Perindopril (erbumine)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.120246
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.119745
DPYD dihydropyrimidine dehydrogenase 0.103311
TIMP3 TIMP metallopeptidase inhibitor 3 0.0728436
MTSS1 metastasis suppressor 1 0.0683559
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0675715
MSN moesin 0.0659796
LMO7 LIM domain 7 0.0643547
SLC35F3 solute carrier family 35, member F3 0.0630767
PDLIM5 PDZ and LIM domain 5 0.0602
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0573938
PDE4D phosphodiesterase 4D, cAMP-specific 0.0561353
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0557463
SULF1 sulfatase 1 0.0552964
RASAL2 RAS protein activator like 2 0.0541069
DOCK5 dedicator of cytokinesis 5 0.0511978
PODXL podocalyxin-like 0.0498189
FOXO1 forkhead box O1 0.0497573
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0493801
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.047535
ITGA6 integrin, alpha 6 0.0441634
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0434796
RAI14 retinoic acid induced 14 0.0426992
RABGAP1L RAB GTPase activating protein 1-like 0.0423892
ALCAM activated leukocyte cell adhesion molecule 0.0423127
EGFR epidermal growth factor receptor 0.0409635
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0409566
EFNA5 ephrin-A5 0.0400416
UTRN utrophin 0.0368903
RAD51B RAD51 paralog B 0.0367065
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0366655
MACF1 microtubule-actin crosslinking factor 1 0.0359974
AMOTL1 angiomotin like 1 0.0358616
MECOM MDS1 and EVI1 complex locus 0.0345887
AKAP13 A kinase (PRKA) anchor protein 13 0.034494
LAMC2 laminin, gamma 2 0.0339328
NRIP1 nuclear receptor interacting protein 1 0.0336927
ANO1 anoctamin 1, calcium activated chloride channel 0.0336868
PSD3 pleckstrin and Sec7 domain containing 3 0.0328868
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0327795
EXOC4 exocyst complex component 4 0.0326978
EXT1 exostosin glycosyltransferase 1 0.0322623
APLP2 amyloid beta (A4) precursor-like protein 2 0.0320069
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0315919
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.031147
DGKH diacylglycerol kinase, eta 0.0305732
CDK6 cyclin-dependent kinase 6 0.0303097
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0298805
MPRIP myosin phosphatase Rho interacting protein 0.0297176
TSC22D1 TSC22 domain family, member 1 0.0294651
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0293495
GRB10 growth factor receptor-bound protein 10 0.0293426
SMYD3 SET and MYND domain containing 3 0.028692
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0281549
THSD4 thrombospondin, type I, domain containing 4 0.0276549
CEMIP cell migration inducing protein, hyaluronan binding 0.0274248
RIN2 Ras and Rab interactor 2 0.0272918
HDAC9 histone deacetylase 9 0.0271471
PICALM phosphatidylinositol binding clathrin assembly protein 0.0267677
RCOR1 REST corepressor 1 0.0265617
ZEB1 zinc finger E-box binding homeobox 1 0.026299
HSPG2 heparan sulfate proteoglycan 2 0.0259798
RNF217 ring finger protein 217 0.0259019
BCAR3 breast cancer anti-estrogen resistance 3 0.0258182
NRG1 neuregulin 1 0.025623
BLCAP bladder cancer associated protein 0.0252527
ABI3BP ABI family, member 3 (NESH) binding protein 0.0250725
MYH9 myosin, heavy chain 9, non-muscle 0.0248221
TNS3 tensin 3 0.0247732
PTK2 protein tyrosine kinase 2 0.0247116
CAPRIN2 caprin family member 2 0.024322
N4BP2L2 NEDD4 binding protein 2-like 2 0.0242601
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0241925
MYO10 myosin X 0.0241758
HMGA2 high mobility group AT-hook 2 0.0241615
SETX senataxin 0.0240395
MAML2 mastermind-like 2 (Drosophila) 0.0239801
OSMR oncostatin M receptor 0.0238254
PCDH1 protocadherin 1 0.0234167
PTHLH parathyroid hormone-like hormone 0.0233894
DST dystonin 0.0233552
MCL1 myeloid cell leukemia 1 0.0232968
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0231064
BCL2L1 BCL2-like 1 0.0223993
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0223649
TGM2 transglutaminase 2 0.0223209
ATXN1 ataxin 1 0.0221297
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0221036
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.02187
DOK5 docking protein 5 0.0218515
JMJD1C jumonji domain containing 1C 0.0218031
PLS3 plastin 3 0.0214794
TPM3 tropomyosin 3 0.0213398
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0211591
PALLD palladin, cytoskeletal associated protein 0.0211484
LUZP1 leucine zipper protein 1 0.021028
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0209526
EXOC6B exocyst complex component 6B 0.0209109
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0209097
PRELID2 PRELI domain containing 2 0.0208634

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.207244
TMSB10 thymosin beta 10 -0.118725
PTMA prothymosin, alpha -0.111726
TPT1 tumor protein, translationally-controlled 1 -0.102007
S100A10 S100 calcium binding protein A10 -0.095715
RPS21 ribosomal protein S21 -0.0931168
MT2A metallothionein 2A -0.0900812
RPLP1 ribosomal protein, large, P1 -0.0810484
LOC112694756 uncharaterized LOC112694756 -0.0809087
RPS6 ribosomal protein S6 -0.0804297
RPS8 ribosomal protein S8 -0.079497
TMSB4X thymosin beta 4, X-linked -0.07642
GNAS GNAS complex locus -0.076128
LMNA lamin A/C -0.0753614
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0704836
RPL11 ribosomal protein L11 -0.0674241
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0668967
KRT17 keratin 17, type I -0.0665743
RPLP2 ribosomal protein, large, P2 -0.066407
PGK1 phosphoglycerate kinase 1 -0.0615654
IFITM3 interferon induced transmembrane protein 3 -0.0591394
RPS19 ribosomal protein S19 -0.0571074
H1-0 H1.0 linker histone -0.0568733
B2M beta-2-microglobulin -0.0546181
RPS24 ribosomal protein S24 -0.0533408
RPL8 ribosomal protein L8 -0.0521861
RPS13 ribosomal protein S13 -0.0512829
KDM3A lysine (K)-specific demethylase 3A -0.0495571
RPL23 ribosomal protein L23 -0.04881
RPL12 ribosomal protein L12 -0.0480068
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0477387
RPL34 ribosomal protein L34 -0.047267
RPL35A ribosomal protein L35a -0.0449538
RPL37 ribosomal protein L37 -0.0445989
S100A6 S100 calcium binding protein A6 -0.0438772
S100A2 S100 calcium binding protein A2 -0.0438174
STC1 stanniocalcin 1 -0.0424099
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0422941
RPL19 ribosomal protein L19 -0.0422511
RPS3 ribosomal protein S3 -0.0420516
RPL27A ribosomal protein L27a -0.0418882
EIF1 eukaryotic translation initiation factor 1 -0.0416029
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0413634
RPS25 ribosomal protein S25 -0.0411365
S100A9 S100 calcium binding protein A9 -0.0408116
FTL ferritin, light polypeptide -0.0407017
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0390313
MT1X metallothionein 1X -0.0390037
RPLP0 ribosomal protein, large, P0 -0.0387248
RACK1 receptor for activated C kinase 1 -0.0386554
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0386529
HLA-B major histocompatibility complex, class I, B -0.0385714
ENO1 enolase 1, (alpha) -0.0385491
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0384613
OGA O-GlcNAcase -0.0383036
RLF rearranged L-myc fusion -0.0379287
RPS27A ribosomal protein S27a -0.0378355
NAP1L1 nucleosome assembly protein 1-like 1 -0.0372423
RPL26 ribosomal protein L26 -0.0369626
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0364708
RPS20 ribosomal protein S20 -0.0352937
RPL30 ribosomal protein L30 -0.0352176
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0349864
RPL5 ribosomal protein L5 -0.0345359
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0337514
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0334218
RPS12 ribosomal protein S12 -0.0333786
RPL31 ribosomal protein L31 -0.0330626
GOLGA4 golgin A4 -0.0329517
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0327481
NAMPT nicotinamide phosphoribosyltransferase -0.0327119
BHLHE40 basic helix-loop-helix family, member e40 -0.0325953
CANX calnexin -0.0324925
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0321427
YBX1 Y box binding protein 1 -0.032141
IER3 immediate early response 3 -0.0320962
MORF4L2 mortality factor 4 like 2 -0.0320318
RPS14 ribosomal protein S14 -0.0317587
RPL32 ribosomal protein L32 -0.0316904
CAV1 caveolin 1, caveolae protein, 22kDa -0.0313736
ARF1 ADP-ribosylation factor 1 -0.0312139
MATR3 matrin 3 -0.0311782
AHNAK AHNAK nucleoprotein -0.031047
CAVIN1 caveolae associated protein 1 -0.0309786
RPL28 ribosomal protein L28 -0.0305721
RPL35 ribosomal protein L35 -0.0304237
RPL7A ribosomal protein L7a -0.0302899
ANXA2 annexin A2 -0.0301173
RPL36 ribosomal protein L36 -0.030109
RPS11 ribosomal protein S11 -0.0300505
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0299704
SQSTM1 sequestosome 1 -0.0299102
RPS27 ribosomal protein S27 -0.0298178
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0297841
ANXA1 annexin A1 -0.0297079
RPS29 ribosomal protein S29 -0.0296555
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.02914
FSCN1 fascin actin-bundling protein 1 -0.0291263
RPS16 ribosomal protein S16 -0.0291258
VDAC1 voltage-dependent anion channel 1 -0.0290807