Perindopril (erbumine)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.109523
FNDC3B fibronectin type III domain containing 3B 0.0720509
NAMPT nicotinamide phosphoribosyltransferase 0.0635256
FN1 fibronectin 1 0.0611164
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0550981
TRIO trio Rho guanine nucleotide exchange factor 0.0483101
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0469156
GRB10 growth factor receptor-bound protein 10 0.0414238
DPYD dihydropyrimidine dehydrogenase 0.041025
DST dystonin 0.0408943
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0401988
USP34 ubiquitin specific peptidase 34 0.0398409
LOX lysyl oxidase 0.0393102
PSD3 pleckstrin and Sec7 domain containing 3 0.0374377
RBM39 RNA binding motif protein 39 0.0368331
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0362155
IGFBP3 insulin-like growth factor binding protein 3 0.0360664
GPC6 glypican 6 0.0358054
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0351595
HMGA2 high mobility group AT-hook 2 0.0345484
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0330974
CD44 CD44 molecule (Indian blood group) 0.0330589
RICTOR RPTOR independent companion of MTOR, complex 2 0.0315976
RAI14 retinoic acid induced 14 0.0315574
KYNU kynureninase 0.0306901
AKAP13 A kinase (PRKA) anchor protein 13 0.0289586
FAM20C family with sequence similarity 20, member C 0.0280184
ANKRD28 ankyrin repeat domain 28 0.0278521
EXT1 exostosin glycosyltransferase 1 0.0278011
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.027714
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0276616
SOD2 superoxide dismutase 2, mitochondrial 0.0271478
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0265609
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0264931
CDH13 cadherin 13 0.0258016
KDM2A lysine (K)-specific demethylase 2A 0.0257743
JMJD1C jumonji domain containing 1C 0.0254879
PARD3 par-3 family cell polarity regulator 0.0237691
TAS2R14 taste receptor, type 2, member 14 0.0237584
FAM107B family with sequence similarity 107, member B 0.0237495
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0237248
KDM3A lysine (K)-specific demethylase 3A 0.0236289
ATP13A3 ATPase type 13A3 0.023346
AKAP12 A kinase (PRKA) anchor protein 12 0.0233221
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0232913
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0223903
VMP1 vacuole membrane protein 1 0.0223649
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0222321
OXSR1 oxidative stress responsive 1 0.0220034
ETV6 ets variant 6 0.0219148
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0215803
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0215319
ATXN1 ataxin 1 0.0213537
MSRB3 methionine sulfoxide reductase B3 0.0210263
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0210082
ZEB2 zinc finger E-box binding homeobox 2 0.0206115
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.020565
EHBP1 EH domain binding protein 1 0.0205443
SYT1 synaptotagmin I 0.0201866
NTN4 netrin 4 0.0201495
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0201025
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.019939
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0197372
COPA coatomer protein complex, subunit alpha 0.0195517
ZFAND3 zinc finger, AN1-type domain 3 0.0195452
RAD51B RAD51 paralog B 0.0193739
RAB1A RAB1A, member RAS oncogene family 0.0191256
FNIP1 folliculin interacting protein 1 0.0190569
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0189689
AOPEP aminopeptidase O (putative) 0.0189065
ERRFI1 ERBB receptor feedback inhibitor 1 0.0187858
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0187237
GLCCI1 glucocorticoid induced 1 0.0187116
MECOM MDS1 and EVI1 complex locus 0.0186255
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0183903
IQGAP1 IQ motif containing GTPase activating protein 1 0.0180398
EFNA5 ephrin-A5 0.0180329
MBNL1 muscleblind-like splicing regulator 1 0.0179703
EXOC4 exocyst complex component 4 0.0178267
RUNX2 runt-related transcription factor 2 0.0177797
FAM13A family with sequence similarity 13, member A 0.0177253
LPP LIM domain containing preferred translocation partner in lipoma 0.0176994
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0176837
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0176089
OSMR oncostatin M receptor 0.0174981
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0173654
PRELID2 PRELI domain containing 2 0.0173575
KMT2C lysine (K)-specific methyltransferase 2C 0.0173388
MACF1 microtubule-actin crosslinking factor 1 0.0171819
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0171791
HDAC9 histone deacetylase 9 0.0165182
HDLBP high density lipoprotein binding protein 0.0165159
ZSWIM6 zinc finger, SWIM-type containing 6 0.0164861
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0164273
ELL2 elongation factor, RNA polymerase II, 2 0.0164213
NF1 neurofibromin 1 0.0163583
COL12A1 collagen, type XII, alpha 1 0.0163225
SEC31A SEC31 homolog A (S. cerevisiae) 0.0162443
LTBP1 latent transforming growth factor beta binding protein 1 0.016234
GOLGA4 golgin A4 0.0161469

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147639
MT2A metallothionein 2A -0.0855817
TMSB10 thymosin beta 10 -0.0773774
FTL ferritin, light polypeptide -0.062542
VIM vimentin -0.060187
RPLP1 ribosomal protein, large, P1 -0.0475739
RPS19 ribosomal protein S19 -0.0428748
RPS6 ribosomal protein S6 -0.0363738
RPL35A ribosomal protein L35a -0.032101
RPS8 ribosomal protein S8 -0.0294866
RPL23 ribosomal protein L23 -0.0294219
PTMA prothymosin, alpha -0.0291362
RPS12 ribosomal protein S12 -0.0288281
RPL36 ribosomal protein L36 -0.0270893
RPLP2 ribosomal protein, large, P2 -0.0254681
RPL37A ribosomal protein L37a -0.0241804
HMGA1 high mobility group AT-hook 1 -0.0231827
FTH1 ferritin, heavy polypeptide 1 -0.0231696
RPL34 ribosomal protein L34 -0.022953
RPL31 ribosomal protein L31 -0.0222556
RPS29 ribosomal protein S29 -0.0212774
EIF1 eukaryotic translation initiation factor 1 -0.0210887
RPL32 ribosomal protein L32 -0.0207527
NDRG1 N-myc downstream regulated 1 -0.0199857
RPS21 ribosomal protein S21 -0.0197251
RPL28 ribosomal protein L28 -0.0195285
B2M beta-2-microglobulin -0.0190351
RPS23 ribosomal protein S23 -0.0183581
RPL12 ribosomal protein L12 -0.0180827
RPL9 ribosomal protein L9 -0.0180204
RPS25 ribosomal protein S25 -0.0178142
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0176486
RPS24 ribosomal protein S24 -0.0175809
RPL11 ribosomal protein L11 -0.0174926
RPL19 ribosomal protein L19 -0.0170449
RPS13 ribosomal protein S13 -0.016936
RPS17 ribosomal protein S17 -0.0168597
POTEF POTE ankyrin domain family, member F -0.0165263
RPS11 ribosomal protein S11 -0.0161233
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.01606
RPL5 ribosomal protein L5 -0.0159644
ANGPTL4 angiopoietin-like 4 -0.0158798
RPS27 ribosomal protein S27 -0.0158507
RPS16 ribosomal protein S16 -0.0157943
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0152695
RPL30 ribosomal protein L30 -0.0152212
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0151935
EGR1 early growth response 1 -0.0150871
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0149683
RPL37 ribosomal protein L37 -0.0148679
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0148066
RPS5 ribosomal protein S5 -0.0145296
RACK1 receptor for activated C kinase 1 -0.0142316
TPT1 tumor protein, translationally-controlled 1 -0.0140446
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0138869
RPS3 ribosomal protein S3 -0.0137772
S100A10 S100 calcium binding protein A10 -0.0136914
PFN1 profilin 1 -0.0136362
S100A9 S100 calcium binding protein A9 -0.0133871
SEC61G Sec61 gamma subunit -0.0133003
RPL35 ribosomal protein L35 -0.0132331
LOC112694756 uncharaterized LOC112694756 -0.013077
RPLP0 ribosomal protein, large, P0 -0.0129997
TIMP1 TIMP metallopeptidase inhibitor 1 -0.012955
RPS14 ribosomal protein S14 -0.0127915
RPL7A ribosomal protein L7a -0.0127141
RPL38 ribosomal protein L38 -0.0125406
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0124547
HLA-B major histocompatibility complex, class I, B -0.0124435
PKM pyruvate kinase, muscle -0.0122698
IFITM3 interferon induced transmembrane protein 3 -0.0122096
RPL18 ribosomal protein L18 -0.0120831
RPL15 ribosomal protein L15 -0.0120499
G0S2 G0/G1 switch 2 -0.0119536
RPL27A ribosomal protein L27a -0.0115158
RPL26 ribosomal protein L26 -0.0113703
RPL13A ribosomal protein L13a -0.0111949
ACTG1 actin gamma 1 -0.0108319
GSTP1 glutathione S-transferase pi 1 -0.0105025
IER3 immediate early response 3 -0.0104259
C15ORF48 chromosome 15 open reading frame 48 -0.0102837
IFI6 interferon, alpha-inducible protein 6 -0.0101687
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0101503
RPL7 ribosomal protein L7 -0.0100237
ATP5F1E ATP synthase F1 subunit epsilon -0.00993884
RPS20 ribosomal protein S20 -0.00983723
RPS15 ribosomal protein S15 -0.00980485
RPS10 ribosomal protein S10 -0.00949426
S100A6 S100 calcium binding protein A6 -0.00946426
MT1X metallothionein 1X -0.00933914
TPI1 triosephosphate isomerase 1 -0.00922574
SLC38A1 solute carrier family 38, member 1 -0.00914332
RPS27A ribosomal protein S27a -0.00906645
NDUFA4 NDUFA4, mitochondrial complex associated -0.00896701
RPL8 ribosomal protein L8 -0.00891992
RPL27 ribosomal protein L27 -0.00879616
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00876028
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.00875343
YBX1 Y box binding protein 1 -0.00874332
VDAC1 voltage-dependent anion channel 1 -0.00862888