Perindopril (erbumine)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.132092
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.065613
TOP2A topoisomerase (DNA) II alpha 170kDa 0.053324
MKI67 marker of proliferation Ki-67 0.0446696
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0420788
ERRFI1 ERBB receptor feedback inhibitor 1 0.0401691
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0400698
DSPP dentin sialophosphoprotein 0.0384785
ZCCHC7 zinc finger, CCHC domain containing 7 0.0379633
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0369689
CENPF centromere protein F, 350/400kDa 0.0369326
TMF1 TATA element modulatory factor 1 0.0334227
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0329652
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0327315
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0320115
TTC3 tetratricopeptide repeat domain 3 0.0313659
PCM1 pericentriolar material 1 0.0312859
MACF1 microtubule-actin crosslinking factor 1 0.0303811
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0302365
DLG1 discs, large homolog 1 (Drosophila) 0.0302257
PTK2 protein tyrosine kinase 2 0.0299433
ENO1 enolase 1, (alpha) 0.0297906
LDHA lactate dehydrogenase A 0.0295239
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0290139
PCBP2 poly(rC) binding protein 2 0.0289494
TXNIP thioredoxin interacting protein 0.028442
ERBIN erbb2 interacting protein 0.0274089
CTBP2 C-terminal binding protein 2 0.0273996
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0272975
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0269798
SYNE2 spectrin repeat containing, nuclear envelope 2 0.026775
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0265145
TOR1AIP2 torsin A interacting protein 2 0.0264232
PARD3 par-3 family cell polarity regulator 0.025949
ANKRD11 ankyrin repeat domain 11 0.025787
EHBP1 EH domain binding protein 1 0.0249298
MBNL1 muscleblind-like splicing regulator 1 0.0247073
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0243884
ADD3 adducin 3 (gamma) 0.0242687
MYH9 myosin, heavy chain 9, non-muscle 0.0240418
GOLGB1 golgin B1 0.0238349
SRRM1 serine/arginine repetitive matrix 1 0.0235988
LMO7 LIM domain 7 0.0231643
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0229998
CUX1 cut-like homeobox 1 0.0229378
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0229241
WWC1 WW and C2 domain containing 1 0.0229158
CLOCK clock circadian regulator 0.0229129
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0223703
ANKRD17 ankyrin repeat domain 17 0.0221956
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0221033
FLNB filamin B, beta 0.0220979
RNF213 ring finger protein 213 0.021525
SERINC5 serine incorporator 5 0.0213415
MSI2 musashi RNA-binding protein 2 0.0212581
FNIP1 folliculin interacting protein 1 0.0210388
LPP LIM domain containing preferred translocation partner in lipoma 0.0209445
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0201439
KDM2A lysine (K)-specific demethylase 2A 0.019759
DSG2 desmoglein 2 0.0194534
PAPOLA poly(A) polymerase alpha 0.0192975
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.019278
AKAP13 A kinase (PRKA) anchor protein 13 0.0191914
TLN1 talin 1 0.0191063
UBA6 ubiquitin-like modifier activating enzyme 6 0.018951
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0188649
CLTC clathrin, heavy chain (Hc) 0.0186219
RBM47 RNA binding motif protein 47 0.0184786
NF1 neurofibromin 1 0.0184614
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0182961
RAD50 RAD50 homolog (S. cerevisiae) 0.018254
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0182304
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0181938
BIRC6 baculoviral IAP repeat containing 6 0.0181354
FRMD5 FERM domain containing 5 0.0180595
SETD5 SET domain containing 5 0.0179432
DSCAM Down syndrome cell adhesion molecule 0.0179013
EPCAM epithelial cell adhesion molecule 0.0178177
PTBP3 polypyrimidine tract binding protein 3 0.0178156
COG6 component of oligomeric golgi complex 6 0.0177857
DOCK5 dedicator of cytokinesis 5 0.0177683
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0176752
ITPRID2 ITPR interacting domain containing 2 0.0176313
CMIP c-Maf inducing protein 0.0176055
SFPQ splicing factor proline/glutamine-rich 0.0175794
LCOR ligand dependent nuclear receptor corepressor 0.0175315
AGO3 argonaute RISC catalytic component 3 0.0174567
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0174501
ZFHX3 zinc finger homeobox 3 0.0172285
FRYL FRY-like 0.0170907
NCOR1 nuclear receptor corepressor 1 0.0170785
NFIA nuclear factor I/A 0.0170154
DIAPH2 diaphanous-related formin 2 0.0169926
PATJ PATJ crumbs cell polarity complex component 0.0169318
MYOF myoferlin 0.0168319
APOLD1 apolipoprotein L domain containing 1 0.0168306
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0167922
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.016784
ARF4 ADP-ribosylation factor 4 0.0167132
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0167118

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188236
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.115047
LOC112694756 uncharaterized LOC112694756 -0.0866783
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0727933
TPT1 tumor protein, translationally-controlled 1 -0.0684698
TMSB10 thymosin beta 10 -0.0633222
TXNRD1 thioredoxin reductase 1 -0.0561188
RPL35A ribosomal protein L35a -0.042649
RPLP1 ribosomal protein, large, P1 -0.0420392
RPS8 ribosomal protein S8 -0.037819
HMGA1 high mobility group AT-hook 1 -0.0367528
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0355213
RPLP0 ribosomal protein, large, P0 -0.0334055
S100A10 S100 calcium binding protein A10 -0.032381
RPS6 ribosomal protein S6 -0.0310045
MT2A metallothionein 2A -0.0309744
PRELID2 PRELI domain containing 2 -0.0304221
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0304055
RPL23 ribosomal protein L23 -0.0297266
KIAA1217 KIAA1217 -0.0296557
RPL27A ribosomal protein L27a -0.0292667
RPLP2 ribosomal protein, large, P2 -0.0284489
RPS24 ribosomal protein S24 -0.0282453
RPS12 ribosomal protein S12 -0.0278756
RPL9 ribosomal protein L9 -0.027254
RPL30 ribosomal protein L30 -0.0272124
EIF1 eukaryotic translation initiation factor 1 -0.027137
FHIT fragile histidine triad -0.0269997
RPS21 ribosomal protein S21 -0.0265979
RPL4 ribosomal protein L4 -0.0262134
RPL34 ribosomal protein L34 -0.0259186
RRBP1 ribosome binding protein 1 -0.0254642
RPL11 ribosomal protein L11 -0.0247175
RPL26 ribosomal protein L26 -0.0242755
RPL37A ribosomal protein L37a -0.0242172
WWOX WW domain containing oxidoreductase -0.0235666
RPS19 ribosomal protein S19 -0.0229667
SDC4 syndecan 4 -0.0226146
RPS20 ribosomal protein S20 -0.0221887
RPL36 ribosomal protein L36 -0.0210266
FTL ferritin, light polypeptide -0.0200563
KRT8 keratin 8, type II -0.0199747
RPL35 ribosomal protein L35 -0.0197897
OGA O-GlcNAcase -0.0192236
ICAM1 intercellular adhesion molecule 1 -0.018985
PLEC plectin -0.0187055
EGR1 early growth response 1 -0.0187035
RPL12 ribosomal protein L12 -0.0186476
RPS27A ribosomal protein S27a -0.0183263
RPL38 ribosomal protein L38 -0.0181477
WDR45B WD repeat domain 45B -0.0176869
RACK1 receptor for activated C kinase 1 -0.0173527
LSR lipolysis stimulated lipoprotein receptor -0.0172806
RPL27 ribosomal protein L27 -0.0172757
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.017236
RPS17 ribosomal protein S17 -0.0172205
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0169997
ANKRD12 ankyrin repeat domain 12 -0.0169203
METTL15 methyltransferase like 15 -0.0165751
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0163771
SEPTIN2 septin 2 -0.0163313
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.016253
RPS2 ribosomal protein S2 -0.0162039
RPL19 ribosomal protein L19 -0.0159109
MORF4L1 mortality factor 4 like 1 -0.0157042
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0156223
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0154118
RPS16 ribosomal protein S16 -0.0153735
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0153501
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0152219
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0151456
RPL28 ribosomal protein L28 -0.015021
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0150125
AHNAK AHNAK nucleoprotein -0.0149869
TM9SF3 transmembrane 9 superfamily member 3 -0.0148591
PTBP1 polypyrimidine tract binding protein 1 -0.0148204
FUS FUS RNA binding protein -0.0147134
WDR26 WD repeat domain 26 -0.0146154
ANXA2 annexin A2 -0.0145956
FLNA filamin A, alpha -0.0145793
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0145228
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0142304
S100A9 S100 calcium binding protein A9 -0.0141685
HLA-B major histocompatibility complex, class I, B -0.0140723
FTH1 ferritin, heavy polypeptide 1 -0.0138514
CARS1 cysteinyl-tRNA synthetase 1 -0.0137973
TUBB4B tubulin, beta 4B class IVb -0.013691
RPS27 ribosomal protein S27 -0.0136626
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0135654
MATR3 matrin 3 -0.0134862
EIF4H eukaryotic translation initiation factor 4H -0.013446
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0133569
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0132252
RPS15 ribosomal protein S15 -0.0131392
QRICH1 glutamine-rich 1 -0.0130193
RBM39 RNA binding motif protein 39 -0.0129354
SENP5 SUMO1/sentrin specific peptidase 5 -0.012883
IER3 immediate early response 3 -0.0128521
HMGB1 high mobility group box 1 -0.0127385
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0125629