Perindopril (erbumine)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ARHGAP26 Rho GTPase activating protein 26 0.165061
PDE4D phosphodiesterase 4D, cAMP-specific 0.10307
TXNRD1 thioredoxin reductase 1 0.100243
TM4SF1 transmembrane 4 L six family member 1 0.090348
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0799875
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0790606
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0741278
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0701962
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0670516
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0661256
MCL1 myeloid cell leukemia 1 0.0653729
VMP1 vacuole membrane protein 1 0.0628039
ECT2 epithelial cell transforming 2 0.0623172
ASPH aspartate beta-hydroxylase 0.0600013
TRIO trio Rho guanine nucleotide exchange factor 0.0591466
SMAD3 SMAD family member 3 0.0577746
EREG epiregulin 0.0551495
USP34 ubiquitin specific peptidase 34 0.0547098
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0544864
KYNU kynureninase 0.0531662
SLC35F3 solute carrier family 35, member F3 0.0515744
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0513122
NAV2 neuron navigator 2 0.0507869
MAML3 mastermind-like 3 (Drosophila) 0.0502766
CEMIP cell migration inducing protein, hyaluronan binding 0.0496299
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0458192
EFNA5 ephrin-A5 0.0455703
DGKD diacylglycerol kinase, delta 130kDa 0.0455104
FAM107B family with sequence similarity 107, member B 0.0442213
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0435414
MSN moesin 0.0424816
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0418693
RASA2 RAS p21 protein activator 2 0.0412984
ADAM17 ADAM metallopeptidase domain 17 0.0411192
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0404597
FNDC3B fibronectin type III domain containing 3B 0.0401576
EEF2 eukaryotic translation elongation factor 2 0.0400296
BIRC3 baculoviral IAP repeat containing 3 0.0399738
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0381735
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.037623
SBF2 SET binding factor 2 0.0374055
CD44 CD44 molecule (Indian blood group) 0.0368121
PLCB4 phospholipase C, beta 4 0.0367777
CMIP c-Maf inducing protein 0.0366128
PDE10A phosphodiesterase 10A 0.0356217
ARL5B ADP-ribosylation factor-like 5B 0.0355158
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.035271
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0349036
NRIP1 nuclear receptor interacting protein 1 0.0346564
STC1 stanniocalcin 1 0.03465
ZCCHC7 zinc finger, CCHC domain containing 7 0.0336416
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0334525
KDM7A lysine (K)-specific demethylase 7A 0.0331088
AKAP13 A kinase (PRKA) anchor protein 13 0.0324947
SOD2 superoxide dismutase 2, mitochondrial 0.032246
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0322276
PGK1 phosphoglycerate kinase 1 0.0320961
RNF145 ring finger protein 145 0.0319521
TOP1 topoisomerase (DNA) I 0.0319427
TBC1D22A TBC1 domain family, member 22A 0.031875
EXOC6B exocyst complex component 6B 0.0317773
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0311906
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0311046
THSD4 thrombospondin, type I, domain containing 4 0.0310947
USP9X ubiquitin specific peptidase 9, X-linked 0.0310799
CTBP2 C-terminal binding protein 2 0.0293521
SAMD4A sterile alpha motif domain containing 4A 0.0291252
TBC1D5 TBC1 domain family, member 5 0.0288863
SHB Src homology 2 domain containing adaptor protein B 0.0285465
FMNL2 formin-like 2 0.0285364
HIPK2 homeodomain interacting protein kinase 2 0.0285288
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0283624
DUSP5 dual specificity phosphatase 5 0.028135
DST dystonin 0.0279868
UBA2 ubiquitin-like modifier activating enzyme 2 0.0279046
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.027623
ATG7 autophagy related 7 0.0274886
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.027365
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0272763
PRELID2 PRELI domain containing 2 0.0269401
SH3KBP1 SH3-domain kinase binding protein 1 0.0268961
TNIP1 TNFAIP3 interacting protein 1 0.0268492
ZFAND3 zinc finger, AN1-type domain 3 0.0268374
CORO1C coronin, actin binding protein, 1C 0.026801
SDCCAG8 serologically defined colon cancer antigen 8 0.0267021
ATP13A3 ATPase type 13A3 0.026348
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0263372
ZSWIM6 zinc finger, SWIM-type containing 6 0.0261992
NUP58 nucleoporin 58 0.026123
BPTF bromodomain PHD finger transcription factor 0.0261133
KRT81 keratin 81, type II 0.0258086
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0255838
PARD3 par-3 family cell polarity regulator 0.0254816
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0253684
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0253203
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0252086
HMGA2 high mobility group AT-hook 2 0.0250957
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0250752
IPO7 importin 7 0.0249714
ZNF146 zinc finger protein 146 0.02474

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.149018
IGFBP3 insulin-like growth factor binding protein 3 -0.133177
TMSB10 thymosin beta 10 -0.123069
AKAP12 A kinase (PRKA) anchor protein 12 -0.116575
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.110256
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102805
VIM vimentin -0.083942
RPS19 ribosomal protein S19 -0.080609
RPS6 ribosomal protein S6 -0.0781125
ACTG1 actin gamma 1 -0.0687121
RPLP1 ribosomal protein, large, P1 -0.0644234
MT1X metallothionein 1X -0.0592937
NDRG1 N-myc downstream regulated 1 -0.0574254
OSMR oncostatin M receptor -0.051728
S100A6 S100 calcium binding protein A6 -0.0507792
LOC112694756 uncharaterized LOC112694756 -0.0458995
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0435064
B2M beta-2-microglobulin -0.0403835
BASP1 brain abundant, membrane attached signal protein 1 -0.0393412
RRBP1 ribosome binding protein 1 -0.039233
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0370732
RPL23 ribosomal protein L23 -0.0318893
PTMA prothymosin, alpha -0.0316382
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0309443
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0308893
RPS2 ribosomal protein S2 -0.0301999
HILPDA hypoxia inducible lipid droplet-associated -0.0301314
LDHA lactate dehydrogenase A -0.029463
RPL26 ribosomal protein L26 -0.0288714
ZMYND8 zinc finger, MYND-type containing 8 -0.0270195
ETNK1 ethanolamine kinase 1 -0.0269791
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0253288
TNS1 tensin 1 -0.0246057
WSB1 WD repeat and SOCS box containing 1 -0.0244647
IGFBP4 insulin-like growth factor binding protein 4 -0.0243129
PDGFA platelet-derived growth factor alpha polypeptide -0.0238058
RPS8 ribosomal protein S8 -0.0236708
NGLY1 N-glycanase 1 -0.0234236
DUSP16 dual specificity phosphatase 16 -0.0231712
RPL12 ribosomal protein L12 -0.022852
RPS12 ribosomal protein S12 -0.0226911
RPS20 ribosomal protein S20 -0.0222584
RPL8 ribosomal protein L8 -0.0216124
HMGA1 high mobility group AT-hook 1 -0.020842
TNS3 tensin 3 -0.02072
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0206786
AUTS2 autism susceptibility candidate 2 -0.0201709
PLSCR1 phospholipid scramblase 1 -0.01995
EEF1G eukaryotic translation elongation factor 1 gamma -0.0197085
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0194146
LIMCH1 LIM and calponin homology domains 1 -0.0193971
NTN4 netrin 4 -0.0190822
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0190275
FN1 fibronectin 1 -0.0186596
RPL23A ribosomal protein L23a -0.0183051
YBX1 Y box binding protein 1 -0.0181826
VCL vinculin -0.0174286
SP100 SP100 nuclear antigen -0.0174161
EXT1 exostosin glycosyltransferase 1 -0.0174077
LOXL2 lysyl oxidase-like 2 -0.0173934
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0172796
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0172166
HDGF hepatoma-derived growth factor -0.0170991
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0170224
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0170018
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0167429
CALD1 caldesmon 1 -0.0166615
RPS21 ribosomal protein S21 -0.0164872
RPL27 ribosomal protein L27 -0.0162972
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0159274
RSRC2 arginine/serine-rich coiled-coil 2 -0.0158264
NT5C2 5'-nucleotidase, cytosolic II -0.0158108
SET SET nuclear proto-oncogene -0.0157852
PDIA3 protein disulfide isomerase family A, member 3 -0.0157556
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0157403
C1D C1D nuclear receptor corepressor -0.0155619
SELENOS selenoprotein S -0.0155538
RPL35 ribosomal protein L35 -0.0154753
GNAS GNAS complex locus -0.0153099
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0151488
RPL39 ribosomal protein L39 -0.0150761
MGLL monoglyceride lipase -0.0150392
PALLD palladin, cytoskeletal associated protein -0.0148727
NACA nascent polypeptide-associated complex alpha subunit -0.0146707
RPS17 ribosomal protein S17 -0.0143507
NRP2 neuropilin 2 -0.0141902
SRP54 signal recognition particle 54kDa -0.014148
PTPRM protein tyrosine phosphatase, receptor type, M -0.0141457
RAI1 retinoic acid induced 1 -0.0141208
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0141187
RPL37A ribosomal protein L37a -0.0140681
RAB7A RAB7A, member RAS oncogene family -0.0140293
COL5A2 collagen, type V, alpha 2 -0.0139901
RPL28 ribosomal protein L28 -0.0139802
CCDC88A coiled-coil domain containing 88A -0.0138416
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0138138
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0137992
RAB2A RAB2A, member RAS oncogene family -0.0135448
TMSB4X thymosin beta 4, X-linked -0.013458
RPL36 ribosomal protein L36 -0.01335