Perindopril (erbumine)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.122175
DST dystonin 0.0934582
AHNAK AHNAK nucleoprotein 0.0683087
VCL vinculin 0.0680451
SLC35F3 solute carrier family 35, member F3 0.065692
ERRFI1 ERBB receptor feedback inhibitor 1 0.0627902
EGFR epidermal growth factor receptor 0.0497881
MACF1 microtubule-actin crosslinking factor 1 0.0432032
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0421809
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0417511
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0414834
ZNF780B zinc finger protein 780B 0.0402368
TRIO trio Rho guanine nucleotide exchange factor 0.038637
THSD4 thrombospondin, type I, domain containing 4 0.0382856
CARD18 caspase recruitment domain family, member 18 0.0365105
PTK2 protein tyrosine kinase 2 0.0355724
RASAL2 RAS protein activator like 2 0.0350133
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0329884
LPP LIM domain containing preferred translocation partner in lipoma 0.0326409
EXOC4 exocyst complex component 4 0.0321515
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0317069
SBF2 SET binding factor 2 0.0310149
PHF14 PHD finger protein 14 0.0296676
RABGAP1L RAB GTPase activating protein 1-like 0.0294833
EHBP1 EH domain binding protein 1 0.0288572
TCF12 transcription factor 12 0.0281835
SDK1 sidekick cell adhesion molecule 1 0.0268494
ZBTB20 zinc finger and BTB domain containing 20 0.0267776
UBASH3B ubiquitin associated and SH3 domain containing B 0.0266774
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0261541
UTRN utrophin 0.0261471
CD44 CD44 molecule (Indian blood group) 0.0258236
EXT1 exostosin glycosyltransferase 1 0.025534
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0254243
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0253116
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0252358
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0250294
TPM1 tropomyosin 1 (alpha) 0.0240212
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0238683
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0238474
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0237157
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0237029
ARHGAP29 Rho GTPase activating protein 29 0.0233304
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0224634
DOCK1 dedicator of cytokinesis 1 0.0224561
FRMD5 FERM domain containing 5 0.022357
ANO6 anoctamin 6 0.0223172
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0223138
ZFAND3 zinc finger, AN1-type domain 3 0.0223113
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0222087
TNS3 tensin 3 0.0218504
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0217997
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0215441
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0212458
AFAP1 actin filament associated protein 1 0.0207801
MAP4 microtubule-associated protein 4 0.0206747
MED13L mediator complex subunit 13-like 0.0204736
RAD51B RAD51 paralog B 0.0203086
FAF1 Fas (TNFRSF6) associated factor 1 0.0202571
HMGA2 high mobility group AT-hook 2 0.019533
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0193213
DIAPH2 diaphanous-related formin 2 0.0193064
MSRB3 methionine sulfoxide reductase B3 0.0190262
BIRC2 baculoviral IAP repeat containing 2 0.019022
MAML3 mastermind-like 3 (Drosophila) 0.0185111
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0184184
SMYD3 SET and MYND domain containing 3 0.0183745
RNF220 ring finger protein 220 0.0181798
AKAP13 A kinase (PRKA) anchor protein 13 0.0181421
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0181074
MYOF myoferlin 0.0179748
SPIDR scaffolding protein involved in DNA repair 0.0179257
ATM ATM serine/threonine kinase 0.0178592
ZNF407 zinc finger protein 407 0.0178347
RNF213 ring finger protein 213 0.0176518
ARHGAP32 Rho GTPase activating protein 32 0.0174535
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0173428
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0172302
MAP1B microtubule-associated protein 1B 0.0171534
ZNF644 zinc finger protein 644 0.0170243
RIN2 Ras and Rab interactor 2 0.0170238
BICD1 bicaudal D homolog 1 (Drosophila) 0.0170107
FER fer (fps/fes related) tyrosine kinase 0.0169504
ARB2A ARB2 cotranscriptional regulator A 0.0169068
MBNL2 muscleblind-like splicing regulator 2 0.0168105
ERBIN erbb2 interacting protein 0.0167592
ATXN1 ataxin 1 0.0165977
VMP1 vacuole membrane protein 1 0.0164603
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0164433
TTC28 tetratricopeptide repeat domain 28 0.0162959
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0162915
FAT1 FAT atypical cadherin 1 0.0160555
IGF1R insulin-like growth factor 1 receptor 0.0160092
IQGAP1 IQ motif containing GTPase activating protein 1 0.0160039
RGS20 regulator of G-protein signaling 20 0.0158571
FBXL17 F-box and leucine-rich repeat protein 17 0.0154426
MYO9A myosin IXA 0.0152226
AHNAK2 AHNAK nucleoprotein 2 0.0151978
ZNF146 zinc finger protein 146 0.0151932
MBD5 methyl-CpG binding domain protein 5 0.0151266

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.172847
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121107
VIM vimentin -0.0753307
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0708251
PTMA prothymosin, alpha -0.0623774
TMSB10 thymosin beta 10 -0.0509313
RPL35A ribosomal protein L35a -0.0428072
RPLP1 ribosomal protein, large, P1 -0.0396168
MT2A metallothionein 2A -0.0393324
FTL ferritin, light polypeptide -0.0339068
RPLP2 ribosomal protein, large, P2 -0.0335902
LOC112694756 uncharaterized LOC112694756 -0.0290271
RPS8 ribosomal protein S8 -0.02828
FOSL1 FOS-like antigen 1 -0.0273525
S100A6 S100 calcium binding protein A6 -0.0268419
HMGA1 high mobility group AT-hook 1 -0.0254279
SPAG9 sperm associated antigen 9 -0.0254278
YBX1 Y box binding protein 1 -0.0252908
RPLP0 ribosomal protein, large, P0 -0.0247867
RPS24 ribosomal protein S24 -0.0243416
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0235031
SNX14 sorting nexin 14 -0.0231424
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0229406
RPL11 ribosomal protein L11 -0.0227839
TPT1 tumor protein, translationally-controlled 1 -0.0224945
EIF1 eukaryotic translation initiation factor 1 -0.0218405
RPS12 ribosomal protein S12 -0.0217279
RPL28 ribosomal protein L28 -0.0216969
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0216831
RPL37A ribosomal protein L37a -0.0212675
ACTG1 actin gamma 1 -0.0211479
MORF4L2 mortality factor 4 like 2 -0.0210603
RPL23 ribosomal protein L23 -0.0202814
RPL12 ribosomal protein L12 -0.0198892
RPS25 ribosomal protein S25 -0.0197776
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0197185
NAP1L1 nucleosome assembly protein 1-like 1 -0.0195145
S100A10 S100 calcium binding protein A10 -0.0193485
RPS19 ribosomal protein S19 -0.0177094
WDR45B WD repeat domain 45B -0.0173307
RPS5 ribosomal protein S5 -0.0172778
RPL27A ribosomal protein L27a -0.0172001
ICAM1 intercellular adhesion molecule 1 -0.0169677
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0169299
FBL fibrillarin -0.0168889
RPS3 ribosomal protein S3 -0.0168317
RPS13 ribosomal protein S13 -0.0166296
GNAS GNAS complex locus -0.0165515
ADM adrenomedullin -0.0165072
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0164041
RPS6 ribosomal protein S6 -0.0163884
RPS27A ribosomal protein S27a -0.0163737
RACK1 receptor for activated C kinase 1 -0.0159034
B2M beta-2-microglobulin -0.0158222
RPS20 ribosomal protein S20 -0.0156771
RPS21 ribosomal protein S21 -0.0155205
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0147761
TRA2A transformer 2 alpha homolog (Drosophila) -0.0143552
RPL34 ribosomal protein L34 -0.01431
RPL36A ribosomal protein L36a -0.014307
SEC24A SEC24 family member A -0.0142833
RPL30 ribosomal protein L30 -0.0141081
GOLGA4 golgin A4 -0.0139945
DDIT4 DNA-damage-inducible transcript 4 -0.0139091
EGR1 early growth response 1 -0.0136881
RPL9 ribosomal protein L9 -0.0135935
PFN1 profilin 1 -0.0134111
ACBD3 acyl-CoA binding domain containing 3 -0.0132706
MATR3 matrin 3 -0.0132455
RPS2 ribosomal protein S2 -0.013146
RPL31 ribosomal protein L31 -0.0130176
RPL8 ribosomal protein L8 -0.0129821
ARF4 ADP-ribosylation factor 4 -0.0128535
SEPTIN7 septin 7 -0.0128083
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0127257
CALR calreticulin -0.012658
CALU calumenin -0.0126216
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0125735
TFRC transferrin receptor -0.0125381
IFITM3 interferon induced transmembrane protein 3 -0.0123011
HM13 histocompatibility (minor) 13 -0.0122552
NAV2 neuron navigator 2 -0.0122299
UBE2O ubiquitin-conjugating enzyme E2O -0.0121797
RB1CC1 RB1-inducible coiled-coil 1 -0.0121399
RPL36 ribosomal protein L36 -0.0121164
NOP58 NOP58 ribonucleoprotein -0.0121048
RPL26 ribosomal protein L26 -0.0120215
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0119039
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0117767
ANGPTL4 angiopoietin-like 4 -0.0117001
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0116047
RPL38 ribosomal protein L38 -0.0115273
NDRG1 N-myc downstream regulated 1 -0.0114633
MCL1 myeloid cell leukemia 1 -0.0114282
GARS1 glycyl-tRNA synthetase 1 -0.0111563
NPR2 natriuretic peptide receptor 2 -0.0111093
ZNF292 zinc finger protein 292 -0.0110569
RPS17 ribosomal protein S17 -0.0110534
GTF2B general transcription factor IIB -0.0109902
RPS14 ribosomal protein S14 -0.0108921