Perindopril (erbumine)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in A-427 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Perindopril (erbumine)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0862355
RASAL2 RAS protein activator like 2 0.060522
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0589291
ANXA1 annexin A1 0.0577426
PLK2 polo-like kinase 2 0.0558417
PARD3 par-3 family cell polarity regulator 0.055365
LDHA lactate dehydrogenase A 0.0540407
EHBP1 EH domain binding protein 1 0.0535497
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0533812
EEF2 eukaryotic translation elongation factor 2 0.0506125
FSTL5 follistatin-like 5 0.0501585
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0489244
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0467516
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0459932
ERBIN erbb2 interacting protein 0.0418505
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0400649
RAB7A RAB7A, member RAS oncogene family 0.0391007
TBC1D5 TBC1 domain family, member 5 0.0383731
GCG glucagon 0.03726
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0367419
SYT1 synaptotagmin I 0.0352624
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0349822
CARD16 caspase recruitment domain family, member 16 0.0335008
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0333498
PCBP2 poly(rC) binding protein 2 0.0326532
NF1 neurofibromin 1 0.0325622
CELF2 CUGBP, Elav-like family member 2 0.0322508
USP53 ubiquitin specific peptidase 53 0.0315534
ARL5B ADP-ribosylation factor-like 5B 0.0315336
RAD51B RAD51 paralog B 0.0314715
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0313274
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0308007
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.029762
H1-0 H1.0 linker histone 0.0294888
BIRC6 baculoviral IAP repeat containing 6 0.0286599
ARF4 ADP-ribosylation factor 4 0.0285026
ECT2 epithelial cell transforming 2 0.0284028
MGAT4C MGAT4 family, member C 0.028323
ADIPOR2 adiponectin receptor 2 0.0280287
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0278521
HSPB1 heat shock 27kDa protein 1 0.0273233
TGM2 transglutaminase 2 0.0272786
BCL6 B-cell CLL/lymphoma 6 0.026705
CLDN1 claudin 1 0.0266972
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0261564
RAB1A RAB1A, member RAS oncogene family 0.024709
PUM1 pumilio RNA-binding family member 1 0.0246608
KSR2 kinase suppressor of ras 2 0.0244159
PICALM phosphatidylinositol binding clathrin assembly protein 0.0240695
CDK17 cyclin-dependent kinase 17 0.0240479
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.0237612
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0237003
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.02323
RPS4X ribosomal protein S4, X-linked 0.0232025
LMO7 LIM domain 7 0.0228145
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0227721
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0225075
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.02248
ZCCHC7 zinc finger, CCHC domain containing 7 0.0223391
GPBP1 GC-rich promoter binding protein 1 0.021985
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0217242
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0214579
IARS1 isoleucyl-tRNA synthetase 1 0.0213592
SLMAP sarcolemma associated protein 0.0212063
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0211167
TSPAN5 tetraspanin 5 0.020982
NSUN6 NOP2/Sun domain family, member 6 0.0208848
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0208158
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0207864
FER fer (fps/fes related) tyrosine kinase 0.0207223
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0204167
TPR translocated promoter region, nuclear basket protein 0.0203739
ANXA2 annexin A2 0.0203556
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0203512
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0201354
MAP4 microtubule-associated protein 4 0.0201278
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0201206
FAT1 FAT atypical cadherin 1 0.0201178
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0197709
USP34 ubiquitin specific peptidase 34 0.0193054
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0192955
TUT4 terminal uridylyl transferase 4 0.0192842
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0192222
ZNF407 zinc finger protein 407 0.0190051
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0187169
MARCHF6 membrane associated ring-CH-type finger 6 0.0185826
CNOT1 CCR4-NOT transcription complex, subunit 1 0.018433
ELP4 elongator acetyltransferase complex subunit 4 0.018373
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0183651
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.018239
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0182141
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0181288
RLF rearranged L-myc fusion 0.0179651
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0178377
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0177398
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0175164
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0172748
MED13L mediator complex subunit 13-like 0.0172099
PHF21A PHD finger protein 21A 0.0166722
THSD4 thrombospondin, type I, domain containing 4 0.0165805

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.147385
RPS2 ribosomal protein S2 -0.135332
TMSB10 thymosin beta 10 -0.125889
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.118769
ANKRD12 ankyrin repeat domain 12 -0.0957584
RPS12 ribosomal protein S12 -0.0898527
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0806393
RPS6 ribosomal protein S6 -0.0697731
RPL26 ribosomal protein L26 -0.0691103
ACTG1 actin gamma 1 -0.0671334
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0616725
RPL38 ribosomal protein L38 -0.0612451
RPS8 ribosomal protein S8 -0.059909
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0592616
RPLP2 ribosomal protein, large, P2 -0.0582849
RRM2 ribonucleotide reductase M2 -0.0575279
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.057363
RPL9 ribosomal protein L9 -0.055214
RPL23 ribosomal protein L23 -0.0550386
RPS29 ribosomal protein S29 -0.0532956
RPL37A ribosomal protein L37a -0.0532806
TPT1 tumor protein, translationally-controlled 1 -0.0528952
CNRIP1 cannabinoid receptor interacting protein 1 -0.0520346
RPLP1 ribosomal protein, large, P1 -0.0508273
RPS21 ribosomal protein S21 -0.0506814
RPL19 ribosomal protein L19 -0.0501112
RTN4 reticulon 4 -0.0500347
RPL11 ribosomal protein L11 -0.0494917
NLGN1 neuroligin 1 -0.0493673
RPS19 ribosomal protein S19 -0.0489497
KTN1 kinectin 1 (kinesin receptor) -0.0488128
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0487184
RPS23 ribosomal protein S23 -0.0479058
CLTC clathrin, heavy chain (Hc) -0.0471257
PTMS parathymosin -0.0468517
PCDH7 protocadherin 7 -0.0462693
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0459549
RPL37 ribosomal protein L37 -0.0455309
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0439708
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0422252
TMEM41B transmembrane protein 41B -0.0419577
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0416973
RPS27A ribosomal protein S27a -0.0415457
RPL36 ribosomal protein L36 -0.041471
EIF1 eukaryotic translation initiation factor 1 -0.0412306
PDE4D phosphodiesterase 4D, cAMP-specific -0.0411221
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0407586
KIF5B kinesin family member 5B -0.0395427
RPL12 ribosomal protein L12 -0.039445
RPS13 ribosomal protein S13 -0.0381107
RPL7 ribosomal protein L7 -0.0380767
RPS20 ribosomal protein S20 -0.0380265
VIM vimentin -0.0379329
WWOX WW domain containing oxidoreductase -0.037825
RPL36A ribosomal protein L36a -0.03769
TXNRD1 thioredoxin reductase 1 -0.0374569
PRRC2C proline-rich coiled-coil 2C -0.0366153
ATP11A ATPase, class VI, type 11A -0.0360181
IPO7 importin 7 -0.0354851
RPL8 ribosomal protein L8 -0.0352513
RPS27 ribosomal protein S27 -0.0341815
RPS25 ribosomal protein S25 -0.0340229
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0339236
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0335442
RPL35A ribosomal protein L35a -0.033473
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.033266
NIPBL Nipped-B homolog (Drosophila) -0.0331873
SET SET nuclear proto-oncogene -0.0325407
SQSTM1 sequestosome 1 -0.0315798
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0313679
PTMA prothymosin, alpha -0.0309592
NEGR1 neuronal growth regulator 1 -0.0309561
RPS3 ribosomal protein S3 -0.0305717
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0305523
RAB10 RAB10, member RAS oncogene family -0.0302879
TENM3 teneurin transmembrane protein 3 -0.0302153
SETD5 SET domain containing 5 -0.0301771
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0299712
OGA O-GlcNAcase -0.0294472
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0291286
TNPO1 transportin 1 -0.0285851
KDM5A lysine (K)-specific demethylase 5A -0.0279889
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0279886
GOLGA4 golgin A4 -0.0279605
FTL ferritin, light polypeptide -0.0278771
SOS1 son of sevenless homolog 1 (Drosophila) -0.0278449
RPL34 ribosomal protein L34 -0.0276287
RPL31 ribosomal protein L31 -0.027405
RPS18 ribosomal protein S18 -0.0271924
ZC3H12B zinc finger CCCH-type containing 12B -0.0271296
WNK1 WNK lysine deficient protein kinase 1 -0.027099
ATP5F1E ATP synthase F1 subunit epsilon -0.0269238
HSPA8 heat shock 70kDa protein 8 -0.0266666
ZNF217 zinc finger protein 217 -0.026382
SLC38A2 solute carrier family 38, member 2 -0.0261794
RIMKLB ribosomal modification protein rimK-like family member B -0.0260508
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0259606
XPOT exportin, tRNA -0.025791
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0251142
TUBB6 tubulin, beta 6 class V -0.0250537