Perindopril (erbumine)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DLC1 DLC1 Rho GTPase activating protein 0.204851
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.19257
ZEB1 zinc finger E-box binding homeobox 1 0.131804
TXNRD1 thioredoxin reductase 1 0.118168
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0907554
PTK2 protein tyrosine kinase 2 0.0882552
C2CD2 C2 calcium-dependent domain containing 2 0.0845155
STC1 stanniocalcin 1 0.0843087
ELL2 elongation factor, RNA polymerase II, 2 0.0816527
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0744235
MAST4 microtubule associated serine/threonine kinase family member 4 0.0716437
ANTXR2 anthrax toxin receptor 2 0.0674791
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0641576
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0640247
NAV3 neuron navigator 3 0.0623366
ZFAND3 zinc finger, AN1-type domain 3 0.0579218
UPP1 uridine phosphorylase 1 0.0560669
JMJD1C jumonji domain containing 1C 0.0539452
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0517706
GPHN gephyrin 0.0511595
TCF12 transcription factor 12 0.0497951
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0483132
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0469639
NF1 neurofibromin 1 0.0453503
SETX senataxin 0.0419842
RASA2 RAS p21 protein activator 2 0.0416337
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0414696
ANKRD17 ankyrin repeat domain 17 0.0411139
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0411131
ATP13A3 ATPase type 13A3 0.0403913
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0403834
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0389712
AKAP12 A kinase (PRKA) anchor protein 12 0.0388597
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0384755
TOP1 topoisomerase (DNA) I 0.03749
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0374588
MKI67 marker of proliferation Ki-67 0.0374495
DSCAM Down syndrome cell adhesion molecule 0.0374101
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0373562
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0371759
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0367102
ACACA acetyl-CoA carboxylase alpha 0.0366178
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0361654
SRPK2 SRSF protein kinase 2 0.0360761
CAPN2 calpain 2, (m/II) large subunit 0.0357407
RABGAP1L RAB GTPase activating protein 1-like 0.0351543
RBM25 RNA binding motif protein 25 0.0350295
FER fer (fps/fes related) tyrosine kinase 0.0346361
ZFP36L1 ZFP36 ring finger protein-like 1 0.034125
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0334917
DIAPH3 diaphanous-related formin 3 0.0331128
FHL2 four and a half LIM domains 2 0.0327563
TASOR2 transcription activation suppressor family member 2 0.032747
LAMB3 laminin, beta 3 0.0323898
ARHGAP22 Rho GTPase activating protein 22 0.0321166
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0317769
DST dystonin 0.0316557
SGMS2 sphingomyelin synthase 2 0.0313439
TMEM41B transmembrane protein 41B 0.0311649
USP34 ubiquitin specific peptidase 34 0.0305453
ZNF438 zinc finger protein 438 0.0302853
CD274 CD274 molecule 0.0302386
AHNAK AHNAK nucleoprotein 0.0301597
APP amyloid beta (A4) precursor protein 0.0300281
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.0297905
ECPAS Ecm29 proteasome adaptor and scaffold 0.0297689
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0297387
SPIDR scaffolding protein involved in DNA repair 0.0297011
BIRC2 baculoviral IAP repeat containing 2 0.0294653
G0S2 G0/G1 switch 2 0.0294247
VMP1 vacuole membrane protein 1 0.0293972
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0293492
STK4 serine/threonine kinase 4 0.0291633
EEF2 eukaryotic translation elongation factor 2 0.0289831
UBC ubiquitin C 0.0289241
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0289104
WDR43 WD repeat domain 43 0.0282504
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0282288
EXOC4 exocyst complex component 4 0.0280699
TM9SF3 transmembrane 9 superfamily member 3 0.028023
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0278685
TAS2R14 taste receptor, type 2, member 14 0.0276819
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0275254
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0272554
FAF1 Fas (TNFRSF6) associated factor 1 0.0271612
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0270269
TRIM44 tripartite motif containing 44 0.0266438
IPO7 importin 7 0.0266324
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0265265
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0263991
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0263504
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0263207
AGO2 argonaute RISC catalytic component 2 0.0261141
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0261119
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0260102
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0259562
ANXA5 annexin A5 0.0259238
RAD21 RAD21 homolog (S. pombe) 0.0258617
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0258067
ATM ATM serine/threonine kinase 0.0255423

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.124352
RPS6 ribosomal protein S6 -0.0838261
NDRG1 N-myc downstream regulated 1 -0.0625857
FRMD6 FERM domain containing 6 -0.0609638
RPS8 ribosomal protein S8 -0.0533326
MT2A metallothionein 2A -0.0529348
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0517049
NABP1 nucleic acid binding protein 1 -0.051283
RPL23 ribosomal protein L23 -0.0490548
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0434216
RPL12 ribosomal protein L12 -0.0430884
RPLP1 ribosomal protein, large, P1 -0.0420644
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0414754
RPL37A ribosomal protein L37a -0.0409251
RPL35A ribosomal protein L35a -0.0396567
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0396354
RPS19 ribosomal protein S19 -0.0375076
RPLP2 ribosomal protein, large, P2 -0.0360166
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0351666
FTL ferritin, light polypeptide -0.0337933
RPL8 ribosomal protein L8 -0.0326137
RPS2 ribosomal protein S2 -0.0321639
INTS6 integrator complex subunit 6 -0.0321392
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0306871
CALR calreticulin -0.0304872
MCTP1 multiple C2 domains, transmembrane 1 -0.0304363
ZNF292 zinc finger protein 292 -0.0301014
RPS20 ribosomal protein S20 -0.0299003
RPL36 ribosomal protein L36 -0.029661
RPL28 ribosomal protein L28 -0.0283022
RPS29 ribosomal protein S29 -0.0281415
COPA coatomer protein complex, subunit alpha -0.0279285
RPL34 ribosomal protein L34 -0.0276965
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0269947
RPL13A ribosomal protein L13a -0.0269209
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0267093
TMSB10 thymosin beta 10 -0.0265605
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0258264
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0253244
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.024991
EEF1G eukaryotic translation elongation factor 1 gamma -0.024243
MSH4 mutS homolog 4 -0.0241523
RPL27 ribosomal protein L27 -0.0239538
RPL9 ribosomal protein L9 -0.023786
MYRFL myelin regulatory factor-like -0.0233541
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0230355
RRBP1 ribosome binding protein 1 -0.0227876
RPL35 ribosomal protein L35 -0.0220905
TPT1 tumor protein, translationally-controlled 1 -0.0219938
RAB7A RAB7A, member RAS oncogene family -0.0217761
CALU calumenin -0.0216559
SETD5 SET domain containing 5 -0.021267
ASPH aspartate beta-hydroxylase -0.020987
RPS16 ribosomal protein S16 -0.0208775
RPS25 ribosomal protein S25 -0.0205262
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0204841
PTMA prothymosin, alpha -0.0204593
RPS21 ribosomal protein S21 -0.0204518
TPM4 tropomyosin 4 -0.0202571
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0201897
GNAS GNAS complex locus -0.020085
EGR1 early growth response 1 -0.0198518
FN1 fibronectin 1 -0.0197927
SAMD4A sterile alpha motif domain containing 4A -0.0196069
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0194794
RPL31 ribosomal protein L31 -0.019379
CALD1 caldesmon 1 -0.0193596
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0193539
RPS12 ribosomal protein S12 -0.0189766
RYBP RING1 and YY1 binding protein -0.018574
RPS14 ribosomal protein S14 -0.018327
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.018229
RPL38 ribosomal protein L38 -0.0182259
RPL14 ribosomal protein L14 -0.01813
KDM3A lysine (K)-specific demethylase 3A -0.0180808
IFRD1 interferon-related developmental regulator 1 -0.0178662
FNDC3B fibronectin type III domain containing 3B -0.0178452
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0178426
RPS27A ribosomal protein S27a -0.0175033
RPL30 ribosomal protein L30 -0.0174699
NAMPT nicotinamide phosphoribosyltransferase -0.0173672
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0170563
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0170503
MROH1 maestro heat-like repeat family member 1 -0.0169397
LMAN1 lectin, mannose-binding, 1 -0.0169384
RPS13 ribosomal protein S13 -0.0165764
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0164124
EXT1 exostosin glycosyltransferase 1 -0.0163905
SEC62 SEC62 homolog (S. cerevisiae) -0.0162986
YBX1 Y box binding protein 1 -0.0162204
RPS17 ribosomal protein S17 -0.0161215
FBXO11 F-box protein 11 -0.0159164
ACBD3 acyl-CoA binding domain containing 3 -0.015792
S100A9 S100 calcium binding protein A9 -0.0157154
USP53 ubiquitin specific peptidase 53 -0.0157005
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0156806
RPS3 ribosomal protein S3 -0.0156547
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -0.0154522
GOLGA2 golgin A2 -0.0153363
LARS1 leucyl-tRNA synthetase 1 -0.0153287