0149705
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0145039
DGKG diacylglycerol kinase, gamma 90kDa -0.0144891
FTH1 ferritin, heavy polypeptide 1 -0.0143969
INSIG1 insulin induced gene 1 -0.0143765
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0142782
HELZ helicase with zinc finger -0.0141233
ZNF292 zinc finger protein 292 -0.0140941
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0139846
GNAS GNAS complex locus -0.0139622
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0139254
WTAP Wilms tumor 1 associated protein -0.013894
CTBP2 C-terminal binding protein 2 -0.0138475
INSIG2 insulin induced gene 2 -0.0136918
LPCAT2 lysophosphatidylcholine acyltransferase 2 -0.0134507
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0133776
DDIT4 DNA-damage-inducible transcript 4 -0.0131948
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0131572
AMPD3 adenosine monophosphate deaminase 3 -0.0129359
RRM2 ribonucleotide reductase M2 -0.0128243
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0128165
KDM6A lysine (K)-specific demethylase 6A -0.0126179
PLXNA2 plexin A2 -0.0125715
TPI1 triosephosphate isomerase 1 -0.0125551
MIMS1 mitochondrial inner membrane scaffold 1 -0.0123341
CALR calreticulin -0.0122494
PDIA6 protein disulfide isomerase family A, member 6 -0.012246
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0120077
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0118378
ZMYND8 zinc finger, MYND-type containing 8 -0.0118255
CCND1 cyclin D1 -0.011769
SH3KBP1 SH3-domain kinase binding protein 1 -0.0117296
FAM13A family with sequence similarity 13, member A -0.0117178
FLNA filamin A, alpha -0.0116829
FSTL1 follistatin-like 1 -0.0116276
SOX9 SRY (sex determining region Y)-box 9 -0.011585
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0115115
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0114797
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0114547
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0113507
RUNX1 runt-related transcription factor 1 -0.0111853
ANKRD33B ankyrin repeat domain 33B -0.0110157
FNDC3A fibronectin type III domain containing 3A -0.0110105
GRK5 G protein-coupled receptor kinase 5 -0.0108017
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0107363
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0106675
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0106548
WSB1 WD repeat and SOCS box containing 1 -0.0104687
DTNA dystrobrevin, alpha -0.0103997
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0103766
CHD1L chromodomain helicase DNA binding protein 1-like -0.0103511
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0103508
KIAA1549L KIAA1549-like -0.0103348
RIGI RNA sensor RIG-I -0.0102843
THBS2 thrombospondin 2 -0.0102026
PIAS2 protein inhibitor of activated STAT, 2 -0.0101827
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0100539