Perindopril (erbumine)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Perindopril (erbumine)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.264387
GRAMD1B GRAM domain containing 1B 0.147747
THSD4 thrombospondin, type I, domain containing 4 0.125017
TXNRD1 thioredoxin reductase 1 0.105065
RAD51B RAD51 paralog B 0.100645
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.095442
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0867751
PDE4D phosphodiesterase 4D, cAMP-specific 0.0827441
YBX3 Y box binding protein 3 0.0761861
EXOC4 exocyst complex component 4 0.0729841
ERRFI1 ERBB receptor feedback inhibitor 1 0.0703013
TRIO trio Rho guanine nucleotide exchange factor 0.0680742
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0630667
RIMS2 regulating synaptic membrane exocytosis 2 0.0619614
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0610861
DOCK5 dedicator of cytokinesis 5 0.0579502
PDE10A phosphodiesterase 10A 0.0544173
IGF1R insulin-like growth factor 1 receptor 0.0543962
PTK2 protein tyrosine kinase 2 0.0531386
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0530192
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0525163
ZBTB20 zinc finger and BTB domain containing 20 0.0524201
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.051184
ZFAND3 zinc finger, AN1-type domain 3 0.049546
OSMR oncostatin M receptor 0.0492017
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0487469
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0480639
EML4 echinoderm microtubule associated protein like 4 0.0477254
AFF3 AF4/FMR2 family, member 3 0.0463084
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0458168
MCL1 myeloid cell leukemia 1 0.0452029
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0444055
USP34 ubiquitin specific peptidase 34 0.0443629
SMAD3 SMAD family member 3 0.0438909
ANO6 anoctamin 6 0.0435776
HMGA2 high mobility group AT-hook 2 0.0434487
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0427829
RABGAP1L RAB GTPase activating protein 1-like 0.0421836
ATP11A ATPase, class VI, type 11A 0.0408279
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0407598
SFPQ splicing factor proline/glutamine-rich 0.0397553
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.039727
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0394903
SMYD3 SET and MYND domain containing 3 0.0391533
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0380647
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0380176
GPHN gephyrin 0.0374219
ELL2 elongation factor, RNA polymerase II, 2 0.0370392
BIRC2 baculoviral IAP repeat containing 2 0.0367007
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0360022
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0359503
CDK17 cyclin-dependent kinase 17 0.0358479
DST dystonin 0.0356763
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0348606
EGFR epidermal growth factor receptor 0.0346626
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0340582
DNAH14 dynein, axonemal, heavy chain 14 0.033888
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.033676
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0330141
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0330113
NABP1 nucleic acid binding protein 1 0.0329066
NF1 neurofibromin 1 0.0328906
SPIDR scaffolding protein involved in DNA repair 0.0327591
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0325961
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0324881
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0322277
TAS2R14 taste receptor, type 2, member 14 0.0321105
FMNL2 formin-like 2 0.0320487
BICD1 bicaudal D homolog 1 (Drosophila) 0.0320247
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0319313
TBC1D5 TBC1 domain family, member 5 0.0316346
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0313301
EXT1 exostosin glycosyltransferase 1 0.0308641
MACF1 microtubule-actin crosslinking factor 1 0.0302068
EXOC6B exocyst complex component 6B 0.0298019
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.029734
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.029683
ATXN1 ataxin 1 0.0295177
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0290789
TM4SF1 transmembrane 4 L six family member 1 0.0288222
THADA thyroid adenoma associated 0.028811
WDR70 WD repeat domain 70 0.0287315
EHBP1 EH domain binding protein 1 0.0286093
BASP1 brain abundant, membrane attached signal protein 1 0.0279386
WWOX WW domain containing oxidoreductase 0.0274766
TTC28 tetratricopeptide repeat domain 28 0.0274396
CCDC91 coiled-coil domain containing 91 0.0272671
RNF213 ring finger protein 213 0.0271742
R3HDM2 R3H domain containing 2 0.0271467
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0269675
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0265462
PRH1 proline-rich protein HaeIII subfamily 1 0.0263038
FER fer (fps/fes related) tyrosine kinase 0.0262505
FAF1 Fas (TNFRSF6) associated factor 1 0.0260015
BMAL2 basic helix-loop-helix ARNT like 2 0.0255728
TFPI2 tissue factor pathway inhibitor 2 0.0253344
CMIP c-Maf inducing protein 0.0252296
RICTOR RPTOR independent companion of MTOR, complex 2 0.0251445
DENND5B DENN/MADD domain containing 5B 0.0250135
ETV6 ets variant 6 0.0250092

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.222413
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0622741
VIM vimentin -0.0605431
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0582714
TMSB10 thymosin beta 10 -0.0549095
TPI1 triosephosphate isomerase 1 -0.0510128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0460667
RPS8 ribosomal protein S8 -0.0451985
RPL23 ribosomal protein L23 -0.0445116
PFN1 profilin 1 -0.0438023
PTMA prothymosin, alpha -0.0434389
RPL37 ribosomal protein L37 -0.0418536
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0407502
RPLP1 ribosomal protein, large, P1 -0.0400547
RPL12 ribosomal protein L12 -0.0386754
RPLP0 ribosomal protein, large, P0 -0.0372019
RPS27 ribosomal protein S27 -0.0358147
RPS21 ribosomal protein S21 -0.0358059
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0342174
YBX1 Y box binding protein 1 -0.0337181
RPL35A ribosomal protein L35a -0.0336861
GOLGA4 golgin A4 -0.0331114
RPS6 ribosomal protein S6 -0.0329988
RPL37A ribosomal protein L37a -0.0327257
RPL26 ribosomal protein L26 -0.0304086
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0301182
RPS19 ribosomal protein S19 -0.0293222
RPL8 ribosomal protein L8 -0.0283053
EEF2 eukaryotic translation elongation factor 2 -0.0281986
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0265046
WDR45B WD repeat domain 45B -0.0241577
HMGA1 high mobility group AT-hook 1 -0.024137
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0239708
RPS12 ribosomal protein S12 -0.0239365
EIF1 eukaryotic translation initiation factor 1 -0.0239189
RPLP2 ribosomal protein, large, P2 -0.0233219
PDIA6 protein disulfide isomerase family A, member 6 -0.0232416
RPL19 ribosomal protein L19 -0.0231887
EGR1 early growth response 1 -0.0225079
KMT2E lysine (K)-specific methyltransferase 2E -0.0224639
RPL35 ribosomal protein L35 -0.0222732
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0222577
CAMTA1 calmodulin binding transcription activator 1 -0.0221883
FTL ferritin, light polypeptide -0.0220406
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0219417
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0216996
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0216472
SEPTIN7 septin 7 -0.021507
RPL32 ribosomal protein L32 -0.0214104
UBE2H ubiquitin-conjugating enzyme E2H -0.0209548
RPS10 ribosomal protein S10 -0.0205514
RPS29 ribosomal protein S29 -0.020485
RACK1 receptor for activated C kinase 1 -0.0204093
RPL36 ribosomal protein L36 -0.0201998
PCBP2 poly(rC) binding protein 2 -0.0201748
TFG TRK-fused gene -0.0199376
RPL28 ribosomal protein L28 -0.019926
PDIA3 protein disulfide isomerase family A, member 3 -0.0197489
COPA coatomer protein complex, subunit alpha -0.0195912
SRP54 signal recognition particle 54kDa -0.0193474
ATP5F1E ATP synthase F1 subunit epsilon -0.0192897
S100A10 S100 calcium binding protein A10 -0.0192413
RPL11 ribosomal protein L11 -0.0189234
POTEF POTE ankyrin domain family, member F -0.0188174
RPS14 ribosomal protein S14 -0.0187192
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0184788
RPS25 ribosomal protein S25 -0.0184447
EEF1G eukaryotic translation elongation factor 1 gamma -0.0184342
RPS17 ribosomal protein S17 -0.0182561
RPL13A ribosomal protein L13a -0.0181836
LOC112694756 uncharaterized LOC112694756 -0.0180787
MIS18BP1 MIS18 binding protein 1 -0.0179641
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0179098
RPS4X ribosomal protein S4, X-linked -0.0178723
MT2A metallothionein 2A -0.0176631
ACBD3 acyl-CoA binding domain containing 3 -0.0174864
RPS15 ribosomal protein S15 -0.0174581
RPL18 ribosomal protein L18 -0.0173958
RPL36A ribosomal protein L36a -0.0172939
GARS1 glycyl-tRNA synthetase 1 -0.0170302
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0169479
TUBA1B tubulin, alpha 1b -0.0162513
ENO1 enolase 1, (alpha) -0.0159309
TAGLN2 transgelin 2 -0.0159252
MT1X metallothionein 1X -0.0157479
RAB1A RAB1A, member RAS oncogene family -0.0157219
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0157077
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0156591
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0156107
ARF4 ADP-ribosylation factor 4 -0.0155704
RPL9 ribosomal protein L9 -0.0154413
TPM2 tropomyosin 2 (beta) -0.0153332
RPL34 ribosomal protein L34 -0.0151069
PER1 period circadian clock 1 -0.0150207
LDHB lactate dehydrogenase B -0.0149497
ZC3H15 zinc finger CCCH-type containing 15 -0.0149232
OAZ1 ornithine decarboxylase antizyme 1 -0.0149165
VDAC1 voltage-dependent anion channel 1 -0.0149059
TMEM165 transmembrane protein 165 -0.0148281
TBC1D23 TBC1 domain family, member 23 -0.0147084