Perindopril (erbumine)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLIT2 slit homolog 2 (Drosophila) 0.145072
ERBB4 erb-b2 receptor tyrosine kinase 4 0.122474
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.118932
TENM3 teneurin transmembrane protein 3 0.113691
RAD51B RAD51 paralog B 0.0973616
NPAS3 neuronal PAS domain protein 3 0.0970297
FMNL2 formin-like 2 0.0690213
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0677598
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0663423
CDH18 cadherin 18, type 2 0.0638698
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0628459
NEBL nebulette 0.061231
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.059508
CADM2 cell adhesion molecule 2 0.0565954
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0561183
ARHGAP32 Rho GTPase activating protein 32 0.0520846
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0494837
SOX5 SRY (sex determining region Y)-box 5 0.0482158
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0478854
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0468505
TTC28 tetratricopeptide repeat domain 28 0.0451512
LDHA lactate dehydrogenase A 0.0427265
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0403558
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0402332
ZCCHC7 zinc finger, CCHC domain containing 7 0.0400148
PTMA prothymosin, alpha 0.0371729
PRICKLE1 prickle homolog 1 (Drosophila) 0.0364844
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.036264
ACACA acetyl-CoA carboxylase alpha 0.034271
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0340306
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0329603
EEF2 eukaryotic translation elongation factor 2 0.0328456
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.032636
ENO1 enolase 1, (alpha) 0.0324783
TBC1D32 TBC1 domain family, member 32 0.0321098
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0320087
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0311299
ZFP36L1 ZFP36 ring finger protein-like 1 0.0304918
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0300312
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0294572
OSBPL10 oxysterol binding protein-like 10 0.0294215
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0292896
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0288023
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0286127
CELF2 CUGBP, Elav-like family member 2 0.0284246
PTPRG protein tyrosine phosphatase, receptor type, G 0.0278835
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0272752
PTK2 protein tyrosine kinase 2 0.0270372
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0270128
TBC1D5 TBC1 domain family, member 5 0.0265551
TAOK1 TAO kinase 1 0.0259206
USP34 ubiquitin specific peptidase 34 0.0258741
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0257706
DENND1A DENN/MADD domain containing 1A 0.0256628
EMP1 epithelial membrane protein 1 0.0255551
MCTP1 multiple C2 domains, transmembrane 1 0.0251674
SBF2 SET binding factor 2 0.0250751
KTN1 kinectin 1 (kinesin receptor) 0.0250243
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.024939
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0244915
TOX thymocyte selection-associated high mobility group box 0.0244335
LIMS1 LIM and senescent cell antigen-like domains 1 0.0241861
PARD3 par-3 family cell polarity regulator 0.023573
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.023226
RSL1D1 ribosomal L1 domain containing 1 0.0230359
SRPK2 SRSF protein kinase 2 0.0229166
PIAS2 protein inhibitor of activated STAT, 2 0.0227135
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.022657
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0226264
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.022607
SERBP1 SERPINE1 mRNA binding protein 1 0.0225939
SRRM1 serine/arginine repetitive matrix 1 0.0225269
MYH10 myosin, heavy chain 10, non-muscle 0.0221969
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0221915
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0220027
SMYD3 SET and MYND domain containing 3 0.0217327
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0216763
ESYT2 extended synaptotagmin-like protein 2 0.0216717
MACF1 microtubule-actin crosslinking factor 1 0.0215903
KMT2C lysine (K)-specific methyltransferase 2C 0.0215552
TTC17 tetratricopeptide repeat domain 17 0.0210063
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0206701
ZNF638 zinc finger protein 638 0.0206581
LARS1 leucyl-tRNA synthetase 1 0.020446
PHIP pleckstrin homology domain interacting protein 0.0204206
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0202643
ZNF407 zinc finger protein 407 0.0200816
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0199239
TTC3 tetratricopeptide repeat domain 3 0.0198988
RFLNA refilin A 0.0197758
CCNY cyclin Y 0.0197493
TRIO trio Rho guanine nucleotide exchange factor 0.0194149
ARB2A ARB2 cotranscriptional regulator A 0.0193551
CTBP2 C-terminal binding protein 2 0.0192298
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0190749
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.019069
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0190404
RABGAP1L RAB GTPase activating protein 1-like 0.018941
ACTG1 actin gamma 1 0.0187774
ARID1B AT rich interactive domain 1B (SWI1-like) 0.018704

decreased expression

Symbol Name Standardized Value
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0553835
VCL vinculin -0.0358231
EGR1 early growth response 1 -0.0334082
RPLP1 ribosomal protein, large, P1 -0.027913
ZNF608 zinc finger protein 608 -0.027903
ADGRG6 adhesion G protein-coupled receptor G6 -0.0273098
LOC112694756 uncharaterized LOC112694756 -0.0225819
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.022401
RPS19 ribosomal protein S19 -0.0196245
PDE4D phosphodiesterase 4D, cAMP-specific -0.0173214
RTN4 reticulon 4 -0.0170668
RPL23 ribosomal protein L23 -0.0168145
RPL9 ribosomal protein L9 -0.0165238
TPT1 tumor protein, translationally-controlled 1 -0.0165094
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0163076
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0158282
RPS28 ribosomal protein S28 -0.0154135
PABPN1 poly(A) binding protein, nuclear 1 -0.015334
COL5A2 collagen, type V, alpha 2 -0.0153023
HMGB2 high mobility group box 2 -0.0151658
ATP5F1E ATP synthase F1 subunit epsilon -0.0144117
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0142154
RPL34 ribosomal protein L34 -0.0141751
RIGI RNA sensor RIG-I -0.0139557
RPL26 ribosomal protein L26 -0.0136356
ZNFX1 zinc finger, NFX1-type containing 1 -0.0135766
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0133385
PRELID2 PRELI domain containing 2 -0.0131617
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0130413
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0129993
GNAS GNAS complex locus -0.0128841
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0128767
NID1 nidogen 1 -0.0127015
RPL35 ribosomal protein L35 -0.0125729
VMP1 vacuole membrane protein 1 -0.012555
ZC3H12B zinc finger CCCH-type containing 12B -0.0124924
TMEM41B transmembrane protein 41B -0.0124642
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0122635
RPS20 ribosomal protein S20 -0.0120081
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0117942
RPL13A ribosomal protein L13a -0.0116688
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.011517
NEGR1 neuronal growth regulator 1 -0.0113756
RPS21 ribosomal protein S21 -0.0113582
RPS6 ribosomal protein S6 -0.0113283
ELOVL5 ELOVL fatty acid elongase 5 -0.0112288
RPL36A ribosomal protein L36a -0.0112096
HHIP hedgehog interacting protein -0.0111306
PITPNB phosphatidylinositol transfer protein, beta -0.0111127
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0110328
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.011027
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.010964
RPLP2 ribosomal protein, large, P2 -0.0109243
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0107199
MIDEAS mitotic deacetylase associated SANT domain protein -0.0105618
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -0.0103479
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0103108
TJP1 tight junction protein 1 -0.0102493
WDPCP WD repeat containing planar cell polarity effector -0.0101617
HELB helicase (DNA) B -0.0101264
DENND5A DENN/MADD domain containing 5A -0.0100513
RPL28 ribosomal protein L28 -0.0100124
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0100041
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.00998062
VIM vimentin -0.00994904
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -0.00994424
IFI6 interferon, alpha-inducible protein 6 -0.0097902
FBXO11 F-box protein 11 -0.00977204
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.00973188
MAP1B microtubule-associated protein 1B -0.00970983
RPL11 ribosomal protein L11 -0.00961708
BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough -0.00960063
RAB7A RAB7A, member RAS oncogene family -0.00959961
RPL36 ribosomal protein L36 -0.0094071
PROS1 protein S (alpha) -0.0093821
FAM169A family with sequence similarity 169, member A -0.00936845
PNRC1 proline-rich nuclear receptor coactivator 1 -0.00936347
ANKRD12 ankyrin repeat domain 12 -0.00930766
KLF6 Kruppel-like factor 6 -0.00926515
WDR26 WD repeat domain 26 -0.00925388
SCLT1 sodium channel and clathrin linker 1 -0.00921141
ISG15 ISG15 ubiquitin-like modifier -0.00919373
IL6ST interleukin 6 signal transducer -0.00916014
TDRD7 tudor domain containing 7 -0.00915815
ADNP activity-dependent neuroprotector homeobox -0.00912605
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00910802
CDCA2 cell division cycle associated 2 -0.00898965
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.00898464
NCAPG non-SMC condensin I complex, subunit G -0.00887685
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.00886594
ZNF33A zinc finger protein 33A -0.00882539
TET2 tet methylcytosine dioxygenase 2 -0.00876703
CTCF CCCTC-binding factor (zinc finger protein) -0.0087426
BHLHE40 basic helix-loop-helix family, member e40 -0.00870551
TSC22D2 TSC22 domain family, member 2 -0.00870239
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0086329
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00863224
FERMT2 fermitin family member 2 -0.00857013
RAD21 RAD21 homolog (S. pombe) -0.00855445
CHSY1 chondroitin sulfate synthase 1 -0.00844941