| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Perindopril (erbumine) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Perindopril (erbumine)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.215555 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.203094 |
| C3 | complement component 3 | 0.151491 |
| IGF2 | insulin-like growth factor 2 | 0.106953 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0805104 |
| DSPP | dentin sialophosphoprotein | 0.0715545 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.069726 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0513574 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0495129 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0482781 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0446386 |
| PCBP2 | poly(rC) binding protein 2 | 0.0430547 |
| RPS6 | ribosomal protein S6 | 0.0417358 |
| CFB | complement factor B | 0.0400456 |
| TF | transferrin | 0.0374136 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0362343 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0350365 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0349787 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0326974 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0318124 |
| VEGFA | vascular endothelial growth factor A | 0.0311428 |
| FTL | ferritin, light polypeptide | 0.031109 |
| LDHA | lactate dehydrogenase A | 0.0301862 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0300609 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0298785 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0286854 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0261152 |
| OPTN | optineurin | 0.0255093 |
| TMEM51 | transmembrane protein 51 | 0.0252489 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0250714 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0249502 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0242777 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0240548 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0240137 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0240044 |
| NFIA | nuclear factor I/A | 0.0235696 |
| FGG | fibrinogen gamma chain | 0.0234224 |
| GSE1 | Gse1 coiled-coil protein | 0.0233969 |
| IFNGR1 | interferon gamma receptor 1 | 0.0230528 |
| MATN3 | matrilin 3 | 0.0228263 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0223246 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0220841 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0219453 |
| PTK2 | protein tyrosine kinase 2 | 0.0218276 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0216176 |
| GOLGA4 | golgin A4 | 0.0215691 |
| RBM39 | RNA binding motif protein 39 | 0.0215645 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0214607 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0209186 |
| CLU | clusterin | 0.0208302 |
| APOE | apolipoprotein E | 0.0200969 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0199689 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | 0.0198806 |
| SET | SET nuclear proto-oncogene | 0.0198597 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0196891 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0196134 |
| FN1 | fibronectin 1 | 0.0195745 |
| ECE1 | endothelin converting enzyme 1 | 0.0195256 |
| MBNL3 | muscleblind-like splicing regulator 3 | 0.0193562 |
| ZFP36 | ZFP36 ring finger protein | 0.0193427 |
| CCNL1 | cyclin L1 | 0.0192616 |
| CHKA | choline kinase alpha | 0.0192439 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.019195 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0188386 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0185616 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0184653 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0183576 |
| ZNF292 | zinc finger protein 292 | 0.0183426 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0180734 |
| RPS4X | ribosomal protein S4, X-linked | 0.0180153 |
| BAG6 | BCL2-associated athanogene 6 | 0.01796 |
| MEF2A | myocyte enhancer factor 2A | 0.0177648 |
| SEPTIN9 | septin 9 | 0.0176283 |
| RPL3 | ribosomal protein L3 | 0.0175079 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0173223 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0172801 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0172469 |
| METTL15 | methyltransferase like 15 | 0.0171411 |
| PCM1 | pericentriolar material 1 | 0.0170901 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0168789 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0167867 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0167136 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0167051 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0166415 |
| JMJD1C | jumonji domain containing 1C | 0.0166307 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.016473 |
| KIF1B | kinesin family member 1B | 0.0164355 |
| CADM1 | cell adhesion molecule 1 | 0.0164217 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0164152 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.016412 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0163872 |
| RNF145 | ring finger protein 145 | 0.0162737 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0159801 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0159142 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0158713 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0158083 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0157753 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0157394 |
| WNK2 | WNK lysine deficient protein kinase 2 | 0.015538 |
| EFNA1 | ephrin-A1 | 0.0154931 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.246372 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.175709 |
| SLC38A2 | solute carrier family 38, member 2 | -0.155639 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.108839 |
| EHBP1 | EH domain binding protein 1 | -0.105313 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0998251 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0795004 |
| MT2A | metallothionein 2A | -0.0687401 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0678307 |
| ASPH | aspartate beta-hydroxylase | -0.0667864 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0661884 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0657782 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0652469 |
| VCL | vinculin | -0.0580034 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0542746 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0531782 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0502349 |
| FRMD5 | FERM domain containing 5 | -0.0495327 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0464088 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0452211 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0443389 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0437546 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0437397 |
| ATXN1 | ataxin 1 | -0.0435638 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0425661 |
| TMSB10 | thymosin beta 10 | -0.0420399 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0418914 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0411833 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0409786 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0405295 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0403499 |
| SDC4 | syndecan 4 | -0.0398577 |
| RPS24 | ribosomal protein S24 | -0.0396551 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0376189 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0369695 |
| BCL2L1 | BCL2-like 1 | -0.0355105 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.035093 |
| RAI14 | retinoic acid induced 14 | -0.0348051 |
| FAM107B | family with sequence similarity 107, member B | -0.0336867 |
| EGR1 | early growth response 1 | -0.0333884 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0332017 |
| HMGA1 | high mobility group AT-hook 1 | -0.0325493 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0315932 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0315664 |
| MCL1 | myeloid cell leukemia 1 | -0.0315522 |
| FAM135A | family with sequence similarity 135, member A | -0.0313629 |
| SVIL | supervillin | -0.0308878 |
| ITGAV | integrin, alpha V | -0.0308693 |
| FILIP1L | filamin A interacting protein 1-like | -0.0302835 |
| ACTG1 | actin gamma 1 | -0.0302497 |
| GK | glycerol kinase | -0.0301998 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.029877 |
| TRIM26 | tripartite motif containing 26 | -0.0294548 |
| LOC112694756 | uncharaterized LOC112694756 | -0.029327 |
| MYO1E | myosin IE | -0.0292271 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0290033 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0287128 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.028696 |
| STK17A | serine/threonine kinase 17a | -0.0282968 |
| FERMT1 | fermitin family member 1 | -0.0282333 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0276657 |
| PEG3 | paternally expressed 3 | -0.0273682 |
| RUNX1 | runt-related transcription factor 1 | -0.0272383 |
| TPM4 | tropomyosin 4 | -0.0269152 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.026445 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0263623 |
| NPR2 | natriuretic peptide receptor 2 | -0.026313 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0259672 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0259573 |
| ITGB5 | integrin, beta 5 | -0.0257761 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0256411 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.0249073 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0247856 |
| ATP10A | ATPase, class V, type 10A | -0.0246886 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0243519 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0243108 |
| FOXP1 | forkhead box P1 | -0.0241967 |
| FUS | FUS RNA binding protein | -0.0239901 |
| RNF213 | ring finger protein 213 | -0.0238764 |
| RIGI | RNA sensor RIG-I | -0.023776 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0236757 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0234211 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0232464 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.023041 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0226332 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0226155 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0224561 |
| CP | ceruloplasmin (ferroxidase) | -0.0222535 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0221355 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0219642 |
| KRT23 | keratin 23, type I | -0.0218652 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0218435 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0216711 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0214051 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0213633 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0213631 |
| DENND4A | DENN/MADD domain containing 4A | -0.0212276 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0209383 |
| SQSTM1 | sequestosome 1 | -0.0209213 |
| MX2 | MX dynamin-like GTPase 2 | -0.0207853 |
