| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An alpha-amino acid ester that is the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline (Chemical Entities of Biological Interest Ontology, CHEBI_8024) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/107807 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Perindopril relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZG16B | zymogen granule protein 16B | 2.93 |
| HBB | hemoglobin, beta | 1.06 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.99 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.79 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.77 |
| ARHGAP44 | Rho GTPase activating protein 44 | 0.62 |
| CHDH | choline dehydrogenase | 0.52 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.52 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | 0.51 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.46 |
| HDAC11 | histone deacetylase 11 | 0.45 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.44 |
| ZNRD1 | zinc ribbon domain containing 1 | 0.43 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.41 |
| S100A14 | S100 calcium binding protein A14 | 0.41 |
| NDRG2 | NDRG family member 2 | 0.39 |
| TTC39A | tetratricopeptide repeat domain 39A | 0.37 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | 0.37 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 0.36 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | 0.35 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.35 |
| MED10 | mediator complex subunit 10 | 0.35 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.33 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | 0.33 |
| B2M | beta-2-microglobulin | 0.32 |
| MDM4 | MDM4, p53 regulator | 0.32 |
| CNTNAP1 | contactin associated protein 1 | 0.31 |
| ZNF496 | zinc finger protein 496 | 0.31 |
| RNF126 | ring finger protein 126 | 0.31 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.3 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 0.3 |
| TNNC2 | troponin C type 2 (fast) | 0.3 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | 0.3 |
| WDYHV1 | WDYHV motif containing 1 | 0.29 |
| CCDC9 | coiled-coil domain containing 9 | 0.28 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | 0.27 |
| ADM | adrenomedullin | 0.27 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.26 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.26 |
| LAMA1 | laminin, alpha 1 | 0.26 |
| VSIG10 | V-set and immunoglobulin domain containing 10 | 0.26 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.26 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | 0.26 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.26 |
| TMEM41B | transmembrane protein 41B | 0.26 |
| NOS1 | nitric oxide synthase 1 (neuronal) | 0.25 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 0.25 |
| RPL26 | ribosomal protein L26 | 0.24 |
| NPHP4 | nephronophthisis 4 | 0.24 |
| TSNARE1 | t-SNARE domain containing 1 | 0.24 |
| TMEM248 | transmembrane protein 248 | 0.24 |
| POLL | polymerase (DNA directed), lambda | 0.23 |
| NUP62 | nucleoporin 62kDa | 0.23 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | 0.23 |
| GLRX | glutaredoxin (thioltransferase) | 0.23 |
| PLEKHG6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | 0.23 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | 0.23 |
| FLNB | filamin B, beta | 0.23 |
| ZNF669 | zinc finger protein 669 | 0.23 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | 0.22 |
| TSPAN5 | tetraspanin 5 | 0.22 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 0.22 |
| MTRF1L | mitochondrial translational release factor 1-like | 0.22 |
| NUCB2 | nucleobindin 2 | 0.22 |
| SET | SET nuclear proto-oncogene | 0.22 |
| ATG4D | autophagy related 4D, cysteine peptidase | 0.22 |
| KDM4D | lysine (K)-specific demethylase 4D | 0.22 |
| ERCC8 | excision repair cross-complementation group 8 | 0.22 |
| PLXNB1 | plexin B1 | 0.22 |
| PCGF2 | polycomb group ring finger 2 | 0.22 |
| SGTB | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | 0.22 |
| ISL2 | ISL LIM homeobox 2 | 0.22 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.21 |
| ZNF410 | zinc finger protein 410 | 0.21 |
| TTC9C | tetratricopeptide repeat domain 9C | 0.21 |
| S100A16 | S100 calcium binding protein A16 | 0.21 |
| REX1BD | required for excision 1-B domain containing | 0.21 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | 0.21 |
| HYPK | huntingtin interacting protein K | 0.21 |
| ZNF584 | zinc finger protein 584 | 0.21 |
| ANKRD44 | ankyrin repeat domain 44 | 0.21 |
| PMF1 | polyamine-modulated factor 1 | 0.21 |
| JRKL | JRK-like | 0.21 |
| SPPL2A | signal peptide peptidase like 2A | 0.21 |
| KCTD2 | potassium channel tetramerization domain containing 2 | 0.2 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.2 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.2 |
| CRCP | CGRP receptor component | 0.2 |
| ZNF524 | zinc finger protein 524 | 0.2 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | 0.2 |
| RGL2 | ral guanine nucleotide dissociation stimulator-like 2 | 0.2 |
| C12ORF73 | chromosome 12 open reading frame 73 | 0.2 |
| LGALSL | lectin, galactoside-binding-like | 0.2 |
| ARG2 | arginase 2 | 0.2 |
| DCLRE1A | DNA cross-link repair 1A | 0.2 |
| SUMO2 | small ubiquitin-like modifier 2 | 0.2 |
| MTCH2 | mitochondrial carrier 2 | 0.2 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 0.2 |
| TJAP1 | tight junction associated protein 1 (peripheral) | 0.2 |
| BOD1 | biorientation of chromosomes in cell division 1 | 0.19 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFP37 | ZFP37 zinc finger protein | -2.28 |
| ACTBL2 | actin, beta-like 2 | -1.64 |
| KLHL23 | kelch-like family member 23 | -1.38 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -1.09 |
| CCNDBP1 | cyclin D-type binding-protein 1 | -1.08 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.76 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.7 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | -0.68 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.62 |
| ZFHX2 | zinc finger homeobox 2 | -0.62 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | -0.6 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | -0.59 |
| ZMAT3 | zinc finger, matrin-type 3 | -0.56 |
| INSR | insulin receptor | -0.55 |
| PRKCB | protein kinase C, beta | -0.53 |
| HDDC3 | HD domain containing 3 | -0.53 |
| MED12L | mediator complex subunit 12-like | -0.51 |
| RASA4 | RAS p21 protein activator 4 | -0.48 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.47 |
| CNTRL | centriolin | -0.46 |
| RNF170 | ring finger protein 170 | -0.45 |
| TMEM242 | transmembrane protein 242 | -0.45 |
| WWC3 | WWC family member 3 | -0.44 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | -0.43 |
| SBSN | suprabasin | -0.43 |
| HIKESHI | heat shock protein nuclear import factor hikeshi | -0.43 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | -0.43 |
| CALHM2 | calcium homeostasis modulator 2 | -0.42 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.42 |
| NBEAL1 | neurobeachin-like 1 | -0.41 |
| HSPA1L | heat shock 70kDa protein 1-like | -0.41 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.4 |
| PTMA | prothymosin, alpha | -0.4 |
| SLC41A3 | solute carrier family 41, member 3 | -0.4 |
| C15ORF61 | chromosome 15 open reading frame 61 | -0.4 |
| SNAP91 | synaptosomal-associated protein, 91kDa | -0.39 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.39 |
| CLTA | clathrin, light chain A | -0.39 |
| PLEKHA7 | pleckstrin homology domain containing, family A member 7 | -0.38 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.38 |
| FAM104A | family with sequence similarity 104, member A | -0.38 |
| LRRCC1 | leucine rich repeat and coiled-coil centrosomal protein 1 | -0.38 |
| HECA | headcase homolog (Drosophila) | -0.38 |
| DCHS1 | dachsous cadherin-related 1 | -0.37 |
| CERK | ceramide kinase | -0.37 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | -0.37 |
| ZNF33A | zinc finger protein 33A | -0.37 |
| NEMP1 | nuclear envelope integral membrane protein 1 | -0.37 |
| FAT2 | FAT atypical cadherin 2 | -0.37 |
| ZSCAN25 | zinc finger and SCAN domain containing 25 | -0.36 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.36 |
| TPCN1 | two pore segment channel 1 | -0.35 |
| FAM126B | family with sequence similarity 126, member B | -0.35 |
| DTNB | dystrobrevin, beta | -0.35 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.34 |
| LRP5 | low density lipoprotein receptor-related protein 5 | -0.34 |
| METAP2 | methionyl aminopeptidase 2 | -0.34 |
| ZBED5 | zinc finger, BED-type containing 5 | -0.33 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.33 |
| C11ORF95 | chromosome 11 open reading frame 95 | -0.33 |
| ZNF729 | zinc finger protein 729 | -0.33 |
| ANKRD26 | ankyrin repeat domain 26 | -0.33 |
| NCKAP1L | NCK-associated protein 1-like | -0.33 |
| RNF146 | ring finger protein 146 | -0.33 |
| CAB39L | calcium binding protein 39-like | -0.33 |
| TMEM159 | transmembrane protein 159 | -0.33 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.33 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.32 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | -0.32 |
| SYPL1 | synaptophysin-like 1 | -0.32 |
| LATS2 | large tumor suppressor kinase 2 | -0.32 |
| CBARP | CACN subunit beta associated regulatory protein | -0.31 |
| TSC22D1 | TSC22 domain family, member 1 | -0.31 |
| DEPDC1B | DEP domain containing 1B | -0.31 |
| FAM120C | family with sequence similarity 120C | -0.31 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.3 |
| SLC25A30 | solute carrier family 25, member 30 | -0.3 |
| AAMDC | adipogenesis associated, Mth938 domain containing | -0.3 |
| MRPL20 | mitochondrial ribosomal protein L20 | -0.3 |
| GEMIN2 | gem (nuclear organelle) associated protein 2 | -0.3 |
| SHLD2 | shieldin complex subunit 2 | -0.3 |
| DOCK3 | dedicator of cytokinesis 3 | -0.3 |
| FN1 | fibronectin 1 | -0.29 |
| FAM117A | family with sequence similarity 117, member A | -0.29 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | -0.29 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -0.28 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.28 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.28 |
| RMDN2 | regulator of microtubule dynamics 2 | -0.28 |
| ABLIM2 | actin binding LIM protein family, member 2 | -0.28 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.28 |
| IMMT | inner membrane protein, mitochondrial | -0.28 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.28 |
| ZADH2 | zinc binding alcohol dehydrogenase domain containing 2 | -0.28 |
| ADSS1 | adenylosuccinate synthase 1 | -0.27 |
| HKDC1 | hexokinase domain containing 1 | -0.27 |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | -0.27 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.27 |
| FAM234B | family with sequence similarity 234 member B | -0.27 |
| C12ORF66 | chromosome 12 open reading frame 66 | -0.27 |
