Perindopril (erbumine)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.122941
LMO7 LIM domain 7 0.0856681
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0641755
ITPRID2 ITPR interacting domain containing 2 0.0605927
PDE4B phosphodiesterase 4B, cAMP-specific 0.0603526
ANXA1 annexin A1 0.0599931
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0583405
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0553501
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0509149
LAMC2 laminin, gamma 2 0.0493025
RUNX2 runt-related transcription factor 2 0.0468059
FAT1 FAT atypical cadherin 1 0.0422057
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0416386
EREG epiregulin 0.0389982
EZR ezrin 0.0387716
TOP1 topoisomerase (DNA) I 0.0364314
OXR1 oxidation resistance 1 0.0361455
EGFR epidermal growth factor receptor 0.0351749
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0338539
KMT2C lysine (K)-specific methyltransferase 2C 0.0324774
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0321366
ATXN1 ataxin 1 0.0320439
PLAUR plasminogen activator, urokinase receptor 0.0318606
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0314341
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0305894
RNF43 ring finger protein 43 0.0298984
TXNRD1 thioredoxin reductase 1 0.0291041
KDM6A lysine (K)-specific demethylase 6A 0.0281456
GOLGA4 golgin A4 0.0272008
DSPP dentin sialophosphoprotein 0.026759
MACF1 microtubule-actin crosslinking factor 1 0.0261208
PUM2 pumilio RNA-binding family member 2 0.0246051
LDHA lactate dehydrogenase A 0.0241362
GCLC glutamate-cysteine ligase, catalytic subunit 0.0238997
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0236371
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0227878
NUP58 nucleoporin 58 0.0224599
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0224004
ANLN anillin, actin binding protein 0.0220377
FAM3C family with sequence similarity 3, member C 0.0216084
AREG amphiregulin 0.0214297
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.021258
ZMYM2 zinc finger, MYM-type 2 0.0211669
ZNRF3 zinc and ring finger 3 0.0209475
ARHGAP42 Rho GTPase activating protein 42 0.0209463
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0203941
ARHGAP32 Rho GTPase activating protein 32 0.0202879
AXIN2 axin 2 0.0202057
UBA6 ubiquitin-like modifier activating enzyme 6 0.0200444
FERMT1 fermitin family member 1 0.0199821
RANBP9 RAN binding protein 9 0.0199705
ZNF292 zinc finger protein 292 0.0194799
CLTC clathrin, heavy chain (Hc) 0.0194019
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0191252
FAR1 fatty acyl CoA reductase 1 0.0191172
ITGA6 integrin, alpha 6 0.019116
BIRC3 baculoviral IAP repeat containing 3 0.0190541
SLTM SAFB-like, transcription modulator 0.019021
SNX9 sorting nexin 9 0.0190047
SLMAP sarcolemma associated protein 0.0188658
SFPQ splicing factor proline/glutamine-rich 0.0185669
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0180903
YAP1 Yes-associated protein 1 0.0180621
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0179761
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0177817
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0175155
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0174248
KITLG KIT ligand 0.0173608
GSK3B glycogen synthase kinase 3 beta 0.0172454
COG5 component of oligomeric golgi complex 5 0.017192
EIF4B eukaryotic translation initiation factor 4B 0.0165923
RAD51B RAD51 paralog B 0.0164678
TSC22D2 TSC22 domain family, member 2 0.0164437
ANXA2 annexin A2 0.0164007
USP6NL USP6 N-terminal like 0.0163979
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0163463
ESYT2 extended synaptotagmin-like protein 2 0.0163453
FOXO1 forkhead box O1 0.0162836
UTRN utrophin 0.0162671
BBX bobby sox homolog (Drosophila) 0.0162115
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0159664
NEK7 NIMA-related kinase 7 0.0159261
WAC WW domain containing adaptor with coiled-coil 0.0158831
VMP1 vacuole membrane protein 1 0.0157294
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0157189
KIAA0040 KIAA0040 0.0156902
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.015573
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0154929
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0154535
CHD1 chromodomain helicase DNA binding protein 1 0.0153944
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0153816
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0152548
DST dystonin 0.0151287
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0150796
SPATA13 spermatogenesis associated 13 0.0149205
PTBP2 polypyrimidine tract binding protein 2 0.0147067
HSPA8 heat shock 70kDa protein 8 0.0146261
NDRG1 N-myc downstream regulated 1 0.0144371
WDR43 WD repeat domain 43 0.0143777
FNDC3A fibronectin type III domain containing 3A 0.0143685

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.153314
TMSB10 thymosin beta 10 -0.134734
RPL35A ribosomal protein L35a -0.132437
ACTG1 actin gamma 1 -0.125681
RPS6 ribosomal protein S6 -0.125318
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123793
TPT1 tumor protein, translationally-controlled 1 -0.119874
RPLP1 ribosomal protein, large, P1 -0.0989736
RPS8 ribosomal protein S8 -0.0975505
IER3 immediate early response 3 -0.0898581
RPS29 ribosomal protein S29 -0.0689026
RPL34 ribosomal protein L34 -0.0686882
RPS19 ribosomal protein S19 -0.0680895
RPL31 ribosomal protein L31 -0.0654548
RPS24 ribosomal protein S24 -0.0653059
RPL37A ribosomal protein L37a -0.0619292
RPL23 ribosomal protein L23 -0.0617464
RPS25 ribosomal protein S25 -0.0613785
RPLP2 ribosomal protein, large, P2 -0.059618
RPS12 ribosomal protein S12 -0.0587467
RPS27A ribosomal protein S27a -0.055544
RPS13 ribosomal protein S13 -0.0552382
RPL12 ribosomal protein L12 -0.0521182
RPL9 ribosomal protein L9 -0.0499446
RPL11 ribosomal protein L11 -0.0495358
RPL26 ribosomal protein L26 -0.0494014
RPL19 ribosomal protein L19 -0.0481605
RPLP0 ribosomal protein, large, P0 -0.0476427
RPS3 ribosomal protein S3 -0.0474735
RPS23 ribosomal protein S23 -0.0473667
RPS17 ribosomal protein S17 -0.0470424
RPL5 ribosomal protein L5 -0.0460454
RPL36 ribosomal protein L36 -0.0435221
EIF1 eukaryotic translation initiation factor 1 -0.0431679
FTL ferritin, light polypeptide -0.0419415
RPS14 ribosomal protein S14 -0.0418507
S100A6 S100 calcium binding protein A6 -0.0413992
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0402256
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0388616
RPS21 ribosomal protein S21 -0.0384044
RPS16 ribosomal protein S16 -0.0376109
RPL37 ribosomal protein L37 -0.0373117
RPL32 ribosomal protein L32 -0.0371324
RPL7A ribosomal protein L7a -0.0367524
RPL15 ribosomal protein L15 -0.0351958
RACK1 receptor for activated C kinase 1 -0.0336803
HLA-B major histocompatibility complex, class I, B -0.033557
RPS11 ribosomal protein S11 -0.0329911
EGR1 early growth response 1 -0.0325863
RPS27 ribosomal protein S27 -0.031867
RPL35 ribosomal protein L35 -0.0308545
RPL8 ribosomal protein L8 -0.0305928
RPS5 ribosomal protein S5 -0.030143
RPL13A ribosomal protein L13a -0.029945
RPS15 ribosomal protein S15 -0.0296177
RPL30 ribosomal protein L30 -0.0291237
RPS10 ribosomal protein S10 -0.0284759
HLA-A major histocompatibility complex, class I, A -0.0276949
RPS28 ribosomal protein S28 -0.0271661
S100A9 S100 calcium binding protein A9 -0.0270679
RPL36A ribosomal protein L36a -0.0266842
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0254899
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0254452
RPL28 ribosomal protein L28 -0.025444
RPL10A ribosomal protein L10a -0.0252915
RPL18 ribosomal protein L18 -0.0249676
LOC102724023 ES1 protein homolog, mitochondrial -0.0248698
RPL38 ribosomal protein L38 -0.0245405
MT2A metallothionein 2A -0.0240959
RPL7 ribosomal protein L7 -0.0240861
RPS20 ribosomal protein S20 -0.0235275
RPL27A ribosomal protein L27a -0.0222335
RPL27 ribosomal protein L27 -0.0221382
HMGA1 high mobility group AT-hook 1 -0.0207177
NACA nascent polypeptide-associated complex alpha subunit -0.0207042
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0201787
ATP5F1B ATP synthase F1 subunit beta -0.0196839
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0190351
RPL4 ribosomal protein L4 -0.0190186
ENO1 enolase 1, (alpha) -0.0189497
CUX1 cut-like homeobox 1 -0.0184124
UBC ubiquitin C -0.0183506
S100A10 S100 calcium binding protein A10 -0.018195
POTEF POTE ankyrin domain family, member F -0.0177808
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0177314
LMNA lamin A/C -0.0177003
RPL39 ribosomal protein L39 -0.0176648
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0173887
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0173084
RPS4X ribosomal protein S4, X-linked -0.0170007
LOC112694756 uncharaterized LOC112694756 -0.0169071
S100A11 S100 calcium binding protein A11 -0.0168624
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0167219
RPL36AL ribosomal protein L36a-like -0.0164106
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0160538
GNAS GNAS complex locus -0.0159049
TPI1 triosephosphate isomerase 1 -0.0158034
KPNB1 karyopherin (importin) beta 1 -0.0156819
LDHB lactate dehydrogenase B -0.0151374
VDAC1 voltage-dependent anion channel 1 -0.0148989