Perindopril (erbumine)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0825678
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0581818
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0485744
NCKAP1 NCK-associated protein 1 0.0421506
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0395723
WDR43 WD repeat domain 43 0.0378772
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0345303
ADAM9 ADAM metallopeptidase domain 9 0.034022
RHEB Ras homolog enriched in brain 0.0302265
ZNF292 zinc finger protein 292 0.0296295
PUM1 pumilio RNA-binding family member 1 0.0289362
THBS1 thrombospondin 1 0.0288655
ACSL3 acyl-CoA synthetase long-chain family member 3 0.027378
TPM3 tropomyosin 3 0.0272726
TSC22D2 TSC22 domain family, member 2 0.0268341
RBM39 RNA binding motif protein 39 0.0267326
PCBP2 poly(rC) binding protein 2 0.0265069
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0249294
USP3 ubiquitin specific peptidase 3 0.0247118
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0243922
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0236202
PEG10 paternally expressed 10 0.0235682
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0231909
NOP58 NOP58 ribonucleoprotein 0.0226727
LYPLA1 lysophospholipase I 0.0224529
CDC73 cell division cycle 73 0.0221957
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0218889
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0217944
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0211921
MATR3 matrin 3 0.0210628
ELOVL5 ELOVL fatty acid elongase 5 0.0210097
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0208003
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0207987
FUBP1 far upstream element (FUSE) binding protein 1 0.0207652
H1-4 H1.4 linker histone, cluster member 0.0207454
FXR1 fragile X mental retardation, autosomal homolog 1 0.0198044
SFPQ splicing factor proline/glutamine-rich 0.0196062
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0195905
SP3 Sp3 transcription factor 0.0193389
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0192508
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0191962
RBM33 RNA binding motif protein 33 0.018347
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0182554
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0181452
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0181151
KDM1A lysine (K)-specific demethylase 1A 0.0180613
EWSR1 EWS RNA-binding protein 1 0.0178312
IPO7 importin 7 0.017641
PTK2 protein tyrosine kinase 2 0.0176206
GLS2 glutaminase 2 (liver, mitochondrial) 0.017616
TMEM64 transmembrane protein 64 0.017514
QKI QKI, KH domain containing, RNA binding 0.0174912
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0174248
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0173719
TRA2A transformer 2 alpha homolog (Drosophila) 0.0170706
MEMO1 mediator of cell motility 1 0.0170211
ANLN anillin, actin binding protein 0.0168133
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0166307
RYBP RING1 and YY1 binding protein 0.0160828
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0160773
SRSF3 serine/arginine-rich splicing factor 3 0.0160585
BCLAF1 BCL2-associated transcription factor 1 0.0159546
RANBP9 RAN binding protein 9 0.0159416
EEF2 eukaryotic translation elongation factor 2 0.0158221
CSDE1 cold shock domain containing E1, RNA-binding 0.015745
HDAC9 histone deacetylase 9 0.0156884
AHCTF1 AT hook containing transcription factor 1 0.0156056
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0154338
EVI5 ecotropic viral integration site 5 0.0153405
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0151755
DMXL1 Dmx-like 1 0.0151273
FIGN fidgetin 0.0149864
IPO5 importin 5 0.0146577
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0146191
ANXA2 annexin A2 0.0142973
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0140178
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0139506
TBC1D12 TBC1 domain family, member 12 0.0137651
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 0.0137605
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0136921
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0136589
TLK2 tousled-like kinase 2 0.013654
KMT2E lysine (K)-specific methyltransferase 2E 0.0136218
IQGAP1 IQ motif containing GTPase activating protein 1 0.0135537
UBQLN1 ubiquilin 1 0.0133076
OSBPL9 oxysterol binding protein-like 9 0.0132398
MORF4L1 mortality factor 4 like 1 0.0132197
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0131365
MTF2 metal response element binding transcription factor 2 0.0130033
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0129834
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0129634
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0129347
ANKRD11 ankyrin repeat domain 11 0.0128409
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0126754
CCNL1 cyclin L1 0.0126444
RFX7 regulatory factor X, 7 0.0126345
MB21D2 Mab-21 domain containing 2 0.0126278
RIOK3 RIO kinase 3 0.0126258
PRTG protogenin 0.0126171
ATG5 autophagy related 5 0.0125689

decreased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 -0.21063
VIM vimentin -0.169348
CADM2 cell adhesion molecule 2 -0.127479
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.127185
TMSB10 thymosin beta 10 -0.125995
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.119399
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.111824
PCDH9 protocadherin 9 -0.104921
PCLO piccolo presynaptic cytomatrix protein -0.104597
COL3A1 collagen, type III, alpha 1 -0.0978099
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0976178
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0879116
ADGRL2 adhesion G protein-coupled receptor L2 -0.0814243
COL1A2 collagen, type I, alpha 2 -0.0728408
RPS8 ribosomal protein S8 -0.0705786
RPS16 ribosomal protein S16 -0.0645064
COL5A2 collagen, type V, alpha 2 -0.0639337
TPT1 tumor protein, translationally-controlled 1 -0.0636856
PTMA prothymosin, alpha -0.0616401
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0587189
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0574745
TENM3 teneurin transmembrane protein 3 -0.057178
ANKRD12 ankyrin repeat domain 12 -0.0560593
RPS6 ribosomal protein S6 -0.0552414
RPL35A ribosomal protein L35a -0.0511107
ENO1 enolase 1, (alpha) -0.0498325
PARD3B par-3 family cell polarity regulator beta -0.0485264
WSB1 WD repeat and SOCS box containing 1 -0.0477471
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0468485
GNAS GNAS complex locus -0.0461349
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0451018
MDK midkine (neurite growth-promoting factor 2) -0.0434943
PHIP pleckstrin homology domain interacting protein -0.043472
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.041336
ACTG1 actin gamma 1 -0.0412913
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.041026
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0398478
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0396428
RPL23 ribosomal protein L23 -0.0389766
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0386418
RPL19 ribosomal protein L19 -0.037685
RPL37 ribosomal protein L37 -0.0375049
PGK1 phosphoglycerate kinase 1 -0.0358819
LRRC4C leucine rich repeat containing 4C -0.0355309
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0348982
B2M beta-2-microglobulin -0.0348183
NCAM2 neural cell adhesion molecule 2 -0.0345731
HMCN1 hemicentin 1 -0.0341008
PRELID2 PRELI domain containing 2 -0.0339702
ADGRV1 adhesion G protein-coupled receptor V1 -0.0334838
CNRIP1 cannabinoid receptor interacting protein 1 -0.0333358
GPC3 glypican 3 -0.0325811
H1-0 H1.0 linker histone -0.0325565
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0324896
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0319686
FTL ferritin, light polypeptide -0.0316151
MYL12B myosin, light chain 12B, regulatory -0.0313262
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0313044
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0310947
RPLP1 ribosomal protein, large, P1 -0.0307259
RPS13 ribosomal protein S13 -0.0306276
EIF1 eukaryotic translation initiation factor 1 -0.0305703
RPL31 ribosomal protein L31 -0.0305464
PLPP1 phospholipid phosphatase 1 -0.0303482
ISG15 ISG15 ubiquitin-like modifier -0.0301727
ITGAV integrin, alpha V -0.0301193
CSMD3 CUB and Sushi multiple domains 3 -0.0293352
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.029267
FST follistatin -0.0289346
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0286256
KCTD16 potassium channel tetramerization domain containing 16 -0.0286177
RPL11 ribosomal protein L11 -0.0279633
RAD51B RAD51 paralog B -0.0278411
SAMD4A sterile alpha motif domain containing 4A -0.0275905
NACA nascent polypeptide-associated complex alpha subunit -0.0275026
RPS19 ribosomal protein S19 -0.0274521
NTM neurotrimin -0.0271692
RPS12 ribosomal protein S12 -0.0269503
SOX2 SRY (sex determining region Y)-box 2 -0.0269226
NRG1 neuregulin 1 -0.0267731
RPS21 ribosomal protein S21 -0.0263404
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0262473
LPIN2 lipin 2 -0.0262236
HSPB1 heat shock 27kDa protein 1 -0.0261407
APOE apolipoprotein E -0.0260084
S100A10 S100 calcium binding protein A10 -0.0258359
MAML2 mastermind-like 2 (Drosophila) -0.0258341
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.025782
PRRC2C proline-rich coiled-coil 2C -0.025713
NEBL nebulette -0.0256788
SLIT2 slit homolog 2 (Drosophila) -0.0254581
RPLP0 ribosomal protein, large, P0 -0.0253545
LOC112694756 uncharaterized LOC112694756 -0.025165
SQSTM1 sequestosome 1 -0.0248391
TENM2 teneurin transmembrane protein 2 -0.024824
RPL37A ribosomal protein L37a -0.0244228
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0241531
RPS3 ribosomal protein S3 -0.024132
PCDH7 protocadherin 7 -0.0239431
RPS25 ribosomal protein S25 -0.0236007