Perindopril (erbumine)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.12676
GDA guanine deaminase 0.106645
KYNU kynureninase 0.100804
PDE10A phosphodiesterase 10A 0.0991569
COL5A2 collagen, type V, alpha 2 0.0880952
SAMD4A sterile alpha motif domain containing 4A 0.0821599
COL8A1 collagen, type VIII, alpha 1 0.0664059
PDE4D phosphodiesterase 4D, cAMP-specific 0.0664058
PM20D1 peptidase M20 domain containing 1 0.0600111
EFNA5 ephrin-A5 0.0527587
DST dystonin 0.052132
TRIO trio Rho guanine nucleotide exchange factor 0.04354
MYOF myoferlin 0.0428213
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0412753
NAMPT nicotinamide phosphoribosyltransferase 0.0400559
LIMCH1 LIM and calponin homology domains 1 0.0363457
NEK7 NIMA-related kinase 7 0.0359513
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0358696
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0350003
PDLIM5 PDZ and LIM domain 5 0.0343357
ZEB2 zinc finger E-box binding homeobox 2 0.0341917
TBXT T-box transcription factor T 0.0333894
ADGRD1 adhesion G protein-coupled receptor D1 0.0320713
PTEN phosphatase and tensin homolog 0.0290036
SMYD3 SET and MYND domain containing 3 0.0285195
COL4A5 collagen, type IV, alpha 5 0.0277561
AGTPBP1 ATP/GTP binding protein 1 0.0276119
PBX1 pre-B-cell leukemia homeobox 1 0.0271778
NTN4 netrin 4 0.0261757
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0254268
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0230666
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0225795
TGFBI transforming growth factor, beta-induced, 68kDa 0.0216864
CD109 CD109 molecule 0.0214358
ASPH aspartate beta-hydroxylase 0.0213673
TXNRD1 thioredoxin reductase 1 0.0211333
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0200488
LAMA1 laminin, alpha 1 0.0200305
ALPK2 alpha-kinase 2 0.0198286
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0198232
HDAC4 histone deacetylase 4 0.0194975
PALLD palladin, cytoskeletal associated protein 0.0192364
IGF1R insulin-like growth factor 1 receptor 0.0190389
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0188951
RABGAP1L RAB GTPase activating protein 1-like 0.0187793
P3H2 prolyl 3-hydroxylase 2 0.0185226
OSMR oncostatin M receptor 0.0178965
AOPEP aminopeptidase O (putative) 0.0177078
COL4A6 collagen, type IV, alpha 6 0.0176041
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0175111
CTIF CBP80/20-dependent translation initiation factor 0.0174574
EXOC4 exocyst complex component 4 0.0173502
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0169948
SMAD2 SMAD family member 2 0.0169577
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0169276
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0165676
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0164962
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0163015
PLCB4 phospholipase C, beta 4 0.0157535
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0155764
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0153645
INTS6 integrator complex subunit 6 0.0153248
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0151287
NFX1 nuclear transcription factor, X-box binding 1 0.0150046
SORBS2 sorbin and SH3 domain containing 2 0.0149896
DGKD diacylglycerol kinase, delta 130kDa 0.0149525
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0147624
ELL2 elongation factor, RNA polymerase II, 2 0.0146912
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0144627
RPH3AL rabphilin 3A-like (without C2 domains) 0.0143003
MBD5 methyl-CpG binding domain protein 5 0.0141705
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0140118
TMX4 thioredoxin-related transmembrane protein 4 0.0139311
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0138474
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0137819
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0136213
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0135824
DISP1 dispatched homolog 1 (Drosophila) 0.0135607
DPYD dihydropyrimidine dehydrogenase 0.0134639
TGFBR1 transforming growth factor, beta receptor 1 0.0133205
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0128113
CHL1 cell adhesion molecule L1-like 0.0127022
PHF20 PHD finger protein 20 0.0126454
ENAH enabled homolog (Drosophila) 0.0126341
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.012513
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0124672
ZCCHC7 zinc finger, CCHC domain containing 7 0.0124522
MYPN myopalladin 0.0124442
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0123758
EXOC6B exocyst complex component 6B 0.0123286
ATAD1 ATPase family, AAA domain containing 1 0.0121468
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0121224
SMOC1 SPARC related modular calcium binding 1 0.0118987
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0118708
AFG2A AFG2 AAA ATPase homolog A 0.0117958
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0116101
ATXN1 ataxin 1 0.0115716
ADGRB3 adhesion G protein-coupled receptor B3 0.0115284
BCAR3 breast cancer anti-estrogen resistance 3 0.0112358
RAB3B RAB3B, member RAS oncogene family 0.0110918

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12741
VIM vimentin -0.119527
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105725
TMSB10 thymosin beta 10 -0.0950502
PTMA prothymosin, alpha -0.0944726
TPT1 tumor protein, translationally-controlled 1 -0.0833421
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.077546
RPS6 ribosomal protein S6 -0.0738726
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0619477
FTL ferritin, light polypeptide -0.0609798
RPLP1 ribosomal protein, large, P1 -0.059109
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0577577
RPS8 ribosomal protein S8 -0.0514609
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0504457
RPL35A ribosomal protein L35a -0.0500802
RPS24 ribosomal protein S24 -0.0470481
RPL37A ribosomal protein L37a -0.0461494
RPS19 ribosomal protein S19 -0.043223
MCL1 myeloid cell leukemia 1 -0.0425163
PGK1 phosphoglycerate kinase 1 -0.0422785
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0422404
RPL12 ribosomal protein L12 -0.0419501
RPS12 ribosomal protein S12 -0.0416184
RPL31 ribosomal protein L31 -0.0410614
RPS23 ribosomal protein S23 -0.0385673
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0378098
RPL9 ribosomal protein L9 -0.0375846
RPL19 ribosomal protein L19 -0.0368916
STC1 stanniocalcin 1 -0.035554
RPLP2 ribosomal protein, large, P2 -0.0354091
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0350159
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0350065
NAP1L1 nucleosome assembly protein 1-like 1 -0.0348969
B2M beta-2-microglobulin -0.0348685
S100A6 S100 calcium binding protein A6 -0.0348438
ENO1 enolase 1, (alpha) -0.0341188
RPLP0 ribosomal protein, large, P0 -0.0338372
NRCAM neuronal cell adhesion molecule -0.0332546
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0331504
RPL23 ribosomal protein L23 -0.032692
RPL26 ribosomal protein L26 -0.0325457
RPS27A ribosomal protein S27a -0.0320256
S100A10 S100 calcium binding protein A10 -0.0319776
PKM pyruvate kinase, muscle -0.0316484
RPL34 ribosomal protein L34 -0.0316213
RPS14 ribosomal protein S14 -0.0311348
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0303434
EIF4A1 eukaryotic translation initiation factor 4A1 -0.030019
RPS3 ribosomal protein S3 -0.0296981
RPS21 ribosomal protein S21 -0.0293075
RPL36A ribosomal protein L36a -0.0288985
GNAS GNAS complex locus -0.0278442
DOCK4 dedicator of cytokinesis 4 -0.0277022
RPL7A ribosomal protein L7a -0.0276644
RPS25 ribosomal protein S25 -0.0270954
ACTG1 actin gamma 1 -0.0266227
RPS29 ribosomal protein S29 -0.0265068
UBC ubiquitin C -0.0261569
RPL37 ribosomal protein L37 -0.0259827
RPS13 ribosomal protein S13 -0.0257165
RPS17 ribosomal protein S17 -0.0254374
CDH13 cadherin 13 -0.0249793
RGS2 regulator of G-protein signaling 2 -0.0249589
FN1 fibronectin 1 -0.024876
RPL11 ribosomal protein L11 -0.0247298
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0245487
RPS16 ribosomal protein S16 -0.0242912
HILPDA hypoxia inducible lipid droplet-associated -0.0241191
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0236551
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0236186
NDRG1 N-myc downstream regulated 1 -0.0236094
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0231678
KMT2E lysine (K)-specific methyltransferase 2E -0.0231455
TPI1 triosephosphate isomerase 1 -0.0226884
HLA-B major histocompatibility complex, class I, B -0.0226819
SOX4 SRY (sex determining region Y)-box 4 -0.0226266
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0225247
SPAG9 sperm associated antigen 9 -0.0224301
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0222717
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0221575
PDIA3 protein disulfide isomerase family A, member 3 -0.0219062
RPS27 ribosomal protein S27 -0.0218996
RACK1 receptor for activated C kinase 1 -0.0218912
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0218844
PFN1 profilin 1 -0.0218275
LMNA lamin A/C -0.0217919
RPL36 ribosomal protein L36 -0.0217089
HLA-A major histocompatibility complex, class I, A -0.0214779
EIF1 eukaryotic translation initiation factor 1 -0.0211903
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0210997
MT2A metallothionein 2A -0.0208335
NALF1 NALCN channel auxiliary factor 1 -0.0206747
SRGN serglycin -0.0204686
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0204395
TM4SF1 transmembrane 4 L six family member 1 -0.0202388
RPL38 ribosomal protein L38 -0.0201947
RPL32 ribosomal protein L32 -0.0200666
FAM13A family with sequence similarity 13, member A -0.0200508
LDHA lactate dehydrogenase A -0.0199374
PLAUR plasminogen activator, urokinase receptor -0.0195374