Perindopril (erbumine)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.150931
ASPH aspartate beta-hydroxylase 0.0989599
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0668152
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0523775
FNDC3B fibronectin type III domain containing 3B 0.0493312
ALCAM activated leukocyte cell adhesion molecule 0.0380065
TRIO trio Rho guanine nucleotide exchange factor 0.0369341
ELL2 elongation factor, RNA polymerase II, 2 0.0338374
DSCAM Down syndrome cell adhesion molecule 0.03175
LMO7 LIM domain 7 0.0315808
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0300983
RNF145 ring finger protein 145 0.0298469
NAMPT nicotinamide phosphoribosyltransferase 0.0277189
MYO6 myosin VI 0.0271104
NCKAP1 NCK-associated protein 1 0.026986
MBNL1 muscleblind-like splicing regulator 1 0.0267456
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0264912
GOLGA4 golgin A4 0.0263467
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0258372
TXNRD1 thioredoxin reductase 1 0.0254271
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0253506
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0250824
PTK2 protein tyrosine kinase 2 0.0246592
CCNL1 cyclin L1 0.0242952
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0229773
MARCHF6 membrane associated ring-CH-type finger 6 0.0225151
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0221061
LAMC2 laminin, gamma 2 0.022037
COPA coatomer protein complex, subunit alpha 0.0213632
MSMO1 methylsterol monooxygenase 1 0.0212624
KDM6A lysine (K)-specific demethylase 6A 0.02099
ADAM9 ADAM metallopeptidase domain 9 0.0207353
APLP2 amyloid beta (A4) precursor-like protein 2 0.0207315
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.020699
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0206564
TFG TRK-fused gene 0.0204972
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0201496
PAPOLA poly(A) polymerase alpha 0.0200185
ERBIN erbb2 interacting protein 0.0196073
TSC22D2 TSC22 domain family, member 2 0.0192746
WAC WW domain containing adaptor with coiled-coil 0.0191187
SMAD3 SMAD family member 3 0.0187513
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0187166
SPAG9 sperm associated antigen 9 0.0187124
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0187055
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0186428
RUNX1 runt-related transcription factor 1 0.0182363
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0181836
ANXA2 annexin A2 0.0181664
MSN moesin 0.0181578
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0181379
SEC23A Sec23 homolog A (S. cerevisiae) 0.0181235
CD109 CD109 molecule 0.0181187
ECT2 epithelial cell transforming 2 0.0179724
YTHDC1 YTH domain containing 1 0.017799
RBM39 RNA binding motif protein 39 0.0177758
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0177108
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0175645
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.017392
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.017363
DST dystonin 0.0170881
RICTOR RPTOR independent companion of MTOR, complex 2 0.0170443
PUM2 pumilio RNA-binding family member 2 0.0168394
RAD21 RAD21 homolog (S. pombe) 0.016833
ARRDC3 arrestin domain containing 3 0.0168142
USP9X ubiquitin specific peptidase 9, X-linked 0.0165862
KMT2C lysine (K)-specific methyltransferase 2C 0.01653
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0165222
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.016258
CHD1 chromodomain helicase DNA binding protein 1 0.0160598
TOP2B topoisomerase (DNA) II beta 180kDa 0.0160198
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0159728
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0158759
SLMAP sarcolemma associated protein 0.0158246
TMEM39A transmembrane protein 39A 0.0158244
SGMS2 sphingomyelin synthase 2 0.0158056
MYO5B myosin VB 0.0154322
PTBP2 polypyrimidine tract binding protein 2 0.0153959
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0153642
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0152961
CAPN2 calpain 2, (m/II) large subunit 0.0151798
TMF1 TATA element modulatory factor 1 0.0150822
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0150761
WDFY3 WD repeat and FYVE domain containing 3 0.0150661
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0150362
ZFAND3 zinc finger, AN1-type domain 3 0.0150281
GLS2 glutaminase 2 (liver, mitochondrial) 0.0149922
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0149553
ANLN anillin, actin binding protein 0.0149391
MYH9 myosin, heavy chain 9, non-muscle 0.0149391
RYK receptor-like tyrosine kinase 0.014936
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0148959
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0148775
ERRFI1 ERBB receptor feedback inhibitor 1 0.0148772
IQGAP1 IQ motif containing GTPase activating protein 1 0.0148607
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0147997
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0147642
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0147612
PUM1 pumilio RNA-binding family member 1 0.014647
PCBP2 poly(rC) binding protein 2 0.014255

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.132972
TMSB10 thymosin beta 10 -0.105721
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.093615
PTMA prothymosin, alpha -0.083035
ACTG1 actin gamma 1 -0.0708311
IFI27 interferon, alpha-inducible protein 27 -0.0678295
RPL35A ribosomal protein L35a -0.0529712
ISG15 ISG15 ubiquitin-like modifier -0.0505319
RPL23 ribosomal protein L23 -0.0495342
RPLP1 ribosomal protein, large, P1 -0.0492147
IFI6 interferon, alpha-inducible protein 6 -0.0474856
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0466601
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0449966
RPS19 ribosomal protein S19 -0.0403471
IFITM3 interferon induced transmembrane protein 3 -0.0394176
RNF213 ring finger protein 213 -0.0389771
TPT1 tumor protein, translationally-controlled 1 -0.0384341
FBXO32 F-box protein 32 -0.0379763
RPL34 ribosomal protein L34 -0.0377286
IFI16 interferon, gamma-inducible protein 16 -0.037005
S100A6 S100 calcium binding protein A6 -0.0365287
RPLP2 ribosomal protein, large, P2 -0.035133
SOX4 SRY (sex determining region Y)-box 4 -0.0348554
RPS8 ribosomal protein S8 -0.034738
HLA-B major histocompatibility complex, class I, B -0.034624
S100A10 S100 calcium binding protein A10 -0.0337027
HLA-A major histocompatibility complex, class I, A -0.0331119
WSB1 WD repeat and SOCS box containing 1 -0.0328267
FTH1 ferritin, heavy polypeptide 1 -0.032448
RPL19 ribosomal protein L19 -0.0323438
EIF1 eukaryotic translation initiation factor 1 -0.0314405
RPS29 ribosomal protein S29 -0.0312812
RPS23 ribosomal protein S23 -0.031204
G0S2 G0/G1 switch 2 -0.0309326
CSTB cystatin B (stefin B) -0.0307403
RPL8 ribosomal protein L8 -0.029895
IFITM1 interferon induced transmembrane protein 1 -0.0294863
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0287533
RPS14 ribosomal protein S14 -0.0276475
LAMB3 laminin, beta 3 -0.0275183
RPS27 ribosomal protein S27 -0.0269941
RPS6 ribosomal protein S6 -0.026827
S100A9 S100 calcium binding protein A9 -0.0259743
RPL37 ribosomal protein L37 -0.025804
RPL12 ribosomal protein L12 -0.0255961
TMSB4X thymosin beta 4, X-linked -0.0254369
RPS13 ribosomal protein S13 -0.0253715
RPL28 ribosomal protein L28 -0.0253007
MT2A metallothionein 2A -0.0242694
RPS12 ribosomal protein S12 -0.0238728
LOC112694756 uncharaterized LOC112694756 -0.0233325
SQSTM1 sequestosome 1 -0.022467
MX2 MX dynamin-like GTPase 2 -0.0224189
RPS17 ribosomal protein S17 -0.0222614
C15ORF48 chromosome 15 open reading frame 48 -0.0221218
MX1 MX dynamin-like GTPase 1 -0.0219119
MDK midkine (neurite growth-promoting factor 2) -0.0214551
RPS16 ribosomal protein S16 -0.0208638
TPI1 triosephosphate isomerase 1 -0.0205794
RPL32 ribosomal protein L32 -0.0204766
RPL9 ribosomal protein L9 -0.0204714
RACK1 receptor for activated C kinase 1 -0.0202031
IFIH1 interferon induced with helicase C domain 1 -0.0201173
GNAS GNAS complex locus -0.0200946
RPS25 ribosomal protein S25 -0.0200344
RPL36 ribosomal protein L36 -0.0197166
SP100 SP100 nuclear antigen -0.0193917
HSPB1 heat shock 27kDa protein 1 -0.0192868
ENO2 enolase 2 (gamma, neuronal) -0.0191372
RPL37A ribosomal protein L37a -0.019129
RPS21 ribosomal protein S21 -0.0189704
RPL30 ribosomal protein L30 -0.0186998
RPL15 ribosomal protein L15 -0.018641
LY6E lymphocyte antigen 6 complex, locus E -0.0182223
IGFBP3 insulin-like growth factor binding protein 3 -0.0182198
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0179049
RPS27A ribosomal protein S27a -0.0178584
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.017409
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0172329
RPS10 ribosomal protein S10 -0.0169432
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.0169324
RPS20 ribosomal protein S20 -0.016705
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0166448
WARS1 tryptophanyl-tRNA synthetase 1 -0.0166427
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0166273
PKM pyruvate kinase, muscle -0.0164594
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0163945
LPP LIM domain containing preferred translocation partner in lipoma -0.0163194
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0161216
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0160998
RPL31 ribosomal protein L31 -0.0160803
RPS24 ribosomal protein S24 -0.0157078
CD63 CD63 molecule -0.0155378
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0154016
S100A11 S100 calcium binding protein A11 -0.0152943
HLA-E major histocompatibility complex, class I, E -0.0149579
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0148945
RPS15 ribosomal protein S15 -0.014772
COX7C cytochrome c oxidase subunit VIIc -0.0146833
B2M beta-2-microglobulin -0.0146611