| Dataset | PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | KD perturbation targeting MAP3K7/CHD1 in LAPC4 cell line (Study accession: SRP310151) (PerturbAtlas) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Perturb_10412_KD_MAP3K7/CHD1_SRP310151 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP3K7 | mitogen-activated protein kinase kinase kinase 7 | 12.406 |
| SCNN1B | sodium channel, non voltage gated 1 beta subunit | 11.3108 |
| TTC9 | tetratricopeptide repeat domain 9 | 9.70096 |
| DPYSL2 | dihydropyrimidinase-like 2 | 8.31681 |
| DSC2 | desmocollin 2 | 7.80902 |
| TRPV6 | transient receptor potential cation channel, subfamily V, member 6 | 7.7709 |
| IGSF3 | immunoglobulin superfamily, member 3 | 7.34667 |
| TMEM38B | transmembrane protein 38B | 6.53145 |
| HLA-C | major histocompatibility complex, class I, C | 5.99564 |
| TMEM98 | transmembrane protein 98 | 5.5411 |
| CA8 | carbonic anhydrase VIII | 5.49822 |
| TMSB15A | thymosin beta 15a | 5.41078 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 5.32894 |
| RMI2 | RecQ mediated genome instability 2 | 5.14442 |
| LBR | lamin B receptor | 5.13795 |
| ASS1 | argininosuccinate synthase 1 | 5.0468 |
| SCD5 | stearoyl-CoA desaturase 5 | 5.0468 |
| SLC18B1 | solute carrier family 18, subfamily B, member 1 | 5.02074 |
| KCNG1 | potassium channel, voltage gated modifier subfamily G, member 1 | 4.88543 |
| TUBA1B | tubulin, alpha 1b | 4.83674 |
| PTK7 | protein tyrosine kinase 7 (inactive) | 4.64379 |
| VCX3B | variable charge, X-linked 3B | 4.59857 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 4.58628 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 4.57789 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 4.21586 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 4.03426 |
| CENPM | centromere protein M | 3.9751 |
| SUSD4 | sushi domain containing 4 | 3.92456 |
| BIRC5 | baculoviral IAP repeat containing 5 | 3.88714 |
| E2F2 | E2F transcription factor 2 | 3.83401 |
| HUNK | hormonally up-regulated Neu-associated kinase | 3.81592 |
| FOXQ1 | forkhead box Q1 | 3.7666 |
| RAB34 | RAB34, member RAS oncogene family | 3.59593 |
| CHST1 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | 3.55426 |
| SLC39A11 | solute carrier family 39, member 11 | 3.55426 |
| ATP6AP2 | ATPase, H+ transporting, lysosomal accessory protein 2 | 3.54023 |
| PADI2 | peptidyl arginine deiminase, type II | 3.51928 |
| HOPX | HOP homeobox | 3.46732 |
| PPAPDC1A | phosphatidic acid phosphatase type 2 domain containing 1A | 3.46511 |
| WSB2 | WD repeat and SOCS box containing 2 | 3.43841 |
| PDLIM3 | PDZ and LIM domain 3 | 3.42641 |
| PHGDH | phosphoglycerate dehydrogenase | 3.36361 |
| CD164 | CD164 molecule, sialomucin | 3.34758 |
| BCL11B | B-cell CLL/lymphoma 11B (zinc finger protein) | 3.30018 |
| PDXP | pyridoxal (pyridoxine, vitamin B6) phosphatase | 3.2523 |
| LPPR1 | lipid phosphate phosphatase-related protein type 1 | 3.17275 |
| PFKP | phosphofructokinase, platelet | 3.15346 |
| ATL2 | atlastin GTPase 2 | 3.15346 |
| SMC1A | structural maintenance of chromosomes 1A | 3.12594 |
| HMGB2 | high mobility group box 2 | 3.09647 |
| GALNT16 | polypeptide N-acetylgalactosaminyltransferase 16 | 3.09126 |
| AURKB | aurora kinase B | 3.08303 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 3.07269 |
| CDCA5 | cell division cycle associated 5 | 3.05691 |
| RRM2 | ribonucleotide reductase M2 | 3.01428 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 2.99584 |
| PXDN | peroxidasin | 2.99584 |
| FGFR3 | fibroblast growth factor receptor 3 | 2.99254 |
| CORO2A | coronin, actin binding protein, 2A | 2.98299 |
| PRKCH | protein kinase C, eta | 2.95984 |
| TMEM170B | transmembrane protein 170B | 2.95035 |
| EFR3B | EFR3 homolog B (S. cerevisiae) | 2.9094 |
| FZD3 | frizzled class receptor 3 | 2.90729 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 2.83714 |
| FGD5 | FYVE, RhoGEF and PH domain containing 5 | 2.79732 |
| RASSF5 | Ras association (RalGDS/AF-6) domain family member 5 | 2.79235 |
| ACOT7 | acyl-CoA thioesterase 7 | 2.76691 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 2.72114 |
| PCNA | proliferating cell nuclear antigen | 2.72106 |
| SLCO5A1 | solute carrier organic anion transporter family, member 5A1 | 2.71469 |
| ASCL2 | achaete-scute family bHLH transcription factor 2 | 2.70378 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 2.65916 |
| CDC45 | cell division cycle 45 | 2.65115 |
| KIAA0040 | KIAA0040 | 2.65115 |
| HMGB1 | high mobility group box 1 | 2.60945 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | 2.5958 |
| B3GAT1 | beta-1,3-glucuronyltransferase 1 | 2.58256 |
| REEP3 | receptor accessory protein 3 | 2.4551 |
| SKA1 | spindle and kinetochore associated complex subunit 1 | 2.44815 |
| ASF1B | anti-silencing function 1B histone chaperone | 2.43839 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 2.43435 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 2.41102 |
| STAP2 | signal transducing adaptor family member 2 | 2.41074 |
| FAM64A | family with sequence similarity 64, member A | 2.38149 |
| HIPK3 | homeodomain interacting protein kinase 3 | 2.3255 |
| MT2A | metallothionein 2A | 2.32232 |
| SMYD2 | SET and MYND domain containing 2 | 2.31762 |
| WDR62 | WD repeat domain 62 | 2.31693 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.29507 |
| KIF22 | kinesin family member 22 | 2.27231 |
| FANCG | Fanconi anemia, complementation group G | 2.27216 |
| MCM3 | minichromosome maintenance complex component 3 | 2.26797 |
| LMNB1 | lamin B1 | 2.25994 |
| KIFAP3 | kinesin-associated protein 3 | 2.25912 |
| ATAD5 | ATPase family, AAA domain containing 5 | 2.23635 |
| SLC22A15 | solute carrier family 22, member 15 | 2.20679 |
| TENM3 | teneurin transmembrane protein 3 | 2.20544 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 | 2.18751 |
| KIFC1 | kinesin family member C1 | 2.18118 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 2.17715 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -20.0 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | -20.0 |
| PTPRT | protein tyrosine phosphatase, receptor type, T | -20.0 |
| SDC2 | syndecan 2 | -20.0 |
| COL12A1 | collagen, type XII, alpha 1 | -20.0 |
| BGN | biglycan | -20.0 |
| PGC | progastricsin (pepsinogen C) | -20.0 |
| PPP1R1B | protein phosphatase 1, regulatory (inhibitor) subunit 1B | -20.0 |
| IFI44L | interferon-induced protein 44-like | -20.0 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -20.0 |
| CLDN1 | claudin 1 | -19.301 |
| KRT15 | keratin 15, type I | -17.1624 |
| TGFB2 | transforming growth factor, beta 2 | -16.9527 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -16.7247 |
| STAC2 | SH3 and cysteine rich domain 2 | -16.7109 |
| NEURL1 | neuralized E3 ubiquitin protein ligase 1 | -15.9645 |
| BRINP1 | bone morphogenetic protein/retinoic acid inducible neural-specific 1 | -15.666 |
| VSTM2A | V-set and transmembrane domain containing 2A | -15.3899 |
| CLEC7A | C-type lectin domain family 7, member A | -15.2333 |
| LRP2 | low density lipoprotein receptor-related protein 2 | -15.0104 |
| GABRB2 | gamma-aminobutyric acid (GABA) A receptor, beta 2 | -14.7748 |
| CA1 | carbonic anhydrase I | -14.3011 |
| THBS1 | thrombospondin 1 | -13.5689 |
| UNC5B | unc-5 homolog B (C. elegans) | -12.3731 |
| PRSS23 | protease, serine, 23 | -11.6965 |
| SH3PXD2A | SH3 and PX domains 2A | -11.6402 |
| CDK6 | cyclin-dependent kinase 6 | -11.4317 |
| ADRA2A | adrenoceptor alpha 2A | -11.3907 |
| KRT6A | keratin 6A, type II | -11.1415 |
| STEAP4 | STEAP family member 4 | -10.6838 |
| CLU | clusterin | -10.6464 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | -10.5418 |
| NLGN1 | neuroligin 1 | -10.3107 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -10.2225 |
| KRT16 | keratin 16, type I | -10.1377 |
| LMCD1 | LIM and cysteine-rich domains 1 | -10.0474 |
| FSTL5 | follistatin-like 5 | -9.37868 |
| LBH | limb bud and heart development | -9.36516 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -8.37473 |
| SLC43A1 | solute carrier family 43 (amino acid system L transporter), member 1 | -8.13913 |
| KRT14 | keratin 14, type I | -8.03158 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -8.00315 |
| SOCS2 | suppressor of cytokine signaling 2 | -7.80857 |
| NAV2 | neuron navigator 2 | -7.75724 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -7.74906 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -7.7264 |
| PCDH9 | protocadherin 9 | -7.68759 |
| CBLN2 | cerebellin 2 precursor | -7.61288 |
| ITM2C | integral membrane protein 2C | -7.54437 |
| CCDC141 | coiled-coil domain containing 141 | -7.27738 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -7.25409 |
| CNTN1 | contactin 1 | -7.1794 |
| FREM3 | FRAS1 related extracellular matrix 3 | -7.00914 |
| ADAM23 | ADAM metallopeptidase domain 23 | -6.87004 |
| RAP1GAP | RAP1 GTPase activating protein | -6.72506 |
| RALYL | RALY RNA binding protein-like | -6.66346 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -6.64131 |
| TSPAN1 | tetraspanin 1 | -6.58719 |
| RHOBTB1 | Rho-related BTB domain containing 1 | -6.53145 |
| PCDH7 | protocadherin 7 | -6.41562 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -6.36227 |
| STEAP3 | STEAP family member 3, metalloreductase | -6.28508 |
| GABRA2 | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | -6.28508 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -6.13822 |
| NOV | nephroblastoma overexpressed | -6.13822 |
| SYT11 | synaptotagmin XI | -6.09936 |
| CPAMD8 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | -6.02518 |
| SLC40A1 | solute carrier family 40 (iron-regulated transporter), member 1 | -5.99564 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -5.99564 |
| ALCAM | activated leukocyte cell adhesion molecule | -5.91198 |
| NFIB | nuclear factor I/B | -5.90554 |
| ETNK2 | ethanolamine kinase 2 | -5.81872 |
| PDZRN3 | PDZ domain containing ring finger 3 | -5.79357 |
| KRT80 | keratin 80, type II | -5.79357 |
| ZPLD1 | zona pellucida-like domain containing 1 | -5.71837 |
| EPDR1 | ependymin related 1 | -5.6738 |
| SCGN | secretagogin, EF-hand calcium binding protein | -5.54114 |
| GHR | growth hormone receptor | -5.41078 |
| CNTN5 | contactin 5 | -5.41078 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -5.23859 |
| IFI44 | interferon-induced protein 44 | -5.0875 |
| RND3 | Rho family GTPase 3 | -5.00077 |
| CYP4F8 | cytochrome P450, family 4, subfamily F, polypeptide 8 | -4.9821 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | -4.95419 |
| PPL | periplakin | -4.92581 |
| ENPP3 | ectonucleotide pyrophosphatase/phosphodiesterase 3 | -4.83446 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -4.81022 |
| BIN1 | bridging integrator 1 | -4.79581 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -4.78937 |
| FOSL2 | FOS-like antigen 2 | -4.64703 |
| NETO1 | neuropilin (NRP) and tolloid (TLL)-like 1 | -4.64703 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -4.46803 |
| TLL2 | tolloid-like 2 | -4.37709 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | -4.37564 |
| TRIP6 | thyroid hormone receptor interactor 6 | -4.33796 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -4.28555 |
| S1PR3 | sphingosine-1-phosphate receptor 3 | -4.20961 |
| MACC1 | metastasis associated in colon cancer 1 | -4.18156 |
| SATB1 | SATB homeobox 1 | -4.16982 |
| KRT5 | keratin 5, type II | -4.16249 |
