Periodontitis Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology) (Experimental Factor Ontology, EFO_0000649)
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Genes

69 genes associated with the disease Periodontitis in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1.762
FTO fat mass and obesity associated 1.508
RPGRIP1L RPGRIP1-like 1.508
THADA thyroid adenoma associated 1.302
ZFP36L2 ZFP36 ring finger protein-like 2 1.302
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 1.202
TIGAR TP53 induced glycolysis regulatory phosphatase 1.202
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 1.202
LCN9 lipocalin 9 1.202
PAEP progestagen-associated endometrial protein 1.202
OBP2A odorant binding protein 2A 1.202
CCND2 cyclin D2 1.202
GLT6D1 glycosyltransferase 6 domain containing 1 1.202
TRA2B transformer 2 beta homolog (Drosophila) 1.202
FGF23 fibroblast growth factor 23 1.202
KCNT1 potassium channel, sodium activated subfamily T, member 1 1.202
ZFHX3 zinc finger homeobox 3 1.11
PRMT8 protein arginine methyltransferase 8 1.106
CRACR2A calcium release activated channel regulator 2A 1.106
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 1.074
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 1.074
PDE2A phosphodiesterase 2A, cGMP-stimulated 1.074
FCHSD2 FCH and double SH3 domains 2 1.074
STARD10 StAR-related lipid transfer (START) domain containing 10 1.074
EHBP1L1 EH domain binding protein 1-like 1 1.061
ZNRD2 zinc ribbon domain containing 2 1.061
FAM89B family with sequence similarity 89, member B 1.061
KCNK7 potassium channel, two pore domain subfamily K, member 7 1.061
FRMD8 FERM domain containing 8 1.061
SCYL1 SCY1-like 1 (S. cerevisiae) 1.061
MAP3K11 mitogen-activated protein kinase kinase kinase 11 1.061
LTBP3 latent transforming growth factor beta binding protein 3 1.061
AKAP6 A kinase (PRKA) anchor protein 6 1.058
NPAS3 neuronal PAS domain protein 3 1.058
ERI1 exoribonuclease 1 1.054
PPP1R3B protein phosphatase 1, regulatory subunit 3B 1.054
SIGLEC14 sialic acid binding Ig-like lectin 14 0.986
HAS1 hyaluronan synthase 1 0.986
SPACA6 sperm acrosome associated 6 0.986
SIGLEC5 sialic acid binding Ig-like lectin 5 0.986
SIGLEC6 sialic acid binding Ig-like lectin 6 0.986
ZNF175 zinc finger protein 175 0.986
HLA-DRA major histocompatibility complex, class II, DR alpha 0.983
BTNL2 butyrophilin-like 2 0.983
TSBP1 testis expressed basic protein 1 0.983
RETREG3 reticulophagy regulator family member 3 0.946
MLX MLX, MAX dimerization protein 0.946
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 0.946
PSMC3IP PSMC3 interacting protein 0.946
COASY CoA synthase 0.946
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.946
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 0.946
TUBG2 tubulin, gamma 2 0.946
NAGLU N-acetylglucosaminidase, alpha 0.946
TUBG1 tubulin, gamma 1 0.946
IGF2 insulin-like growth factor 2 0.636
TH tyrosine hydroxylase 0.636
ASCL2 achaete-scute family bHLH transcription factor 2 0.636
INS-IGF2 INS-IGF2 readthrough 0.636
INS insulin 0.636
SHISA9 shisa family member 9 0.558
ATP5MC1 ATP synthase membrane subunit c locus 1 0.54
CALCOCO2 calcium binding and coiled-coil domain 2 0.54
GIP gastric inhibitory polypeptide 0.54
TTLL6 tubulin tyrosine ligase-like family member 6 0.54
SNF8 SNF8, ESCRT-II complex subunit 0.54
UBE2Z ubiquitin-conjugating enzyme E2Z 0.54
ITGB6 integrin, beta 6 0.522
RBMS1 RNA binding motif, single stranded interacting protein 1 0.522