Perindopril (erbumine)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.112118
GPHN gephyrin 0.057336
ITGA6 integrin, alpha 6 0.0551372
DSPP dentin sialophosphoprotein 0.0523273
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0496735
FAT1 FAT atypical cadherin 1 0.0486971
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0413426
GOLGA4 golgin A4 0.0372881
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0364177
RNF43 ring finger protein 43 0.0358624
EREG epiregulin 0.0357284
CEMIP cell migration inducing protein, hyaluronan binding 0.0342071
FTH1 ferritin, heavy polypeptide 1 0.031877
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0298282
PTEN phosphatase and tensin homolog 0.0297663
RNF145 ring finger protein 145 0.0286369
TRIM2 tripartite motif containing 2 0.028423
LDHA lactate dehydrogenase A 0.0260643
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0259998
TBC1D5 TBC1 domain family, member 5 0.0256548
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0248431
SHROOM3 shroom family member 3 0.0243311
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0242473
NALF1 NALCN channel auxiliary factor 1 0.0240821
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0239856
LMO7 LIM domain 7 0.0239251
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0236938
CD46 CD46 molecule, complement regulatory protein 0.0231827
KMT2C lysine (K)-specific methyltransferase 2C 0.0229741
ARHGAP32 Rho GTPase activating protein 32 0.0221089
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0219617
TTC3 tetratricopeptide repeat domain 3 0.0218493
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0217405
DERA deoxyribose-phosphate aldolase (putative) 0.0217031
USP6NL USP6 N-terminal like 0.0215459
PNISR PNN-interacting serine/arginine-rich protein 0.0214449
PELI1 pellino E3 ubiquitin protein ligase 1 0.0212024
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0206342
PTBP3 polypyrimidine tract binding protein 3 0.0206316
ERBIN erbb2 interacting protein 0.0200452
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0199454
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0196304
ABHD2 abhydrolase domain containing 2 0.0189585
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0185795
MON2 MON2 homolog (S. cerevisiae) 0.0183122
RFX7 regulatory factor X, 7 0.0182796
CLTC clathrin, heavy chain (Hc) 0.0177416
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0177192
KLF3 Kruppel-like factor 3 (basic) 0.0176708
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0175474
GOLGB1 golgin B1 0.0173432
GSK3B glycogen synthase kinase 3 beta 0.0173242
FNBP4 formin binding protein 4 0.0172686
SENP6 SUMO1/sentrin specific peptidase 6 0.0171118
DSG2 desmoglein 2 0.0170731
CADPS Ca++-dependent secretion activator 0.0170309
EPCAM epithelial cell adhesion molecule 0.0169971
RBM39 RNA binding motif protein 39 0.0168154
EHF ets homologous factor 0.0167187
AKAP9 A kinase (PRKA) anchor protein 9 0.0166427
PTPRE protein tyrosine phosphatase, receptor type, E 0.0166064
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0165921
TXNRD1 thioredoxin reductase 1 0.0165222
PTK2 protein tyrosine kinase 2 0.016518
GDF15 growth differentiation factor 15 0.0162663
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.016257
SCAF11 SR-related CTD-associated factor 11 0.0162106
SERINC5 serine incorporator 5 0.0161133
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0159161
PNN pinin, desmosome associated protein 0.0157775
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0156429
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0156372
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0156205
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0154683
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0154493
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0154483
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0154343
PAPOLA poly(A) polymerase alpha 0.0153098
CHD9 chromodomain helicase DNA binding protein 9 0.0152883
KDM7A lysine (K)-specific demethylase 7A 0.0151602
THOC2 THO complex 2 0.0151515
DENND4C DENN/MADD domain containing 4C 0.0151407
TMF1 TATA element modulatory factor 1 0.0151113
FOXP1 forkhead box P1 0.0150359
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.0148126
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0147193
CHD1 chromodomain helicase DNA binding protein 1 0.0144947
PCCA propionyl CoA carboxylase, alpha polypeptide 0.014448
ABHD17C abhydrolase domain containing 17C 0.0144441
TC2N tandem C2 domains, nuclear 0.0144211
MED13 mediator complex subunit 13 0.0143847
DSCAM Down syndrome cell adhesion molecule 0.0143822
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.0142503
MMP12 matrix metallopeptidase 12 0.0141084
MBD5 methyl-CpG binding domain protein 5 0.0139473
WDR43 WD repeat domain 43 0.0138396
PUM2 pumilio RNA-binding family member 2 0.0138373
GCLC glutamate-cysteine ligase, catalytic subunit 0.0138364
OGA O-GlcNAcase 0.013814
BCLAF1 BCL2-associated transcription factor 1 0.0137591

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.127029
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0987346
TMSB10 thymosin beta 10 -0.0892003
TPT1 tumor protein, translationally-controlled 1 -0.0881809
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0791442
VCL vinculin -0.073971
AHNAK AHNAK nucleoprotein -0.0518427
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0517254
NPSR1 neuropeptide S receptor 1 -0.0502314
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0495311
TPM4 tropomyosin 4 -0.0429188
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0423261
ACTG1 actin gamma 1 -0.0412658
ONECUT3 one cut homeobox 3 -0.0403711
NDRG1 N-myc downstream regulated 1 -0.0345822
RPS8 ribosomal protein S8 -0.0339073
RPS27A ribosomal protein S27a -0.0337691
FLNB filamin B, beta -0.0330487
RPLP1 ribosomal protein, large, P1 -0.0326679
ANTXR2 anthrax toxin receptor 2 -0.0317438
RPL23 ribosomal protein L23 -0.0315354
MYO1E myosin IE -0.0310586
PKM pyruvate kinase, muscle -0.0296626
PSD3 pleckstrin and Sec7 domain containing 3 -0.0285017
RPS12 ribosomal protein S12 -0.0280838
LOC112694756 uncharaterized LOC112694756 -0.027641
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0276134
PTMA prothymosin, alpha -0.0273783
PDLIM5 PDZ and LIM domain 5 -0.0266296
ACTN4 actinin, alpha 4 -0.0264266
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0260119
RPL34 ribosomal protein L34 -0.0249949
UBC ubiquitin C -0.0249304
RPL35A ribosomal protein L35a -0.0240354
RPL9 ribosomal protein L9 -0.0232822
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0230278
LAMA4 laminin, alpha 4 -0.0229573
S100A10 S100 calcium binding protein A10 -0.0229571
RPS6 ribosomal protein S6 -0.0225213
EGFR epidermal growth factor receptor -0.0224268
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0221645
ASPH aspartate beta-hydroxylase -0.0220608
SLC35F3 solute carrier family 35, member F3 -0.0220075
PDIA4 protein disulfide isomerase family A, member 4 -0.021829
IER3 immediate early response 3 -0.021818
S100A6 S100 calcium binding protein A6 -0.0213754
RPS25 ribosomal protein S25 -0.0212972
CALR calreticulin -0.0211477
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0210729
RPL26 ribosomal protein L26 -0.0210302
RPL37A ribosomal protein L37a -0.0210208
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0208121
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.020692
USP53 ubiquitin specific peptidase 53 -0.0203911
GREB1L growth regulation by estrogen in breast cancer-like -0.0203607
SLC38A2 solute carrier family 38, member 2 -0.0193849
FBXO11 F-box protein 11 -0.0193572
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0192862
RPS24 ribosomal protein S24 -0.0189887
EXT1 exostosin glycosyltransferase 1 -0.0188687
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0185816
RPL31 ribosomal protein L31 -0.0184752
F3 coagulation factor III (thromboplastin, tissue factor) -0.0184443
RPLP2 ribosomal protein, large, P2 -0.0181518
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0177975
EGR1 early growth response 1 -0.0173603
KLF5 Kruppel-like factor 5 (intestinal) -0.017307
JUN jun proto-oncogene -0.0172354
MT2A metallothionein 2A -0.0170026
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0168453
RPS17 ribosomal protein S17 -0.0163936
GRB10 growth factor receptor-bound protein 10 -0.0161734
RPS20 ribosomal protein S20 -0.0159797
MAML3 mastermind-like 3 (Drosophila) -0.0158603
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.015841
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0157085
MYH9 myosin, heavy chain 9, non-muscle -0.0155759
TFF1 trefoil factor 1 -0.0152768
RPL36 ribosomal protein L36 -0.0151621
RPL28 ribosomal protein L28 -0.0151259
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0150625
RPS19 ribosomal protein S19 -0.01502
PALLD palladin, cytoskeletal associated protein -0.0145738
RAP1B RAP1B, member of RAS oncogene family -0.0144456
MCL1 myeloid cell leukemia 1 -0.0143169
SOX4 SRY (sex determining region Y)-box 4 -0.0142455
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0141922
AGR2 anterior gradient 2 -0.014105
RPL19 ribosomal protein L19 -0.0139088
RIGI RNA sensor RIG-I -0.0136675
IFRD1 interferon-related developmental regulator 1 -0.0135715
RPL37 ribosomal protein L37 -0.0134313
KLF6 Kruppel-like factor 6 -0.0132825
TPM1 tropomyosin 1 (alpha) -0.0132181
MBNL1 muscleblind-like splicing regulator 1 -0.0131728
INTS6 integrator complex subunit 6 -0.012944
FTL ferritin, light polypeptide -0.0129111
RPL12 ribosomal protein L12 -0.0127674
SQSTM1 sequestosome 1 -0.0127288
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0126965