Perindopril (erbumine)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.246303
FMN1 formin 1 0.144605
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0918243
FNDC3B fibronectin type III domain containing 3B 0.0597368
FRMD5 FERM domain containing 5 0.0541032
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0472728
RUNX1 runt-related transcription factor 1 0.0450629
ANKRD28 ankyrin repeat domain 28 0.040174
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0370017
LAMP2 lysosomal-associated membrane protein 2 0.035598
CD44 CD44 molecule (Indian blood group) 0.0349392
TXNRD1 thioredoxin reductase 1 0.034485
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0339938
RASAL2 RAS protein activator like 2 0.0321222
NAV2 neuron navigator 2 0.0315711
PRELID2 PRELI domain containing 2 0.0303277
LINGO2 leucine rich repeat and Ig domain containing 2 0.0295516
MSN moesin 0.0292202
TENM1 teneurin transmembrane protein 1 0.0287011
TBC1D5 TBC1 domain family, member 5 0.0280557
CDK6 cyclin-dependent kinase 6 0.0271317
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0270762
CENPF centromere protein F, 350/400kDa 0.0270654
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0264192
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.025215
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0250736
ERBIN erbb2 interacting protein 0.0249507
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0245304
HDAC9 histone deacetylase 9 0.024168
DST dystonin 0.0240246
INPP5F inositol polyphosphate-5-phosphatase F 0.0236994
SPTBN1 spectrin, beta, non-erythrocytic 1 0.023589
SPAG9 sperm associated antigen 9 0.0231777
CHD1 chromodomain helicase DNA binding protein 1 0.0230151
AFDN afadin, adherens junction formation factor 0.022038
CLIC4 chloride intracellular channel 4 0.0217254
FER fer (fps/fes related) tyrosine kinase 0.0217073
WWTR1 WW domain containing transcription regulator 1 0.0214748
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0213528
OSBPL10 oxysterol binding protein-like 10 0.021272
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0208074
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0207374
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0204921
EXT1 exostosin glycosyltransferase 1 0.0204562
LPP LIM domain containing preferred translocation partner in lipoma 0.020444
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0203221
TP63 tumor protein p63 0.020143
TRIO trio Rho guanine nucleotide exchange factor 0.0197507
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.019718
CA8 carbonic anhydrase VIII 0.0194673
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0192012
SOX6 SRY (sex determining region Y)-box 6 0.0189001
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.018718
MYH9 myosin, heavy chain 9, non-muscle 0.0185113
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0184144
FBXL17 F-box and leucine-rich repeat protein 17 0.018354
USP53 ubiquitin specific peptidase 53 0.0183492
ZBTB38 zinc finger and BTB domain containing 38 0.0179999
OXSR1 oxidative stress responsive 1 0.0178828
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0178647
ANXA2 annexin A2 0.017701
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0175898
COG5 component of oligomeric golgi complex 5 0.0175868
ATP13A3 ATPase type 13A3 0.0172527
PTPRG protein tyrosine phosphatase, receptor type, G 0.0171531
SOD2 superoxide dismutase 2, mitochondrial 0.0170703
CEP128 centrosomal protein 128kDa 0.0167505
MAML2 mastermind-like 2 (Drosophila) 0.016645
PRKCSH protein kinase C substrate 80K-H 0.0164902
QKI QKI, KH domain containing, RNA binding 0.0162941
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0162253
CCSER2 coiled-coil serine-rich protein 2 0.0161807
ZNF697 zinc finger protein 697 0.0160367
ANLN anillin, actin binding protein 0.0159186
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0157917
ARL15 ADP-ribosylation factor-like 15 0.0157809
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0155188
DPYD dihydropyrimidine dehydrogenase 0.0153913
PBX3 pre-B-cell leukemia homeobox 3 0.0152571
TSC22D2 TSC22 domain family, member 2 0.0152003
FHIT fragile histidine triad 0.0151074
FNIP1 folliculin interacting protein 1 0.0150216
CLTC clathrin, heavy chain (Hc) 0.0150026
EXOC4 exocyst complex component 4 0.0149719
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0146448
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0145341
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0143944
DOCK5 dedicator of cytokinesis 5 0.0141059
AMOTL1 angiomotin like 1 0.0140532
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0138599
IL1RAP interleukin 1 receptor accessory protein 0.0138255
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0138251
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0137926
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.0137849
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0137161
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0137081
CXCL8 chemokine (C-X-C motif) ligand 8 0.0135719
VMP1 vacuole membrane protein 1 0.0135272
CAPRIN1 cell cycle associated protein 1 0.0135049
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0134654

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.161664
NLGN1 neuroligin 1 -0.125797
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0967698
RPL35A ribosomal protein L35a -0.0771189
PTMA prothymosin, alpha -0.0749534
RPS6 ribosomal protein S6 -0.0742098
FTL ferritin, light polypeptide -0.0729367
TMSB10 thymosin beta 10 -0.0712739
RPL23 ribosomal protein L23 -0.0666825
RPS3 ribosomal protein S3 -0.0653722
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0640759
RPLP1 ribosomal protein, large, P1 -0.0619546
IFI6 interferon, alpha-inducible protein 6 -0.0543194
RPL37A ribosomal protein L37a -0.0477593
RPLP2 ribosomal protein, large, P2 -0.0469479
RPS8 ribosomal protein S8 -0.0453611
MT2A metallothionein 2A -0.044261
HLA-B major histocompatibility complex, class I, B -0.0429395
RPS12 ribosomal protein S12 -0.0419907
RPL34 ribosomal protein L34 -0.0415511
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0410641
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0409896
B2M beta-2-microglobulin -0.0376242
TPT1 tumor protein, translationally-controlled 1 -0.0376012
LSAMP limbic system-associated membrane protein -0.0372553
RPS21 ribosomal protein S21 -0.0366306
RPL38 ribosomal protein L38 -0.0354724
RPS13 ribosomal protein S13 -0.0354577
RPL11 ribosomal protein L11 -0.0343177
S100A9 S100 calcium binding protein A9 -0.0337967
RPL36 ribosomal protein L36 -0.0337239
ANGPTL4 angiopoietin-like 4 -0.0335779
RPL31 ribosomal protein L31 -0.0330381
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0326083
RPL36A ribosomal protein L36a -0.0321567
RPS14 ribosomal protein S14 -0.0316178
RPS23 ribosomal protein S23 -0.0314904
RPS24 ribosomal protein S24 -0.0311489
RPL19 ribosomal protein L19 -0.0310968
RPS27A ribosomal protein S27a -0.0285328
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0283579
RPS29 ribosomal protein S29 -0.0281621
RPS19 ribosomal protein S19 -0.0268799
RPS16 ribosomal protein S16 -0.0268508
PKM pyruvate kinase, muscle -0.0261927
RPL12 ribosomal protein L12 -0.0261678
RPL32 ribosomal protein L32 -0.0246984
RRBP1 ribosome binding protein 1 -0.0246387
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0244832
RPL27 ribosomal protein L27 -0.0244681
PRAME preferentially expressed antigen in melanoma -0.0243297
EIF1 eukaryotic translation initiation factor 1 -0.0243069
MSI2 musashi RNA-binding protein 2 -0.0237366
CTSD cathepsin D -0.0232454
NDRG1 N-myc downstream regulated 1 -0.0232229
RPL9 ribosomal protein L9 -0.0231101
RPL5 ribosomal protein L5 -0.0226622
ENO2 enolase 2 (gamma, neuronal) -0.0225513
HLA-A major histocompatibility complex, class I, A -0.0225464
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0223745
APOD apolipoprotein D -0.0223191
RACK1 receptor for activated C kinase 1 -0.0219824
RPL28 ribosomal protein L28 -0.0218709
RPL30 ribosomal protein L30 -0.0213838
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0209437
TPI1 triosephosphate isomerase 1 -0.0208884
GNAS GNAS complex locus -0.0208848
SFTPA2 surfactant protein A2 -0.0208665
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0206089
RPS4X ribosomal protein S4, X-linked -0.0204461
IFITM3 interferon induced transmembrane protein 3 -0.0203785
RPS25 ribosomal protein S25 -0.0203568
SEPTIN7 septin 7 -0.0203378
RPS17 ribosomal protein S17 -0.0203062
RPL26 ribosomal protein L26 -0.020265
RPL37 ribosomal protein L37 -0.0201337
RPS27 ribosomal protein S27 -0.0200568
S100A10 S100 calcium binding protein A10 -0.0200359
ACTG1 actin gamma 1 -0.0194086
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0192952
NAP1L1 nucleosome assembly protein 1-like 1 -0.0185041
SEC61G Sec61 gamma subunit -0.0184788
RPL8 ribosomal protein L8 -0.0184137
ZMYND8 zinc finger, MYND-type containing 8 -0.0181915
EIF5B eukaryotic translation initiation factor 5B -0.0181184
RPS11 ribosomal protein S11 -0.0180647
RPS15 ribosomal protein S15 -0.018061
HLA-E major histocompatibility complex, class I, E -0.0179744
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0179109
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0178917
CYB5R3 cytochrome b5 reductase 3 -0.0177548
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0176922
RPS10 ribosomal protein S10 -0.0176777
HSPB1 heat shock 27kDa protein 1 -0.0172816
RPL15 ribosomal protein L15 -0.0171429
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.016989
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0169261
KPNB1 karyopherin (importin) beta 1 -0.0167876
WSB1 WD repeat and SOCS box containing 1 -0.0166618
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0165532