| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting DOT1L in K562 cell line (Study accession: SRP292382) (PerturbAtlas) |
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200 genes differentially expressed following the Perturb_10165_KD_DOT1L_SRP292382 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SAMD14 | sterile alpha motif domain containing 14 | 20.0 |
| ASTN1 | astrotactin 1 | 20.0 |
| DLD | dihydrolipoamide dehydrogenase | 20.0 |
| ERI2 | ERI1 exoribonuclease family member 2 | 20.0 |
| LRRC47 | leucine rich repeat containing 47 | 20.0 |
| TUBA1C | tubulin, alpha 1c | 20.0 |
| H2AFY | H2A histone family, member Y | 20.0 |
| HCN3 | hyperpolarization activated cyclic nucleotide gated potassium channel 3 | 20.0 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | 20.0 |
| PRR29 | proline rich 29 | 20.0 |
| TSTD2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 | 18.4559 |
| UBXN11 | UBX domain protein 11 | 18.2676 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 16.9488 |
| ZNF740 | zinc finger protein 740 | 15.5376 |
| SPATA31C1 | SPATA31 subfamily C, member 1 | 14.1452 |
| NAV2 | neuron navigator 2 | 12.1808 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 11.9004 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 11.7612 |
| MINA | MYC induced nuclear antigen | 11.6185 |
| MPPE1 | metallophosphoesterase 1 | 11.0279 |
| SLC26A1 | solute carrier family 26 (anion exchanger), member 1 | 10.8405 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 10.7791 |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 9.92957 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | 9.52881 |
| ZC3H14 | zinc finger CCCH-type containing 14 | 9.47978 |
| MROH1 | maestro heat-like repeat family member 1 | 9.20446 |
| DAPK3 | death-associated protein kinase 3 | 8.81098 |
| VSIG2 | V-set and immunoglobulin domain containing 2 | 8.78044 |
| SNX24 | sorting nexin 24 | 8.77372 |
| TSPEAR | thrombospondin-type laminin G domain and EAR repeats | 8.6231 |
| TONSL | tonsoku-like, DNA repair protein | 8.5296 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 8.39133 |
| RPL27A | ribosomal protein L27a | 8.35109 |
| CCDC152 | coiled-coil domain containing 152 | 8.33143 |
| SZT2 | seizure threshold 2 homolog (mouse) | 8.29272 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 8.0432 |
| ACTR3C | ARP3 actin-related protein 3 homolog C (yeast) | 8.01944 |
| HMHA1 | histocompatibility (minor) HA-1 | 7.73942 |
| APEX2 | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 | 7.71801 |
| THUMPD1 | THUMP domain containing 1 | 7.6404 |
| CGREF1 | cell growth regulator with EF-hand domain 1 | 7.45824 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 7.45757 |
| APC2 | adenomatosis polyposis coli 2 | 7.21652 |
| TICRR | TOPBP1-interacting checkpoint and replication regulator | 7.21345 |
| C7ORF34 | chromosome 7 open reading frame 34 | 7.16414 |
| POLH | polymerase (DNA directed), eta | 7.08847 |
| RNF224 | ring finger protein 224 | 7.04876 |
| OR10Z1 | olfactory receptor, family 10, subfamily Z, member 1 | 6.83386 |
| OR52A5 | olfactory receptor, family 52, subfamily A, member 5 | 6.79656 |
| DUOXA2 | dual oxidase maturation factor 2 | 6.77561 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 6.56726 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | 6.55051 |
| PPP1R16A | protein phosphatase 1, regulatory subunit 16A | 6.49451 |
| FAM228B | family with sequence similarity 228, member B | 6.3431 |
| RABL6 | RAB, member RAS oncogene family-like 6 | 6.32956 |
| FES | FES proto-oncogene, tyrosine kinase | 6.21504 |
| TSPAN4 | tetraspanin 4 | 6.16255 |
| MRPS18C | mitochondrial ribosomal protein S18C | 6.14973 |
| SLC34A3 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 | 6.1232 |
| SEPP1 | selenoprotein P, plasma, 1 | 6.08753 |
| SLC25A45 | solute carrier family 25, member 45 | 5.89302 |
| TMEM213 | transmembrane protein 213 | 5.87675 |
| NOXO1 | NADPH oxidase organizer 1 | 5.77545 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 5.68696 |
| VIPR2 | vasoactive intestinal peptide receptor 2 | 5.59065 |
| MAN1B1 | mannosidase, alpha, class 1B, member 1 | 5.57916 |
| RNH1 | ribonuclease/angiogenin inhibitor 1 | 5.54561 |
| TNRC6C | trinucleotide repeat containing 6C | 5.51257 |
| C11ORF21 | chromosome 11 open reading frame 21 | 5.47855 |
| DNAAF3 | dynein, axonemal, assembly factor 3 | 5.47365 |
| CTNS | cystinosin, lysosomal cystine transporter | 5.46585 |
| MGAT3 | mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase | 5.42775 |
| SLC46A1 | solute carrier family 46 (folate transporter), member 1 | 5.39695 |
| CYSRT1 | cysteine-rich tail protein 1 | 5.38431 |
| AIMP2 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 | 5.3575 |
| STAG3 | stromal antigen 3 | 5.34477 |
| IGSF22 | immunoglobulin superfamily, member 22 | 5.20333 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 5.183 |
| ACTL9 | actin-like 9 | 5.17911 |
| UBXN6 | UBX domain protein 6 | 5.11764 |
| ATP5E | ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit | 5.08984 |
| SKIV2L2 | superkiller viralicidic activity 2-like 2 (S. cerevisiae) | 4.92007 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 4.90708 |
| HYI | hydroxypyruvate isomerase (putative) | 4.89836 |
| ITGA7 | integrin, alpha 7 | 4.88225 |
| COA3 | cytochrome c oxidase assembly factor 3 | 4.83471 |
| OGG1 | 8-oxoguanine DNA glycosylase | 4.8298 |
| ZNF627 | zinc finger protein 627 | 4.75928 |
| FANCA | Fanconi anemia, complementation group A | 4.73441 |
| SLC24A5 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 | 4.7146 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 4.70331 |
| NOC2L | nucleolar complex associated 2 homolog (S. cerevisiae) | 4.69593 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 4.64269 |
| RHOC | ras homolog family member C | 4.61446 |
| INSL6 | insulin-like 6 | 4.606 |
| SLC9A3 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 | 4.53737 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | 4.53061 |
| PTOV1 | prostate tumor overexpressed 1 | 4.47174 |
| DPAGT1 | dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) | 4.43078 |
| PTCH1 | patched 1 | 4.31121 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RAB31 | RAB31, member RAS oncogene family | -20.0 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | -20.0 |
| SPC24 | SPC24, NDC80 kinetochore complex component | -20.0 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | -19.5229 |
| COL4A3BP | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | -17.8327 |
| UQCC2 | ubiquinol-cytochrome c reductase complex assembly factor 2 | -16.8321 |
| CDC42SE1 | CDC42 small effector 1 | -14.5217 |
| AFAP1 | actin filament associated protein 1 | -13.8533 |
| CTSB | cathepsin B | -13.7556 |
| RAPSN | receptor-associated protein of the synapse | -13.6099 |
| NOL7 | nucleolar protein 7, 27kDa | -13.5873 |
| ECHDC2 | enoyl CoA hydratase domain containing 2 | -13.4469 |
| MROH5 | maestro heat-like repeat family member 5 | -13.4413 |
| BRD7 | bromodomain containing 7 | -13.3213 |
| UFSP2 | UFM1-specific peptidase 2 | -12.8906 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -12.4651 |
| HDDC2 | HD domain containing 2 | -12.2111 |
| HDLBP | high density lipoprotein binding protein | -12.0737 |
| LHFPL5 | lipoma HMGIC fusion partner-like 5 | -11.6515 |
| DHX8 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | -11.3471 |
| SH3D21 | SH3 domain containing 21 | -11.0855 |
| NECAB1 | N-terminal EF-hand calcium binding protein 1 | -10.9983 |
| LDLRAD2 | low density lipoprotein receptor class A domain containing 2 | -9.52702 |
| JMJD1C | jumonji domain containing 1C | -9.28905 |
| PNCK | pregnancy up-regulated nonubiquitous CaM kinase | -9.26017 |
| ZNF446 | zinc finger protein 446 | -7.76045 |
| C12ORF73 | chromosome 12 open reading frame 73 | -7.76045 |
| NARFL | nuclear prelamin A recognition factor-like | -7.63588 |
| GPR137 | G protein-coupled receptor 137 | -7.62035 |
| EPHA1 | EPH receptor A1 | -7.24279 |
| APOM | apolipoprotein M | -7.14208 |
| ATXN2 | ataxin 2 | -7.08847 |
| C19ORF80 | chromosome 19 open reading frame 80 | -7.05779 |
| TFIP11 | tuftelin interacting protein 11 | -6.60908 |
| TCP1 | t-complex 1 | -6.57856 |
| PEX14 | peroxisomal biogenesis factor 14 | -6.51903 |
| SNRNP35 | small nuclear ribonucleoprotein 35kDa (U11/U12) | -6.09213 |
| SAR1B | secretion associated, Ras related GTPase 1B | -6.06062 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | -6.00769 |
| NCAPG | non-SMC condensin I complex, subunit G | -5.95877 |
| STAT5A | signal transducer and activator of transcription 5A | -5.86482 |
| UQCC3 | ubiquinol-cytochrome c reductase complex assembly factor 3 | -5.8383 |
| SH2D7 | SH2 domain containing 7 | -5.71473 |
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | -5.61567 |
| PKD2L2 | polycystic kidney disease 2-like 2 | -5.61006 |
| UHRF1BP1 | UHRF1 binding protein 1 | -5.58887 |
| COL5A1 | collagen, type V, alpha 1 | -5.5729 |
| CARD14 | caspase recruitment domain family, member 14 | -5.4798 |
| BTD | biotinidase | -5.38872 |
| BMP6 | bone morphogenetic protein 6 | -5.30546 |
| FAM35A | family with sequence similarity 35, member A | -5.22464 |
| DIMT1 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) | -5.22389 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -5.11506 |
| KIFC2 | kinesin family member C2 | -5.04 |
| UTS2B | urotensin 2B | -5.02085 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -5.0024 |
| PDHX | pyruvate dehydrogenase complex, component X | -4.75488 |
| DNASE1 | deoxyribonuclease I | -4.7037 |
| PHACTR1 | phosphatase and actin regulator 1 | -4.53405 |
| RNF34 | ring finger protein 34, E3 ubiquitin protein ligase | -4.46913 |
| GPLD1 | glycosylphosphatidylinositol specific phospholipase D1 | -4.41599 |
| OXSM | 3-oxoacyl-ACP synthase, mitochondrial | -4.41341 |
| PACS2 | phosphofurin acidic cluster sorting protein 2 | -4.38629 |
| IFT20 | intraflagellar transport 20 | -4.3696 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -4.30835 |
| METTL12 | methyltransferase like 12 | -4.28464 |
| C10ORF95 | chromosome 10 open reading frame 95 | -4.12446 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -4.0996 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | -4.01133 |
| ZNF154 | zinc finger protein 154 | -3.88496 |
| RNF207 | ring finger protein 207 | -3.87905 |
| LRRC41 | leucine rich repeat containing 41 | -3.81133 |
| DOPEY1 | dopey family member 1 | -3.7508 |
| KLC3 | kinesin light chain 3 | -3.73194 |
| NUDT19 | nudix (nucleoside diphosphate linked moiety X)-type motif 19 | -3.72671 |
| SLC9A5 | solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 | -3.67483 |
| SLC22A23 | solute carrier family 22, member 23 | -3.6202 |
| ACTN4 | actinin, alpha 4 | -3.59685 |
| TRIM37 | tripartite motif containing 37 | -3.57052 |
| FBXL15 | F-box and leucine-rich repeat protein 15 | -3.52313 |
| FBXO44 | F-box protein 44 | -3.49291 |
| FAM222B | family with sequence similarity 222, member B | -3.4827 |
| USP24 | ubiquitin specific peptidase 24 | -3.46489 |
| CCDC18 | coiled-coil domain containing 18 | -3.46084 |
| SATB2 | SATB homeobox 2 | -3.43192 |
| BCCIP | BRCA2 and CDKN1A interacting protein | -3.35287 |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | -3.33044 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -3.33044 |
| ZNF596 | zinc finger protein 596 | -3.26412 |
| ZFHX3 | zinc finger homeobox 3 | -3.19787 |
| VTI1B | vesicle transport through interaction with t-SNAREs 1B | -3.17318 |
| GJD3 | gap junction protein, delta 3, 31.9kDa | -3.08358 |
| C6ORF25 | chromosome 6 open reading frame 25 | -3.07811 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -3.04104 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | -3.04063 |
| ZNF706 | zinc finger protein 706 | -3.02634 |
| FAHD1 | fumarylacetoacetate hydrolase domain containing 1 | -3.01213 |
| SIK2 | salt-inducible kinase 2 | -2.95035 |
| SLC5A10 | solute carrier family 5 (sodium/sugar cotransporter), member 10 | -2.90422 |
| POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | -2.89995 |
