| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Perindopril (erbumine) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Perindopril (erbumine)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.289112 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0955501 |
| CALCA | calcitonin-related polypeptide alpha | 0.0888075 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | 0.0883708 |
| TENM1 | teneurin transmembrane protein 1 | 0.0849952 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0629899 |
| VGF | VGF nerve growth factor inducible | 0.0612037 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0606879 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0525854 |
| INHBA | inhibin, beta A | 0.0523814 |
| TXNRD1 | thioredoxin reductase 1 | 0.0515423 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0495962 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0472619 |
| CPE | carboxypeptidase E | 0.0463046 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0456054 |
| MCL1 | myeloid cell leukemia 1 | 0.0444838 |
| FGF14 | fibroblast growth factor 14 | 0.0435767 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0416462 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0399539 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0397648 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0390901 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.0390561 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0386539 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0382496 |
| CENPF | centromere protein F, 350/400kDa | 0.0370613 |
| PTCHD4 | patched domain containing 4 | 0.0361526 |
| DST | dystonin | 0.0359527 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0358784 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0351593 |
| FAT1 | FAT atypical cadherin 1 | 0.0337015 |
| RIT2 | Ras-like without CAAX 2 | 0.0331197 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0325614 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0324382 |
| MKI67 | marker of proliferation Ki-67 | 0.0314311 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0314267 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.031164 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0309161 |
| AOPEP | aminopeptidase O (putative) | 0.0298039 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0297899 |
| COL22A1 | collagen, type XXII, alpha 1 | 0.0295416 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0289706 |
| ASPH | aspartate beta-hydroxylase | 0.0288928 |
| NBEA | neurobeachin | 0.0287823 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0280606 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0276604 |
| IRS2 | insulin receptor substrate 2 | 0.027449 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0272421 |
| SCG2 | secretogranin II | 0.0270434 |
| TOX | thymocyte selection-associated high mobility group box | 0.0269399 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0265451 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0261679 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0259332 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0258906 |
| CHST8 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 | 0.0257861 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0253857 |
| SMYD3 | SET and MYND domain containing 3 | 0.0252345 |
| CNTNAP2 | contactin associated protein-like 2 | 0.0252105 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0249273 |
| SYT1 | synaptotagmin I | 0.0246876 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0243874 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0243426 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | 0.0239196 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.023829 |
| SIK2 | salt-inducible kinase 2 | 0.0238263 |
| EFNA5 | ephrin-A5 | 0.0237443 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0236845 |
| MT2A | metallothionein 2A | 0.0236045 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0234746 |
| EGR1 | early growth response 1 | 0.0234514 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0228692 |
| RNF213 | ring finger protein 213 | 0.0224763 |
| AHR | aryl hydrocarbon receptor | 0.0224526 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.0223619 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0222531 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0221611 |
| TUSC3 | tumor suppressor candidate 3 | 0.0218212 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0217723 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.021484 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0213445 |
| PEX5L | peroxisomal biogenesis factor 5-like | 0.0212474 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0210912 |
| PCM1 | pericentriolar material 1 | 0.0209937 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | 0.0208653 |
| CNKSR3 | CNKSR family member 3 | 0.0208302 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0206435 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0206224 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | 0.0205731 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0205427 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0202806 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0202258 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0201873 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.020168 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0200315 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0198845 |
| KIF26B | kinesin family member 26B | 0.0197951 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0197681 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.019423 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.019406 |
| HMGB3 | high mobility group box 3 | 0.0193576 |
| CBX5 | chromobox homolog 5 | 0.0192952 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.0649911 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0599155 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0490996 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0384704 |
| DTNA | dystrobrevin, alpha | -0.0382151 |
| ZNF292 | zinc finger protein 292 | -0.0315022 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0302573 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0257451 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0255069 |
| FAM162A | family with sequence similarity 162, member A | -0.0252286 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.024714 |
| PGK1 | phosphoglycerate kinase 1 | -0.0236198 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0233664 |
| JAM3 | junctional adhesion molecule 3 | -0.0220895 |
| RPS8 | ribosomal protein S8 | -0.0217371 |
| CA8 | carbonic anhydrase VIII | -0.0212347 |
| WDR45B | WD repeat domain 45B | -0.0210926 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0204041 |
| FAM13A | family with sequence similarity 13, member A | -0.0202796 |
| GPC6 | glypican 6 | -0.0180218 |
| VEGFA | vascular endothelial growth factor A | -0.0171963 |
| RPL26 | ribosomal protein L26 | -0.0170617 |
| RORA | RAR-related orphan receptor A | -0.0167926 |
| ESRRG | estrogen-related receptor gamma | -0.0164465 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0161699 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0158993 |
| RAB40C | RAB40C, member RAS oncogene family | -0.0157865 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0155405 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0154485 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.014857 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.014183 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0137278 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0134098 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0133809 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0133205 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0131312 |
| MEF2A | myocyte enhancer factor 2A | -0.0130132 |
| GNAS | GNAS complex locus | -0.0125839 |
| RPS27 | ribosomal protein S27 | -0.0124013 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0122981 |
| SRP54 | signal recognition particle 54kDa | -0.0121469 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0119624 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0117672 |
| RPS17 | ribosomal protein S17 | -0.0116404 |
| RPS2 | ribosomal protein S2 | -0.0115061 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0115038 |
| RPL37A | ribosomal protein L37a | -0.0114815 |
| DENND1A | DENN/MADD domain containing 1A | -0.0113584 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0112219 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0109403 |
| RLF | rearranged L-myc fusion | -0.0109306 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0108157 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0108129 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | -0.0107518 |
| RPL23 | ribosomal protein L23 | -0.0105945 |
| CDON | cell adhesion associated, oncogene regulated | -0.0105506 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0104831 |
| RPL36 | ribosomal protein L36 | -0.0104462 |
| ZNF395 | zinc finger protein 395 | -0.0104206 |
| CABIN1 | calcineurin binding protein 1 | -0.0103114 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.0102954 |
| RPS20 | ribosomal protein S20 | -0.0101067 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0100123 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.00997463 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.00991202 |
| PTMA | prothymosin, alpha | -0.00984295 |
| RPL12 | ribosomal protein L12 | -0.00970857 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.00965089 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.00963093 |
| SCARB1 | scavenger receptor class B, member 1 | -0.00955147 |
| RAB7A | RAB7A, member RAS oncogene family | -0.00942558 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00930709 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00929471 |
| RPS6 | ribosomal protein S6 | -0.00922484 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.00915284 |
| NEMF | nuclear export mediator factor | -0.00914136 |
| TSPAN9 | tetraspanin 9 | -0.00910091 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.00898003 |
| SERGEF | secretion regulating guanine nucleotide exchange factor | -0.00889434 |
| ZMAT4 | zinc finger, matrin-type 4 | -0.0088889 |
| INSIG2 | insulin induced gene 2 | -0.00877351 |
| RNF24 | ring finger protein 24 | -0.00873019 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | -0.00872174 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.00867921 |
| RPLP1 | ribosomal protein, large, P1 | -0.00858664 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00850615 |
| RPS12 | ribosomal protein S12 | -0.00845979 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.00841157 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0081992 |
| FBXO42 | F-box protein 42 | -0.00813545 |
| ARF1 | ADP-ribosylation factor 1 | -0.00805741 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.00804372 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | -0.00795976 |
| PKIB | protein kinase (cAMP-dependent, catalytic) inhibitor beta | -0.00794396 |
| RYBP | RING1 and YY1 binding protein | -0.00791977 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.00790182 |
| NOP58 | NOP58 ribonucleoprotein | -0.00786765 |
| ZNF33A | zinc finger protein 33A | -0.00773612 |
| RPS11 | ribosomal protein S11 | -0.00771717 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0076862 |
