Perindopril (erbumine)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in J82 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Perindopril (erbumine)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.115599
ATP13A3 ATPase type 13A3 0.0832339
TXNRD1 thioredoxin reductase 1 0.0792852
SLC12A8 solute carrier family 12, member 8 0.0758082
EXT1 exostosin glycosyltransferase 1 0.0654841
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0646508
DIAPH3 diaphanous-related formin 3 0.0626398
TRIO trio Rho guanine nucleotide exchange factor 0.0607277
MBNL1 muscleblind-like splicing regulator 1 0.0535527
IL6ST interleukin 6 signal transducer 0.0510451
PICALM phosphatidylinositol binding clathrin assembly protein 0.049663
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0487751
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0479199
ANXA1 annexin A1 0.0452939
GLS2 glutaminase 2 (liver, mitochondrial) 0.0443032
PPME1 protein phosphatase methylesterase 1 0.0413341
SPAG9 sperm associated antigen 9 0.0411776
FNDC3B fibronectin type III domain containing 3B 0.0404938
SLIT2 slit homolog 2 (Drosophila) 0.0389006
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0386367
CCNL1 cyclin L1 0.0385899
TPX2 TPX2, microtubule-associated 0.0373068
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0360617
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0354893
FXR1 fragile X mental retardation, autosomal homolog 1 0.0353373
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0347171
NUP153 nucleoporin 153kDa 0.0343741
ARF4 ADP-ribosylation factor 4 0.0335758
ZCCHC7 zinc finger, CCHC domain containing 7 0.0335214
VMP1 vacuole membrane protein 1 0.0333486
GLIS3 GLIS family zinc finger 3 0.0331398
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0325944
GOLGB1 golgin B1 0.0319771
UBQLN1 ubiquilin 1 0.0318348
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0316149
NALF1 NALCN channel auxiliary factor 1 0.0315898
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0315323
CLTC clathrin, heavy chain (Hc) 0.0313666
PTPRM protein tyrosine phosphatase, receptor type, M 0.0309196
CKAP5 cytoskeleton associated protein 5 0.0288356
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.0284399
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0284248
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0283259
ECT2 epithelial cell transforming 2 0.0283161
TMEM178B transmembrane protein 178B 0.0281841
FAR1 fatty acyl CoA reductase 1 0.0279435
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.027374
HEG1 heart development protein with EGF-like domains 1 0.0270077
DST dystonin 0.0266559
SFPQ splicing factor proline/glutamine-rich 0.0265875
ZSWIM6 zinc finger, SWIM-type containing 6 0.0265598
KDM6A lysine (K)-specific demethylase 6A 0.0264329
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0263682
ANKRD10 ankyrin repeat domain 10 0.0263662
MBNL2 muscleblind-like splicing regulator 2 0.0262729
SEC31A SEC31 homolog A (S. cerevisiae) 0.0261904
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.025698
MYH9 myosin, heavy chain 9, non-muscle 0.0256979
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0255064
ANO6 anoctamin 6 0.0254146
NCKAP1 NCK-associated protein 1 0.0252191
PBX3 pre-B-cell leukemia homeobox 3 0.0252074
IPO7 importin 7 0.0249808
RICTOR RPTOR independent companion of MTOR, complex 2 0.0249525
MSN moesin 0.0248854
UTRN utrophin 0.0248092
TGFB2 transforming growth factor, beta 2 0.0247983
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0247815
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0247664
SMAD3 SMAD family member 3 0.0247402
FAF1 Fas (TNFRSF6) associated factor 1 0.0245405
USP9X ubiquitin specific peptidase 9, X-linked 0.0243196
PLK2 polo-like kinase 2 0.0240318
MORF4L2 mortality factor 4 like 2 0.0240109
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0238483
THBS1 thrombospondin 1 0.0238482
PTK2 protein tyrosine kinase 2 0.023781
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0237075
CORO1C coronin, actin binding protein, 1C 0.0235767
WAC WW domain containing adaptor with coiled-coil 0.0235347
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0235149
IQGAP1 IQ motif containing GTPase activating protein 1 0.0233869
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0233821
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0232812
B2M beta-2-microglobulin 0.023273
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0232652
CCDC14 coiled-coil domain containing 14 0.0231506
BBX bobby sox homolog (Drosophila) 0.0229356
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0228595
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0227308
ZFAND3 zinc finger, AN1-type domain 3 0.0226783
COPB1 coatomer protein complex, subunit beta 1 0.0226316
POTEF POTE ankyrin domain family, member F 0.0225879
ANKRD28 ankyrin repeat domain 28 0.0225466
SRP54 signal recognition particle 54kDa 0.0225376
ANKRD17 ankyrin repeat domain 17 0.0225265
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0225254
ZNF148 zinc finger protein 148 0.0225168
POSTN periostin, osteoblast specific factor 0.0224751
AKAP13 A kinase (PRKA) anchor protein 13 0.0221561

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.166264
FN1 fibronectin 1 -0.126184
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125405
FTL ferritin, light polypeptide -0.111377
NDRG1 N-myc downstream regulated 1 -0.106228
IGFBP3 insulin-like growth factor binding protein 3 -0.104618
ABI3BP ABI family, member 3 (NESH) binding protein -0.10314
VIM vimentin -0.0836589
FTH1 ferritin, heavy polypeptide 1 -0.0794221
RPS6 ribosomal protein S6 -0.077946
AKAP12 A kinase (PRKA) anchor protein 12 -0.0692477
PHACTR1 phosphatase and actin regulator 1 -0.0681429
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0673129
HLA-B major histocompatibility complex, class I, B -0.0639853
F3 coagulation factor III (thromboplastin, tissue factor) -0.0582055
RPL35A ribosomal protein L35a -0.0581402
TPT1 tumor protein, translationally-controlled 1 -0.0575687
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0572285
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0569743
CAVIN1 caveolae associated protein 1 -0.0548888
TMSB10 thymosin beta 10 -0.048465
DLG1 discs, large homolog 1 (Drosophila) -0.0474185
PTMA prothymosin, alpha -0.0473047
LOC112694756 uncharaterized LOC112694756 -0.0466631
RPS8 ribosomal protein S8 -0.0454706
RPLP1 ribosomal protein, large, P1 -0.0441654
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0435202
ADM adrenomedullin -0.0433487
ENO1 enolase 1, (alpha) -0.0424987
S100A10 S100 calcium binding protein A10 -0.0423581
DTNA dystrobrevin, alpha -0.0413504
BTG1 B-cell translocation gene 1, anti-proliferative -0.0394054
KPNB1 karyopherin (importin) beta 1 -0.0391828
WSB1 WD repeat and SOCS box containing 1 -0.0388859
RPLP2 ribosomal protein, large, P2 -0.0386281
PTPRF protein tyrosine phosphatase, receptor type, F -0.0382966
RPL37 ribosomal protein L37 -0.0376161
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0364094
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0352616
GNAS GNAS complex locus -0.0352358
ACTG1 actin gamma 1 -0.0351226
TMSB4X thymosin beta 4, X-linked -0.0348222
RPL12 ribosomal protein L12 -0.0343171
IGFBP5 insulin-like growth factor binding protein 5 -0.0335871
RPL23 ribosomal protein L23 -0.0328021
S100A6 S100 calcium binding protein A6 -0.0326674
HMGB1 high mobility group box 1 -0.0321072
AHNAK AHNAK nucleoprotein -0.0318462
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0287737
EIF1 eukaryotic translation initiation factor 1 -0.028078
RPL30 ribosomal protein L30 -0.0278409
IFITM3 interferon induced transmembrane protein 3 -0.0268461
ANXA2 annexin A2 -0.0268317
TPM4 tropomyosin 4 -0.0267514
ZMYND8 zinc finger, MYND-type containing 8 -0.0264163
MT1X metallothionein 1X -0.0264056
FGFR1 fibroblast growth factor receptor 1 -0.0256289
RRBP1 ribosome binding protein 1 -0.0255844
RPL26 ribosomal protein L26 -0.0254756
PLIN2 perilipin 2 -0.0246993
ZNF432 zinc finger protein 432 -0.0244846
RPL34 ribosomal protein L34 -0.0244708
IER3 immediate early response 3 -0.0239815
PGK1 phosphoglycerate kinase 1 -0.0238226
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0236916
RPS20 ribosomal protein S20 -0.0236277
RPL35 ribosomal protein L35 -0.0230108
RPS27A ribosomal protein S27a -0.0228649
RPL31 ribosomal protein L31 -0.022595
JUN jun proto-oncogene -0.022562
YBX1 Y box binding protein 1 -0.0224028
RPL37A ribosomal protein L37a -0.0223243
RPL8 ribosomal protein L8 -0.0222674
LMNA lamin A/C -0.02185
RPL27A ribosomal protein L27a -0.0218009
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0215058
COL5A1 collagen, type V, alpha 1 -0.0210334
RPS21 ribosomal protein S21 -0.0209914
MMP12 matrix metallopeptidase 12 -0.020876
HILPDA hypoxia inducible lipid droplet-associated -0.0208448
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0207947
RPS27 ribosomal protein S27 -0.0207213
RPS12 ribosomal protein S12 -0.0206485
RPL36A ribosomal protein L36a -0.0202089
RPS19 ribosomal protein S19 -0.0201951
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0198905
VDAC1 voltage-dependent anion channel 1 -0.0192615
RPS17 ribosomal protein S17 -0.0191622
RPL5 ribosomal protein L5 -0.0190764
FAM162A family with sequence similarity 162, member A -0.0190578
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0190084
RAI1 retinoic acid induced 1 -0.0188679
RPS3 ribosomal protein S3 -0.0187382
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0186806
CD44 CD44 molecule (Indian blood group) -0.0186593
NAV1 neuron navigator 1 -0.0186497
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0186404
RPS29 ribosomal protein S29 -0.0185045
SQSTM1 sequestosome 1 -0.0184083
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0183749