Perindopril (erbumine)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Perindopril (erbumine) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Perindopril (erbumine)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0521662
EZR ezrin 0.049975
NKD1 naked cuticle homolog 1 (Drosophila) 0.0481639
LMO7 LIM domain 7 0.0423746
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0412296
MAML2 mastermind-like 2 (Drosophila) 0.0401354
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0377444
ATXN1 ataxin 1 0.0358354
SYT1 synaptotagmin I 0.0350296
RUNX1 runt-related transcription factor 1 0.0347631
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0327056
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.030016
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0297426
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0289859
ITGA6 integrin, alpha 6 0.0281317
CEMIP2 cell migration inducing hyaluronidase 2 0.0276494
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.026929
ITPRID2 ITPR interacting domain containing 2 0.0261918
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0254875
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0249583
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0248849
PDE4D phosphodiesterase 4D, cAMP-specific 0.0247935
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0246806
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.02465
DSPP dentin sialophosphoprotein 0.0242393
ANXA2 annexin A2 0.0235941
UTRN utrophin 0.0234138
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0234076
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0224156
VMP1 vacuole membrane protein 1 0.022175
HDAC4 histone deacetylase 4 0.0220928
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0218427
MACF1 microtubule-actin crosslinking factor 1 0.0212823
YAP1 Yes-associated protein 1 0.0211292
ETNK1 ethanolamine kinase 1 0.0205857
ESYT2 extended synaptotagmin-like protein 2 0.0205578
USP34 ubiquitin specific peptidase 34 0.0203351
PROX1 prospero homeobox 1 0.0202924
EMP1 epithelial membrane protein 1 0.0196187
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0194129
CD46 CD46 molecule, complement regulatory protein 0.0194111
FYN FYN proto-oncogene, Src family tyrosine kinase 0.019311
KIZ kizuna centrosomal protein 0.0190109
TBC1D5 TBC1 domain family, member 5 0.0188578
MYH9 myosin, heavy chain 9, non-muscle 0.018801
SVIL supervillin 0.0187626
ZBTB20 zinc finger and BTB domain containing 20 0.0186336
TRIO trio Rho guanine nucleotide exchange factor 0.0186121
ANO6 anoctamin 6 0.0185532
NEBL nebulette 0.0181647
MACC1 metastasis associated in colon cancer 1 0.0179353
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0177253
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0174117
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0171993
NAV2 neuron navigator 2 0.0170653
SPATA13 spermatogenesis associated 13 0.0169853
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0168085
MBD5 methyl-CpG binding domain protein 5 0.0166936
OXR1 oxidation resistance 1 0.0165795
EEF2 eukaryotic translation elongation factor 2 0.016488
KMT2C lysine (K)-specific methyltransferase 2C 0.0162417
ASPH aspartate beta-hydroxylase 0.0161799
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0161482
APP amyloid beta (A4) precursor protein 0.0160805
KLF12 Kruppel-like factor 12 0.0158736
USP9X ubiquitin specific peptidase 9, X-linked 0.0158151
TTC3 tetratricopeptide repeat domain 3 0.0157224
BRWD3 bromodomain and WD repeat domain containing 3 0.0156657
ERRFI1 ERBB receptor feedback inhibitor 1 0.0156162
BIRC6 baculoviral IAP repeat containing 6 0.0156053
EFNB2 ephrin-B2 0.0153129
KDM6A lysine (K)-specific demethylase 6A 0.0152698
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0152676
AFDN afadin, adherens junction formation factor 0.0151228
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0150919
TCF12 transcription factor 12 0.0150593
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0149306
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0149291
SFPQ splicing factor proline/glutamine-rich 0.0143538
KDM7A lysine (K)-specific demethylase 7A 0.014335
CDK6 cyclin-dependent kinase 6 0.0143314
EIF4B eukaryotic translation initiation factor 4B 0.0143003
SBF2 SET binding factor 2 0.014291
MBNL2 muscleblind-like splicing regulator 2 0.0142816
TRIP12 thyroid hormone receptor interactor 12 0.0142416
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0142292
CEMIP cell migration inducing protein, hyaluronan binding 0.0142219
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0141992
AKAP13 A kinase (PRKA) anchor protein 13 0.0141256
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0140736
PUM2 pumilio RNA-binding family member 2 0.0140367
JAG1 jagged 1 0.0139659
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0139607
ABHD2 abhydrolase domain containing 2 0.0138931
JMJD1C jumonji domain containing 1C 0.0138731
PEAK1 pseudopodium-enriched atypical kinase 1 0.0138717
MED13 mediator complex subunit 13 0.0138429
TNS3 tensin 3 0.013752
PTK2 protein tyrosine kinase 2 0.0137082
PICALM phosphatidylinositol binding clathrin assembly protein 0.01346

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.129149
TPT1 tumor protein, translationally-controlled 1 -0.123291
RPL35A ribosomal protein L35a -0.112513
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.109819
TMSB10 thymosin beta 10 -0.10914
RPS6 ribosomal protein S6 -0.100204
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0817679
RPL23 ribosomal protein L23 -0.0718075
RPLP1 ribosomal protein, large, P1 -0.0661068
RPS19 ribosomal protein S19 -0.0636083
RPS8 ribosomal protein S8 -0.0606469
RPL26 ribosomal protein L26 -0.0591162
RPS24 ribosomal protein S24 -0.0569655
RPL37A ribosomal protein L37a -0.053607
ACTG1 actin gamma 1 -0.0497971
RPLP2 ribosomal protein, large, P2 -0.0477088
MT2A metallothionein 2A -0.0459054
RPS12 ribosomal protein S12 -0.0457342
VIM vimentin -0.0452461
FTL ferritin, light polypeptide -0.0420802
RPL12 ribosomal protein L12 -0.0419728
RPS21 ribosomal protein S21 -0.0415768
RPL9 ribosomal protein L9 -0.0409026
RPL19 ribosomal protein L19 -0.0405403
CCND1 cyclin D1 -0.0402365
RPS27A ribosomal protein S27a -0.0402081
RPS13 ribosomal protein S13 -0.039548
RPL31 ribosomal protein L31 -0.0371749
RPL36A ribosomal protein L36a -0.0364131
RPS25 ribosomal protein S25 -0.0359865
RPS3 ribosomal protein S3 -0.0356769
RPL34 ribosomal protein L34 -0.0352226
RBP1 retinol binding protein 1, cellular -0.0347607
SDK1 sidekick cell adhesion molecule 1 -0.0344313
RPS14 ribosomal protein S14 -0.0332352
HMGA1 high mobility group AT-hook 1 -0.0327908
RPL11 ribosomal protein L11 -0.0313712
RPL36 ribosomal protein L36 -0.031307
RPL35 ribosomal protein L35 -0.030897
HMGB1 high mobility group box 1 -0.0307953
RPS23 ribosomal protein S23 -0.030356
RPLP0 ribosomal protein, large, P0 -0.0298462
RPL38 ribosomal protein L38 -0.0296946
KRT18 keratin 18, type I -0.0290153
RPL37 ribosomal protein L37 -0.0280146
RPL5 ribosomal protein L5 -0.0272275
RPS17 ribosomal protein S17 -0.0266176
S100A10 S100 calcium binding protein A10 -0.0265796
RPS5 ribosomal protein S5 -0.0259511
RPS16 ribosomal protein S16 -0.0259377
RPL27A ribosomal protein L27a -0.0259251
RPL28 ribosomal protein L28 -0.0252443
RPS29 ribosomal protein S29 -0.0250066
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0248983
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0242205
PFN1 profilin 1 -0.0239217
CBX3 chromobox homolog 3 -0.0238107
TUBA1B tubulin, alpha 1b -0.0229284
RPS11 ribosomal protein S11 -0.0224641
RPL8 ribosomal protein L8 -0.0222273
S100A6 S100 calcium binding protein A6 -0.0215806
RPL32 ribosomal protein L32 -0.0215587
TPI1 triosephosphate isomerase 1 -0.0215325
EIF5B eukaryotic translation initiation factor 5B -0.0213674
RPL18 ribosomal protein L18 -0.0211857
GNAS GNAS complex locus -0.0211316
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0204515
RPL27 ribosomal protein L27 -0.0203097
RPL7A ribosomal protein L7a -0.0202988
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0202578
LMNA lamin A/C -0.0197963
NAP1L1 nucleosome assembly protein 1-like 1 -0.0197165
RPL30 ribosomal protein L30 -0.0193489
LOC102724023 ES1 protein homolog, mitochondrial -0.0193481
RPS15 ribosomal protein S15 -0.019306
RACK1 receptor for activated C kinase 1 -0.0190592
RPS10 ribosomal protein S10 -0.0189113
NOP56 NOP56 ribonucleoprotein -0.0188848
EIF1 eukaryotic translation initiation factor 1 -0.0188218
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0187196
TUBB4B tubulin, beta 4B class IVb -0.0183348
RPS20 ribosomal protein S20 -0.0182967
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0182665
KPNB1 karyopherin (importin) beta 1 -0.0179562
TMSB4X thymosin beta 4, X-linked -0.0179348
YBX1 Y box binding protein 1 -0.0177974
PA2G4 proliferation-associated 2G4, 38kDa -0.0175338
RPL13A ribosomal protein L13a -0.0173935
DEK DEK proto-oncogene -0.017275
IER3 immediate early response 3 -0.0169571
ACTN4 actinin, alpha 4 -0.0166256
EGR1 early growth response 1 -0.0165363
RBM25 RNA binding motif protein 25 -0.0165286
RPS4X ribosomal protein S4, X-linked -0.0163375
KRT8 keratin 8, type II -0.0161026
RPL10A ribosomal protein L10a -0.0159433
RPS27 ribosomal protein S27 -0.0158851
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0158028
RPL7 ribosomal protein L7 -0.0158007
PKM pyruvate kinase, muscle -0.0151422