Perindopril (erbumine)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.115577
ZBTB20 zinc finger and BTB domain containing 20 0.0766094
LIMCH1 LIM and calponin homology domains 1 0.0720407
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0490273
EGFR epidermal growth factor receptor 0.0483651
FNIP1 folliculin interacting protein 1 0.0478069
ZFP36L1 ZFP36 ring finger protein-like 1 0.0466243
LDHA lactate dehydrogenase A 0.0461603
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0457003
SVIL supervillin 0.0455531
TBC1D5 TBC1 domain family, member 5 0.0428
N4BP2L2 NEDD4 binding protein 2-like 2 0.0415012
SEPTIN9 septin 9 0.0394135
BICC1 BicC family RNA binding protein 1 0.0391488
POTEF POTE ankyrin domain family, member F 0.038962
ANKRD36 ankyrin repeat domain 36 0.0385027
ALCAM activated leukocyte cell adhesion molecule 0.037805
BICD1 bicaudal D homolog 1 (Drosophila) 0.0377577
SETD5 SET domain containing 5 0.0352213
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0351006
VMP1 vacuole membrane protein 1 0.0345491
MKI67 marker of proliferation Ki-67 0.0335324
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0327974
BPTF bromodomain PHD finger transcription factor 0.0314573
GLIS3 GLIS family zinc finger 3 0.0313183
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0307345
PCBP2 poly(rC) binding protein 2 0.0305968
PTK2 protein tyrosine kinase 2 0.0302341
ZNF148 zinc finger protein 148 0.0298496
MBD5 methyl-CpG binding domain protein 5 0.0298307
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.029659
DLC1 DLC1 Rho GTPase activating protein 0.0296477
PAX8 paired box 8 0.0296436
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0290156
ARHGAP29 Rho GTPase activating protein 29 0.0286134
RNF145 ring finger protein 145 0.0285653
TAOK1 TAO kinase 1 0.0284035
VCAN versican 0.0280556
MACC1 metastasis associated in colon cancer 1 0.0270706
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0270502
AFF1 AF4/FMR2 family, member 1 0.0269563
ITGB8 integrin, beta 8 0.0258911
RBPMS RNA binding protein with multiple splicing 0.025735
TTC3 tetratricopeptide repeat domain 3 0.0256475
ADAM10 ADAM metallopeptidase domain 10 0.0252774
ERBIN erbb2 interacting protein 0.0252263
ZNF609 zinc finger protein 609 0.0250285
STAU2 staufen double-stranded RNA binding protein 2 0.0245445
ENO2 enolase 2 (gamma, neuronal) 0.0244275
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0243751
VEGFA vascular endothelial growth factor A 0.0242426
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0242253
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0240676
LPP LIM domain containing preferred translocation partner in lipoma 0.0240475
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0236806
UTRN utrophin 0.0235089
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0234764
NDRG1 N-myc downstream regulated 1 0.0234735
HDGF hepatoma-derived growth factor 0.0233955
AEBP2 AE binding protein 2 0.0231467
ZNF652 zinc finger protein 652 0.0231462
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0229638
ANXA1 annexin A1 0.0227889
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0227304
NFIB nuclear factor I/B 0.0225897
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0218628
DIAPH3 diaphanous-related formin 3 0.0216737
RHEX regulator of hemoglobinization and erythroid cell expansion 0.0216282
RAD51B RAD51 paralog B 0.0212667
KDM6A lysine (K)-specific demethylase 6A 0.0209646
BBX bobby sox homolog (Drosophila) 0.0208594
WASF2 WAS protein family, member 2 0.0208227
CDK13 cyclin-dependent kinase 13 0.0207542
RBM26 RNA binding motif protein 26 0.0206277
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.0205952
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0205723
MAML2 mastermind-like 2 (Drosophila) 0.0203325
APLP2 amyloid beta (A4) precursor-like protein 2 0.0203234
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0201504
CCNL1 cyclin L1 0.0201285
FIGN fidgetin 0.0201073
TCF12 transcription factor 12 0.0200527
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0199763
ZNF462 zinc finger protein 462 0.0199126
MACF1 microtubule-actin crosslinking factor 1 0.0198797
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.019709
BRWD1 bromodomain and WD repeat domain containing 1 0.0196819
PTPRK protein tyrosine phosphatase, receptor type, K 0.0195639
FOXP1 forkhead box P1 0.0194114
APOLD1 apolipoprotein L domain containing 1 0.0192894
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0192842
KIF5C kinesin family member 5C 0.0192189
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0190604
EGR1 early growth response 1 0.0189016
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0188601
ATXN1 ataxin 1 0.018834
B2M beta-2-microglobulin 0.0188074
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0186843
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0185794
KMT2E lysine (K)-specific methyltransferase 2E 0.0184845

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159503
TPT1 tumor protein, translationally-controlled 1 -0.124036
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122007
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.110488
ACTG1 actin gamma 1 -0.0859895
RPL35A ribosomal protein L35a -0.0854722
RPL23 ribosomal protein L23 -0.0851652
TMSB10 thymosin beta 10 -0.0787422
AHNAK AHNAK nucleoprotein -0.0760546
LAMB3 laminin, beta 3 -0.0727759
RPS8 ribosomal protein S8 -0.0721389
RPLP1 ribosomal protein, large, P1 -0.0672178
FTL ferritin, light polypeptide -0.060093
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0574754
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0572599
RPL12 ribosomal protein L12 -0.0551141
RPS19 ribosomal protein S19 -0.0545638
RPL19 ribosomal protein L19 -0.0526399
TMSB4X thymosin beta 4, X-linked -0.0483038
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0482341
S100A10 S100 calcium binding protein A10 -0.0479905
RPL26 ribosomal protein L26 -0.0475473
SQSTM1 sequestosome 1 -0.0472868
RPS24 ribosomal protein S24 -0.0468528
RPL31 ribosomal protein L31 -0.0468272
RPL34 ribosomal protein L34 -0.0466187
SMAD3 SMAD family member 3 -0.0462344
MYH9 myosin, heavy chain 9, non-muscle -0.0431861
OGA O-GlcNAcase -0.0429044
HMGB1 high mobility group box 1 -0.0424741
RPL11 ribosomal protein L11 -0.0421894
TJP1 tight junction protein 1 -0.0419018
RPL35 ribosomal protein L35 -0.0399369
RPLP2 ribosomal protein, large, P2 -0.039594
CDCP1 CUB domain containing protein 1 -0.0394359
RPL9 ribosomal protein L9 -0.0391296
RPL28 ribosomal protein L28 -0.038093
RPS6 ribosomal protein S6 -0.037113
RPS27A ribosomal protein S27a -0.0368677
CANX calnexin -0.0365386
RPL38 ribosomal protein L38 -0.0361625
RACK1 receptor for activated C kinase 1 -0.0351257
PTMA prothymosin, alpha -0.0348103
VCL vinculin -0.0344777
RPS12 ribosomal protein S12 -0.0344695
WWOX WW domain containing oxidoreductase -0.0343426
KLF6 Kruppel-like factor 6 -0.0334201
GNAS GNAS complex locus -0.0333649
RPL32 ribosomal protein L32 -0.0328496
ACTN4 actinin, alpha 4 -0.0320098
VEZT vezatin, adherens junctions transmembrane protein -0.0318549
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.030895
RPLP0 ribosomal protein, large, P0 -0.0308724
RPL37A ribosomal protein L37a -0.0308395
RPL4 ribosomal protein L4 -0.0308213
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0305968
RPS20 ribosomal protein S20 -0.0304989
APP amyloid beta (A4) precursor protein -0.0303186
LOC112694756 uncharaterized LOC112694756 -0.0299298
RTN4 reticulon 4 -0.0297541
EIF1 eukaryotic translation initiation factor 1 -0.0287048
CCND1 cyclin D1 -0.0286089
RPS14 ribosomal protein S14 -0.0284744
TUBB tubulin, beta class I -0.028105
MATR3 matrin 3 -0.0280509
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0279951
RPS21 ribosomal protein S21 -0.0279674
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0278735
WDR45B WD repeat domain 45B -0.0276503
RPL36 ribosomal protein L36 -0.0274661
FLNA filamin A, alpha -0.0274178
RRBP1 ribosome binding protein 1 -0.0263814
PLEC plectin -0.0263036
RPS5 ribosomal protein S5 -0.0261227
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0260985
RPS11 ribosomal protein S11 -0.0260786
TUBB4B tubulin, beta 4B class IVb -0.0260704
NRIP1 nuclear receptor interacting protein 1 -0.0260164
SNX9 sorting nexin 9 -0.0259781
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0259283
RPS17 ribosomal protein S17 -0.0255156
FTH1 ferritin, heavy polypeptide 1 -0.0254534
S100A9 S100 calcium binding protein A9 -0.0254532
HDLBP high density lipoprotein binding protein -0.0251324
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0251163
RPS27 ribosomal protein S27 -0.0250329
RPS2 ribosomal protein S2 -0.0249994
RPS16 ribosomal protein S16 -0.0248963
RPL27 ribosomal protein L27 -0.0248139
UPP1 uridine phosphorylase 1 -0.0247045
SEPTIN7 septin 7 -0.024565
IER3 immediate early response 3 -0.0244806
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0244114
FUS FUS RNA binding protein -0.0240744
RASA2 RAS p21 protein activator 2 -0.0239782
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0239414
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0237824
RPL30 ribosomal protein L30 -0.0235042
SENP5 SUMO1/sentrin specific peptidase 5 -0.0234799
ARF1 ADP-ribosylation factor 1 -0.0232933