Perindopril (erbumine)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0824656
IGFBP3 insulin-like growth factor binding protein 3 0.0672411
KYNU kynureninase 0.0562834
CXCL8 chemokine (C-X-C motif) ligand 8 0.0558862
HDAC9 histone deacetylase 9 0.0519863
ZCCHC7 zinc finger, CCHC domain containing 7 0.046338
DST dystonin 0.0450078
GOLGB1 golgin B1 0.0426193
EXT1 exostosin glycosyltransferase 1 0.0410407
INHBA inhibin, beta A 0.0388751
TTC3 tetratricopeptide repeat domain 3 0.0385714
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0381117
FNIP1 folliculin interacting protein 1 0.0325525
AKAP12 A kinase (PRKA) anchor protein 12 0.032038
LOX lysyl oxidase 0.0304535
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0275407
CALD1 caldesmon 1 0.0254028
MBD5 methyl-CpG binding domain protein 5 0.0250916
ATM ATM serine/threonine kinase 0.0248599
ZBTB20 zinc finger and BTB domain containing 20 0.0237008
BBS9 Bardet-Biedl syndrome 9 0.0231372
FNDC3B fibronectin type III domain containing 3B 0.0230997
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0220868
TNNC1 troponin C type 1 (slow) 0.021972
CLTC clathrin, heavy chain (Hc) 0.0216227
SEC31A SEC31 homolog A (S. cerevisiae) 0.021317
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0211589
EGFR epidermal growth factor receptor 0.0208408
COG5 component of oligomeric golgi complex 5 0.0204759
MACF1 microtubule-actin crosslinking factor 1 0.0203036
ANKRD17 ankyrin repeat domain 17 0.0196848
CREB5 cAMP responsive element binding protein 5 0.019663
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0194481
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0191502
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0187507
NAMPT nicotinamide phosphoribosyltransferase 0.018686
VMP1 vacuole membrane protein 1 0.0183845
ZFAND3 zinc finger, AN1-type domain 3 0.0183731
MSN moesin 0.0183552
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0179998
ANTXR2 anthrax toxin receptor 2 0.0178912
PDE4D phosphodiesterase 4D, cAMP-specific 0.0178305
TTC17 tetratricopeptide repeat domain 17 0.0178034
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0177698
STC1 stanniocalcin 1 0.0176408
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0173359
ANKRD11 ankyrin repeat domain 11 0.0171948
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0170469
BPTF bromodomain PHD finger transcription factor 0.0170247
MON2 MON2 homolog (S. cerevisiae) 0.0170019
SEC24D SEC24 family member D 0.0169071
NALF1 NALCN channel auxiliary factor 1 0.0168997
COPB1 coatomer protein complex, subunit beta 1 0.0166435
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0162038
WDPCP WD repeat containing planar cell polarity effector 0.016053
NLGN1 neuroligin 1 0.0155764
GRAMD1B GRAM domain containing 1B 0.0154872
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.015378
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0153219
IGFBP5 insulin-like growth factor binding protein 5 0.0151805
SAMD4A sterile alpha motif domain containing 4A 0.015131
APP amyloid beta (A4) precursor protein 0.0150257
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0149445
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0148961
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0148354
ATXN1 ataxin 1 0.0147398
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.014668
NAV3 neuron navigator 3 0.0146437
PTPRG protein tyrosine phosphatase, receptor type, G 0.0145493
EHBP1 EH domain binding protein 1 0.0144697
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0144456
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0144395
BIRC2 baculoviral IAP repeat containing 2 0.0144046
RABGAP1L RAB GTPase activating protein 1-like 0.0143353
USP34 ubiquitin specific peptidase 34 0.0142096
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0141807
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0141608
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0140802
ANLN anillin, actin binding protein 0.014035
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.0139014
IARS1 isoleucyl-tRNA synthetase 1 0.0138373
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0137531
ALPK1 alpha-kinase 1 0.0137131
ZNF638 zinc finger protein 638 0.0136874
USO1 USO1 vesicle transport factor 0.0135077
PHF14 PHD finger protein 14 0.0134864
SBF2 SET binding factor 2 0.013446
ANKRD36 ankyrin repeat domain 36 0.0134367
FAF1 Fas (TNFRSF6) associated factor 1 0.0132537
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0130764
LRRC49 leucine rich repeat containing 49 0.0130675
SUCO SUN domain containing ossification factor 0.0130159
SND1 staphylococcal nuclease and tudor domain containing 1 0.0129961
MAST4 microtubule associated serine/threonine kinase family member 4 0.0129835
MCTP2 multiple C2 domains, transmembrane 2 0.012861
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0128461
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0126418
LIMS1 LIM and senescent cell antigen-like domains 1 0.0126204
NRDC nardilysin convertase 0.0126037
SCFD2 sec1 family domain containing 2 0.0125382

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.163315
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14864
FTL ferritin, light polypeptide -0.110106
TMSB10 thymosin beta 10 -0.0784929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0739402
PTMA prothymosin, alpha -0.0498764
HILPDA hypoxia inducible lipid droplet-associated -0.0473373
RPLP1 ribosomal protein, large, P1 -0.0428125
LOC112694756 uncharaterized LOC112694756 -0.039641
RPL28 ribosomal protein L28 -0.0382152
RPL35A ribosomal protein L35a -0.0350315
RPS6 ribosomal protein S6 -0.0337573
GNAS GNAS complex locus -0.0321322
RPS8 ribosomal protein S8 -0.0306684
RPL23 ribosomal protein L23 -0.0295621
RPS19 ribosomal protein S19 -0.0273853
SQSTM1 sequestosome 1 -0.0271243
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0262632
TPT1 tumor protein, translationally-controlled 1 -0.02575
YBX1 Y box binding protein 1 -0.0237944
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0234107
FAM13A family with sequence similarity 13, member A -0.023238
RPL34 ribosomal protein L34 -0.023213
WSB1 WD repeat and SOCS box containing 1 -0.0230571
AHNAK AHNAK nucleoprotein -0.0221997
CALR calreticulin -0.0221563
RACK1 receptor for activated C kinase 1 -0.0216415
PKM pyruvate kinase, muscle -0.0214551
RPS24 ribosomal protein S24 -0.0214453
TPM4 tropomyosin 4 -0.0214272
TRA2A transformer 2 alpha homolog (Drosophila) -0.021336
KDM3A lysine (K)-specific demethylase 3A -0.0210469
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0206999
WDR45B WD repeat domain 45B -0.0205851
VIM vimentin -0.0204793
MXI1 MAX interactor 1, dimerization protein -0.0204458
RPL12 ribosomal protein L12 -0.0203606
RPL9 ribosomal protein L9 -0.0201626
RPLP2 ribosomal protein, large, P2 -0.0198954
RPL37A ribosomal protein L37a -0.0194159
RPS12 ribosomal protein S12 -0.0192356
USP3 ubiquitin specific peptidase 3 -0.0188322
S100A6 S100 calcium binding protein A6 -0.0188223
RPS21 ribosomal protein S21 -0.0184603
RPL19 ribosomal protein L19 -0.0183841
SEC61G Sec61 gamma subunit -0.0182983
ADM adrenomedullin -0.0182889
EIF1 eukaryotic translation initiation factor 1 -0.0181667
RPL11 ribosomal protein L11 -0.0181564
RPL26 ribosomal protein L26 -0.0181203
PDIA4 protein disulfide isomerase family A, member 4 -0.0180711
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0176364
RPS20 ribosomal protein S20 -0.0174294
S100A10 S100 calcium binding protein A10 -0.0173578
RPS29 ribosomal protein S29 -0.0173393
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0172727
RTN4 reticulon 4 -0.0170986
GARS1 glycyl-tRNA synthetase 1 -0.0168924
HLA-B major histocompatibility complex, class I, B -0.0168048
RPL36 ribosomal protein L36 -0.016741
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0166696
KPNB1 karyopherin (importin) beta 1 -0.0165044
LMNA lamin A/C -0.0164634
RPS5 ribosomal protein S5 -0.0161758
RPLP0 ribosomal protein, large, P0 -0.0158565
RPL38 ribosomal protein L38 -0.0156622
RLF rearranged L-myc fusion -0.0156311
TPI1 triosephosphate isomerase 1 -0.0156054
RPS27A ribosomal protein S27a -0.015299
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0152675
SEPTIN7 septin 7 -0.0152383
RPL13A ribosomal protein L13a -0.0149335
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0149193
MT1X metallothionein 1X -0.0146121
RPS2 ribosomal protein S2 -0.0145449
FLNA filamin A, alpha -0.0144928
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0144895
RPS17 ribosomal protein S17 -0.0144798
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0144335
S100A9 S100 calcium binding protein A9 -0.0142926
TSC22D2 TSC22 domain family, member 2 -0.0141131
RRBP1 ribosome binding protein 1 -0.0141113
RPS11 ribosomal protein S11 -0.013693
RPL32 ribosomal protein L32 -0.0136513
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0136486
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0135713
RPS27 ribosomal protein S27 -0.0133793
RPL27A ribosomal protein L27a -0.0132934
RPS14 ribosomal protein S14 -0.0132542
HELZ helicase with zinc finger -0.0130379
CLEC1B C-type lectin domain family 1, member B -0.012997
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0128482
RPL31 ribosomal protein L31 -0.0127161
SDC4 syndecan 4 -0.0125643
RPS16 ribosomal protein S16 -0.0125007
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0123576
HMGB1 high mobility group box 1 -0.0123438
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0123314
CAVIN1 caveolae associated protein 1 -0.0122208
FUS FUS RNA binding protein -0.0121915